Methods for modulating proteins not previously known as proteases

ABSTRACT

The present invention relates to the proteins not previously identified as proteases; the use of those peptides in screening for compounds that modulate protease activity; treating individuals in need of treatment with the compounds or proteases; and in methods for diagnosing a disease or disorder associated with a protease of the instant invention.

FIELD OF THE INVENTION

[0001] The present invention relates to enzymes which, hitherto, have not been used to hydrolyze peptide bonds and have not been identified as having proteolytic activity, and their novel use as proteases and to the identification of compounds that modulate their protease activity. The invention also relates to the use of the novel proteases and identified compounds to treat individuals having a disease or disorder involving a protease-mediated pathway.

BACKGROUND

[0002] Proteases are enzymes that breakdown peptide bonds by irreversibly catalyzing the hydrolysis of bond(s) in substrates. They are generally classified as either exopeptidases that cleave amino acids from the ends of a protein, or as endopeptidases, which cleave peptide bonds within the protein. Some recognize specific sequences and cleave proteins only once or twice, while others degrade proteins completely into amino acids. Some proteases are secreted to cause the destruction of proteins in extracellular material while others are secreted into an area, such as the stomach, to breakdown proteins, such as those present in foods. Others are involved in regulating physiological processes via biological cascades, and may be expressed intracellularly or extracellularly and may be soluble membrane anchored or integral membrane proteins.

[0003] Proteolytic mechanisms are involved in a large number of diverse processes within the body. Their normal functions include modulation of apoptosis (caspases) (Salvesen and Dixon, Cell, 1997, 91:443-46), control of blood pressure (renin, angiotensin-converting enzymes) (van Hooft et al., 1991, N Engl J Med. 324(19):1305-11, and chapters 254 and 359 in Barrett et al., HANDBOOK OF PROTEOLYTIC ENZYMES, 1998, Academic Press, San Diego), tissue remodeling and tumor invasion (collagenase) (Vu et al., 1998, Cell 93:411-22, Werb, 1997, Cell, 91:439-442), development of Alzheimer's Disease (.beta.-secretase) (De Strooper et al., 1999, Nature 398:518-22), protein turnover and cell-cycle regulation (proteosome) (Bastians et al., 1999, Mol. Biol. Cell. 10:3927-41, Gottesman, et al., 1997, Cell, 91:435-38, Larsen et al., 1997, Cell, 91:431-34), inflammation (TNF-.alpha. convertase) (Black et al., Nature, 1997, 385:729-33), and protein turnover (Bochtler et al., 1999, Annu. Rev. Biophys Biomol Struct.28:295-317). Proteases may be classified into several major groups including serine proteases, cysteine proteases, aspartyl proteases, metalloproteases, threonine proteases, and other proteases.

[0004] 1. Aspartyl Proteases

[0005] Aspartyl proteases, also known as acid proteases, are a widely distributed family of proteolytic enzymes in vertebrates, fungi, plants, retroviruses and some plant viruses. Aspartate proteases of eukaryotes are monomeric enzymes which consist of two domains. Each domain contains an active site centered on a catalytic aspartyl residue. The two domains most probably evolved from the duplication of an ancestral gene encoding a primordial domain. Enzymes in this class include cathepsin E, renin, presenilin (PS 1), and the APP secretases.

[0006] 2. Cysteine Proteases

[0007] Another class of proteases which perform a wide variety of functions within the body are the cysteine proteases. Among their roles are the processing of precursor proteins, and intracelluar degradation of proteins marked for disposal via the ubiquitin pathway. Eukaryotic cysteine proteases are a family of proteolytic enzymes which contain an active site cysteine. Catalysis proceeds through a thioester intermediate and is facilitated by a nearby histidine side chain; an asparagine completes the essential catalytic triad. Peptidases in this family with important roles in disease include the caspases, calpain, hedgehog, and Ubiquitin hydolases.

[0008] Cysteine proteases are produced by a large number of cells including those of the immune system (macrophages, monocytes, etc.). These immune cells exercise their protective role in the body, in part, by migrating to sites of inflammation and secreting molecules, among the secreted molecules are cysteine proteases.

[0009] Under some conditions, the inappropriate regulation of cysteine proteases of the immune system can lead to autoimmune diseases such as rheumatoid arthritis. For example, the over-secretion of the cysteine protease cathepsin C causes the degradation of elastin, collagen, laminin, and other structural proteins found in bones. Bone subjected to this inappropriate digestion is more susceptible to metastasis.

[0010] Caspase—Apopotosis

[0011] A cascade of protease reactions is believed to be responsible for the apoptotic changes observed in mammalian cells undergoing programmed cell death. This cascade involves many members of the aspartate-specific cysteine proteases of the caspase family, including caspases 2, 3, 6, 7, 8 and 10 (Salvesen and Dixit, Cell 1997, 91:443-446). Cancer cells that escape apoptotic signals, generated by cytotoxic chemotherapeutics or loss of normal cellular survival signals (as in metastatic cells), can go on to develop palpable tumors.

[0012] Calpain—Axonal Death, Dystrophies

[0013] Calcium-dependent cysteine proteases, collectively called calpain, are widely distributed in mammalian cells (Wang, 2000, Trends Neurosci. 23(1):20-26). The calpains are nonlysosomal intracellular cysteine proteases. The mammalian calpains include 2 ubiquitous proteins, CAPN1 and CAPN2, as well as 2 stomach-specific proteins, and CAPN3, which is muscle-specific (Herasse et al., 1999, Mol. Cell. Biol. 19(6):4047-55). The ubiquitous enzymes consist of heterodimers with distinct large subunits associated with a common small subunit, all of which are encoded by different genes. The large subunits of calpains can be subdivided into 4 domains; domains I and III, whose functions remain unknown, show no homology with known proteins. The former, however, may be important for the regulation of the proteolytic activity. Domain II shows similarity with other cysteine proteases, which share histidine, cysteine, and asparagine residues at their active sites. Domain IV is calmodulin-like. CAPN5 and CAPN6 differ from previously identified vertebrate calpains in that they lack a calmodulin-like domain IV (Ohno et al., 1990, Cytogenet. Cell Genet. 53(4):225-29).

[0014] Hedgehog—Cancer

[0015] The organization and morphology of the developing embryo are established through a series of inductive interactions. One family of vertebrate genes has been described related to the Drosophila gene ‘hedgehog’ (hh) that encodes inductive signals during embryogenesis (Johnson and Tabin, 1997, Cell 90:979-990). “Hedgehog” encodes a secreted protein that is involved in establishing cell fates at several points during Drosophila development (Marigo et al., 1995, Genomics 28:44-51). There are three known mammalian homologs of hh: Sonic hedgehog (Shh), Indian hedgehog (Ihh), and desert hedgehog (Dhh) (Johnson and Tabin, 1997, Cell 90:979-990). Like its Drosophila cognate, Shh encodes a signal that is instrumental in patterning the early embryo. It is expressed in Hensen's node, the floorplate of the neural tube, the early gut endoderm, the posterior of the limb buds, and throughout the notochord (Chiang et al., 1996, Nature 383:407-413). It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Oro et al., Science 276: 817-821, 1997, showed that transgenic mice overexpressing SHH in the skin developed many features of the basal cell nevus syndrome, demonstrating that SHH is sufficient to induce basal cell carcinomas (BCCs) in mice. The data suggested that SHH may have a role in human tumorigenesis. Activating mutations of SHH or another ‘hedgehog’ gene may be an alternative pathway for BCC formation in humans. The human mutation his 133tyr (his 134tyr in mouse) is a candidate. It is distinct from loss-of-function mutations reported for individuals with holoprosencephaly (Oro et al., 1997, Science 276:817-821). His 133 lies adjacent in the catalytic site to his 134, one of the conserved residues thought to be necessary for catalysis. SHH may be a dominant oncogene in multiple human tumors, a mirror of the tumor suppressor activity of the opposing ‘patched’ (PTCH) gene (Aszterbaum et al., 1998, J. Invest. Derm. 110:885-888). The rapid and frequent appearance of Shh-induced tumors in the mice suggested that disruption of the SHH-PTC pathway is sufficient to create BCCs.

[0016] Ubiquitin Hydrolases—Apoptosis, Checkpoint Integrity

[0017] Ubiquitin carboxyl-terminal hydrolases (3.1.2.15) (deubiquitinating enzymes) are thiol proteases that recognize and hydrolyze the peptide bond at the C-terminal glycine of ubiquitin. These enzymes are involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins. In eukaryotic cells, the covalent attachment of ubiquitin to proteins plays a role in a variety of cellular processes. In many cases, ubiquitination leads to protein degradation by the 26S proteasome. Protein ubiquitination is reversible, and the removal of ubiquitin is catalyzed by deubiquitinating enzymes, or DUBs. A defect in these enzymes, catalyzing the removal of ubiquitin from ubiquinated proteins, may be characteristic of neurodegenerative diseases such as Alzheimer's, Parkinson's, progressive supranuclear palsy, and Pick's and Kuf's disease. Papain—Cathepsins K S and B, are also useful for bone resorbtion, and Ag processing (Prosite PS00139).

[0018] Cysteine Protease AEP

[0019] The cysteine protease AEP plays another role in the immune functions. It has been implicated in the protease step required for antigen processing in B cells. Manouryetal. Nature 396:695-699 (1998).

[0020] 3. Metalloproteases

[0021] Collagenase—Invasion

[0022] Matrix degradation is an essential step in the spread of cancer. The 72- and 92-kD type IV collagenases are members of a group of secreted zinc metalloproteases which, in mammals, degrade the collagens of the extracellular matrix. Other members of this group include interstitial collagenase and stromelysin (Nagase et al., 1992, Matrix Suppl. 1:421-424). By targeted disruption in embryonic stem cells, Vu et al. (Cell, 1998, 934:11-22) created homozygous mice with a null mutation in the MMP9/gelatinase B gene. These mice exhibited an abnormal pattern of skeletal growth plate vascularization and ossification. Growth plates from MMP9-null mice in culture showed a delayed release of an angiogenic activator, establishing a role for this proteinase in controlling angiogenesis.

[0023] MMP2 (gelatinase A) have been associated with the aggressiveness of human cancers (Chenard et al., 1999, Int. J. Cancer, 82:208-12). In a study comparing basal cell carcinomas (BCC) with the more aggressive squamous cell carcinomas (SCC), both MMP2 and MMP9 were expressed at a higher level in SCC (Dumas et al., 1999, Anticancer Res., 19(4B):2929-38). Additionally, expression of MMP2 and MMP9 in T lymphocytes has recently been shown to be modulated by the Ras/MAP kinase signaling pathways (Esparza et al., 1999, Blood, 94:2754-66) (see also, Li et al., 1998, Biochim. Biophys. Acta, 1405:110-20).

[0024] ADAMS—TNF, Inflammation Growth Factor Processing

[0025] The ADAM peptidases are a family of proteins containing a disintegrin and metalloproteinase (ADAM) domain (Werb and Yan, Science, 1998, 282:1279-1280). Members of this family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains (Primakoff and Myles, Trends in Genet., 2000, 16:83-87). Activity of these proteases can be linked to TNF, inflammation, and/or growth factor processing.

[0026] ADAM proteases have also been characterized as having a pro- and metalloproteinase domain, a disintegrin domain, a cysteine-rich region and an EGF repeat (Blobel, 1997, Cell, 90:589-592 which is hereby incorporated herein by reference in its entirety including any figures, tables, or drawings). They have been associated with the release from the plasma membrane of numerous proteins including Tumor Necrosis Factor-.alpha. (TNF-.alpha.), kit-ligand, TGF.alpha., Fas-ligand, cytokine receptors such as the 11-6 receptor and the NGF receptor, as well as adhesion proteins such as L-selectin, and the b amyloid precursor proteins (Blobel, 1997, Cell, 90:589-592).

[0027] Tumor necrosis factor-.alpha. is synthesized as a proinflammatory cytokine from a 233-amino acid precursor. Conversion of the membrane-bound precursor to a secreted mature protein is mediated by a protease termed TNF-.alpha. convertase. TNF-.alpha. is involved in a variety of diseases. ADAM17, which contains a disintegrin and metalloproteinase domains, is also called ‘tumor necrosis factor-.alpha. converting enzyme’ (TACE) (Black et al., Nature, 1997, 385:729-33). The gene encodes an 824-amino acid polypeptide containing the features of the ADAM family: a secretory signal sequence, a disintegrin domain, and a metalloprotease domain. Expression studies showed that the encoded protein cleaves precursor tumor necrosis factor-.alpha. to its mature form. This enzyme may also play a role in the processing of Transforming Growth Factor-.alpha. (TGF-.alpha.), as mice which lack the gene are similar in phenotype to those that lack TGF-.alpha. (Peschon et al., Science, 282:1281-1284, 1998).

[0028] Neprylisin—Endothelin-Converting Enzyme

[0029] Carboxypeptidases specifically remove COOH-terminal basic amino acids (arginine or lysine). They have important functions in many biologic processes, including activation, inactivation, or modulation of peptide hormone activity, neurotransmitter processing, and alteration of physical properties of proteins and enzymes.

[0030] Dipeptidase—ACE

[0031] Angiotensin I converting enzyme (EC 3.4.15.1), or kininase II, is adipeptidyl carboxypeptidase that plays an important role in blood pressure regulation and electrolyte balance by hydrolyzing angiotensin I into angiotensin II, a potent vasopressor, andaldosterone-stimulating peptide. The enzyme is also able to inactivate bradykinin, a potent vasodilator. Although angiotensin-converting enzyme has been studied primarily in the context of its role in blood pressure regulation, this widely distributed enzyme has many other physiologic functions. There are two forms of ACE: a testis-specific isozyme and a somatic isozyme which has two active centers.

[0032] Matrix Metalloproteases—Tissue Remodeling and Inflammation

[0033] The matrix metalloproteases (MMPs) are a family of related matrix-degrading enzymes that are important in tissue remodeling and repair during development and inflammation (Belotti et al., 1999, Int. J. Biol. Markers 14(4):232-38). Abnormal expression is associated with various diseases such as tumor invasiveness (Johansson and Kahari, 2000, Histol. Histopathol. 15(I):225-37), arthritis (Malemud et al., 1999, Front. Biosci. 4:D762-71), and atherosclerosis (Nagase, 1997, Biol. Chem. 378(3-4):151-60). MMP activity may also be related to tobacco-induced pulmonary emphysema (Dhami et al., Am. J. Respir. Cell Mol. Biol., 2000, 22:244-52).

[0034] Metalloprotease Processing of Growth Factors

[0035] In addition to the processing of TGF-.alpha. described above, metalloproteases have been directly demonstrated to be active in the processing of the precursor of other growth factors such as heparin-binding EGF (proHB-EFG) (Izumi et al., EMBO J, 1998,17:7260-72), and amphiregulin (Brown et al., 1998, J. Biol. Chem., 27:17258-68).

[0036] Additionally, metalloproteases have recently been shown to be instrumental in the communication whereby stimulation of a GPCR pathway results in stimulation of the MAP kinase pathway (Prenzel et al., 1999, Nature, 402:884-888). The growth factor intermediate in the pathway, HB-EGF is released by the cell in a proteolytic step regulated by the GPCR pathway involving an uncharacterized metalloprotease. After release, the HB-EGF is bound by the extracellular matrix and then presented to the EGF receptors on the surface, resulting in the activation of the MAP kinase pathway (Prenzel et al., 1999, Nature, 402:884-888).

[0037] A recent study by Gallea-Robache et al., 1997, Cytokine,(5):340-6, has also implicated a metalloprotease family displaying different substrate specificites in the shedding of other growth factors including macrophage colony-stimulating factor (M-CSF) and stem cell factor (SCF) (Gallea-Robache et al., 1997, Cytokine 9:340-46). The shedding of M-CSF (also known as CSF-1) has been linked to activation of Protein Kinase C by phorbol esters (Stein et al., 1991, Oncogene, 6:601-05).

[0038] 4. Serine Proteases

[0039] The serine proteases are a class which includes trypsin, kallikrein, chymotrypsin, elastase, thrombin, tissue plasminogen activator (tpA), urokinase plasminogen activator (uPA), plasmin (Werb, Cell, 1997, 91:439-442), kallikrein (Clements, Biol. Res., 1998, 31(3): 151-59), and cathepsin G (Shamamian et al., Surgery, 2000, 127:142-47). These proteases have in common a well-conserved catalytic triad of amino acid residues in their active site consisting of histidine-57, aspartic acid-102, and serine-195 (using the chymotrypsin numbering system). Serine protease activity has been linked to coagulation and they may have use as tumor markers.

[0040] Serine proteases can be further subclassified by their specificity in substrates. The elastases prefer to cleave substrates adjacent to small aliphatic residues such as valine, chymases prefer to cleave near large aromatic hydrophobic residures, and tryptases prefer positively charged residues. One additional class of serine protease has been described recently which prefers to cleave adjacent to a proline. This prolyl endopeptidase has been implicated in the progression of memory loss in Alzheimer's patients (Toide et al., 1998, Rev. Neurosci. 9(1):17-29).

[0041] A partial list of proteases known to belong to this large and important family include: blood coagulation factors VII, IX, X, XI and XII; thrombin; plasminogen; complement components C1r, C1s, C2; complement factors B, D and I; complement-activating component of RA-reactive factor; elastases 1, 2, 3A, 3B (protease E); hepatocyte growth factor activator; glandular (tissue) kallikreins including EGF-binding protein types A, B, and C; NGF-.gamma. chain, gamma.-renin, and prostate specific antigen (PSA); plasma kallikrein; mast cell proteases; myeloblastin (proteinase 3) (Wegener's autoantigen); plasminogen activators (urokinase-type, and tissue-type); and the trypsins I, II, III, and IV. These peptidases play key roles in coagulation, tumorigenesis, control of blood pressure, release of growth factors, and other roles. (http://www.babraham.co.uk/Merops/Merops.htm).

[0042] 5. Threonine Peptidases—(Prosite PDOC00326/PDOC00668) Proteasomal Subunits

[0043] The proteasome is a multicatalytic threonine proteinase complex involved in ATP/ubiquitin dependent non-lysosomal proteolysis of cellular substrates. It is responsible for selective elimination of proteins with aberrant structures, as well as naturally occurring short-lived proteins related to metabolic regulation and cell-cycle progression (Momand et al., 2000, Gene 242(1-2):15-29, Bochtler et al., 1999, Annu. Rev. Biophys Biomol Struct.28:295-317). The proteasome inhibitor lactacystin reversibly inhibits proliferation of human endothelial cells, suggesting a role for proteasomes in angiogenesis (Kumeda, et al., Anticancer Res. 1999 September-October; 19(5B):3961-8). Another important function of the proteasome in higher vertebrates is to generate the peptides presented on MHC-class 1 molecules to circulating lymphocytes (Castelli et al., 1997, Int. J. Clin. Lab. Res. 27(2):103-10). The proteasome has a sedimentation coefficient of 26S and is composed of a 20S catalytic core and a 22S regulatory complex. Eukaryotic 20S proteasomes have a molecular mass of 700 to 800 kD and consist of a set of over 15 kinds of polypeptides of 21 to 32 kD. All eukaryotic 20S proteasome subunits can be classified grossly into 2 subfamilies, alpha. and beta., by their high similarity with either the alpha. or .beta. subunits of the archaebacterium Thermoplasma acidophilum (Mayr et al., 1999, Biol. Chem. 380(10):1183-92). Several of the components have been identified as threonine peptidases, suggesting that this class of peptidases plays a key role in regulating metabolic pathways and cell-cycle progression, among other functions (Yorgin et al., 2000, J. Immunol 164(6):2915-23).

[0044] 6. Peptidases of Unknown Catalytic Mechanism

[0045] The prenyl-protein specific protease responsible for post-translational processing of the Ras proto-oncogene and other prenylated proteins falls into this class. This class also includes several viral peptidases that may play a role in mammalian infection, including cardiovirus endopeptidase 2A (encephalomyocarditis virus) (Molla et al., 1993, J. Virol 67(8):4688-95), NS2-3 protease (hepatitis C virus) (Blight et al., 1998, Antivir. Ther. 3(Suppl 3):71-81), endopeptidase (infectious pancreatic necrosis virus) (Lejal et al., J. Gen. Virol., 2000, 81:983-992), and the Npro endopeptidase (hog cholera virus) (Tratschin et al., 1998, J. Virol. 72(9):7681-84).

[0046] Consequently, proteases, as well as protease agonists and antagonists, are useful as therapeutic agents in treating various conditions or diseases and in diagnostic and research practices.

[0047] Proteases are also of commercial and industrial importance, as they are used to process leather and wool, produce food and beverages and to manufacture of cleaning products.

SUMMARY

[0048] The present disclosure identifies the proteins having SEQ ID NOs 1-92 as proteases where the sequences had not been so identified. As a result, the present invention is directed to a method of identifying a test or endogenous compound that modulates the protease activity of a protein selected from the group consisting of SEQ ID NOs. 1-92, or a functional variant thereof, comprising (i) combining (a) a protease comprising a sequence of any one of SEQ ID NOs. 1-92, or a functional variant or fragment thereof, (b) a compound and (c) a substrate for said protein and (ii) detecting an alteration in the interactions between the protease and the substrate in the presence and absence of the test compound.

[0049] Thus the present invention provides proteases described in any one of SEQ ID NOs. 1-92. See “List 1” below. The present invention also provides nucleic acid sequences encoding proteins described in any one of SEQ ID NOs. 1-92.

[0050] Thus, the present invention contemplates a method of cleaving a peptide bond in a desired protein comprising contacting said desired protein with a protease comprising a sequence selected from the group consisting of SEQ ID NOs. 1-92, under conditions wherein the protease hydrolyzes at least one peptide bond in the desired protein.

[0051] Another embodiment is to a method for identifying a compound that modulates the activity of a protease comprising, (a) contacting a protease having an amino acid sequence selected from the group consisting SEQ ID NOs. 1-92 or a functional fragment or variant thereof, with a test compound; (b) measuring the activity of said protease before and after said contacting step; and (c) determining whether said test compound modulates the activity of said protease.

[0052] In one embodiment, the method further comprises contacting a substrate for the protease before and after contacting the protease with the test compound. In another embodiment, the detecting step comprises measuring the level of proteolytic activity. In another embodiment, this detecting step comprises measuring the amount of product generated from cleavage of the substrate by the protease. In yet another embodiment, the test compound is an inhibitor of proteolytic function of the protease. In another embodiment, the test compound is a competitive inhibitor. In one other embodiment, the test compound is an activator of proteolytic function of the protease.

[0053] The present invention also contemplates a method for identifying a compound that modulates the activity of a protease in a cell comprising (a) expressing, in a cell, a protease having an amino acid sequence selected from the group consisting SEQ ID NOs 1-92; (b) exposing said cell to a test compound; and (c) monitoring an alteration in cell phenotype or proteolytic activity.

[0054] In another embodiment, the invention envisions method for treating a disease or disorder by administering to a patient in need of such treatment a compound that modulates the activity of a protease having an amino acid sequence selected from the group consisting of SEQ ID NOs 1-92. In one embodiment, the compound modulates protease activity in vitro. In another embodiment, the compound is a protease inhibitor.

[0055] In yet another aspect of the present invention, there is provided a method for detection of a protease in a sample as a diagnostic tool for a disease or disorder, comprising (a) contacting the sample with a nucleic acid probe which hybridizes under hybridization assay conditions to a nucleic acid target encoding a protease having an amino acid sequence selected from the group consisting of SEQ ID NOs 1-92, or fragments thereof, or the complements of the sequences and fragments thereof; and (b) detecting the presence or amount of the probe:target region hybrid as an indication of the disease.

[0056] In another aspect, a method for detection of a protease in a sample as a diagnostic tool for a disease or disorder is provided. This method comprises (a) comparing a nucleic acid target region encoding a protease in a sample, wherein the protease has an amino acid sequence selected from the group consisting of SEQ ID NOs 1-92 or one or more fragments thereof, with a control nucleic acid target region encoding the protease polypeptide, or one or more fragments thereof; and (b) detecting differences in nucleotide or predicted amino acid sequence or amount between the target region and the control target region, as an indication of said disease or disorder.

[0057] Another method of the present invention is for treating a disease or disorder by administering to a patient in need of such treatment a pharmaceutical composition comprising a compound that modulates the activity of a protease having an amino acid sequence selected from the group consisting of SEQ ID NOs 1-92.

[0058] In another aspect, a method for treating a disease or disorder is provided, wherein the method comprises administering to a patient in need of such treatment a pharmaceutical composition comprising a protease having an amino acid sequence selected from the group consisting of SEQ ID NOs 1-92.

[0059] In either method, the pharmaceutical composition further comprises an excipient selected from the group consisting of calcium carbonate, calcium phosphate, various sugars, starches, cellulose derivatives, gelatin, and polymers such as polyethylene glycols.

[0060] Also provided by the present invention is an antibody that binds to a part of a protein comprising the sequence described in any one of SEQ ID NOs. 1-92. In another embodiment, the antibody is used to identify and/or detect the presence of protease polypeptides in a sample. In another embodiment, the antibody is used to monitor cell cycle regulation or to determine immuno-localization of protease polypeptides within a cell. In another embodiment, the antibody is therapeutically effective.

[0061] The present invention also contemplates a method of treating an individual in need of treatment, comprising administering to the individual a protein comprising a sequence described in any one of SEQ ID NOs. 1-92, or a functional variant thereof. In one embodiment, the administering step is achieved by injecting, swallowing, infusing, topically applying or inhaling an aerosol. In another embodiment, the protein may be in the form of a pharmaceutical composition.

[0062] In another embodiment, the individual is a mammal. In another embodiment, the mammal is selected from the group consisting of a human, primate, rat, mouse, rabbit, pig, cattle, sheep, goat, cat or dog. In another embodiment, the mammal is a human.

[0063] Yet another aspect of the invention envisions a method for identifying a compound that modulates the activity of a protease comprising, (a) contacting a protease having an amino acid sequence selected from the group consisting SEQ ID NOs 1-92, or a functional variant thereof with a test compound; (b) measuring the catalytic activity of the protease; and (c) determining whether the test compound modulates the activity of the protease and/or binds to the protease.

[0064] A further aspect entails a method for identifying a compound that modulates (e.g., inhibits or stimulates) the activity of a protease in a cell comprising (a) expressing, in a cell, a protease having an amino acid sequence, or a fragment thereof, selected from the group consisting SEQ ID NOs 1-92; (b) exposing the cell to a test compound; and (c) monitoring a change in cell phenotype or proteolytic activity. In one other aspect, the invention provides a method for treating a disease or disorder by administering to a patient in need of such treatment a compound that modulates the activity of a protease having an amino acid sequence selected from the group consisting of SEQ ID NOs 1-92. In one embodiment, the compound modulates protease activity in vitro. In another embodiment, the compound is a protease inhibitor.

[0065] The present invention may be used to treat diseases or disorders which involve, as an example without limitation, the following genes: GD2, Lewis-Y, 72 kd glycoprotein (gp72, decay-accelerating factor, CD55, DAF, C3/C5 convertases), CO17-1A (EpCAM, 17-1A, EGP-40), TAG-72, CSAg-P (CSAp), 45kd glycoprotein, HT-29 ag, NG2, A33 (43 kd gp), 38kd gp, MUC-1, CEA, EGFR (HER1), HER2, HER3, HER4, HN-1 ligand, CA125, Syndecan-1, Lewis-X, PgP, FAP stromal Ag (fibroblast activation protein), EDG Receptors (endoglin receptors), ED-B, Laminin-5 (gamma2), Cox-2(+LN-5), AlphaVbeta3 integrin, AlphaVbeta5 integrin, uPAR (urokinase plasminogen activator receptor), Endoglin (CD105) and Folate receptor osteopontin. Others involved are well-known by those skilled in the art. Or, other diseases or disorders discloses herein or which are well-known in the art.

[0066] Thus, in another embodiment, the disease or disorder is selected from the group consisting of cancers, immune-related diseases and disorders, cardiovascular disease, brain or neuronal-associated diseases, and metabolic disorders. The disease or disorder is selected from the group consisting of cancers of tissues; cancers of hematopoietic origin; diseases of the central nervous system; diseases of the peripheral nervous system; Alzheimer's disease; Parkinson's disease; multiple sclerosis; amyotrophic lateral sclerosis; viral infections; infections caused by prions; infections caused by bacteria; infections caused by fungi; and ocular diseases.

[0067] In another embodiment, the disease or disorder is selected from the group consisting of migraines; pain; sexual dysfunction; mood disorders; attention disorders; cognition disorders; hypotension; hypertension; psychotic disorders; neurological disorders; dyskinesias; metabolic disorders; and organ transplant rejection.

[0068] One other aspect of the invention envisages a method for detecting a protease in a sample as a diagnostic tool or marker or biomarker for a disease or disorder, comprising (a) contacting the sample with a nucleic acid probe which hybridizes under hybridization assay conditions to a nucleic acid target encoding a protease having an amino acid sequence selected from the group consisting of SEQ ID NOs 1-92, or a functional variant thereof, or complements thereof; and (b) detecting the presence or amount of the probe:nucleic acid target hybrid as an indication of the disease.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0069] The present invention uses proteins which, hitherto, have not been used to hydrolyze peptide bonds and have not been identified as having proteolytic activity, to screen for compounds that modulate protease activity and for treating individuals having a disease or disorder involving a pathway in which one or more protease are involved via the compound or protease, itself.

[0070] The inventors recognized that isolated proteins having sequences described in SEQ ID NOs. 1-92, or a functional variant thereof are capable of hydrolyzing peptide bonds because their primary amino acid structure comprises proteolytic domains, when previously not though to do so. Accordingly, the invention provides novel uses of proteins as protease enzymes. The term “protease” refers to a protein or polypeptide sequence represented by SEQ ID NOs: 1-92 and includes functional variants thereof, as well as fragments derived from the polypeptides and variants. Variants and fragments of the invention have protease activity. The full-length protein sequence, a variant or a fragment thereof, can be isolated or purified from a cell that naturally expresses it, or produced by recombinant, chemical, or known protein synthesis methods, as provided herein.

[0071] A polypeptide that retains “protease activity” is one that retains the ability to catalyze the hydrolysis of a peptide bond. The ninety-two proteins identified as proteases in the present invention, can be serine-, cysteine-, aspartic-, threonine-, or metallo-proteases, based upon the sequences of their active and catalytic domains. The “active domain” refers to the region of a protein having a sequence described in any one of SEQ ID NOs. 1-92, that contains amino acid residues that perform the catalytic function of the protease; see Table 2 below which lists the boundaries of the “active domains” for each of the ninety-two identified proteases of the present invention. Similarly, the “catalytic domain” refers to the amino acid residues in any one of the protein sequences of SEQ ID NOs. 1-92 that are integral in catalyzing a chemical reaction, such as in hydrolysis of peptide bonds. Thus, the term “catalytic activity” defines the rate at which a protease catalytic domain cleaves a substrate. The term “substrate” as used herein refers to a polypeptide or protein or other molecule known to one skilled in the art which is cleaved by a protease of the invention.

[0072] The term “cleaved” refers to the severing of a covalent bond between amino acid residues or other moieties.

[0073] The term “therapeutic effect” refers to the inhibition, activation or replacement of factors causing or contributing to the abnormal condition. A therapeutic effect relieves to some extent one or more of the symptoms of the abnormal condition. In reference to the treatment of abnormal conditions, a therapeutic effect can refer to, without limitation, one or more of the following: (a) an increase in the proliferation, growth, and/or differentiation of cells; (b) inhibition (i.e., slowing or stopping) of cell death; (c) inhibition of degeneration; (d) relieving to some extent one or more of the symptoms associated with the abnormal condition; and (e) enhancing the function of the affected population of cells.

[0074] An “abnormal condition” refers to a function in the cells or tissues of an organism that deviates from their normal functions in that organism. An abnormal condition can relate to, for example without limitation, cell proliferation, cell differentiation, or cell survival. Abnormal cell proliferative conditions include, for example, cancers such as fibrotic and mesangial disorders, abnormal angiogenesis and vasculogenesis, wound healing, psoriasis, diabetes mellitus, and inflammation. Abnormal differentiation conditions include, but are not limited to neurodegenerative disorders, slow wound healing rates, and slow tissue grafting healing rates. Abnormal cell survival conditions relate to, for example without limitation, conditions in which programmed cell death (apoptosis) pathways are activated or abrogated. A number of proteases are associated with the apoptosis pathways.

[0075] The abnormal condition can be prevented or treated with an identified test compound or novel protease of the invention when the cells or tissues of the organism exist within the organism or outside of the organism. Cells existing outside the organism can be maintained or grown in cell culture dishes. For cells harbored within the organism, many techniques exist in the art to administer compounds, including (but not limited to) oral, parenteral, dermal, injection, and aerosol applications. For cells outside of the organism, multiple techniques exist in the art to administer the compounds, including (but not limited to) cell microinjection techniques, transformation techniques, and carrier techniques.

[0076] A “functional part,” “functional variant” or “functional fragment” is a portion of a full-length protease of any one of SEQ ID NOs. 1-92 that comprises the amino acid residues required to catalyze hydrolysis of a peptide bond, i.e., residues that convey proteolytic activity upon a protein of SEQ ID NOs. 1-92. SEQ ID NOs. 1.

[0077] A “variant” polypeptide of the invention can differ in amino acid sequence from a protease selected from the sequences represented in SEQ ID NOs. 1-92, or a functional variant thereof by one or more substitutions, deletions, insertions, inversions, and truncations or a combination of any of these. Any one of the novel proteases can be made to contain amino acid substitutions that substitute a given amino acid with another amino acid of similar characteristics. See Bowie et al., Science 247:1306-1310 (1990). A “variant,” according to the invention retains protease activity.

[0078] The term “polyclonal” refers to antibodies that are heterogenous populations of antibody molecules derived from the sera of animals immunized with an antigen or an antigenic functional derivative thereof. For the production of polyclonal antibodies, various host animals may be immunized by injection with the antigen. Various adjuvants may be used to increase the immunological response, depending on the host species.

[0079] “Monoclonal antibodies” are substantially homogenous populations of antibodies to a particular antigen. They may be obtained by any technique which provides for the production of antibody molecules by continuous cell lines in culture. Monoclonal antibodies may be obtained by methods known to those skilled in the art (Kohler et al., Nature, 1975, 256:495-497, and U.S. Pat. No. 4,376,110, both of which are hereby incorporated by reference herein in their entirety including any figures, tables, or drawings).

[0080] The term “antibody fragment” refers to a portion of an antibody, often the hypervariable region and portions of the surrounding heavy and light chains, that displays specific binding affinity for a particular molecule. A hypervariable region is a portion of an antibody that physically binds to the polypeptide target.

[0081] “Operatively linked” indicates that the inventive protease sequence and the heterologous protein are both in-frame or are chemically attached to each other.

[0082] The term “specific binding affinity” describes an antibody that binds to a protease polypeptide with greater affinity than it binds to other polypeptides under specified conditions. Antibodies can be used to identify an endogenous source of protease polypeptides, to monitor cell cycle regulation, and for immuno-localization of protease polypeptides within the cell. They may also be used therapeutically.

[0083] The term “antibody fragment” refers to a portion of an antibody, often the hypervariable region and portions of the surrounding heavy and light chains, that displays specific binding affinity for a particular molecule. A hypervariable region is a portion of an antibody that physically binds to the polypeptide target.

[0084] An antibody fragment of the present invention includes a “single-chain antibody,” a phrase used in this description to denote a linear polypeptide that binds antigen with specificity and that comprises variable or hypervariable regions from the heavy and light chain chains of an antibody. Such single chain antibodies can be produced by conventional methodology. The Vh and VI regions of the Fv fragment can be covalently joined and stabilized by the insertion of a disulfide bond. See Glockshuber, et al., Biochemistry 1362 (1990). Alternatively, the Vh and VI regions can be joined by the insertion of a peptide linker. A gene encoding the Vh, VI and peptide linker sequences can be constructed and expressed using a recombinant expression vector. See Colcher, et al., J. Nat'l Cancer Inst. 82:1191 (1990). Amino acid sequences comprising hypervariable regions from the Vh and VI antibody chains can also be constructed using disulfide bonds or peptide linkers.

[0085] The identified serine-, cysteine-, aspartic-, threonine-, and metallo-proteases of the present invention were found to either

[0086] (i) share less than 90% sequence identity to known proteases;

[0087] (ii) share less than 90% sequence identity to a protein encoded by a gene of known function which is not identified as a protease;

[0088] (iii) be identical to a protein product of a gene of unknown function;

[0089] (iv) be identical to a protein product of a gene of known function, which is not identified as a protease; or

[0090] (v) share less than 90% identity to a protein product of a gene of unknown function.

[0091] The proteins of the present invention may be modified, for example, so as to change residues which do not abrogate proteolytic activity. Amino acids that are not critical for function can be identified by methods known in the art, such as site-directed mutagenesis, crystallization, nuclear magnetic resonance, photoaffinity labeling or alanine-scanning mutagenesis (Cunningham et al., Science 244:1081-1085 (1989); Smith et al., J. Mol. Biol. 224:899-904 (1992); de Vos et al. Science 255:306-312 (1992)). Modified proteins can be tested for biological activity such as protease binding to substrate, cleavage, or in vitro, or in vitro activity. Such modifications are described in detail in the art. See, for example, U.S. Pat. No. 6,331,427 to Robison. The proteins of the present invention may also be used for targeted enzyme prodrug therapy (“TEPT”) which are described in U.S. provisional application serial Nos. 60/225,774 and 60/279,609, and which are incorporated herein by reference.

[0092] As an embodiment of the invention, any one of the proteases can be made to contain amino acid substitutions.

[0093] A polypeptide having the full-length sequence of any one of SEQ ID NOs. 1-92, or a functional part thereof, can also be joined to another polypeptide with which it is not normally associated. Thus, a protease amino acid sequence of SEQ ID NOs. 1-92 is operatively linked, at either its N-terminus or C-terminus, or in a side chain, to a heterologous protein having an amino acid sequence not substantially homologous to the protease

[0094] A fusion protein may, or may not, affect the protease activity of a protein having a sequence of any one of SEQ ID NOs. 1-92, or a functional part thereof. For example, the fusion protein can be a GST-fusion protein in which the protease sequences are fused to the C-terminus of the GST sequences or an influenza HA marker. Other types of fusion proteins include, but are not limited to, enzymatic fusion proteins, for example beta-galactosidase fusions, yeast two-hybrid GAL fusions, poly-His fusions and Ig fusions. Such fusion proteins, particularly poly-His fusions, can facilitate the purification of protease of the invention. In certain host cells, expression and/or secretion of a protein can be increased by using a heterologous signal sequence fused to a protease of the invention that transports the protease to an extracellular matrix or localizes the protease in the cell membrane.

[0095] Other fusion proteins may affect the protease activity of a protein having a sequence of any one of SEQ ID NOs. 1-92, or of a functional part thereof. For example, without limitation, one or more of the protease domains (or parts thereof) in any one of SEQ ID NOs. 1-92 may be replaced by domains from another protease or other type of protease. Similarly, a substrate binding, or subregion thereof, can be replaced, for example, with the corresponding domain or subregion from another protease with different substrate specificity. Accordingly, chimeric proteases can be produced from any one of SEQ ID NOs. 1-92, or a functional variant thereof which have altered cleavage characteristics, such that release of substrate is faster or slower than that of the unmodified protease or sequence recognized by the protease is altered Likewise, the affinity for substrate can be altered or even proteolysis of the substrate prevented. Non-functional variants of SEQ ID NOs. 1-92 may be engineered to contain one or more amino acid substitutions, deletions, insertions, inversions, or truncations in a critical residue or critical region. Modifications can be made to SEQ ID NOs. 1-92 to affect the function, for example, of one or more of the regions corresponding to substrate binding, subcellular localization (such as membrane association), proteolytic cleavage or effector binding.

[0096] Biologically active fragments of SEQ ID NOs. 1-92 can comprise a domain or region identified by analysis of the polypeptide sequence by well-known methods, Such biologically active fragments include, but are not limited to domains comprising one or more cleavage sites, substrate binding sites, glycosylation sites, cAMP and cGMP-dependent phosphorylation sites, N-myristoylation sites, activator binding sites, casein kinase 11 phosphorylation sites, palmitoylation sites, amidation sites. Such domains or sites can be identified by means of routine procedures for computerized homology or motif analysis.

[0097] Variants of the polypeptides of the invention having the sequences described in SEQ ID NOs. 1-92 also encompass derivatives or analogs in which (i) an amino acid is substituted with an amino acid residue that is not one encoded by the genetic code, (ii the mature polypeptide is fused with another compound, such as a compound to increase the half-life of the polypeptide (for example, polyethylene glycol), or (iii) additional amino acids are fused to the mature polypeptide, such as a leader or secretory sequence or a sequence for purification of the mature polypeptide or a pro-protein sequence. Known modifications include, but are not limited to, acetylation, acylation, ADP-ribosylation, amidation, covalent attachment of flavin, covalent attachment of a heme moiety, covalent attachment of a nucleotide or nucleotide derivative, covalent attachment of a lipid or lipid derivative, covalent attachment of phosphatidylinositol, cross-linking, cyclization, disulfide bond formation, demethylation, formation of covalent crosslinks, formation of cystine, formation of pyroglutamate, formylation, gamma carboxylation, glycosylation, GPI anchor formation, hydroxylation, iodination, methylation, myristoylation, oxidation, proteolytic processing, phosphorylation, prenylation, racemization, selenoylation, sulfation, transfer-RNA mediated addition of amino acids to proteins such as arginylation, and ubiquitination.

[0098] Particularly common modifications include glycosylation, lipid attachment, sulfation, gamma-carboxylation of glutamic acid residues, hydroxylation and ADP-ribosylation. See PROTEINS—STRUCTURE AND MOLECULAR PROPERTIES, 2nd Ed., T. E. Creighton, W. H. Freeman and Company, New York (1993); Wold, F., POSTTRANSLATIONAL COVALENT MODIFICATION OF PROTEINS. B. C. Johnson, Ed., Academic Press, New York 1-12 (1983); Seifter et al. (Meth. Enzymol. 182: 626-646 (1990)) and Rattan et al. (Ann. N.Y. Acad. Sci. 663:48-62 (1992)).

[0099] Modifications can be made anywhere in a polypeptide, including the peptide backbone, the amino acid side-chains and the amino or carboxyl termini. Blockage of the amino or carboxyl group in a polypeptide, or both, by a covalent modification, is common in naturally-occurring and synthetic polypeptides.

[0100] A protease of the present invention may be modified by the process in which it is synthesized. With recombinantly-produced polypeptides, for example, the modifications will be determined by the host cell post-translational modification capacity and the modification signals in the polypeptide amino acid sequence. Accordingly, when glycosylation is desired, a polypeptide should be expressed in a glycosylating host, generally a eukaryotic cell. The same type of modification may be present in the same or varying degree at several sites in a given polypeptide. Also, a given polypeptide may contain more than one type of modification.

[0101] The protein sequences of SEQ ID NOs. 1-92, or a functional variant thereof,can be used to identify compounds that modulate protease activity. Such compounds may increase or decrease affinity or rate of binding to a substrate or activator, compete with substrate or activator for binding to the protease or displace substrate or activator bound to the protease. For instance, a compound may be a mutated protease or a functional variant thereof, or appropriate fragments containing mutations that compete for substrate, activator or other protein that interacts with the protease. Accordingly, a fragment that competes for substrate or activator, for example with a higher affinity, or a fragment that binds substrate or activator but does not allow release, is encompassed by the invention.

[0102] Thus, compounds that activate or inactivate or bind to (i.e., “modulate”) a protease having a primary amino acid sequence described in SEQ ID NOs. 1-92 of the instant invention can be identified by a simple screening assay.

[0103] According to the present invention, the newly identified protease protein can be used in an assay for screening for a compound that modulates the activity of a protein which comprises the steps of (i) combining a protease having a sequence of any one of SEQ ID NOs. 1-92, or a functional variant thereof with a test compound and substrate and (ii) detecting a biochemical change in an interaction between the protease and the substrate in the presence and absence of the test compound.

[0104] The activity of the novel proteases can be determined by examining the ability to cleave substrate in the presence of chemically synthesized peptide ligands. Thus, modulators of the protease polypeptide's activity may, among other things, alter a protease function, such as a binding property of a protease for a natural or synthetic substrate or inhibitor, or an activity such as cleaving protein or polypeptide substrates, membrane localization, processing the pro-form of a polypeptide chain to the active product, transmembrane signaling of various forms, and/or the modification of the extracellular matrix or small molecule fluorescent substrate. (see, for example, THE HANDBOOK OF PROTEOLYTIC ENZYMES, 1998, Academic Press, San Diego, which is hereby incorporated by reference, including any drawings).

[0105] According to the assays of the present invention, one of skill in the art may determine the effect, if any, of the test compound upon proteolytic cleavage; upon a cellular response, such as development, differentiation, apoptosis or rate of proliferation; or upon a change in substrate levels. An indicator of a compound's ability to modulate a protease of the invention may be measured by parameters other than those intrinsic to the function of the specific protease. A screening assay may also involve monitoring biological events that are affected by the action of the test compound, such as, for example, when the action of a pathway in which the protease functions, or is made to function, that indicate protease activity. Thus, the expression or activity of genes that are up- or down-regulated in response to a protease-dependent cascade can be assayed.

[0106] A screening assay of the invention may also expose a test compound to some or all of the proteases of the invention to determine the specificity of the compound in modulating the novel proteases. The present invention is particularly useful for screening compounds by using a protease polypeptide in any of a variety of drug screening techniques. The compounds to be screened include, but are not limited to, extracellular, intracellular, biological or chemical origin. The protease polypeptide employed in such a test may be in any form, such as free in solution, attached to a solid support, borne on a cell surface or located intracellularly. One skilled in the art can measure the change in rate that a protease of the invention cleaves a substrate (See, for example, THE HANDBOOK OF PROTEOLYTIC ENZYMES, 1998, Academic Press, San Diego.) One skilled in the art can also, for example, measure the formation of complexes between a protease polypeptide and the compound being tested. Alternatively, one skilled in the art can examine the diminution in complex formation between a protease polypeptide and its substrate caused by the compound being tested.

[0107] Examples of assays include, but are not limited to, a yeast growth assay, an Aequorin assay, a Luciferase assay, a mitogenesis assay, a quench fluorescent substrate cleavage assay, as well as other binding and/or catalytic function-based assays of protease activity that are generally known in the art. See, for example, THE HANDBOOK OF PROTEOLYTIC ENZYMES, 1998, Academic Press, San Diego.

[0108] The use of cDNAs encoding proteins in drug discovery programs is well-known. Assays capable of testing thousands of unknown compounds per day in high-throughput screens (HTSs) are thoroughly documented. The literature is replete with examples of the use of enzymatic assays in HTS binding assays for drug discovery (see, Williams, Medicinal Research Reviews, 1991, 11:147-184.; Sweetnam, et al., J. Natural Products, 1993, 56:441-455 for review). Recombinant proteins are preferred for enzymatic binding assay HTS because they allow for better specificity (higher relative purity), provide the ability to generate large amounts of material, and can be used in a broad variety of formats (see Hodgson, Bio/Technology, 1992, 10:973-980 which is incorporated herein by reference in its entirety). To this end, a variety of heterologous systems is available for functional expression of recombinant proteins that are well known to those skilled in the art. Such systems include bacteria (Strosberg, et al., Trends in Pharmacological Sciences, 1992, 13:95-98), yeast (Pausch, Trends in Biotechnology, 1997, 15:487-494), several kinds of insect cells (Vanden Broeck, Int. Rev. Cytology, 1996, 164:189-268), amphibian cells (Jayawickreme et al., Current Opinion in Biotechnology, 1997, 8:629-634) and several mammalian cell lines (CHO, HEK293, COS, etc.; see, Gerhardt, et al., Eur. J. Pharmacology, 1997, 334:1-23). These examples do not preclude the use of other possible cell expression systems, including cell lines obtained from nematodes (PCT application WO 98/37177).

[0109] The invention also contemplates production of the protease. The invention further includes a method for producing a protease having an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-92 by recombinant techniques, by culturing recombinant prokaryotic or eukaryotic host cells comprising nucleic acid sequence encoding said protease under conditions effective to promote expression of the protein, and subsequent recovery of the protein from the host cell or the cell culture medium.

[0110] Foreign protein production, including the production and secretion of mammalian proteins, has been reported previously in filamentous fungi. See U.S. Pat. Nos. 6,103,490, 5,840,570, 5,679,543 and 5,364,770.

[0111] The invention also contemplates the ability of determining whether a protease can bind to a substrate, inhibitor or other molecule can also be determined by real-time Bimolecular Interaction Analysis (BIA). Sjolander, S. and Urbaniczky, C. (1991) Anal. Chem., 63:2338-2345 and Szabo et al. (1995) Curr. Opin. Struct. Biol., 5:699-705. “BIA” is a technology for studying biospecific interactions in real time, without labeling any of the interactants. Changes in the optical phenomenon surface plasmon resonance (SPR) can be used as an indication of real-time reactions between biological molecules. Similarly, a microphysiometer can be used to detect the interaction of a test compound with the polypeptide without the labeling of either the test compound or the polypeptide. McConnell, H. M. et al. (1992) Science, 257:1906-1912.

[0112] The proteins of SEQ ID NOs. 1-92 can also be used in a two-hybrid assay or three-hybrid assay (see, e.g., U.S. Pat. No. 5,283,317; Zervos et al. (1993) Cell, 72:223-232; Madura et al. (1993) J. Biol. Chem., 268:12046-12054; Bartel et al. (1993) Biotechniques, 14:920-924; Iwabuchi et al. (1993) Oncogene, 8:1693-1696; and Brent WO94/10300), to identify other proteins which bind to or interact with the proteins of the invention and modulate their activity.

[0113] Binding can be determined by binding assays which are well known to the skilled artisan, including, but not limited to, gel-shift assays, Western blots, radiolabeled competition assay, phage-based expression cloning, co-fractionation by chromatography, co-precipitation, cross linking, interaction trap/two-hybrid analysis, southwestern analysis, ELISA, and the like, which are described in, for example, Current Protocols in Molecular Biology, 1999, John Wiley & Sons, NY, which is incorporated herein by reference in its entirety. The compounds to be screened include, but are not limited to, compounds of extracellular, intracellular, biological or chemical origin.

[0114] Other assays can be used to examine enzymatic activity including, but not limited to, photometric, radiometric, HPLC, electrochemical, and the like, which are described in, for example, ENZYME ASSAYS: A PRACTICAL APPROACH, eds. R. Eisenthal and M. J. Danson, 1992, Oxford University Press, which is incorporated herein by reference in its entirety.

[0115] Test compounds of the present invention can be obtained, for example, without limitation, from biological libraries; spatially addressable parallel solid phase or solution phase libraries; synthetic library methods requiring deconvolution; the ‘one-bead one-compound’ library method; and synthetic library methods using affinity chromatography selection. The biological library approach is limited to polypeptide libraries, while the other four approaches are applicable to polypeptide, non-peptide oligomer or small molecule libraries of compounds (Lam, K. S. (1997) Anticancer Drug Des. 12:145). Examples of methods for the synthesis of molecular libraries can be found in the art, for example in DeWitt et al. (1993) Proc. Natl. Acad. Sci. U.S.A., 90:6909; Erb et al. (1994) Proc. Natl Acad. Sci. U.S.A., 91:11422; Zuckermann et al. (1994). J. Med. Chem., 37:2678; Cho et al.(1993) Science, 261:1303; Carell et al. (1994) Angew. Chem. Int. Ed. Engl., 33:2059; Carell et al. (1994) Angew. Chem. Int. Ed. Engl., 33:2061; and in Gallop et al. (1994) J. Med. Chem., 37:1233.

[0116] The invention does not restrict the sources for suitable test compounds, which may be obtained from natural sources such as plant, animal or mineral extracts, or non-natural sources such as small molecule libraries, including the products of combinatorial chemical approaches to library construction, and peptide libraries.

[0117] Libraries of compounds may be presented in solution (e.g., Houghten (1992) Biotechniques, 13:412-421), or on beads (Lam(1991) Nature, 354:82-84), chips (Fodor (1993) Nature, 364;555-556), bacteria (Ladner U.S. Pat. No. 5,223,409), spores (Ladner U.S. Pat. No. '409), plasmids (Cull et al. (1992) Proc. Natl. Acad. Sci. U.S.A., 89:1865-1869) or on phage (Scott and Smith (1990) Science, 249:386-390); (Devlin (1990) Science, 249:404-406); (Cwirla et al. (1990) Proc. Natl. Acad. Sci., 97:6378-6382); (Felici (1991) J. Mol. Biol., 222:301-310); (Ladner supra or a library of mammilian cellsTest compounds include, for example, peptides such as soluble peptides, including Ig-tailed fusion peptides and members of random peptide libraries (see, e.g., Lam et al., Nature 354:82-84 (1991); Houghten et al., Nature 354:84-86 (1991)) and combinatorial chemistry-derived molecular libraries made of D- and/or L-configuration amino acids; phosphopeptides (e.g., members of random and partially degenerate, directed phosphopeptide libraries, see, e.g., Songyang et al., Cell 72:767-778 (1993)); antibodies (e.g., polyclonal, monoclonal, humanized, anti-idiotypic, chimeric, and single chain antibodies as well as Fab, F(ab′)₂, Fab expression library fragments, and epitope-binding fragments of antibodies); and small organic and inorganic molecules such as those obtained from combinatorial and natural product libraries. Preferably, these inhibitors will have molecular weights from 100 to 200 daltons, from 200 to 300 daltons, from 300 to 400 daltons, from 400 to 600 daltons, from 600 to 1000 daltons, from 1000 to 2000 daltons, from 2000 to 4000 daltons, from 4000 to 8000 daltons and from 8000 to 60 daltons.

[0118] The test compound may also be a drug or a chemical. Examples of such compounds include, but are not limited to, phenylmethylsulfonyl fluoride (PMSF), diisopropylfluorophosphate (DFP) (chapter 3, Barrett et al., Handbook of Proteolytic Enzymes, 1998, Academic Press, San Diego), 3,4-dichloroisocoumarin (DCI) (Id., chapter 16), serpins (Id., chapter 37), E-64 (trans-epoxysuccinyl L-leucylamido-(4-guanidino) butane) (Id., chapter 188), peptidyl-diazomethanes, peptidyl-O-acyl-hydroxamates, epoxysuccinyl-peptides (Id., chapter 210), DAN, EPNP (1,2-epoxy-3(p-nitrophenoxy)propane) (Id., chapter 298), thiorphan (dl-3-Mercapto-2-benzylpropanoyl-glycine) (Id., chapter 362), CGS 26303, PD 069185 (Id., chapter 363), and COT989-00 (N-4-hydroxy-N1-[1-(s)-(4-aminosulfonyl)phenylethyl-aminocarboxyl-2-cyclohexylethyl)-2R-[4-methyl)phenylpropyl]succinamide) (Id., chapter 401). Other protease inhibitors include, but are not limited to, aprotinin, amastatin, antipain, calcineurin autoinhibitory fragment, and histatin 5 (Id.). Compounds that can traverse cell membranes and are resistant to acid hydrolysis are potentially advantageous as therapeutics as they can become highly bioavailable after being administered orally to patients.

[0119] Compounds identified through such screening assays that modulate the activity of a protein having a sequence described in any one of SEQ ID NOs. 1-92, or a functional variant thereof can be used to treat a subject with a disorder mediated by a protease pathway, by treating cells that express the protease. These methods of treatment include the steps of administering the compound(s) that modulate activity, for example in a pharmaceutical composition to a subject in need of such treatment.

[0120] Alternatively, or in conjunction, a protease of SEQ ID NOs. 1-92 may be therapeutically administered to a subject in need of such treatment in a pharmaceutical composition. Such substances, useful for treatment of protease-related disorders or diseases, preferably show positive results in one or more in vitro assays for an activity corresponding to treatment of the disease or disorder in question.

[0121] A compound identified according to an assay described herein, or a protein having a sequence of any one of SEQ ID NOs. 1-92, or a functional variant thereof may be administered to an individual to compensate for reduced or aberrant expression or activity of an endogenous protein in vivo. Accordingly, methods for treatment include the use of soluble protease or fragments of the protease protein that compete, for example, with activator or substrate binding. These proteases or fragments can have a higher affinity for the activator or substrate so as to provide effective competition.

[0122] The compound(s) and protease(s) or variants thereof, can be administered to a human patient directly, or in the form of a pharmaceutical composition, admixed with other active ingredients, as in combination therapy, or suitable carriers or excipient(s). Techniques for formulation and administration of the compounds of the instant application may be found in REMINGTON'S PHARMACEUTICAl SCIENCES, Mack Publishing Co., Easton, Pa., latest edition. All methods are well-known in the art.

[0123] Many of the protease modulating compounds of the invention may be provided as salts with pharmaceutically compatible counterions. Pharmaceutically compatible salts may be formed with many acids, including but not limited to hydrochloric, sulfuric, acetic, lactic, tartaric, malic, succinic, etc. Salts tend to be more soluble in aqueous or other protonic solvents that are the corresponding free base forms.

[0124] Pharmaceutical compositions suitable for use in the present invention include compositions where the active ingredients, i.e., a compound identified from a screening assay described herein, or any one of the novel proteases having a sequence described in SEQ ID NOs. 1-92, or a functional variant thereof, are contained in an amount effective to achieve its intended purpose. More specifically, a therapeutically effective amount of a compound or novel protease means an amount of compound effective to prevent, alleviate or ameliorate symptoms of disease or prolong the survival of the subject being treated. Determination of a therapeutically effective amount is well within the capability of those skilled in the art, especially in light of the detailed disclosure provided herein.

[0125] A protease of the present invention may also be used as a diagnostic marker of a disease or disorder. One may compare a nucleic acid target obtained from an individual that encodes a protease of SEQ ID NOs. 1-92, or a functional variant thereof with that of a control nucleic acid target encoding the protease; and then (b) detecting differences in sequence or amount between the target region and the control target region, as an indication of said disease or disorder. A method for detecting a protease in a sample as a diagnostic marker of a disease or disorder may comprise (a) contacting the sample with a nucleic acid probe which hybridizes under hybridization assay conditions to a nucleic acid target encoding a protease having an amino acid sequence selected from the group consisting of SEQ ID NOs 1-92, or a functional variant thereof or the complements of said sequences and fragments thereof; and (b) detecting the presence or amount of the probe:nucleic acid target region hybrid as an indication of the disease.

[0126] Methods for using nucleic acid probes include detecting the presence or amount of protease RNA in a sample by contacting the sample with a nucleic acid probe under conditions such that hybridization occurs and detecting the presence or amount of the probe bound to protease RNA. The nucleic acid duplex formed between the probe and a nucleic acid sequence coding for a protease polypeptide may be used in the identification of the sequence of the nucleic acid detected (Nelson et al., in NONISOTOPIC DNA PROBE TECHNIQUES, Academic Press, San Diego, Kricka, ed., p. 275, 1992, hereby incorporated by reference herein in its entirety, including any drawings, figures, or tables). In another aspect, the invention describes a recombinant cell or tissue comprising a nucleic acid molecule encoding a protease polypeptide having an amino acid sequence selected from the group consisting of those set forth in SEQ ID NOs. 1-92, or a functional variant thereof. Accordingly, such a cell or tissue may be grown or differentiated and introduced into an individual in need of treatment. In such fashion, the novel protease may be introduced into an individual by cellular administration of cells or tissues, rather than by direct injection. Accordingly, cells or tissues may be taken from the individual in question, modified so as to contain cells expressing a protease of any one of SEQ ID NOs. 1-92, or a functional variant thereof and then reintroduced into the same individual. Mesenchymal stem cells and bone marrow stem cells are examples of cells that may be modified and used in such fashion.

[0127] The novel proteases will be useful for screening for compounds that modulate (e.g., activate or inhibit) the catalytic activity of the encoded protease with potential utility in treating cancers, immune-related diseases and disorders, cardiovascular disease, brain or neuronal-associated diseases, and metabolic disorders. More specifically disorders including cancers of tissues, blood, or hematopoietic origin, particularly those involving breast, colon, lung, prostate, cervical, brain, ovarian, bladder, or kidney; central or peripheral nervous system diseases and conditions including migraine, pain, sexual dysfunction, mood disorders, attention disorders, cognition disorders, hypotension, and hypertension; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Tourette's Syndrome; neurodegenerative diseases including Alzheimer's, Parkinson's, multiple sclerosis, and amyotrophic lateral sclerosis; viral or non-viral infections caused by HIV-1, HIV-2 or other viral- or prion-agents or fungal- or bacterial- organisms; metabolic disorders including Diabetes and obesity and their related syndromes, among others; cardiovascular disorders including reperfusion restenosis, coronary thrombosis, clotting disorders, unregulated cell growth disorders, atherosclerosis; ocular disease including glaucoma, retinopathy, and macular degeneration; inflammatory disorders including rheumatoid arthritis, chronic inflammatory bowel disease, chronic inflammatory pelvic disease, multiple sclerosis, asthma, osteoarthritis, psoriasis, atherosclerosis, rhinitis, autoimmunity, and organ transplant rejection.

[0128] Antibody Generation

[0129] The protein sequences of SEQ ID NOs. 1-92 are also useful for producing antibodies specific for the protease, regions, or fragments. The antibody preferably binds to the target protease polypeptide with greater affinity than it binds to other inhibitor polypeptides under specified conditions. Antibodies or antibody fragments are polypeptides that contain regions that can bind other polypeptides. An antibody or antibody fragment with specific binding affinity to a protease polypeptide of the invention can be isolated, enriched, or purified from a prokaryotic or eukaryotic organism. Routine methods known to those skilled in the art enable production of antibodies or antibody fragments, in both prokaryotic and eukaryotic organisms. Purification, enrichment, and isolation of antibodies, which are polypeptide molecules, are described above.

[0130] Antibodies having specific binding affinity to a protease of the invention may be used in methods for detecting the presence and/or amount of protease polypeptide in a sample by contacting the sample with the antibody under conditions such that an immunocomplex forms and detecting the presence and/or amount of the antibody conjugated to the protease polypeptide. In another aspect, the invention features an antibody (e.g., a monoclonal or polyclonal antibody) having specific binding affinity to a protease polypeptide or a protease polypeptide domain or fragment where the polypeptide is selected from the group having a sequence at least about 90% identical to an amino acid sequence selected from the group consisting of those set forth in SEQ ID NO:1-92. Preferably the polypeptide is has at least about 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% 99% or 100% identity with the sequences listed above. By “specific binding affinity” is meant that the antibody binds to the target protease polypeptide with greater affinity than it binds to other polypeptides under specified conditions. Antibodies or antibody fragments are polypeptides that contain regions that can bind other polypeptides. The term “specific binding affinity” describes an antibody that binds to a protease polypeptide with greater affinity than it binds to other polypeptides under specified conditions. Antibodies can be used to identify an endogenous source of protease polypeptides, to monitor cell cycle regulation, and for immuno-localization of protease polypeptides within the cell.

[0131] An antibody of the present invention includes “humanized” monoclonal and polyclonal antibodies. Humanized antibodies are recombinant proteins in which non-human (typically murine) complementarity determining regions of an antibody have been transferred from heavy and light variable chains of the non-human (e.g. murine) immunoglobulin into a human variable domain, followed by the replacement of some human residues in the framework regions of their murine counterparts. Humanized antibodies in accordance with this invention are suitable for use in therapeutic methods. General techniques for cloning murine immunoglobulin variable domains are described, for example, by the publication of Orlandi et al., Proc. Nat'l Acad. Sci. USA 86: 3833 (1989). Techniques for producing humanized monoclonal antibodies are described, for example, by Jones et al., Nature 321:522 (1986), Riechmann et al., Nature 332:323 (1988), Verhoeyen et al., Science 239:1534 (1988), Carter et al., Proc. Nat'l Acad. Sci. USA 89:4285 (1992), Sandhu, Crit. Rev. Biotech. 12:437 (1992), and Singer et al., J. Immun. 150:2844 (1993).

[0132] Antibodies or antibody fragments having specific binding affinity to a protease polypeptide of the invention may be used in methods for detecting the presence and/or amount of protease polypeptide in a sample by probing the sample with the antibody under conditions suitable for protease-antibody immunocomplex formation and detecting the presence and/or amount of the antibody conjugated to the protease polypeptide. Diagnostic kits for performing such methods may be constructed to include antibodies or antibody fragments specific for the protease as well as a conjugate of a binding partner of the antibodies or the antibodies themselves.

[0133] An antibody or antibody fragment with specific binding affinity to a protease polypeptide of the invention can be isolated, enriched, or purified from a prokaryotic or eukaryotic organism. Routine methods known to those skilled in the art enable production of antibodies or antibody fragments, in both prokaryotic and eukaryotic organisms. Purification, enrichment, and isolation of antibodies, which are polypeptide molecules, are described above.

[0134] Antibodies having specific binding affinity to a protease polypeptide of the invention may be used in methods for detecting the presence and/or amount of protease polypeptide in a sample by contacting the sample with the antibody under conditions such that an immunocomplex forms and detecting the presence and/or amount of the antibody conjugated to the protease polypeptide. Diagnostic kits for performing such methods may be constructed to include a first container containing the antibody and a second container having a conjugate of a binding partner of the antibody and a label, such as, for example, a radioisotope. The diagnostic kit may also include notification of an FDA approved use and instructions therefor.

[0135] In another aspect, the invention features a hybridoma which produces an antibody having specific binding affinity to a protease polypeptide or a protease polypeptide domain, where the polypeptide is selected from the group consisting of those set forth in any one of SEQ ID Nos 1-92.

[0136] Table 1 shows each of the ninety-two proteins according to their protease family and percent sequence similarity to known and unknown proteins. None of the proteases are described in publicly available protein databases as possessing protease activity (i.e., as having protease activity or are used as proteases).

[0137] Table 2 shows the beginning and end of the active domain for each of the proteases having a sequence described in SEQ ID NOS: 1-92. A functional variant of one of SEQ ID NOs. 1-92 can be determined in reference to Table 2. For example, one skilled in the art could use a delimited domain, as determined by multiple alignments, to determine which part of a sequence has catalytic activity and is therefore a functional variant, in spite of the fact that the sequences are not full-length sequences. TABLE 1 Classification of novel proteases Cysteine Serine Aspartic Threonine Metallo- peptidase peptidase peptidase peptidase peptidase <90% identity to <90% identity to <90% identity to Identical to Identical to known protease known protease known protease gene of unknown gene of unknown function function SEQ ID NO. 3 SEQ ID NO. 4 SEQ ID NO. 1 SEQ ID NO. 12 SEQ ID NO. 15 Identical to SEQ ID NO. 5 SEQ ID NO. 2 SEQ ID NO. 23 gene of unknown function SEQ ID NO. 10 Identical to SEQ ID NO. 6 Identical to a gene of unknown gene of known function function (non- protease) SEQ ID NO. 17 SEQ ID NO. 11 <90% identity to SEQ ID NO. 32 known gene of known funtion (non-protease) SEQ ID NO. 18 SEQ ID NO. 13 SEQ ID NO. 7 SEQ ID NO. 45 SEQ ID NO. 19 SEQ ID NO. 16 SEQ ID NO. 8 SEQ ID NO. 53 SEQ ID NO. 25 SEQ ID NO. 20 SEQ ID NO. 9 <90% identity to SEQ ID NO. 29 SEQ ID NO. 21 Identical to gene of unknown gene of unknown function function Identical to a SEQ ID NO. 22 SEQ ID NO. 14 gene of known function (non- protease) SEQ ID NO. 30 SEQ ID NO. 24 Identical to a gene of known function (non- protease) SEQ ID NO. 33 SEQ ID NO. 26 SEQ ID NO. 35 SEQ ID NO. 34 SEQ ID NO. 27 SEQ ID NO. 41 SEQ ID NO. 37 SEQ ID NO. 28 SEQ ID NO. 43 SEQ ID NO. 38 Identical to a SEQ ID NO. 47 gene of known function (non- protease) SEQ ID NO. 42 SEQ ID NO. 31 SEQ ID NO. 49 SEQ ID NO. 44 SEQ ID NO. 36 SEQ ID NO. 52 SEQ ID NO. 51 SEQ ID NO. 39 SEQ ID NO. 60 SEQ ID NO. 55 SEQ ID NO. 40 SEQ ID NO. 70 SEQ ID NO. 56 SEQ ID NO. 46 SEQ ID NO. 71 SEQ ID NO. 57 SEQ ID NO. 48 SEQ ID NO. 74 SEQ ID NO. 62 SEQ ID NO. 50 SEQ ID NO. 75 SEQ ID NO. 63 SEQ ID NO. 54 SEQ ID NO. 76 SEQ ID NO. 66 SEQ ID NO. 58 SEQ ID NO. 78 SEQ ID NO. 67 SEQ ID NO. 59 SEQ ID NO. 78 SEQ ID NO. 68 SEQ ID NO. 61 SEQ ID NO. 82 SEQ ID NO. 69 SEQ ID NO. 64 <90% identity to gene of unknown funtion SEQ ID NO. 72 SEQ ID NO. 65 SEQ ID NO. 77 SEQ ID NO. 73 SEQ ID NO. 80 SEQ ID NO. 79 SEQ ID NO. 81 <90% identity to gene of unknown funtion <90% identity to gene of unknown funtion

[0138] TABLE 2 Regions demarcating the active domain of each novel protease Residue Residue number number marking marking the Protease the start of end of the SEQ ID the active active NO.: domain domain 1 104 231 2 66 360 3 1 122 4 3 393 5 15 153 6 235 396 7 117 294 8 164 303 9 384 613 10 76 271 11 36 240 12 234 403 13 56 371 14 1 108 15 258 457 16 59 285 17 637 780 18 44 227 19 97 292 20 6 217 21 118 305 22 1 239 23 92 227 24 26 166 25 192 711 26 148 425 27 294 476 28 51 298 29 175 328 30 2 545 31 149 761 32 593 1829 33 722 914 34 687 884 35 181 346 36 120 282 37 411 586 38 258 444 39 49 236 40 500 741 41 889 1101 42 648 836 43 106 318 44 988 1252 45 1 648 46 22 558 47 304 433 48 137 411 49 414 492 50 84 382 51 243 354 52 21 130 53 19 442 54 158 445 55 650 838 56 470 528 57 698 909 58 22 270 59 741 923 60 68 261 61 140 385 62 30 170 63 564 679 64 154 707 65 110 413 66 1067 1190 67 1078 1357 68 304 558 69 650 838 70 138 402 71 34 297 72 493 668 73 42 333 74 124 388 75 13 240 76 54 260 77 184 294 78 130 409 79 13 254 80 1113 1298 81 412 598 82 673 864 83 227 378 84 137 411 85 288 465 86 18 120 87 1 126 88 1 124 89 154 288 90 108 285 91 117 294

[0139] The amino acid sequences below of List 1, are the ninety-two identified protease sequences of the present invention. LIST 1 SEQ ID NO. 1 NMAILCAMVVGVGLIAGLAVGLTRSCDSSGDGGLGTVPAPSHLPSSTASP SGPPAQDQDICPSSEDESGQWKNFTAELRQPGPDLHVKPLLEEDTYTGTV SISINLSTPTRHLWLHLGESRITWLPDTRHLWLHLQETRITWLPEMKRPS GDQVQIRRCFEYKKQEYVVVEAEEESGDGLYLLTMEFAGWLNSSLLGFTY TENGQVKSIAATDHEPTDARKFFPCFDKPNKKATYTISVTHPKEYEALSH MPVAKEESVDDKWNQTTFKKSVPMSMYLVCFAVHQFHTVKTISDIGKPVS LII SEQ ID NO. 2 MSPPLLLLPLLLLLPLLNVEPAGATLDPVWIPLRQVHPGRRTLNLLRGWG KPAELPKLGPSPGDKPASVPLSKFLDAQYFGEIGLGTPPQNFTVAFDTGS SNLWVPSRRCHFFSVPCWFHHRFNPNASSSFKPSGTKFAIQYGTGRVDGI LSEDKLTIGGIKGASVIFGEALWESSLVFTVSRPDGILRLGFPILSVEGV RPPLDVLVEQGLLDKPVFSFYFNRCWGGGXGCAMYCRIVRLEDPLDTGTP VIVGPTEEIGPCMQPLGESLLAGEYIIRCSEIPKLPAVSLLIGGVWFNLT AQDYVIQFAQGDVRLCLSGFRALDIASPPVPVWILGDVFLGAYVTVFDRG DMKSGARVGLARARPGADLGRRETQAQYRGCRPGDHAHRVALALLSKNIF PLNEPA SEQ ID NO. 3 MDTAAKAIILEQSGKNQGYRDADIRSFWPEGGVCLPGSPDVLESGVCMKA VCKRVAVEGVDVIFSRDAGRYVCDYTYYLSLHHGKGCAALIHVPPLSRGL PASLLGHALRVIIQEMLEEVGK SEQ ID NO. 4 IYVSSWAVQVSQGNREVERLARKFGFVNLGPIFPDGQYFHLRHRGVVQQS LTPHWGHRLHLKKNPKVQWFQQQTLQRRVKRSVVVPTDPWFSKQWYMNSE AQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWANYDPLASYDFND YDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVRML DGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRG VTKGRGGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVP WYSEACASTLTTTYSSGVATDPQIVTTDLHHGCTDQHTGTSASAPLAAGM IALALEANPFLTWRDMQHLVVRASKPAHLQAEDWRTNGVGRQG SEQ ID NO. 5 LVGYAIQYGCIAHCASEYVGGVVMCSGPSMEPTIQNSDTVFAQNLSRHFD SIQRGDIVIAKSPSDPTSNICKRVTGLEGDKILTTSPSDFFKSYSYVPVG HVWLEGDLQNSTDSSYYGPIPYELIRGRIFFIRPLSDFGFLCASLNGHRF SDD SEQ ID NO. 6 MLITVYCVRRDLSEVTFSLQVSPDFELRNFKVLCEAESRVPVEEIQIIHM ERLLIEDHCSLGSYGLKDGDIVVLLQKDNVGPPAPGRAPNQPRVDFSGIA VPGTSSSRPQHPGQQQQRTPAAQRSQGLASGEKVAGLQGLGSPALIRSML LSNPHDLSLLKERNPPLAEALLSGSLETFSQVLMEQQREKALREQERLRL YTADPLDREAQAKIEEEIRQQNIEENMNIAIEEAPESFGQVTMLYINCKV NGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGVAKGVGTQRIIG RVHLAQIQIEGDFLQCSFSILEDQPMDMLLGLDMLRRHQCSIDLKKNVLV IGTTGTQTYFLPEGELPLCSRMVSGQDESSDKEITHSVMDSGRKEH SEQ ID NO. 7 HGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVC ERIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEP SIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEV VEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQR DKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDF LGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNS SVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGSASHCVLAGT KALWNSSVPVCEQIFCPNPPAILNGRHTGTPPGDIPYGKEVSYTCDPHPD RGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVGAVIFSTHLITLFY CLGTLLGTIIFILIIIFLY SEQ ID NO. 8 GGGSPGWGCAGIPDSAPGAGVLQAGAVGPARGGQGAEEVGESAGGGEERR VRHPQAPALRLLNRKPQGGSGEIKTPENDLQRGRLSRGPRTAPPAPGMGD RSGQQERSVPHSPGAPVGTSAAAVNGLLHNGFHPPPVQPPHVCSRGPVGG SDAAPQRLPLLPELQPQPLLPQHDSPAKKCRLRRRMDSGRKNRPPFPWFG MDIGGTLVKLVYFEPKDITAEEEQEEVENLKSIRKYLTSNTAYGKTGIRD VHLELKNLTMCGRKGNLHFIRFPSCAMHRFIQMGSEKNFSSLHTTLCATG GGAFKFEEDFRMIADLQLHKLDELDCLIQGLLYVDSVGFNGKPECYYFEN PTNPELCQKKPYCLDNPYPMLLVNMGSGVSILAVYSKDNYKRVTGTSLGG GTFLGLCCLLTGCETFEEALEMAAKGDSTNVDKLVKDIYGGDYERFGLQG SAVASSFGNNMSKEKRDSISKEDLAPATLVTITNNIGSIARMCALNENID RVVFVGNFLRINMVSMKLLAYAMDFWSKGQLKALFLEHEGYFGAVGALLE LFKMTD SEQ ID NO. 9 MRPVALLLLPSLLALLAHGLSLEAPTVGKGQAPGIEETDGELTAAPTPEQ PERGVHFVTTAPTLKLLNHHPLLEEFLHEGLEKGDEELRPALSFQPDPPA PFTPSALPRLANQDSRPVFTSPTPAMGAVPTQPQSKEGPWSPESESPMLR ITAPLPPGPSMAVPTLGPGEIASTTPPSRAWTPTQEGPGDMGRPWVAEVV SQGAGIGIQGTITSSTASGDDEETTTTTTIITTTITTVQTPGPCSWNFSG PEGSLDSPTDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGETVTV EGLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHY QAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNA TQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAP EGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLS SGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYP VGTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCSGEITDS AGVVLPTEPEPYGRGQDSIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDG DDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHF FEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLM CQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQ GFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSP EKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLD GFYNSRSLDVAKAPAASSTLDAAHIAAAIFLPLVAMVLLVGGVYFYFSRL QGKSSLQLPRPRPRPYNRITIESAFDNPTYETGSLSFAGDERI SEQ ID NO. 10 EKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETPLVTYPGEPTSSEQGG LEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERE RQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERD KAERAKKYGGSVGSQPPPVAPEPGPVPSSPSQEPPPKREYDQCRIQVRLP DGTSLTQTFRAREQLAAVRLYVELHRGEELGGGQDPVQLLSGFPRRAFSE ADMERPLQELGLVPSAVLIVAKKCPS SEQ ID NO. 11 SLHLSERADWQYSQRELDAVEVFFSRTARDNRLGCMFVRCAPSSRYTLLF SHGNAVDLGQMCSFYIGLGSRINCNIFSYDYSGYGVSSGKPSEKNLYADI DAAWQALRTRYGVSPENIILYGQSIGTVPTVDLASRYECAAVILHSPLMS GLRVAFPDTRKTYCFDAFPSIDKISKVTSPVLVIHGTEDEVIDFSHGLAM YERCPRAVEPLWVEGAGHNDIELYAQYLERLKQFIHELPNS SEQ ID NO. 12 MTMEKGMSSGEGLPSRSSQVSAGKITAKELETKQSYKEKRGGFVLVHAGA GYHSESKAKEYKHVCKPACQKAIEKLQAGALATDAVTAALVELEDSPFTN AGMGSNLNLLGEIECDASIMDGKSLNFGAVGALSGIKNPVSVANRLLCEG QKGKLSAGRIPPCFLVGEGAYRWAVDHGIPSCPPNIMTTRFSLAAFKRNK RKLELAERVDTDFMQLKKRRQSSEKENDSGTLDTVGAVVVDHEGNVAAAV SSGGLALKHPGRVGQAALYGCGCWAENTGAHNPYSTAVSTSGCGEHLVRT ILARECSHALQAEDAHQALLETMQNKFISSPFLASEDGVLGGVIVLRSCR CSAEPDSSQNKQTLLVEFLWSHTTESMCVGYMSAQDGKAKTHISRLPPGA VAGQSVAIEGGVCRLESPVN SEQ ID NO. 13 KIKDCYGLGSGQNHFIKDSQWEQQAEIFNASYKKYLDREWEEEPLSTATF YFLLPSCLFAMPPEVKGPSGMACVLGIHWTRSHNFFLYSLNRTLKDKADP EGVWPCAAPIAVSQLSCSSSYLVLACEDGVLTLWDLAKGFPLGVAALPQG CFCQSIHFLKYFSVHKGQNMYPEGQVKSQMKCVVLCTDASLHLVEASGTQ GPTISVLVERPVKHLDKTICAVAPVPALPGMVLIFSKNGSVCLMDVAKRE IICAFAPPGAFPLEVPWKPVFAVSPDHPCFLLRGDYSHETASTDDAGIQY SVFYFNFEACPLLENISKNCTIPQRDLDNMAFPQALPLEKRCERFLQKSY RKLEKNPEKEEEHWARLQRYSLSLQRENFKK SEQ ID NO. 14 MGKGYYLKGKIGKVPVRFLVDSGAQVSVVHPNLWEEVTDGDLDTLQPFEN VVKVANGAEMKILGVWDTAVSLGKLKLKAQFLVANASAEEAIIGTDLQDH NAILDFEH SEQ ID NO. 15 MSFICGLQSAARNHVFFRFNSLSNWRKCNTLASTSRGCHQVQVNHIVNKY QGLGVNQCDRWSFLPGNFHFYSTFNNKRTGGLSSTKSKEIWRITSKCTVW NDAFSRQLLIKEVTAVPSLSVLHPLSPASIRAIRNFHTSPRFQAAPVPLL LMILKPVQKLFAIIVGRGIRKWWQALPPNKKEVVKENIRKNKWKLFLGLS SFGLLFVVFYFTHLEVSPITGRSKLLLLGKEQFRLLSELEYEAWMEEFKN DMLTEKDARYLAVKEVLCHLIECNKDVPGISQINWVIHVVDSPIINAFVL PNGQMFVFTGFLNSVTDIHQLSFLLGHEIAHAVLGHAAEKAGMVHLLDFL GMIFLTMIWAICPRDSLALLCQWIQSKLQEYMFNRPYSRKLEAEADKIGL LLAAKACADIRASSVFWQQMEFVDSLHGQPKMPEWLSTHPSHGNRVEYLD RLIPQALKIREMCNCPPLSNPDPRLLFKLSTKHFLEESEKEDLNITKKQK MDTLPIQKQEQIPLTYIVEKRT SEQ ID NO. 16 MNNLSFSELCCLFCCPPCPGKIASKLAFLPPDPTYTLMCDESGSRWTLHL SERADWQYSSREKDAIECFMTRTSKGNRIACMFVRCSPNAKYTLLFSHGN AVDLGQMSSFYIGLGSRINCNIFSYDYSGYGASSGKPTEKNLYADIEAAW LALRTRYIRPENVIIYGQSIGTVPSVDLAARYESAAVILHSPLTSGMRVA FPDTKKTYCFDAFPNIDKISKITSPVLIIHGTEDEVIDFSHGLALFERCQ RPVEPLWVEGAGHNDVELYGQYLERLKQFVSQELV SEQ ID NO. 17 GSGCLGAEKREGKNRWQGEASMERLLAQLCGSSAAWPLPLWEGDTTGHCF TQLVLSALPHALLAVLSACYLGTPRSPDYILPCSPGWRLRLAASFLLSVF PLLDLLPVALPPGAGPGPIGLEVLAGCVAAVAWISHSLALWVLAHSPHGH SRGPLALALVALLPAPALVLTVLWHCQRGTLLPPLLPGPMARLCLLILQL AALLAYALGWAAPGGPREPWAQEPLLPEDQEPEVAEDGESWLSRFSYAWL APLLARGACGELRQPQDICRLPHRLQPTYLARVFQAHWQEGARLWRALYG AFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLYALG LAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSRPPTGE ALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLIL ALLLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQ ALGARVEACPARELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLMG HQLTATKVFTALALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFLDLPN HNPQAYYSPDPPAEPSTVLELHGALFSWDPVGTSLETFISHLEVKKGMLV GIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFAT IRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGG QRARIALAPAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRL LCTHRTEYLERADAVLLMEAGRLIPAGPPSEILPLVQAVPKAWABNGQES DSATAQSVQNPEKTKEGLEEEQSTSGRLLQEESKKEGAVALHVYQAYWKA VGQGLALAILFSLLLMQATRNAADWWLSHWISQLKAENSSQEAQPSTSPA SMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNS LCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFS SDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYY HVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLPATGATYRFEEE NLRLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLA NPGLVGLSLSYALSLTGLLSGLVSSFTQTEANLVSVERLEEYTCDLPQEP QGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIV GRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQE PFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMGGLDGELGEGG RSLSLGQRQLLCLAPALLTDAKILCIDEATASVDQKTDQLLQQTICKRFA NKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQ SSQQGVPASLGGP SEQ ID NO. 18 MAAVRVLVASRLAAASAFTSLSPGGRTPSQRAALHLSVPRPAARVALVLS GCGVYDGTEIHEASAILVHLSRGGAEVQIFAPDVPQMHVIDHTKGQPSEG ESRNVLTESARIARGKITDLANLSAANHDAAIFPGGFGAAKNLSTFAVDG KDCKVNKEVERVLKEFHQAGKPIGLCCIAPVLAAKVLRGVEVTVGHEQEE GGKWPYAGTAEAIKALGAKHCVKEVSLRSVLGGFFRNSAHEAHVDQKNKV VTTPAFMCETALHYIHDGIGAMVRKVLELTGK SEQ ID NO. 19 MAELTALESLIEMGFPRGRAEKALALTGNQGIEAANDWLMEHEDDPDVDE PLETPLGHILGREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLE LVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEER RREKAEELAARQRVREKIERDKAERAKKYGGSVGSQPPPVAPEPGPVPSS PSQEPPTKREYDQCRIQVRLPDGTSLTQTFRAREQLAAVRLYVELHRGEE LGGGQDPVQLLSGFPRRAFSEADMERPLQELGLVPSAVLIVAKKCPS SEQ ID NO. 20 QVKLKIPFGNKLLDAVCLVPNKSLTYGIILTHGASGDMNLPHLMSLASHL ASHGFFCLRFTCKGLNIVHRIKAYKSVLNYLKTSGEYKLAGVFLGGRSMG SRAAASVMCHIEPDDGDDFVRGLICISYPLHHPKQQHKLRDEDLFRLKEP VLFVSGSADEMCEKNLLEKVAQKMQAPHKIHWIEKANHSMAVKGRSTNDV FKEINTQILFWIQEITEMDKK SEQ ID NO. 21 MNGLSLSELCCLFCCPPCPGRIAAKLAFLPPEATYSLVTEPEPGPGGAGA APLGTLRASSGAPGRWKLHLTERADFQYSQRELDTIEVFPTKSARRNRVS CMYVRCVTGARYTVLFSHSNAVDLGQMSSFYIGLGSRLHCNIFSYDYSGY GASSGRPSERNLYADIDAAWQALRTRYGISPDSIILYGQSIGTVPTVDLA SRYECAAVVLHSPLTSGMRVAFPDTKKTYCFDAFPNIEKVSKITSPVLII HGTEDEVIDFSHGLALYERCPKAVEPLWVEGTRHNDIELYSQYLEGLRRF ISQEL SEQ ID NO. 22 AQGKDQMWYEDALASSHPIELYLHGNAGTRCLFFTLQVLSSLGYHVVTFD YRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATN LVRRLCERETPPDALILESPFTNIREEAKSHPFSIYRYFPGFDWFFLDPI TSSGIKFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSFR DFKVQFVPFHSDLGYRHKYIYKSPELPRILREFLGKSEPEHQH SEQ ID NO. 23 MDASIMDGKDLSAGAVSAVQCIANPIKLARLVMEKTPHCFLTDQGAAQFA AAMGVPEIPGEKLVTERNKKRLEKEKHEKGAQKTDCQKNLGTVGAVALDC KGNVAYATSTGGIVNKMVGRVGDSPCLAGAGGYADNDIGAVSTTGHGESI LKVNLARLTLFHIEQGKTVEEAADLSLGYMKSRVKGLGGLIVVSKTGDWV AKWTSTSMPWAAAKDGKLHFGIDPDDTTITDLP SEQ ID NO. 24 MLRGVLGKTFRLVGYTIQYGCIAHCAFEYVGGVVMCSGPSMEPTIQNSDI VFAENLSRHFYGIQRGDIVIAKSPSDPKSNICKRVIGLEGDKILTTSPSD FFKSHSYVPMGHVWLEGDNLQNSTDSRCYGPIPYGLIRGRIFFKIWPLSD FGFLRASPNGHRFSDD SEQ ID NO. 25 MMDSPKIGNGLPVIGPGTDIGISSLHMVGYLGKNFDSAKVPSDEYCPACR EKGKLKALKTYRISFQESIFLCEDLQCIYPLGSKSLNNLISPDLEECHTP HKPQKRKSLESSYKDSLLLANSKKTRNYIAIDGGKVLNSKHNGEVYDETS SNLPDSSGQQNPIRTADSLERNEILEADTVDMATTKDPATVDVSGTGRPS PQNEGCTSKLEMPLESKCTSFPQALCVQWKNAYALCWLDCILSALVHSEE LKNTVTGLCSKEESIFWRLLTKYNQANTLLYTSQLSGVKDGDCKKLTSEI FAEIETCLNEVRDEIFISLQPQLRCTLGDMESPVFAFPLLLKLETHIEKL FLYSFSWDFECSQCGHQYQNRHMKSLVTFTNVIPEWHPLNAAHFGPCNNC NSKSQIRKMVLEKVSPIFMLHFVEGLPQNDLQHYAFHFEGCLYQITSVIQ YRANNHFITWILDADGNWLECDDLKGPCSERHKKFEVPASEIHIVIWERK ISQVTDKEAACLPLKKTNDQHALSNEKPVSLTSCSVGDAASAETASVTHP KDISVAPRTLSQDTAVTHGDHLLSGPKGLVDNILPLTLEETIQKTASVSQ LNSEAFLLENKPVAENTGILKTNTLLSQESLMASSVSAPCNEKLIQDQFV DISFPSQVVNTNMQSVQLNTEDTVNTKSVNNTDATGLIQGVKSVEIEKDA QLKQFLTPKTEQLKPERVTSQVSNLKKKETTADSQTTTSKSLQNQSLKEN QKKPFVGSWVKGLISRGASFMPLCVSAHNRNTITDLQPSVKGVNNFGGFK TKGINQKASHVSKKARKSASKPPPISKPPAGPPSSNGTAAHPHAHAASEV LEKSGSTSCGAQLNHSSYGNGISSANHEDLVEGQIHKLRLKLRKKLKAEK KKLAALMSSPQSRTVRSENLEQVPQDGSPNDCESIEDLNELPYPIDIASE SACTTVPGVSLYSSQTHEEILAELLSPTPVSTELSENGEGDFRYLGMGDS HIPPPVPSEFNDVSQNTHLRQDHNYCSPTKKNPCEVQPDSLTNNACVRTL NLESPMKTDIFDEFFSSSALNALANDTLDLPHFDEYLFENY SEQ ID NO. 26 MLTGVTDGIFCCLLGTPPNAVGPLESVESSDGYTFVEVKPGRVLRVKHAG PAPAAAPPPPSSASSDAAQGDLSGLVRCQRRITVYRNGRLLVENLGRAPR ADLLHGQNGSGEPPAALEVELADPAGSDGRLAPGSAGSGSGSGSGGRRRR ARRPKRTIHIDCEKRITSCKGAQADVVLFFIHGVGGSLAIWKEQLDFFVR LGYEVVAPDLAGHGASSAPQVAAAYTFYALAEDMRAIFKRYAKKRNVLIG HSYGVSFCTFLAHEYPDLVHKVIMINGGGPTALEPSFCSIFNMPTCVLHC LSPCLAWSFLKAGFARQGAKEKQLLKEGNAFNVSSFVLRAMMSGQYWPEG DEVYHAELTVPVLLVHGMHDKFVPVEEDQRMAEILLLAFLKLIDEGSHMV MLECPETVNTLLHEFLLWEPEPSPKALPEPLPAPPEDKK SEQ ID NO. 27 MRRQWGSAMRAAEQAGCMVSASPAGQPEAGPWSCSGVILSRSPGLVLCHG GIFVPFLPAGSEVLTAGAVFLPGDSCRDDLRLHVQWAPTGAPRGQARTGP PRLARPMRDLSPPPPSQASLSQSCDWRITETLGWFALLGVRLGQEEWRRR GPMAVSPLGAVPKGAPLLVCGSPFGAFCPDIFLNTLSCGVLSNVAGPLLL TDARCLPGTEGGGVFTARPAGALVALVVAPLCWKAGEWVGFTLLCAAAPL FRAARDALHRLPHSTAALAALLPPEVGVPWGLPLRDSGPLWAAAAVLVEC GTVWGSGVAVAPRLVVTCRHVSPREAARVLVRSTTPKSVAIWGRVVFATQ ETCPYDIAVVSLEEDLDDVPIPVPAEHFHEGEAVSVVGFGVFGQSCGPSV TSGILSAVVQVNGTPVMLQTTCAVHSGSSGGPLFSNHSGNLLGIITSNTR DNNTGATYPHLNFSIPITVLQPALQQYSQTQDLGGLRELDRAAEPVRVVW RLQRPLAEAPRSKL SEQ ID NO. 28 MAVARLAAVAAWVPCRSWGWAAVPFGPHRGLSVLLARIPQRAPRWLPACR QKTSLSFLNRPDLPNLAYKKLKGKSPGIIFIPGYLSYMNGTKALAIEEFC KSLGHACIRFDYSGVGSSDGNSEESTLGKWRKDVLSIIDDLADGPQILVG SSLGGWLMLHAAIARPEKVVALIGVATADTLVTKFNQLPVELKKEVEMKG VWSMPSKYSEEGVYNVQYSFIKEAEHHCLLHSPIPVNCPIRLLHGMKDDI VPWHTSMQVADRVLSTDVDVILRKHSDHRMREKADIQLLVYTIDDLIDKL STIVN SEQ ID NO. 29 QQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQNMVKFPLTGLDMTPHV VKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHHGTMQGGHYT AYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRRTAIPSWSANS SVAGSTSSSLCEHWVSRLPGSKPASVTSAASSRRTSLASLSESVEMTGER SEDDGGCFSTRPFVRSVQRQSLSSRSSVTSPLAVNENCMRPSWSLSAKLQ MRSNSPSRFSGDSPIHSSASTLEKIGEAADDKVSISCFGSLRNLSSSYQE PSDSHSLREHKAVGRAPLAVMEGVFKDESDTRRLNSSVVDTQSKHSAQGD RLPPLSGPFDNNNQIAYVDQSDSVDSSPVKEVKAPSHPGSLAKKPESTTK RSPSSKGTSEPEKSLRKGRPALASQESSLSSTSPSSPLPVKVSLKPSRSR SKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALTYT ASSTSAKKASGPATRSPFPPGKSRTSDHSLSREGSRQSLGSDRASATSTS KPNSPRVSQARAGEGRGAGKHVRSSSMASLRSPSTSIKSGLKRDSKSEDK GLSFFKSALRQKETRRSTDLGKTALLSKKAGGSSVKSVCKNTGDDEAERG HQPPASQQPNANTTGKEQLVTKDPASAKHSLLSARKSKSSQLDSGVPSSP GGRQSAEKSSKKLSSSMQTSARPSQKPQ SEQ ID NO. 30 MCGIWALFGSDDCLSVQCLSAMKIAHRGPDAFRFENVNGYTNCCFGFHRL AVVDPLFGMQPIRVKKYPYLWLCYNGEIYNHKKMQQHFEFEYQTKVDGEI ILHLYDKGGIEQTICMLDGVFAFVLLDTANKKVFLGRDTYGVRPLFKAMT EDGFLAVCSEAKGLVTLKHSATPFLKVEPFLPGHYEVLDLKPNGKVASVE MVKYHHCRDVPLHALYDNVEKLFPGFEIETVKNNLRILFNNAVKKRLMTD RRIGCLLSGGLDSSLVAATLLKQLKEAQVQYPLQTFAIGMEDSPDLLAAR KVADHIGSEHYEVLFNSEEGIQALDEVIFSLETYDITTVRASVGMYLISK YIRKNTDSVVIFSGEGSDELTQGYIYFHKAPSPEKAEEESERLLRELYLF DVLRADRTTAAHGLELRVPFLDHRFSSYYLSLPPEMRIPKNGIEKHLLRE TFEDSNLIPKEILWRPKEAFSDGITSVKNSWFKILQEYVEHQVDDAMMAN AAQKFPFNTPKTKEGYYYRQVFERHYPGRADWLSHYWMPKWINATDPSAR TLTHYKSAVKA SEQ ID NO. 31 QANCQIAILYQRFQRVVFGISQLLCFSALISELTNQKEVAAWTYHYSTKA YSWNISRKYCQNRYTDLVAIQNKNEIDYLNKVLPYYSSYYWIGIRKNNKT WTWVGTKKALTNEAENWADNEPNNKRNNEDCVEIYIKSPSAPGKWNDEHC LKKKHALCYTASCQDMSCSKQGECLETIGNYTCSCYPGFYGPECEYVREC GELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIW TNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVG PEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSC KFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCS PSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQD LPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNS VPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPE RLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHF SCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQ GTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACR AVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQE NGHWSTTVPTCQAGPLTIQEALTYFGGAVASTIGLIMGGTLLALLRKRFR QKDDGKCPLNPHSHLGTYGVFTNAAFDPSP SEQ ID NO. 32 MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKP GCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDK YTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKI GDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGET WEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKD NRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHP QPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQT YGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSF CTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQ NYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVG NGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGR GRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQ PLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNS VGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTT STSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGF RVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQS LILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVE GSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTG TPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEH GQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP TNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSK YPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTLQPGSSIPPYNTEVTE TTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYV YTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTVSWERSTT PDITGYRITTTPTNGQQGNSLEEVXTHADQSSCTFDNLSPGLEYNVSVYT VKDDKESVPISDTIIPAVPPPTDLRFTNIGPDTMRVTWAPPPSIDLTNFL VRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQHESTP LRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRHHPEHFSG RPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSD VPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGS KSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQ VTDVQDNSISVKWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTI EGLQPTVEYVVSVYAQNPSGESQPLVQTAVTNIDRPKGLAFTDVDVDSIK IAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQGLRPGSEYT VSVVALHDDMESQPLIGTQSTAIPAPTDLKFTQVTPTSLSAQWTPPNVQL TGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTL TSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAV PANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSPVVIDA STAIDAPSNLRFLATTPNSLLVSWQPPRARITGYIIKYEKPGSPPREVVP RPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLIGRKKTDELPQLVT LPHPNLHGPEILDVPSTVQKTPFVTHPGYDTGNGIQLPGTSGQQPSVGQQ MIFEEHGFRRTTPPTTATPIRHRPRPYPPNVGEEIQIGHIPREDVDYHLY PHGPGLNPNASTGQEALSQTTISWAPFQDTSEYIISCHPVGTDEEPLQFR VPGTSTSATLTGLTRGATYNVIVEALKDQQRHKVREEVVTVGNSVNEGLN QPTDDSCFDPYTVSHYAVGDEWERMSESGFKLLCQCLGFGSGHFRCDSSR WCHDNGVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHEATCYDDG KTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGGEPSPEGTTGQS YNQYSQRYHQRTNTNVNCPIECFMPLDVQADREDSRE SEQ ID NO. 33 RYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGE YSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSI DSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVAL VGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQ EPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDK ARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL VTMQDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSK IIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEIL TKRLRYMVFRSMLRQDVSWFDDPK&TTGALTTRLANDAAQVKGAIGSRLA VITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQAL KDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRK AHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFG ANAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGN VTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLE RFYDPLAGKVLICELFQLLDGKEIKRLNVQWLPAHLGIVSQEPILFDCSI AENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLS GGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTC IVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGT KRQ SEQ ID NO. 34 MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWG SQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESR HLHLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLALFLYWVMAFITKTI KLVKYCQSGLDISNLRFCITGMMVILNGLLMAVEINVIRVRRYVFFMNPQ KVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGK LPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLEN AYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLST SNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYN LLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILK GIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSSKLLTPFFAQT FVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDS YEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIV GQVGCGKSSLLLAILGEMQTLEGKXTHWSKYVYFYRNRYSVAYAAQKPWL LNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGIN LSGGQRQRICVAPALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQD DKRTLVLVTHKLQYLTHADWIIANKDGSVLREGTLKDIQTKDVELYEHWK TLMNRQDQELEKDMEADQTTLERKTLRRANYSREAKAQMEDEDEEEEEEE DEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAI DYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMG LTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTL ESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQ ELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLF LSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNY LNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGE IKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFR MVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPEC KCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLAR AFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTIL TADLVIVMKRGNILEYDTPESLLAQENGVFASFVRADM SEQ ID NO. 35 RAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSAC GQRSSAAHKRYRRLQNWGYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLS TIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRF ARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDR RGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSS YADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILG SGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSPAYLTATWYYY DSILPSFRELALLFEHVQRARNGGLRPLEVRPAPVPDGAPSRYPPVATCH RPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQ VGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQC ELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGH LDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRV VKVEKQVQSIEHKLDLLVGFYSRWLRSGTSASLGAVQVPLFDPDITSDYH SPVDHEDISVSAQTLSISRSVSTNMD SEQ ID NO. 36 QIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNW QRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTW VGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKL KAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPL EAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSP EPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKK TICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAF IIWLARRLKKG SEQ ID NO. 37 QKEGKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTY CDVWMIQNGTLIESGIIGRSRKDFKRYLLNFIAANPLISLVNNFLKYGLN ELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCN SVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVSGLFLTRLR RPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRK LVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKS THSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVL KDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLA TPNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLT KPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDN VQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECT SAVSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFK QITEDTVEFGS SEQ ID NO. 38 MGHLLTLVFILALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTV WNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNN SASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQK QLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCI QMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKMYISQYSEIA IQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPI KKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKS LSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQ PKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCD QFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIWGPSYW CQNTETAAQCNAVEHCKRHVWN SEQ ID NO. 39 LTERADFQYSQRELDTIEVFPTKSARGNRVSCMYVRCVPGARYTVFFSHG NAVDLSQMSSFYIGLGSRLHCNIFYDYSGYGASAGRPSERNLYADIDAAW QALHTRYGISPDSIILYGQSIGTVPTVDLASRYECAAVVLHSPLTSGMRV AFPDTKTYCFDAFPNIEKVSKITSPVLIIHGMEDEVIDFSHGLALYERCP KAVEPLWVEGAGHNDIELYSQYLERLRRFISQELPS SEQ ID NO. 40 NSEPGGGGGEDGSAGLEVSAVQNVADVSVLQKHLRKLVPLLLEDGGEAPA ALEAALEEKSALEQMRKFLSDPQVHTVLVERSTLKEDVGDEGEEEKEFIS YNINIDIHYGVKSNSLAFIKRTPVIDADKPVSSQLRVLTLSEDSPYETLH SFISNAVAPFFKSYIRESGKADRDGDKMAPSVEKKIAELEMGLLHLQQNI EIPEISLPIHPMITNVAKQCYERGEKPKVTDFGDKVEDPTFLNQLQSGVN RWIREIQKVTKLDRDPASGTALQEISFWLNLEPALYRIQEKRESPEVLLT LDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLLSATEL DKIRQALVAIFTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRK LMHVAYEEFEKVMVACFEVFQTWDDEYEKLQVLLRDIVKRKREENLKMVW RINPAHRKLQARLDQMRKFRRQHEQLRAVIVRVLRPQVTAVAQQNQGEVP EPQDMKVAEVLFDAADANAIEEVNLAYENVKEVDGLDVSKEGTEAWEAAM KRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGA IREYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSIIW AKQIDRQLTAYMKRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFD DWARKVQQRNLGVSGRIFTIESTRVRGRTGNVLKLKVNFLPEIITLSKEV RNLKWLGFRVPLAIVNKAHQANQLYPFAISLIESVRTYERTCEKVEERNT ISLLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLAETVFNFQEKVDDL LIIEEKIDLEVRSLETCMYDHKTFSEILNRVQKAVDDLNLHSYSNLPIWV NKLDMEIERILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDAPQVSHKPG GEPKIKNVVHELRITNQVIYLNPPIEECRYKLYQEMFAWKMVVLSLPRIQ SQRYQVGVHYELTEEEKFYRNALTRMPDGPVALEESYSAVMGIVSEVEQY VKVWLQYQCLWDMQAENIYNRLGEDLNKWQALLVQIRKARGTFDNAETKK EFGPVVIDYGKVQSKVNLKYDSWHKEVLSKFGQMLGSNMTEFHSQISKSR QELEQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQ RFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKIVQEDRAV ESRTTDLLTDWEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKA KEALELTDTGLLSGSEERVQVALEELQDLKGVWSELSKVWEQIDQMKEQP WVSVQPRKLRQNLDALLNQLKSFPARLRQYASYEFVQRLLKGYMKINMLV IELKSEALKDRHWKQLMKRLHVNWVVSELTLGQIWDVDLQKNEAIVKDVL LVAQGEMALEEFLKQAKVWNTYELDLVNYQNKCRLIRGWDDLFNKVKEHI NSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGIF TGSADIKHLLPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSL ERLADLLGKIQKALGEYLERERSSFPRFYFVGDEDLLEIIGNSKNVAKLQ KHFKKMFAGVSSIILWEDNSVVLGISSREGEEVMFKTPVSITEHPKINEW LTLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNTYITWIDKYQAQLVV LSAQIAWSENVETALSSMGGGGDAAPLHSVLSNVEVTLNVLADSVLMEQP PLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQT DVLQQLSIQMANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLG GSPFGPAGTGKTESVKALGHQLGRFVLVFNCDETFDFQAMGRIFVGLCQV GAWGCFDEFNRLEERMLSAVSQQVQCIQEALREHSNPNYDKTSAPITCEL LNKQVKVSPDMAIFITMNPAYAGRSNLPDNLKKLFRSLAMTKPDRQLIAQ VMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSAG NVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLVA EDIPLLFSLLSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVGG MWVEKVLQLYQITQINHGLMMVGPSGSGKSMAWRVLLKALERLEGVEGVA HIIDPKAISKDHLYGTLDPNTREWTDGLFTHVLRKIIDSVRGELQKRQWI VFDGDVDPEWVEMLNSVLDDNKLLTLPNGERLSLPPNVRIMFEVQDLKYA TLATVSRCGMVWFSEDVLSTDMIFNNFLARLRSIPLDEGEDEAQRRRKGK EDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFQLEHIMDLTR LRCLGSLFSMLHQACRNVAQYNANHPDFPMQIEQLERYIQRYLVYAILWS LSGDSRLKMRAELGEYIRRITTVPLPTAPNIPIIDYEVSISGEWSPWQAK VPQIEVETHKVAAPDVVVPTLDTVRHEALLYTWLAEHKPLVLCGPPGSGK TMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRRTPNGVVLA PVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQTWV KLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGTF NRAMLRLIPSLRTYAEPLTAAMVEFYTMSQERFTQDTQPHYIYSPREMTR WVRGIFEALRPLETLPVEGLIRIWAHEALRLFQDRLVEDEERRWTDENID TVALKHFPNIDREKANSRPILYSNWLSKDYIPVDQEELRDYVKARLKVFY EEELDVPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVA WMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCK&EKIAFIMDESNVLD SGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELY KWFTSQVIRNLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEA LYQVGKEFTSKMDLEKPNYIVPDYMPVVYDKLPQPPSHREAIVNSCVFVH QTLHQANARLAKRGGRTMAITPRHYLDFINHYANLFHEKRSELEEQQMHL NVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKLKKMVKDQQEAE KKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIKK QHLVEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPTI VNFSAEEISDAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLN YADMLKRVEPLRNELQKLEDDAKDNQQKANEVEQMIRDLEASIARYKEEY AVLISEAQAIKADLAAVEAKVNRSTALLKSLSAERERWEKTSETFKNQMS TIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQANIQFRTDIARTE YLSNADERLRWQASSLPAIJDLCTENAIMLKRFNRYPLIIDPSGQATEFI MNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDPVLNPVLN REVRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVN FTVTRSSLQSQCLNEVLKAERPDVDEKRSDLLKLQGEFQLRLRQLEKSLL QALNEVKGRILDDDTIITTLENLKREAAEVTRKVEETDIVMQEVETVSQQ YLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLDIYHNVLYENPNLKGVT DHTQRLSIITKDLFQVAFNRVARGMLHQDHITFAMLLARIKLKGTVGEPT YDAEFQHFLRGNEIVLSAGSTPRIQGLTVEQAEAVVRLSCLPAFKDLIAK VQADEQFGIWLDSSSPEQTVPYLWSEETPATPIGQAIHRLLLIQAFRPDR LLANAHMFVSTNLGESFMSIMEQPLDLTHIVGTEVKPNTPVLMCSVPGYD ASGHVEDLAAEQNTQITSIAIGSAEGFNQADKAINTAVKSGRWVMLKNVH LAPGWLMQLEKKLHSLQPHACFRLFLTMEIWPKVPVNLLRAGRIFVFEPP PGVKANMLRTFSSIPVSRICKSPNERAPLYFLLAWFHAIIQERLRYAPLG WSKKYEFGESDLRSACDTVDTWLDDTAKASGRQNISPDKIPWSALKTLMA QSIYGGRVDNEFDQRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPD GIRREEFVQWVELLPDTQTPSWLGLPNNAERVLLTTQGVDMISKMLKMQM LEDEDDLAYAETEKKTRTDSTSDGRPAWMRTLHTTASNWLHLIPQTLSHL KRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYL RTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISLAAAS GGAKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVTTS QGATLDACSFGVTGLKLQGATCNNNKLSLSNAISTALPLTQLRWVKQTNT EKKASVVTLPVYLNFTRADLIFTVDFEIATKEDPRSFYERGVAVLCTE SEQ ID NO. 41 MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDL ISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPP TSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEA EPVEPPHSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSPQ HSSSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQ VPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSG LAPILRRKKKKKKLDRRPHEVFVELNELMLDRSQEPHWRETARWIKFEED VEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLPGIAHLVV ETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVL GNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRG KSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPV PVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSA ISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRG GYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDL RDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVL GVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCPAQDLEYLTGRVWVGLWL VVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEH PLLPFYPPEGALEGSLDAGLEPNGSALPPTEGPPSPRNQPNTALLSLILM LGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTY TQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILI FMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAAT VRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGA VLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKV KTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLLPRLF QDRELQALDSEDAEPNFDEDGQDEYNELHMPV SEQ ID NO. 42 DWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQ MTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGIT MLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQ VDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFL SRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECA KTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKV LYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFY TVLLFVTACLQTLVLHQYFEICFVSGMRIKTAVIGAVYRKALVITNSARK SSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSV LAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLK LYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFA VYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRL RIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITF SIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAW IQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGV NLSGGQKQRVSLAPAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGM LKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFL RTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSS SSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDY MKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRL SVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFER TPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAA IIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIR AFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAAL FAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKE YSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVT INGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDL RFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALP DKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDD LIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQ QRGLFYSMAKDAGLV SEQ ID NO. 43 FCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFL ISLIFIYETFYKLYKVFTEHPLLPFYPPEPGGVPGCWSGAKWQLPPTEGP PSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIP ISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPP WMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGS LGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRV TGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLL ILMPAKH SEQ ID NO. 44 MAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLE HHECHFPNKPLPSAGTVPWLQGLICNVNNTCFPQLTPGEEPGRLSNFNDS LVSRLLADARTVLGGASAHRTLAGLGKLIATLRAARSTAQPQPTKQSPLE PPMLDVAELLTSLLRTESLGLALGQAQEPLHSLLEAAEDLAQELLALRSL VELRALLQRPRGTSGPLELLSEALCSVRGPSSTVGPSLNWYEASDLMELV GQEPESALPDSSLSPACSELIGALDSHPLSRLLWRRLKPLILGKLLFAPD TPFTRKLMAQVNRTFEELTLLRDVREVWEMLGFRIFTFMNDSSNVAMLQR LLQMQDEGRRQPRPGGRDHMEALRSFLDPGSGGYSWQDAHADVGHLVGTL GRVTECLSLDKLEAAPSEAALVSRALQLLAEHRFWAGVVFLGPEDSSDPT EHPTPDLGPGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLTDLRYVW GGFVYLQDLVERAAVRVLSGANPRAGLYLQQMPYPCYVDDVFLRVLSRSL PLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCL GPFLLSAALLVLVLKLGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFF SPANLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGRVAASLLSPVAFGFG CESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGLLLLDAALYGLATWY LEAVCPGQYGIPEPWNFPFRRSYWCGPRPPKSPAPCPTPLDPKVLVEEAP PGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTT LSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDE HVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSV AIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDE AELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKA DTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELV LVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEEC AADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETD QGSGPDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFV GLALVFSLIVPPFGHYPALRLSPTMYGAQVSFFSEDAPGDPGPARLLEAL LQEAGLEEPPVQHSSHRFSAPEVPAEVAKVLASGNWTPESPSPACQCSRP GARRLLPDCPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLVR QGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEELWALLSPLPGGA LDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHLP PGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAMSFVP ASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVL IFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVV LTCINLFIGINGSMATFVLELFSDQQKLQEVSRILKQVFLIFPHFCLGRG LIDMVRNQANADAFERLGDRQFQSPLRWEVVGKNLLAMVIQGPLFLLFTL LLQHRSQLLPQPRVRSLPLLGEEDEDVARERERVVQGATQGDVLVLRNLT KVYRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRG EAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPE AQVAQTAGSGLARLGLSWYADRPAGTYSGGNKRKIATALALVGDPAVVFL DEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMV NGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAAEFPGAELRE AHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLY FSKDQGKDEDTEEQKEAGVGVDPAPGLQHPKRVSQFLDDPSTAETVL SEQ ID NO. 45 MRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMS IDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGY ISDVKLLYKIQENMHYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEH ETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTY GWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGS DLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHI ECELNFEIHGSAEIRCEDGKSTEPPKCIEGQEKVACEEPPFIENGAANLH SKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPP VVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVC LEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSE LSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVE YRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDF DNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPRQ SEQ ID NO. 46 MGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCS YTWEAVDTKNNVLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVGDSV LRSATRSLLEFNTTVSCDQQGTNHRVQSSIAFLCGKTLGTPEFVTATECV HYFEWRTTAACKKDIFKANKEVPCYVFDEELRKHDLNPLIKLSGAYLVDD SDPDTSLFINVCRDIDTLRDPGSQLRACPPGTAACLVRGHQAFDVGQPRD GLKLVRKDRLVLSYVREEAGKLDFCDGHSPAVTITFVCPSERREGTIPKL TAKSNCRYEIEWITEYACHRDYLESKTCSLSGEQQDVSIDLTPLAQSGGS SYISDGKEYLFYLNVCGETEIQFCNKKQAAVCQVKKSDTSQVKAAGRYHN QTLRYSDGDLTLIYFGGDECSSGFQRMSVINFECNKTAGNDGKGTPVFTG EVDCTYFFTWDTEYACVKEKEDLLCGATDGKKRYDLSALVRHAEPEQNWE AVDGSQTETEKKHFFINICHRVLQEGKARGCPEDAAVCAVDKNGSKNLGK FISSPMKEKGNIQLSYSDGDDCGHGKKIKTNITLVCKPGDLESAPVLRTS GEGGCFYEFEWHTAAACVLSKTEGENCTVFDSQAGFSFDLSPLTKKNGAY KVETKKYDFYINVCGPVSVSPCQPDSGACQVAKRQVASHDEKTWNLGLSN AKLSYYDGMIQLNYRGGTPYNNERHTPRATLITFLCDRDAGVGFPEYQEE DNSTYNFRWYTSYACPEEPLECVVTDPSTLEQYDLSSLAKSEGGLGGNWY ANDNSGEHVTWRKYYINVCRPLNPVPGC&RYASACQMKYEKDQGSFTEVV SISNLGMAKTGPVVEDSGSLLLEYVNGSACTTSDGRQTTYTTRIHLVCSR GRLNSHPIFSLNWECVVSFLWNTEAACPIQTTTDTDQACSIRDPNSGFVF NLNPLNSSQGYNVSGIGKIFMFNVCGTMPVCGTILGKPASGCEAETQTEE LKNWKPARPVGIEKSLQLSTEGFITLTYKGPLSAKGTADAFIVRFVCNDD VYSGPLKFLHQDIDSGQGIRNTYFEFETALACVPSPVDCQVTDLAGNEYD LTGLSTVRKPWTAVDTSVDGRKRTFYLSVCNPLPYIPGCQGDAVGSCLVS EGNSWNLGVVQMSPQAAANGSLSIMYVNGDKCGNQRFSTRITFECAQISG SPAFQLQDGCEYVFIWRTVEACPVVRVEGDNCEVKDPRHGNLYDLKPLGL NDTIVSAGEYTYYFRVCGKLSSDVCPTSDKSKVVSSCQEKREPQGFHKVA GLLTQKLTYENGLLKMNFTGGDTCHKVYQRSTAIFFYCDRGTQRPVFLKE TSDCSYLFEWRTQYACPPFDLTECSFKDGAGNSFDLSSLSRYSDNWEAIT GTGDPEHYLINVCKSLAPQAGTEPCPPEAAACLLGGSKPVNLGRVRDGPQ WRDGIIVLKYVDGDLCPDGIRKKSTTIRFTCSESQVNSRPMFISAVEDCE YTFAWPTATACPMKSNEHDDCQVTNPSTGHLFDLSSLSGRAGFTAAYSEK GLVYMSICGENENCPPGVGACFGQTRISVGKANKRLRYVDQVLQLVYKDG SPCPSKSGLSYKSVISFVCRPEAPPTNRPMLISLDKQTCTLFFSWHTPLA CEQATECSVRNGSSIVDLSPLIHRTGGYEAYDESEDDASDTNPDFYINIC QPLNPMHGVPCPAGAAVCKVPIDGPPIDIGRVAGPPILNPIANEIYLNFE SSTPCLADKHFNYTSLIAFHCKRGVSMGTPKLLRTSECDFVFEWETPVVC PDEVRMDGCTLTDEQLLYSFNLSSLSTSTFKVTRDSRTYSVGVCTFAVGP EQGGCKDGGVCLLSGTKGASFGRLQSMKLDYRHQDEAVVLSYVNGDRCPP ETDDGVPCVFPFIFNGKSYEECIIESRAKLWCSTTADYDRDHEWGFCRHS NSYRTSSIIFKCDEDEDIGRPQVFSEVRGCDVTFEWKTKVVCPPKKLECK FVQKHKTYDLRLLSSLTGSWSLVHNGVSYYINLCQKIYKGPLGCSERASI CRRTTTGDVQVLGLVHTQKLGVIGDKVVVTYSKGYPCGGNKTASSVIELT CTKTVGRPAFKRFDIDSCTYYFSWDSRAACAVKPQEVQMVNGTITNPING KSFSLGDIYFKLFRASGDMRTNGDNYLYEIQLSSITSSRNPACSGANICQ VKPNDQHFSRKVGTSDKTKYYLQDGDLDVVFASSSKCGKDKTKSVSSTIF FHCDPLVEDGIPEFSHETADCQYLFSWYTSAVCPLGVGFDSENPGDDGQM HKGLSERSQAVGAVLSLLLVALTCCLLALLLYKKERRETVISKLTTCCRR SSNVSYKYSKVNKEEETDENETEWLMEEIQLPPPRQGKEGQENGHITTKS VKALSSLHGDDQDSEDEVLTIPEVKVHSGRGAGAESSHPVRNAQSNALQE REDDRVGLVRGEKARKGKSSSAQQKTVSSTKLVSFHDDSDEDLLHI SEQ ID NO. 47 LGFSLPPHLLFRPRLDLQFLQRFLQILKVLFPSWSSQNALMFLTLLCLTL LGDFDQFTCNLLYVSWRKDLTEHLHRLYFRGRAYYTLNVLRDDIDNPDQR ISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFQSTGWLGPVSIFGYFI LGTVVNKTLMGPIVMKLVHQEKLEGDFRFKHMQIRVNAEPAAFYRAGHVE HMRTDRRLQRLLQTQRELMSKELWLYIGINTFDYLGSILSYVVIAIPIFS GVYGDLSPAELSTLVSKNAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIG QLRETLLDMSLKSQDCEILGESEWGLDTPPGWPAAEPADTAFLLERVSIS APSSDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSV QMLTDFGPHGVLFLPQKPFFTDGTLREQVTYPLKEVYPDSGSADDERILR FLELAGLSNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYA VLDEATSALTEEVESELYRIGQQLGMTFISVGMRQSLEKFHSLVLKLCGG GRWELMRIKVE SEQ ID NO. 48 MAATLILEPAGRCCWDEPVRIAVRGLAPEQPVTLRASLRDEKGALFQAHA RYRADTLGELDLERAPALGGSFAGLEPMGLLWALEPEKPLVRLVKRDVRT PLAVELEVLDGHDPDPGRLLCRVRHERYFLPPGVRREPVRAGRVRGTLFL PPEPGPFPGIVDMFGTGGGLLEYRASLLAGKGFAVMALAYYNYEDLPKTM ETLHLEYFEEAVNYLLSHPEVKGPGVGLLGISKGGELCLSMASFLKGITA AVVINGSVANVGGTLRYKGETLPPVGVNRNRIKVTKDGYADIVDVLNSPL EGPDQKSFIPVERAESTFLFLVGQDDHNWKSEFYANEACKRLQAHGRRKP QIICYPETGHYIEPPYFPLCPASLHALVGSPIIWGGEPRAHAMAQVDAWK QLQTFFHKHLGGHEGTIPSKV SEQ ID NO. 49 MPKAPKQQPPEPEWIGDGESTSPSGEAGRQGRNEQRGKREETARFFEELA VEDKQAGEEEKVLKEKEQQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEK ELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEE EEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKVRXXXFF LPSQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFS ISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNI DVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAE RLEKVYEELPATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRV SLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGF LDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKE LKAGGKSTKQAEKQTKEALTRKQQKCRRKMQDEESQEAPELLKRPKEYTV RFTFPDPPPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPN GVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEY LQRGFNLPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACRE PDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLW VVEEQSVSQIDGDFEDYKREVLEALGEVMVSRPRE SEQ ID NO. 50 KMLSSFLSPQNGTWADTFSLLLALAVALYLGYYWACVLQRPRLVAGPQFL AFLEPHCSITTETFYPTLWCFEGRLQSIFQVLLQSQPLVLYQSDILQTPD GGQLLLDWAKQPDSSQDPDPTTQPIVLLLPGITGSSQDTYVLHLVNQALR DGYQAVVFNNRGCRGEELRTHRAFCASNTEDLETVVNHIKHRYPQAPLLA VGISFGGILVLNHLAQARQAAGLVAALTLSACWDSFETTRSLETPLNSLL FNQPLTAGLCQLVERNRKVIEKVVDIDFVLQARTIRQFDERYTSVAFGYQ DCVTYYKAASPRTKIDAIRIPVLYLSAADDPFSPVCALPIQAAQHSPYVA LLITARGGHIGFLEGLLPWQHWYMSRLLHQYAKAIFQDPEGLPDLRALLP SEDRN SEQ ID NO. 52 LFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQKVENDTSPH REPATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKV KASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRT PEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHP TWLLHIFIPFCIIAFIFIATVIALRKQLCQKLYSSKDVSIHCAKVTLLVP IPTQTTVLQDYSSYGSPTHALSLVPKQDPYGLMR SEQ ID NO. 53 MARGYGATVSLVLLGLGLALAVIVLAVVLSRHQAPCGPQAFAHAAVAADS KVCSDIGRAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGVIFTIYNVT TGAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAPVLSR FLHNSILRPSLQASTLRQLFFNGTEPLRPQDPLPWPALATTLETVATEGV EVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTLYS PPPPAGGAILSFILNVLRGFNFSTESMARPEGRVNVYHHLVETLKFAKGQ RWRLGDPRSHPKLQNASRDLLGETLAQLIRQQIDGRGDHQLSHYSLAEAW GHGTGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNELLDLC ERCPRGSGTTPSPVETGWVELPEGAGPQFQASVPHPPWCPPS SEQ ID NO. 54 MAVTLDKDAYYRRVKRLYSNWRKGEDEYANVDAIVVSVGVDEEIVYAKST ALQTWLFGYELTDTIMVFCDDKIIFMASKKKVEFLKQIANTKGNENANGA PAITLLIREKNESNKSSFDKMIEAIKESKNGKKIGVFSKDKFPGEFMKSW NDCLNKEGFDKIDISAVVAYTIAVKEDGELNLMKKAASITSEVFNKFFKE RVMEIVDADEKVRHSKLAESVEKAIEEKKYLAGADPSTVEMCYPPIIQSG GNYNLKFSVVSDKNHMHFGAITCAMGIRFKSYCSNLVRTLMVDPSQEVQE NYNFLLQLQEELLKELRHGVKICDVYNAVMDVVKKQKPELLNKITKNLGF GMGIEFREGSLVINSKNQYKLKKGMVFSINLGFSDLTNKEGKKPEEKTYA LFIGDTVLVDEDGPATVLTSVKKKVKNVGIFLKNEDEEEEEEEKDEAEDL LGRGSRAALLTERTRNEMTAEEKRRAHQKELAAQLNEEAKRRLTEQKGEQ QIQKARKSNVSYKNPSLMPKEPHIREMKIYIDKKYETVIMPVFGIATPFH IATIKNISMSVEGDYTYLRINFYCPGSALGRNEGNIFPNPEATFVKEITY RASNIKAPGEQTVPALNLQNAFRIIKEVQKRYKTREAEEKEKEGIVKQDS LVINLNRSNPKLKDLYIRPNIAQKRMQGSLEAHVNGFRFTSVRGDKVDIL YNNIKHALFQPCDGEMIIVLHFHLKNAIMFGKKRHTDVQFYTEVGEITTD LGKHQHMEDRDDLYAEQMEREMRHKLKTAFKNFIEKVEALTKEELEFEVP FRDLGFNGAPYRSTCLLQPTSSALVNATEWPPFVVTLDEVELINFERVQF HLKNFDMVIVYKDYSKKVTMINAIPVASLDPIKEWLNSCDLKYTEGVQSL NWTKIMKTIVDDPEGFFEQGGWSFLEPEGEGSDAEEGDSESEIEDETFNP SEDDYEEEEEDSDEDYSSEAEESDYSKESLGSEEESGKDWDELEEEARKA DRESRYEEEEEQSRSMSRKRKASVHSSGRGSNRGSRHSSAPPKKKRK SEQ ID NO. 55 SPILCGAATALNCSLCPQDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWV ALPCYLLYLRHNCRGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVH GRAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVC AIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILACFREKPPFF SAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEED RSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKP SFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSW WGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVIT NSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQN LGPSVLAGVAFMVLLIPLNGAVAVKMPAFQVKQMKLKDSRIKLMSEILNG IKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVT LITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASV SLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLNSL DIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQ AWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEK GINLSGGQRQRVSLAPAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPE GVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFAN FLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTY VVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEE KAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTN DAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQA LLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNA ISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPI YSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSI GVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMM SDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVR YRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEI RIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWW ALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRIL VLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLD KGVVAEFDSPANLIIAARGIFYGMARDAGLA SEQ ID NO. 56 PYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQG YHLWSEAIPLCQALSCGLPEAPKNGMVFGKEYTVGTKANYSCSEGYHLQA GAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQ FQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRILAKQKQPCPS SWGWLTEHLVIILVISCGELPIPPNGHRIGTLSVYGATAIFSCNSGYTLV GSRVRECMANGLWSGSEVRCLATQTKLHSIFYKLLFDVLSSPSLTKAGHC GTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKT PFCVPITCGHPGNPVNGLTQGNQFNLNDVVKFVCNPGYMAEGAARSQCLA SGQWSDMLPTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNNG FYLLGTPVLSCQGDGTWDRPRPQCLLVSCGHPGSPPHSQMSGDSYTVGAV VRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCS SEQ ID NO. 57 PLAFCGSENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGW GSQSSKVHIHHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTES HHLHLYMPAGMAFMAAVTSVVYYHNIETSNFPKLLIALLVYWTLAFITKT IKFVKFLDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTP REVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIG KLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGAPAIWQALSHAFGRRLVL SSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEF LANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMH LSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVIL LYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNE MLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIP IAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTV KALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRP AREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITI RIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSMPFLPCCSPE RETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEA CSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDD PFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKD GTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQG LSRAMSSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYL SSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQ ECTLDQTVYANVFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRI ILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALA VISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFA ETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMATP LPPQEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWM VRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQ NLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDT FEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSD STLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVR KTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADL VIVLKRGAILEFDKPEKLLSRKDSVFASFVRADK SEQ ID NO. 58 MPRNLLYSLLSSHLSPHFSTSVTSAKVAVNGVQLHYQQTGEGDHAVLLLP GMLGSGETDFGPQLKNLNKKLFTVVAWDPRGYGHSRPPDRDFPADFFERD AKDAVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIWGANAY VTDEDSMIYEGIRDVSKWSERTRKPLEALYGYDYFARTCEKWVDGIRQFK HLPDGNICRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGSRLHLM PEGKHNLHLRFADEFNKLAEDFLQ SEQ ID NO. 59 MMREWVLLMSVLLCGLAGPTHLFQPSLVLDMAKVLLDNYCFPENLLGMQE AIQQAIKSHEILSISDPQTLASVLTAGVQSSLNDPRLVISYEPSTPEPPP QVPALTSLSEEELLAWLQRGLRHEVLEGNVGYLRVDSVPGQEVLSMMGEF LVAHVWGNLMGTSALVLDLRHCTGGQVSGIPYIISYLHPGNTILHVDTIY NRPSNTTTEIWTLPQVLGERYGADKDVVVLTSSQTRGVAEDIAHILKQMR RAIVVGERTGGGALDLRKLRIGESDFFFTVPVSRSLGPLGGGSQTWEGSG VLPCVGTPAEQALEKALAILTLRSALPGVVHCLQEVLKDYYTLVDRVPTL LQHLASMDFSTVVSEEDLVTKLNAGLQAASEDPRLLVRAIGPTETPSWPA PDAAAEDSPGVAPELPEDEAIRQALVDSVFQVSVLPGNVGYLRFDSFADA SVLGVLAPYVLRQVWEPLQDTEHLIMDLRHNPGGPSSAVPLLLSYFQGPE AGPVHLFTTYDRRTNITQEHFSHMELPGPRYSTQRGVYLLTSHRTATAAE EFAFLMQSLGWATLVGEITAGNLLHTRTVPLLDTPEGSLALTVPVLTFID NHGEAWLGGGVVPDAIVLAEEALDKAQEVLEFHQSLGALVEGTGHLLEAW IARPEVVGQTSALLRAKLAQGAYRTAVDLESLASQLTADLQEVSGDHRLL VFHSPGELVVEEAPPPPPAVPSPEELTYLIEALFKTEVLPGQLGYLRFDA MAELETVKAVGPQLVRLVWQQLVDTAALVIDLRYNPGSYSTAIPLLCSYF FEAEPRQHLYSVFDRATSKVTEVWTLPQVAGQRYGSHKDLYILMSHTSGS AAEAFAHTMQDLQRATVIGEPTAGGALSVGIYQVGSSPLYASMPTQMAMS ATTGKAWDLAGVEPDITVPMSEALSIAQDIVALRAKVPTVLQTAGKLVAD NYASAELGAKMATKLSGLQSRYSRVTSEVALAEILGADLQMLSGDPHLKA AHIPENAKDRIPGIVPMQIPSPEVFEELIKFSFHTNVLEDNIGYLRFDMF GDGELLTQVSRLLVEHIWKKIMHTDAMIIDMRFNIGGPTSSIPILCSYFF DEGPPVLLDKIYSRPDDSVSELWTHAQVVGERYGSKKSMVILTSSVTAGT AEEFTYIMKRLGRALVIGEVTSGGCQPPQTYHVDDTNLYLTIPTARSVGA SDGSSWEGVGVTPHVVVPAEEALARAKEMLQHNQLRVKRSPGLQDHL SEQ ID NO. 60 MAEVNIIYVTVFILKGITNRPELQAPCFGVFLVIYLVTVLGNLGLITLIK IDTRLHTPMYYFLSHLAFVDLCYSSAITPKMMVNFVVERNTIPFHACATQ LGCFLTFMITECFLLASMAYDCYVAICSPLHYSTLMSRRVCIQLVAVPYI YSFLVALFHTVITFRLTYCGPNLINHFYCDDLPFLALSCSDTHMKEILIF AFAGFDMISSSSIVLTSYIFIIAAILRIRSTQGQHKAISTCGSHMVTVTI FYGTLIFMYLQPKSNHSLDTDKMASVFYTVVIPMLNPLIYSLRNKEVKDA SEQ ID NO. 61 MIQLTATPVSALVDEPVHIRATGLIPFQMVSFQASLEDENGDMFYSQAHY RANEFGEVDLNHASSLGGDYMGVHPMGLFWSLKPEKLLTRLLKRDVMNRP FQVQVKLYDLELIVNNKVASAPKASLTLERWYVAPGVTRIKVREGRLRGA LFLPPGEGLFPGVIDLFGGLGGLLEFPASLLASRGFASLALAYHNYEDLP RKPEVTDLEYFEEAANFLLRHPKVFGSGVGVVSVCQGVQIGLSMAIYLKQ VTATVLINGTNFPFGIPQVYHGQIHQPLPHSAQLISTNALGLLELYRTFE TTQVGASQYLFPIEEAQGQFLFIVGEGDKTINSKAHAEQAIGQLKRHGKN NWTLLSYPGAGHLIEPPYSPLCCASTTHDLRLHWGGEVIPHAAAQEHAWK EIQRFLRKHLIPDVTSQL SEQ ID NO. 62 ISPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILDEVELKGCSSVL GHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLH EQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQ AIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNK LGKDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADV YPLSQTFHKLEA SEQ ID NO. 63 WNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLN KTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLAT FLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEVDLFRDIT FYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWI TGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRNSSGS GESCSANTEALFPAPTCHKSFQALSLLLCRLLIKFVNDTKAPDWQGYFYT VLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKS STVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLVVAPDVL TAVSSKVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEE LKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVS LALFNILRFPLNILPMVISSIVQVQGEAGATSERGPWGSRPRKHGTRQAS FSVAEPGVLCRFSITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG HVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDL EILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDA HVGKHIFENVIGPKGMLKNKSCLISCDLQVKLSVYWDYMKAIGLFISFLS IFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGI AVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSK ELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFF VQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQS DLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAG LVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQI QETAPPSSWPQVGRVEFPNYCLRYREDLDFVLRHINVTINGGEKVGIVGR TGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPV LFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGE NLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFED CTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDA GLV SEQ ID NO. 64 HRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNREN FHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCII PNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALN KWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRG AASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSF VCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTG TPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPA PRCELSVRAGHCKTPEQFFFASPTIPINDFEFPVGTSLNYECRPGYFGKM FSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSC NEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPFPTISNGDFYSNN RTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPR CISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQ TNGRWGPKLPHCSRVCQPPHILHGEHTLSHQDNFSPGQEVFYSCEPSYDL RGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKV SFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCER SEQ ID NO. 65 MRGPPAWPLRLLEPPSPAEPGRLLPVACVWAAASRVPGSLSPFTGLRPAR LWGAGPALLWGVGAARRWRSGCRGGGFGASRGVLGLARLLGLWARGPGSC RCGAFAGPGAPRLPARRFPGGPAAAAWAGDEAWRRGPAAPPGDKGRLRPA AAGLPEARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIY TNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTS LFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQA SVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQA TQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFG ATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSS FYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFA YPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGT ISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTA EEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLK NPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANM VAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQSFISA SEQ ID NO. 66 GILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPR LSVMEEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKKLA LNKLSLNLYENQVVSFLGHNGAGKTTHHNVLFDRLTVEEHLWFYSRLKSM AQEEIRREMDKNIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAI ILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAII SHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAP LSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQH LERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDVLP GAEGPASGEGHAGNLARCSELTQSQASLQSASSVGSARGDEGAGYTDVYG DYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLKVRQFHGLLV KRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQY HNYTQPRGNFIPYANEERREYRRHPAGASLVGGASEGAGTALVGQAGEGA GLARGGDWQPHLTLIWGRGGEDLGPESAAPAPPCAGITVTNHFMNKTSAS LSLDYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGC NPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFL LYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEH DKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMK SPFEWDIVTRGLVAMAVEGVVGFLLTIMCQYNFLRRPQRMPVSTKPVEDD VDVASERQRVLRGDSDNDMCFGLLGVNGAGKTSTFKMLTGDESTTGGEAF VNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDE ARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEP TTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGR LRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFNRNFPEAMLKERH HTKVQYQLKSEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAK KQSDNLEQQETEPPSALQSPLGCLLSLLRPRSAPTELRALVADEPEDLDT EDEGLISFEEERAQLSFNTDTLC SEQ ID NO. 67 MGPGRPAPAPWPRHLLRCVLLLGCLHLGRPGAPGDAALPEPNIFLIFSHG LQGCLEAQGGQVRVTPACNTSLPAQRWKWVSRNRLFNLGTMQCLGTGWPG TNTTASLGMYECDREALNLRWHCRTLGDQLSLLLGARTSNISKPGTLERG DQTRSGQWRIYGSEEDLCALPYHEVYTIQGNSHGKPCTIPFKYDNQWFHG CTSTGREDGHLWCATTQDYGKDERWGFCPIKSNDCETFWDKDQLTDSCYQ FNFQSTLSWREAWASCEQQGADLLSITEIHEQTYINGLLTGYSSTLWIGL NDLDTSGGWQWSDNSPLKYLNWESDQPDNPSEENCGVIRTESSGGWQNRD CSIALPYVCKKKPNATAEPTPPDRWANVKVECEPSWQPFQGHCYRLQAEK RSWQESKKACLRGGGDLVSIHSMAELEFITKQIKQEVEELWIGLNDLKLQ MNFEWSDGSLVSFTHWHPFEPNNFRDSLEDCVTIWGPEGRWNDSPCNQSL PSICKKAGQLSQGAAEEDHGCRKGWTWHSPSCYWLGEDQVTYSEARRLCT DHGSQLVTITNRFEQAFVSSLIYNWEGEYFWTALQDLNSTGSFFWLSGDE VMYTHWNRDQPGYSRGGCVALATGSAMGLWEVKNCTSFRARYICRQSLGT PVTPELPGPDPTPSLTGSCPQGWASDTKLRYCYKVFSSERLQDKKSWVQA QGACQELGAQLLSLASYEEEHFVANMLNKIFGESEPEIHEQHWFWIGLNR RDPRGGQSWRWSDGVGFSYHNFDRSRHDDDDIRGCAVLDLASLQWVAMQC DTQLDWICKIPRGTDVREPDDSPQGRREWLRFQEAEYKFFEHHSTWAQAQ RICTWFQAELTSVHSQAELDFLSHNLQKFSRAQEQHWWIGLHTSESDGRF RWTDGSIINFISWAPGKPRPVGKDKKCVYMTASREDWGDQRCLTALPYIC KRSNVTKETQPPDLPTTALGGCPSDWIQFLNKCFQVQGQEPQSRVKWSEA QFSCEQQEAQLVTITNPLEQAFITASLPNVTFDLWIGLHASQRDFQWVEQ EPLMYANWAPGEPSGPSPAPSGNKPTSCAVVLHSPSAHFTGRWDDRSCTE ETHGFICQKGTDPSLSPSPAALPPAPGTELSYLNGTFRLLQKPLRWHDAL LLCESHNASLAYVPDPYTQAFLTQAARGLRTPLWIGLAGEEGSRRYSWVS EEPLNYVGWQDGEPQQPGGCTYVDVDGAWRTTSCDTKLQGAVCGVSSGPP PPRRISYHGSCPQGLADSAWIPFREHCYSFHMELLLGHKEARQRCQRAGG AVLSILDEMENVFVWEHLQSYEGQSRGAWLGMNFNPKGGTLVWQDNTAVN YSNWGPPGLGPSMLSHNSCYWIQSNSGLWRPGACTNITMGVVCKLPRAEQ SSFSPSALPENPAALVVVLMAVLLLLALLTAALILYRRRQSIERGAFEGA RYSRSSSSPTEATEKILVSDMEMNEQQE SEQ ID NO. 68 MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDPYINIDAGTF SPYEHGEVFVLNDGGEVDLDLGNYERFLDINLYKDNNITTGKIYQHVINK ERRGDYLGKTVQVVPHITDAVQEWVMNQAKVPVDGNKEEPQICLGGTIGD IEGMPFVEAFRQFQFKAKRENFCNIHVSLVPQLSATGEQKTKPTQNSVRA LRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQVICIHDVSSTYRV PVLLEEQSIVKYFKERLHLPIGDSASNLLFKWRNMADRYERLQKICSIAL VGKYTKLRDCYASVFKALEHSALAINHKLNLMYIDSIDLEKITETEDPVK FHEAWQKLCKADGILVPGGFGIRGTLGKLQAISWARTKKIPFLGVCLGMQ LAVIEFARNCLNLKDADSTEFRPNAPVPLVIDMPEHNPGNLGGTMRLGIR RTVFKTENSILRKLYGDVPFIEERHRHRFEVNPNLIKQFEQNDLSFVGQD VDGDRMEIIELANHPYFVGVQFHPEFSSRPMKPSPPYLGLLLAATGNLNA YLQQGCKLSSSDRYSDASDDSFSEPRIAELEIS SEQ ID NO. 69 SPILCGAATALNCSLCPQDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWV ALPCYLLYLRHHCRGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVH GPAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVC AIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILACFREKPPFF SAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEED RSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKP SFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSW WGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVIT NSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQN LGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNG IKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVT LITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASV SLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSL DIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQ AWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEK GINLSGGQRQRVSLAPAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPE GVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFAN FLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTY VVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEE KAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTN DANADSRQNNTSLRLGVYAALGILQGFLVMLAAMANAAGGIQAARVLHQA LLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNA ISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPI YSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRSEAA SLAPCSSRNSQQALWCSGSLSLLSPKQKTGPALPLPHFLLI SEQ ID NO. 70 AFHQGSLILCLALQSDRLLIKGGRIINDDQSLYADVYLEDGLIKQIGENL IVPGGVKTIEANGRMVIPGGIDVNTYLQKPSQGMTAADDFFQGTRAALVG GTTMIIDHVVPEPGSSLLTSFEKWHEAADTKSCCDYSLHVDITSWYDGVR EELEVLVQDKGVNSFQVYMAYKDVYQMSDSQLYEAFTFLKGLGAVILVHA ENGDLIAQEQKRILEMGITGPEGHALSRPEELEAEAVFPAITIAGRINCP VYITKVMSKSAADIIALARKKGPLVFGEPIAASLGTDGTHYWSKNWAKAA AFVTSPPLSPDPTTPDYLTSLLACGDLQVTGSGHCPYSTAQKAVGKDNFT LIPEGVNGIEERMTVVWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKG RIAVGSDADVVIWDPDKLKTITAKSHKSAVEYNIFEGMECHGSPLVVISQ GKIVFEDGNINVNKGMGRFIPRKAFPEHLYQRVKIRNKVFGLQGVSRGMY DGPVYEVPATPKYATPAPSAKSSPSKHQPPPIRNLHQSNFSLSGAQIDDN NPRRTGHRIVAPPGGRSNITSLG SEQ ID NO. 71 MQRALPGARQHLGAILASASVVVKALCAAVLFLYLLSFAVDTGCLAVTPG YLFPPNFWIWTLATHGLMEQHVWDVAISLTTVVVAGRLLEPLWGALELLI FFSVVNVSVGLLGAFAYLLTYMASFNLVYLFTVRIHGALGFLGGVLVALK QTMGDCVVLRVPQVRVSVMPMLLLALLLLLRLATLLQSPALASYGFGLLS SWVYLRFYQRHSRGRGDMADHFAFATFFPEILQPVVGLLANLVHSLLVKV KICQKTVKRYDVGAPSSITISLPGTDPQDAERRRQLALKALNERLKRVED QSIWPSMDDDEEESGAKVDSPLPSDKAPTPPGKGAAPESSLITFEAAPPT L SEQ ID NO. 72 MPVLSRPRPWRGNTLKRTAVLLALAAYGAHKVYPLVRQCLAPARGLQAPA GEPTQEASGVAAAKAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAA LVSRTFLSVYVARLDGRLARCIVRKDPRAFGWQLLQWLLIALPATFVNSA IRYLEGQLALSFRSRLVAHAYRLYFSQQTYYRVSNMDGRLRNPDQSLTED VVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLV VFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHE VELALLQRSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVP IITATGYSESDAEAVKKAALEKKEEELVSERTEAFTIARNLLTAAADAIE RIMSSYKEVTELAGYTARVHEMFQVFEDVQRCHFKRPRELEDAQAGSGTI GRSGVRVEGPLKIRGQVVDVEQGIICENIPIVTPSGEVVVASLNIRVEEG MHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMFYIPQRPYMSV GSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCD WKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDA GIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLE QQLAGIPKMQRRLQELCQILGEAVAPAHVPAPSPQGPGGLQGAST SEQ ID NO. 73 MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQV RYVHHEDYQFCYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHL VCVDMPGHEGTTRSSLDDLSIDGQVKRIHQFVECLKLNKKPFHLVGTSMG GQVAGVYAAYYPSDVSSLCLVCPAGLQYSTDNQFVQRLKELQGSAAVEKI PLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHNNFYRKLFLEI VSEKSRYSLHQNMDKIKVPTQIIWGKQDQVLDVSGADMLAKSIANCQVEL LENCGHSVVMERPRKTAKLIIDFLASVHNTDNNK SEQ ID NO. 74 SDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGL MVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTG VSLLAAYEQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNS FLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLL ELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMSKGAADA IAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTT ADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMS MVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWN PKATKIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTP GAGRFVPRKTFPDFVYKRIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPG SGAPAPASCPGKISVPPVRNLHQSGFSLSGSQADDHIARRTAQKIMAPPG GRSNITSLS SEQ ID NO. 75 MARRSVLYFILLNALINKGQACFCDHYAWTQWTSCSKTCNSGTQSRHRQI VVDKYYQENFCEQICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEKQ GTSNFHYLNHLFTSFFHLDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKA LNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGL TEEEAKHCVRIETKKRVLFAKKTKVEHRCTTNKLSEKHEGSFIQGAEKSI SLIRGGRSEYGAALAWEKGSSGLEEKTFSEWLESVKENPAVIDFELAPIV DLVRNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSGTECLC VCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNN PAPQRGGKRCEGEKRQEEDCTFSIMENNGQPCINDDEEMKEVDLPEIEAD SGCPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGT WRQGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGP SRYTCQGNSWTPPISNSLTCEKDTLTKLKGHCQLGQKQSGSECICMSPEE DCSHHSEDLCVFDTDSNDYFTSPACKFLAEKCLNNQQLHFLHIGSCQDGR QLEWGLERTRLSSNSTKKESCGYDTCYDWEKCSASTSKCVCLLPPQCFKG GNQLYCVKMGSSTSEKTLNICEVGTIRCANRKMEILHPGKCLA SEQ ID NO. 76 MERKNQTAITEFIILGFSNLNELQFLLFTIFFLTYFCTLGGNILIILTTV TDPHLHTPMYYFLGNLAFIDICYTTSNVPQMMVHLLSKKKSISYVGCVVQ LFAFVFFVGSECLLLAAMAYDRYIAICNPLRYSVILSKVLCNQLAASCWA AGFLNSVVHTVLTFCLPFCGNNQINYFFCDIPPLLILSCGNTSVNELALL STGVFIGWTPFLCIVLSYICIISTILRIQSSEGRRKAFSTCASHLAIVFL FYGSAIFTYVRPISTYSLKKDRLVSVLYSVVTPMLNPIIYTLRNKDIKEA VKTIGSKWQPPISSLDSKLTY SEQ ID NO. 77 MDPGKDKEGVPQPSGPPARKKFVIPLDEDEVPPGVAKPLFRSTQSLPTVD TSAQAAPQTYAEYAISQPLEGAGATCPTGSEPLAGETPNQALKPGAKSNS IIVSPRQRGNPVLKFVRNVPWEFGDVIPDYVLGQSTCALFLSLRYHNLHP DYIHGRLQSLGKNFALRVLLVQVDVKDPQQALKELAKMCILADCTLILAW SPEEAGRYLETYKAYEQKPADLLMEKLEQDFVSRVTECLTTVKSVNKTDS QTLLTTFGSLEQLIAASREDLALCPGLGPQKARRLFDVLHEPFLKXTP SEQ ID NO. 78 MLANSASVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMIPGGAKV IDATGKLVIPGGIDTSTHFHQTFMNATCVDDFYHGTKAALVGGTTMIIGH VLPDKETSLVDAYEKCRGLADPKVCCDYALHVGITWWAPKVKAEMETLVR EKGVMSFQMFMTYKDLNWNNLRDSELYQVLHACKDIGAIARVHAENGELV AEASLQPRILDGGTPGAKEALDLGITGPEGIEISRPEELEAEATHRVITI ANRTHCPIYLVNVSSISAGDVIAAAKMQGKVVLAETTTAHATLTGLHYYH QDWSHAAAYVTVPPLRLDTNTSTYLMSLLANDTLNIVASDHRPFTTKQKA MGKEDFTKIPHGVSGVQDRMSVIWERGVVGGKMDENRFVAVTSSNAAKLL NLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFNLYENNRCHGV PLVTISRGRVVYENGVFMCAEGTGKFCPLRSFPDTVYKKLVQREKTLKVR GVDRTPYLGDVAVVVHPGKKEMGTPLADTPTRPVTRHGGMRDLHESSFSL SGSQIDDHVPKRASARILAPPGGRSSGIW SEQ ID NO. 79 VTAVAQQNQGEVPEPQDMKVAEVLFDAADANAIEEVNLAYENVKEVDGLD VSKEGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSR FNALFVRPHIRGAIREYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSH VRDLPPVSGSIIWAKQIDRQLTAYMKRVEDVLGKGWENHVEGQKLKQDGD SFRMKLNTQEIFDDWARKVQQRNLGVSGRIFTIESTRVRGRTGNVLKLKV NFLPEIITLSKEVPNLKWLGFRVPLAIVNKAHQANQLYPFAISLIESVRT YERTCEKVEERNTISLLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLA ETVFNFQEKVCSHVIL SEQ ID NO. 80 MSDSVILRSIKKFGEENDGFESDKSWWSLNPYVFLIRLQDEKKGDGVRVG FFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVE LQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIESEMIKFASYYA GIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVG ELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVII SVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGG EKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGST LVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGPAAATSIFET IDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIK PGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRD QIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQ QFDTLVGEGGGQMSGGQKQRVAIAPALIRNPKILLLDMATSALDNESEAM VQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLER KGVYFTLVTLQSQGNQALNEEDIKGKCFFPILVLDATEDDMLARTFSRGS YQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEV EPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIP DKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGF RAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNV TVANIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMV GQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKAMIYGFCFA FAQCIMFTANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFS YTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFT YPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGK VMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPME RVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRD PKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADII AVMAQGVVIEKGTHEELMAQKGAYYKLVTTGSPIS SEQ ID NO. 81 MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSD WQDKLFMSLGTIMAIAHGSGLPLMMIVFGENTDKFVDTAGNFSFPVNFSL SLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIR QKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVA TFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYA KAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQA APCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVH FSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDE GTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMD EIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRN PKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAA TRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKV LKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQK CNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDM SWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISF IYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI ENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYF SYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKA KLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVP VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEA KKLNVQWLFAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDE ATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQISIADLIVVFQNG RVKEHGTHQQLLAQKGIYFSMVSVQAGTQNL SEQ ID NO. 82 MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY MVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDIND TGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQ FFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATF FTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKA GAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG AAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASP SIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFS YPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGM VSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEI EKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPK ILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAG FDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDA LEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRI MKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQ NSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQD VSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIIS FIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEA IENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMY FSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAK AKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDI PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKE IKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVPAAK EANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLD EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGR VKEHGTHQQLLAQKGIYFSMVSVQAGTKRQ SEQ ID NO. 83 MLLTVYCVRRDLSEVTFSLQVDADFELHNFRALCELESGIPAAESQIVYA ERPLTDNHRSLASYGLKDGDVVILRQKENADPRPPVQFPNLPRIDFSSIA VPGTSSPRQRQPPGTQQSHSSPGEITSSPQGLDNPALLRDMLLANPHELS LLKERNPPLAEALLSGDLEKFSRVLVEQQQDRARREQERIRLFSADPFDL EAQAKIEEDIRQQNIEENMTIAMEEAPESFGQVVMLYINCKVNGHPVKAF VDSGAQMTIMSQACAERCNIMRLVDRRWAGIAKGVGTQKIIGRVHLAQVQ IEGDFLPCSFSILEEQPMDMLLGLDMLKRHQCSIDLKKNVLVIGTTGSQT TFLPEGELPECAIRLAYGAGREDVRPEEI SEQ ID NO. 84 QTGPSVTVTCTEGKNNKQCRIKCEDTAPHAVLPSGSECATSCLDHNSESI ILPMNVTVRDIPHWLNPTRVEVSDQGHL SEQ ID NO. 85 MSATLILEPPGRCCWNEPVRIAVRGLAPEQRVTLRASLRDEKGALFRAHA RYCADARGELDLERAPALGGSFAGLEPMGLLWALEPEKPFWRFLKRDVQI PFVVELEVLDGHDPEPGRLLCQAQHERHFLPPGVRRQSVRAGRVRATLFL PPGPGPFPGIIDIFGIGGGLLEYRASLLAGHGFATLALAYYNFEDLPNNM DNISLEYFEEAVCYMLQHPQVKGPGIGLLGISLGADICLSMASFLKNVSA TVSINGSGISGNTAINYKHSSIPPLGYDLRRIKVAFSGLVDIVDIRNALV GGYKNPSMIPIEKAQGPILLIVGQDDHNWRSELYAQTVSERLQAHGKEKP QIICYPGTGHYIEPPYFPLCPASLHRLLNKHVIWGGEPRAHSKAQEDAWK QILAFFCKHLGGTQKTA SEQ ID NO. 86 ILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPR CTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVL AGMKALWNSSVPVCEXXMIKTVFLFFSLPISNNAHENPKEVAIHLHSQGG SSVHPRTLQTNEENSRYIHTEFKMFSTTQISKMETGLEYDIALANNECKN SYSLVTREIFVIHYIDCALPFPGIICGLPPTIANGDFTSISREYFHYGSV VTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTP PNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPEL PSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHC TPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGF QLKGSSASYCVLAGMESLWNSSVPVCERVTFQANLSPSSVQYLTHDTLRT EESSDYSTWLQNIFFPTGKSCETPPVPVNGMVHVITDIHVGSRINYSCTT GHRLIGHSSAECILSGNTAHWSMKPPICQRIPCGLPPNITNGYFISTDRE YFHYGSVVTYHCNLGSRGRKVFELVGEPSIYCTSKDDQVVVWSGPVPQCI IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPHRVQCQAL NKWEPELPSCSRGYSKRNSPITNKYSGTVLSTMCQPPPEILHGEHTLSHQ DNFLPGQEVFYSCEPSYDLRGAASLHCMPQGDWTPEAPRCTGASLSPSHG SLTPVVLFFLLVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGSASH CVLAGTKALWNSSVPVCEQIFCPNPPAILNGRHTGTPPGDIPYGKEVSYT CDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVGADQCNVP EWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTSAK DKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCI ISGNTVIWDNKTPVCD SEQ ID NO. 87 ICCPDDPQPAKDQLATVPKDIPLDCDCVLTGEDILGEVANRTAQGLEGLV SDSACTVGTIDAEQLSDTDSVQMFLELEKECLCEEGVTPLVELQNQISSE GLAASQDAENLLVISHFSGAALEKEQHLGLLHVRAKDYDTRLDCGYFNTL DSSQVPNAVELIAHVDIMRDTSTVSKEECEKVPFSPRTAEFKSRQPADLD SLEKLDPGGLLNSDHRVSHEEKLSGFIASELAKDNGSLSQGDCSQTEGNG EECIERVTFSFAFNHELTDVTSGPEVEVLYESNLLTDEIHLESGNVTVNQ ENNSLTSMGNVVTCELSVEKVCDEDGEAKELDYQATLLEDQAPAHFHRNF PEQVFQDLQRKSPESEILSLHLLVEELRLNPDGVETVNDTKPELNVASSE GGEMERRDSDSFLNIFPEKQVTKAGNTEPVLEEWIPVLQRPSRTAAVPTV KDALDAALPSPEEGTSIAAVPAPEGTAVVAALVPFPHEDILVASIVSLEE EDVTAAAVSAPERATVPAVTVSVPEGTAAVAAVSSPEETAPAVAAAITQE GMSAVAGFSPEWAALAVTVPITEEDAAAVPTPEVAAIPAASVPTPEVPAI PAAAVPPMEEVSPIGVPFLGVSAHTDSVPISEEGTPVLEEASSTGMWIKE DLDSLVFGIKEVTSTVLHGKVPLAATAGLNSDE SEQ ID NO. 88 SEGNKRRLSTAIALMGRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGK AIVMTSHSMEECDALCTSLAIMVQGKFTCLGSPQHLKSKFGNIYILKVKV KTEDKLEDFKCYVATTFPGEIANVTVFLLLLLKVFGILEEAKEQFDLEDY SVSQITLEQVFLTFANPEKASSDD SEQ ID NO. 89 DCGPPPELPFAFPINPLYDTEFKTGTTLKYTCHPGHGKINSSRLICDAKD SWNYSIPCAIAKCEPPPDIRNGKHSGGDQEFYTYASSVTYSCNPYFSLIG NVSISCTVENETIGVWSPNPPICE SEQ ID NO. 90 ISKDRKERVHQGMVRAATVGYGILREGGSAVDAVEGAVVALEDDPEFNAG CGSVLNTNGEVEMDASIMDGKDLSAGAVSAVQCIANPIKLARLVMEKTPH CFLTDQGAAQFAAAMGVPEIPGEKLVTERNKKRLEKEKHEKGAQKTDCQK NLGTVGAVALDCKGNVAYATSTGGIVNKMVGRVGDSPCLGAGGYADNDIG AVSTTGHGESILKVNLARLTLFHIEQGKTVEEAADLSLGYMKSRVKGLGG LIVVSKTGDWVAKWTSTSMPWAAAKDGKLHFGIDPDDTTITDLP SEQ ID NO. 91 LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCERIICGLPP TIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDD QVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF GMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQ EVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHV LFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF CPNPPAILNGRHTGTPPGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRR TSEPHGNGVWSSPAPRCELPVGADQCNVPEWLPFARPTNLTDDFEFPIGT YLNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHV IKDIQFRSQIKYSCPKG SEQ ID NO. 92 HGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVC ERIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEP SIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEV VEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQR DKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDF LGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNS SVPVCEQIFCPNPPAILNGRHTGTPPGDIPYGKEVSYTCDPHPDRGMTFN LIGESTIRRTSEPHGNGVWSSPAPRCELPVGAGQYPLPHILNGFRICSEV EVFEYLNAVTDSCDPAPGPDPFSLIGESTIYCGDNSVWNHAAPECK

[0140] The present invention is not to be limited in scope by the exemplified embodiments which are intended as illustrations of single aspects of the invention, and any clones, DNA or amino acid sequences which are functionally equivalent are within the scope of the invention. Indeed, various modifications of the invention in addition to those described herein will become apparent to those skilled in the art from the foregoing description and accompanying drawings. Such modifications are intended to fall within the scope of the appended claims.

0 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 92 <210> SEQ ID NO 1 <211> LENGTH: 303 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 1 Asn Met Ala Ile Leu Cys Ala Met Val Val Gly Val Gly Leu Ile Ala 1 5 10 15 Gly Leu Ala Val Gly Leu Thr Arg Ser Cys Asp Ser Ser Gly Asp Gly 20 25 30 Gly Leu Gly Thr Val Pro Ala Pro Ser His Leu Pro Ser Ser Thr Ala 35 40 45 Ser Pro Ser Gly Pro Pro Ala Gln Asp Gln Asp Ile Cys Pro Ser Ser 50 55 60 Glu Asp Glu Ser Gly Gln Trp Lys Asn Phe Thr Ala Glu Leu Arg Gln 65 70 75 80 Pro Gly Pro Asp Leu His Val Lys Pro Leu Leu Glu Glu Asp Thr Tyr 85 90 95 Thr Gly Thr Val Ser Ile Ser Ile Asn Leu Ser Thr Pro Thr Arg His 100 105 110 Leu Trp Leu His Leu Gly Glu Ser Arg Ile Thr Trp Leu Pro Asp Thr 115 120 125 Arg His Leu Trp Leu His Leu Gln Glu Thr Arg Ile Thr Trp Leu Pro 130 135 140 Glu Met Lys Arg Pro Ser Gly Asp Gln Val Gln Ile Arg Arg Cys Phe 145 150 155 160 Glu Tyr Lys Lys Gln Glu Tyr Val Val Val Glu Ala Glu Glu Glu Ser 165 170 175 Gly Asp Gly Leu Tyr Leu Leu Thr Met Glu Phe Ala Gly Trp Leu Asn 180 185 190 Ser Ser Leu Leu Gly Phe Thr Tyr Thr Glu Asn Gly Gln Val Lys Ser 195 200 205 Ile Ala Ala Thr Asp His Glu Pro Thr Asp Ala Arg Lys Phe Phe Pro 210 215 220 Cys Phe Asp Lys Pro Asn Lys Lys Ala Thr Tyr Thr Ile Ser Val Thr 225 230 235 240 His Pro Lys Glu Tyr Glu Ala Leu Ser His Met Pro Val Ala Lys Glu 245 250 255 Glu Ser Val Asp Asp Lys Trp Asn Gln Thr Thr Phe Lys Lys Ser Val 260 265 270 Pro Met Ser Met Tyr Leu Val Cys Phe Ala Val His Gln Phe His Thr 275 280 285 Val Lys Thr Ile Ser Asp Ile Gly Lys Pro Val Ser Leu Ile Ile 290 295 300 <210> SEQ ID NO 2 <211> LENGTH: 407 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION: 230 <223> OTHER INFORMATION: Xaa = Any Amino Acid <400> SEQUENCE: 2 Met Ser Pro Pro Leu Leu Leu Leu Pro Leu Leu Leu Leu Leu Pro Leu 1 5 10 15 Leu Asn Val Glu Pro Ala Gly Ala Thr Leu Asp Pro Val Trp Ile Pro 20 25 30 Leu Arg Gln Val His Pro Gly Arg Arg Thr Leu Asn Leu Leu Arg Gly 35 40 45 Trp Gly Lys Pro Ala Glu Leu Pro Lys Leu Gly Pro Ser Pro Gly Asp 50 55 60 Lys Pro Ala Ser Val Pro Leu Ser Lys Phe Leu Asp Ala Gln Tyr Phe 65 70 75 80 Gly Glu Ile Gly Leu Gly Thr Pro Pro Gln Asn Phe Thr Val Ala Phe 85 90 95 Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Arg Arg Cys His Phe 100 105 110 Phe Ser Val Pro Cys Trp Phe His His Arg Phe Asn Pro Asn Ala Ser 115 120 125 Ser Ser Phe Lys Pro Ser Gly Thr Lys Phe Ala Ile Gln Tyr Gly Thr 130 135 140 Gly Arg Val Asp Gly Ile Leu Ser Glu Asp Lys Leu Thr Ile Gly Gly 145 150 155 160 Ile Lys Gly Ala Ser Val Ile Phe Gly Glu Ala Leu Trp Glu Ser Ser 165 170 175 Leu Val Phe Thr Val Ser Arg Pro Asp Gly Ile Leu Arg Leu Gly Phe 180 185 190 Pro Ile Leu Ser Val Glu Gly Val Arg Pro Pro Leu Asp Val Leu Val 195 200 205 Glu Gln Gly Leu Leu Asp Lys Pro Val Phe Ser Phe Tyr Phe Asn Arg 210 215 220 Cys Trp Gly Gly Gly Xaa Gly Cys Ala Met Tyr Cys Arg Ile Val Arg 225 230 235 240 Leu Glu Asp Pro Leu Asp Thr Gly Thr Pro Val Ile Val Gly Pro Thr 245 250 255 Glu Glu Ile Gly Pro Cys Met Gln Pro Leu Gly Glu Ser Leu Leu Ala 260 265 270 Gly Glu Tyr Ile Ile Arg Cys Ser Glu Ile Pro Lys Leu Pro Ala Val 275 280 285 Ser Leu Leu Ile Gly Gly Val Trp Phe Asn Leu Thr Ala Gln Asp Tyr 290 295 300 Val Ile Gln Phe Ala Gln Gly Asp Val Arg Leu Cys Leu Ser Gly Phe 305 310 315 320 Arg Ala Leu Asp Ile Ala Ser Pro Pro Val Pro Val Trp Ile Leu Gly 325 330 335 Asp Val Phe Leu Gly Ala Tyr Val Thr Val Phe Asp Arg Gly Asp Met 340 345 350 Lys Ser Gly Ala Arg Val Gly Leu Ala Arg Ala Arg Pro Gly Ala Asp 355 360 365 Leu Gly Arg Arg Glu Thr Gln Ala Gln Tyr Arg Gly Cys Arg Pro Gly 370 375 380 Asp His Ala His Arg Val Ala Leu Ala Leu Leu Ser Lys Asn Pro Ile 385 390 395 400 Phe Pro Leu Asn Glu Pro Ala 405 <210> SEQ ID NO 3 <211> LENGTH: 122 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 3 Met Asp Thr Ala Ala Lys Ala Ile Ile Leu Glu Gln Ser Gly Lys Asn 1 5 10 15 Gln Gly Tyr Arg Asp Ala Asp Ile Arg Ser Phe Trp Pro Glu Gly Gly 20 25 30 Val Cys Leu Pro Gly Ser Pro Asp Val Leu Glu Ser Gly Val Cys Met 35 40 45 Lys Ala Val Cys Lys Arg Val Ala Val Glu Gly Val Asp Val Ile Phe 50 55 60 Ser Arg Asp Ala Gly Arg Tyr Val Cys Asp Tyr Thr Tyr Tyr Leu Ser 65 70 75 80 Leu His His Gly Lys Gly Cys Ala Ala Leu Ile His Val Pro Pro Leu 85 90 95 Ser Arg Gly Leu Pro Ala Ser Leu Leu Gly Arg Ala Leu Arg Val Ile 100 105 110 Ile Gln Glu Met Leu Glu Glu Val Gly Lys 115 120 <210> SEQ ID NO 4 <211> LENGTH: 393 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 4 Ile Tyr Val Ser Ser Trp Ala Val Gln Val Ser Gln Gly Asn Arg Glu 1 5 10 15 Val Glu Arg Leu Ala Arg Lys Phe Gly Phe Val Asn Leu Gly Pro Ile 20 25 30 Phe Pro Asp Gly Gln Tyr Phe His Leu Arg His Arg Gly Val Val Gln 35 40 45 Gln Ser Leu Thr Pro His Trp Gly His Arg Leu His Leu Lys Lys Asn 50 55 60 Pro Lys Val Gln Trp Phe Gln Gln Gln Thr Leu Gln Arg Arg Val Lys 65 70 75 80 Arg Ser Val Val Val Pro Thr Asp Pro Trp Phe Ser Lys Gln Trp Tyr 85 90 95 Met Asn Ser Glu Ala Gln Pro Asp Leu Ser Ile Leu Gln Ala Trp Ser 100 105 110 Gln Gly Leu Ser Gly Gln Gly Ile Val Val Ser Val Leu Asp Asp Gly 115 120 125 Ile Glu Lys Asp His Pro Asp Leu Trp Ala Asn Tyr Asp Pro Leu Ala 130 135 140 Ser Tyr Asp Phe Asn Asp Tyr Asp Pro Asp Pro Gln Pro Arg Tyr Thr 145 150 155 160 Pro Ser Lys Glu Asn Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala 165 170 175 Ala Met Ala Asn Asn Gly Phe Cys Gly Val Gly Val Ala Phe Asn Ala 180 185 190 Arg Ile Gly Gly Val Arg Met Leu Asp Gly Thr Ile Thr Asp Val Ile 195 200 205 Glu Ala Gln Ser Leu Ser Leu Gln Pro Gln His Ile His Ile Tyr Ser 210 215 220 Ala Ser Trp Gly Pro Glu Asp Asp Gly Arg Thr Val Asp Gly Pro Gly 225 230 235 240 Ile Leu Thr Arg Glu Ala Phe Arg Arg Gly Val Thr Lys Gly Arg Gly 245 250 255 Gly Leu Gly Thr Leu Phe Ile Trp Ala Ser Gly Asn Gly Gly Leu His 260 265 270 Tyr Asp Asn Cys Asn Cys Asp Gly Tyr Thr Asn Ser Ile His Thr Leu 275 280 285 Ser Val Gly Ser Thr Thr Gln Gln Gly Arg Val Pro Trp Tyr Ser Glu 290 295 300 Ala Cys Ala Ser Thr Leu Thr Thr Thr Tyr Ser Ser Gly Val Ala Thr 305 310 315 320 Asp Pro Gln Ile Val Thr Thr Asp Leu His His Gly Cys Thr Asp Gln 325 330 335 His Thr Gly Thr Ser Ala Ser Ala Pro Leu Ala Ala Gly Met Ile Ala 340 345 350 Leu Ala Leu Glu Ala Asn Pro Phe Leu Thr Trp Arg Asp Met Gln His 355 360 365 Leu Val Val Arg Ala Ser Lys Pro Ala His Leu Gln Ala Glu Asp Trp 370 375 380 Arg Thr Asn Gly Val Gly Arg Gln Gly 385 390 <210> SEQ ID NO 5 <211> LENGTH: 153 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 5 Leu Val Gly Tyr Ala Ile Gln Tyr Gly Cys Ile Ala His Cys Ala Ser 1 5 10 15 Glu Tyr Val Gly Gly Val Val Met Cys Ser Gly Pro Ser Met Glu Pro 20 25 30 Thr Ile Gln Asn Ser Asp Thr Val Phe Ala Gln Asn Leu Ser Arg His 35 40 45 Phe Asp Ser Ile Gln Arg Gly Asp Ile Val Ile Ala Lys Ser Pro Ser 50 55 60 Asp Pro Thr Ser Asn Ile Cys Lys Arg Val Thr Gly Leu Glu Gly Asp 65 70 75 80 Lys Ile Leu Thr Thr Ser Pro Ser Asp Phe Phe Lys Ser Tyr Ser Tyr 85 90 95 Val Pro Val Gly His Val Trp Leu Glu Gly Asp Leu Gln Asn Ser Thr 100 105 110 Asp Ser Ser Tyr Tyr Gly Pro Ile Pro Tyr Glu Leu Ile Arg Gly Arg 115 120 125 Ile Phe Phe Ile Arg Pro Leu Ser Asp Phe Gly Phe Leu Cys Ala Ser 130 135 140 Leu Asn Gly His Arg Phe Ser Asp Asp 145 150 <210> SEQ ID NO 6 <211> LENGTH: 396 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 6 Met Leu Ile Thr Val Tyr Cys Val Arg Arg Asp Leu Ser Glu Val Thr 1 5 10 15 Phe Ser Leu Gln Val Ser Pro Asp Phe Glu Leu Arg Asn Phe Lys Val 20 25 30 Leu Cys Glu Ala Glu Ser Arg Val Pro Val Glu Glu Ile Gln Ile Ile 35 40 45 His Met Glu Arg Leu Leu Ile Glu Asp His Cys Ser Leu Gly Ser Tyr 50 55 60 Gly Leu Lys Asp Gly Asp Ile Val Val Leu Leu Gln Lys Asp Asn Val 65 70 75 80 Gly Pro Arg Ala Pro Gly Arg Ala Pro Asn Gln Pro Arg Val Asp Phe 85 90 95 Ser Gly Ile Ala Val Pro Gly Thr Ser Ser Ser Arg Pro Gln His Pro 100 105 110 Gly Gln Gln Gln Gln Arg Thr Pro Ala Ala Gln Arg Ser Gln Gly Leu 115 120 125 Ala Ser Gly Glu Lys Val Ala Gly Leu Gln Gly Leu Gly Ser Pro Ala 130 135 140 Leu Ile Arg Ser Met Leu Leu Ser Asn Pro His Asp Leu Ser Leu Leu 145 150 155 160 Lys Glu Arg Asn Pro Pro Leu Ala Glu Ala Leu Leu Ser Gly Ser Leu 165 170 175 Glu Thr Phe Ser Gln Val Leu Met Glu Gln Gln Arg Glu Lys Ala Leu 180 185 190 Arg Glu Gln Glu Arg Leu Arg Leu Tyr Thr Ala Asp Pro Leu Asp Arg 195 200 205 Glu Ala Gln Ala Lys Ile Glu Glu Glu Ile Arg Gln Gln Asn Ile Glu 210 215 220 Glu Asn Met Asn Ile Ala Ile Glu Glu Ala Pro Glu Ser Phe Gly Gln 225 230 235 240 Val Thr Met Leu Tyr Ile Asn Cys Lys Val Asn Gly His Pro Leu Lys 245 250 255 Ala Phe Val Asp Ser Gly Ala Gln Met Thr Ile Met Ser Gln Ala Cys 260 265 270 Ala Glu Arg Cys Asn Ile Met Arg Leu Val Asp Arg Arg Trp Ala Gly 275 280 285 Val Ala Lys Gly Val Gly Thr Gln Arg Ile Ile Gly Arg Val His Leu 290 295 300 Ala Gln Ile Gln Ile Glu Gly Asp Phe Leu Gln Cys Ser Phe Ser Ile 305 310 315 320 Leu Glu Asp Gln Pro Met Asp Met Leu Leu Gly Leu Asp Met Leu Arg 325 330 335 Arg His Gln Cys Ser Ile Asp Leu Lys Lys Asn Val Leu Val Ile Gly 340 345 350 Thr Thr Gly Thr Gln Thr Tyr Phe Leu Pro Glu Gly Glu Leu Pro Leu 355 360 365 Cys Ser Arg Met Val Ser Gly Gln Asp Glu Ser Ser Asp Lys Glu Ile 370 375 380 Thr His Ser Val Met Asp Ser Gly Arg Lys Glu His 385 390 395 <210> SEQ ID NO 7 <211> LENGTH: 469 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 7 His Gly Arg Val Leu Leu Pro Leu Asn Leu Gln Leu Gly Ala Lys Val 1 5 10 15 Ser Phe Val Cys Asp Glu Gly Phe Arg Leu Lys Gly Arg Ser Ala Ser 20 25 30 His Cys Val Leu Ala Gly Met Lys Ala Leu Trp Asn Ser Ser Val Pro 35 40 45 Val Cys Glu Arg Ile Ile Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly 50 55 60 Asp Phe Thr Ser Ile Ser Arg Glu Tyr Phe His Tyr Gly Ser Val Val 65 70 75 80 Thr Tyr His Cys Asn Leu Gly Ser Arg Gly Lys Lys Val Phe Glu Leu 85 90 95 Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Lys Asp Asp Gln Val Gly 100 105 110 Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr 115 120 125 Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu 130 135 140 Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Gly 145 150 155 160 Met Lys Gly Pro Ser His Val Lys Cys Gln Ala Leu Asn Lys Trp Glu 165 170 175 Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val 180 185 190 Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly 195 200 205 Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ser 210 215 220 Thr Tyr Leu His Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro 225 230 235 240 Arg Cys Glu Val Lys Ser Cys Asp Asp Phe Leu Gly Gln Leu Pro Asn 245 250 255 Gly His Val Leu Phe Pro Leu Asn Leu Gln Leu Gly Ala Lys Val Asp 260 265 270 Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr 275 280 285 Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val 290 295 300 Cys Glu Arg Lys Ser Cys Glu Thr Pro Pro Val Pro Val Asn Gly Met 305 310 315 320 Val His Val Ile Thr Asp Ile His Val Gly Ser Arg Ile Asn Tyr Ser 325 330 335 Cys Thr Thr Gly Ser Ala Ser His Cys Val Leu Ala Gly Thr Lys Ala 340 345 350 Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Asn 355 360 365 Pro Pro Ala Ile Leu Asn Gly Arg His Thr Gly Thr Pro Pro Gly Asp 370 375 380 Ile Pro Tyr Gly Lys Glu Val Ser Tyr Thr Cys Asp Pro His Pro Asp 385 390 395 400 Arg Gly Met Thr Phe Asn Leu Ile Gly Glu Ser Thr Ile Arg Arg Thr 405 410 415 Ser Glu Pro His Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys 420 425 430 Glu Leu Pro Val Gly Ala Val Ile Phe Ser Thr His Leu Ile Thr Leu 435 440 445 Phe Tyr Cys Leu Gly Thr Leu Leu Gly Thr Ile Ile Phe Ile Leu Ile 450 455 460 Ile Ile Phe Leu Tyr 465 <210> SEQ ID NO 8 <211> LENGTH: 556 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 8 Gly Gly Gly Ser Pro Gly Trp Gly Cys Ala Gly Ile Pro Asp Ser Ala 1 5 10 15 Pro Gly Ala Gly Val Leu Gln Ala Gly Ala Val Gly Pro Ala Arg Gly 20 25 30 Gly Gln Gly Ala Glu Glu Val Gly Glu Ser Ala Gly Gly Gly Glu Glu 35 40 45 Arg Arg Val Arg His Pro Gln Ala Pro Ala Leu Arg Leu Leu Asn Arg 50 55 60 Lys Pro Gln Gly Gly Ser Gly Glu Ile Lys Thr Pro Glu Asn Asp Leu 65 70 75 80 Gln Arg Gly Arg Leu Ser Arg Gly Pro Arg Thr Ala Pro Pro Ala Pro 85 90 95 Gly Met Gly Asp Arg Ser Gly Gln Gln Glu Arg Ser Val Pro His Ser 100 105 110 Pro Gly Ala Pro Val Gly Thr Ser Ala Ala Ala Val Asn Gly Leu Leu 115 120 125 His Asn Gly Phe His Pro Pro Pro Val Gln Pro Pro His Val Cys Ser 130 135 140 Arg Gly Pro Val Gly Gly Ser Asp Ala Ala Pro Gln Arg Leu Pro Leu 145 150 155 160 Leu Pro Glu Leu Gln Pro Gln Pro Leu Leu Pro Gln His Asp Ser Pro 165 170 175 Ala Lys Lys Cys Arg Leu Arg Arg Arg Met Asp Ser Gly Arg Lys Asn 180 185 190 Arg Pro Pro Phe Pro Trp Phe Gly Met Asp Ile Gly Gly Thr Leu Val 195 200 205 Lys Leu Val Tyr Phe Glu Pro Lys Asp Ile Thr Ala Glu Glu Glu Gln 210 215 220 Glu Glu Val Glu Asn Leu Lys Ser Ile Arg Lys Tyr Leu Thr Ser Asn 225 230 235 240 Thr Ala Tyr Gly Lys Thr Gly Ile Arg Asp Val His Leu Glu Leu Lys 245 250 255 Asn Leu Thr Met Cys Gly Arg Lys Gly Asn Leu His Phe Ile Arg Phe 260 265 270 Pro Ser Cys Ala Met His Arg Phe Ile Gln Met Gly Ser Glu Lys Asn 275 280 285 Phe Ser Ser Leu His Thr Thr Leu Cys Ala Thr Gly Gly Gly Ala Phe 290 295 300 Lys Phe Glu Glu Asp Phe Arg Met Ile Ala Asp Leu Gln Leu His Lys 305 310 315 320 Leu Asp Glu Leu Asp Cys Leu Ile Gln Gly Leu Leu Tyr Val Asp Ser 325 330 335 Val Gly Phe Asn Gly Lys Pro Glu Cys Tyr Tyr Phe Glu Asn Pro Thr 340 345 350 Asn Pro Glu Leu Cys Gln Lys Lys Pro Tyr Cys Leu Asp Asn Pro Tyr 355 360 365 Pro Met Leu Leu Val Asn Met Gly Ser Gly Val Ser Ile Leu Ala Val 370 375 380 Tyr Ser Lys Asp Asn Tyr Lys Arg Val Thr Gly Thr Ser Leu Gly Gly 385 390 395 400 Gly Thr Phe Leu Gly Leu Cys Cys Leu Leu Thr Gly Cys Glu Thr Phe 405 410 415 Glu Glu Ala Leu Glu Met Ala Ala Lys Gly Asp Ser Thr Asn Val Asp 420 425 430 Lys Leu Val Lys Asp Ile Tyr Gly Gly Asp Tyr Glu Arg Phe Gly Leu 435 440 445 Gln Gly Ser Ala Val Ala Ser Ser Phe Gly Asn Met Met Ser Lys Glu 450 455 460 Lys Arg Asp Ser Ile Ser Lys Glu Asp Leu Ala Arg Ala Thr Leu Val 465 470 475 480 Thr Ile Thr Asn Asn Ile Gly Ser Ile Ala Arg Met Cys Ala Leu Asn 485 490 495 Glu Asn Ile Asp Arg Val Val Phe Val Gly Asn Phe Leu Arg Ile Asn 500 505 510 Met Val Ser Met Lys Leu Leu Ala Tyr Ala Met Asp Phe Trp Ser Lys 515 520 525 Gly Gln Leu Lys Ala Leu Phe Leu Glu His Glu Gly Tyr Phe Gly Ala 530 535 540 Val Gly Ala Leu Leu Glu Leu Phe Lys Met Thr Asp 545 550 555 <210> SEQ ID NO 9 <211> LENGTH: 993 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 9 Met Arg Pro Val Ala Leu Leu Leu Leu Pro Ser Leu Leu Ala Leu Leu 1 5 10 15 Ala His Gly Leu Ser Leu Glu Ala Pro Thr Val Gly Lys Gly Gln Ala 20 25 30 Pro Gly Ile Glu Glu Thr Asp Gly Glu Leu Thr Ala Ala Pro Thr Pro 35 40 45 Glu Gln Pro Glu Arg Gly Val His Phe Val Thr Thr Ala Pro Thr Leu 50 55 60 Lys Leu Leu Asn His His Pro Leu Leu Glu Glu Phe Leu His Glu Gly 65 70 75 80 Leu Glu Lys Gly Asp Glu Glu Leu Arg Pro Ala Leu Ser Phe Gln Pro 85 90 95 Asp Pro Pro Ala Pro Phe Thr Pro Ser Ala Leu Pro Arg Leu Ala Asn 100 105 110 Gln Asp Ser Arg Pro Val Phe Thr Ser Pro Thr Pro Ala Met Gly Ala 115 120 125 Val Pro Thr Gln Pro Gln Ser Lys Glu Gly Pro Trp Ser Pro Glu Ser 130 135 140 Glu Ser Pro Met Leu Arg Ile Thr Ala Pro Leu Pro Pro Gly Pro Ser 145 150 155 160 Met Ala Val Pro Thr Leu Gly Pro Gly Glu Ile Ala Ser Thr Thr Pro 165 170 175 Pro Ser Arg Ala Trp Thr Pro Thr Gln Glu Gly Pro Gly Asp Met Gly 180 185 190 Arg Pro Trp Val Ala Glu Val Val Ser Gln Gly Ala Gly Ile Gly Ile 195 200 205 Gln Gly Thr Ile Thr Ser Ser Thr Ala Ser Gly Asp Asp Glu Glu Thr 210 215 220 Thr Thr Thr Thr Thr Ile Ile Thr Thr Thr Ile Thr Thr Val Gln Thr 225 230 235 240 Pro Gly Pro Cys Ser Trp Asn Phe Ser Gly Pro Glu Gly Ser Leu Asp 245 250 255 Ser Pro Thr Asp Leu Ser Ser Pro Thr Asp Val Gly Leu Asp Cys Phe 260 265 270 Phe Tyr Ile Ser Val Tyr Pro Gly Tyr Gly Val Glu Ile Lys Val Gln 275 280 285 Asn Ile Ser Leu Arg Glu Gly Glu Thr Val Thr Val Glu Gly Leu Gly 290 295 300 Gly Pro Asp Pro Leu Pro Leu Ala Asn Gln Ser Phe Leu Leu Arg Gly 305 310 315 320 Gln Val Ile Arg Ser Pro Thr His Gln Ala Ala Leu Arg Phe Gln Ser 325 330 335 Leu Pro Pro Pro Ala Gly Pro Gly Thr Phe His Phe His Tyr Gln Ala 340 345 350 Tyr Leu Leu Ser Cys His Phe Pro Arg Arg Pro Ala Tyr Gly Asp Val 355 360 365 Thr Val Thr Ser Leu His Pro Gly Gly Ser Ala Arg Phe His Cys Ala 370 375 380 Thr Gly Tyr Gln Leu Lys Gly Ala Arg His Leu Thr Cys Leu Asn Ala 385 390 395 400 Thr Gln Pro Phe Trp Asp Ser Lys Glu Pro Val Cys Ile Ala Ala Cys 405 410 415 Gly Gly Val Ile Arg Asn Ala Thr Thr Gly Arg Ile Val Ser Pro Gly 420 425 430 Phe Pro Gly Asn Tyr Ser Asn Asn Leu Thr Cys His Trp Leu Leu Glu 435 440 445 Ala Pro Glu Gly Gln Arg Leu His Leu His Phe Glu Lys Val Ser Leu 450 455 460 Ala Glu Asp Asp Asp Arg Leu Ile Ile Arg Asn Gly Asp Asn Val Glu 465 470 475 480 Ala Pro Pro Val Tyr Asp Ser Tyr Glu Val Glu Tyr Leu Pro Ile Glu 485 490 495 Gly Leu Leu Ser Ser Gly Lys His Phe Phe Val Glu Leu Ser Thr Asp 500 505 510 Ser Ser Gly Ala Ala Ala Gly Met Ala Leu Arg Tyr Glu Ala Phe Gln 515 520 525 Gln Gly His Cys Tyr Glu Pro Phe Val Lys Tyr Gly Asn Phe Ser Ser 530 535 540 Ser Thr Pro Thr Tyr Pro Val Gly Thr Thr Val Glu Phe Ser Cys Asp 545 550 555 560 Pro Gly Tyr Thr Leu Glu Gln Gly Ser Ile Ile Ile Glu Cys Val Asp 565 570 575 Pro His Asp Pro Gln Trp Asn Glu Thr Glu Pro Ala Cys Arg Ala Val 580 585 590 Cys Ser Gly Glu Ile Thr Asp Ser Ala Gly Val Val Leu Pro Thr Glu 595 600 605 Pro Glu Pro Tyr Gly Arg Gly Gln Asp Ser Ile Trp Gly Val His Val 610 615 620 Glu Glu Asp Lys Arg Ile Met Leu Asp Ile Arg Val Leu Arg Ile Gly 625 630 635 640 Pro Gly Asp Val Leu Thr Phe Tyr Asp Gly Asp Asp Leu Thr Ala Arg 645 650 655 Val Leu Gly Gln Tyr Ser Gly Pro Arg Ser His Phe Lys Leu Phe Thr 660 665 670 Ser Met Ala Asp Val Thr Ile Gln Phe Gln Ser Asp Pro Gly Thr Ser 675 680 685 Val Leu Gly Tyr Gln Gln Gly Phe Val Ile His Phe Phe Glu Val Pro 690 695 700 Arg Asn Asp Thr Cys Pro Glu Leu Pro Glu Ile Pro Asn Gly Trp Lys 705 710 715 720 Ser Pro Ser Gln Pro Glu Leu Val His Gly Thr Val Val Thr Tyr Gln 725 730 735 Cys Tyr Pro Gly Tyr Gln Val Val Gly Ser Ser Val Leu Met Cys Gln 740 745 750 Trp Asp Leu Thr Trp Ser Glu Asp Leu Pro Ser Cys Gln Arg Val Thr 755 760 765 Ser Cys His Asp Pro Gly Asp Val Glu His Ser Arg Arg Leu Ile Ser 770 775 780 Ser Pro Lys Phe Pro Val Gly Ala Thr Val Gln Tyr Ile Cys Asp Gln 785 790 795 800 Gly Phe Val Leu Met Gly Ser Ser Ile Leu Thr Cys His Asp Arg Gln 805 810 815 Ala Gly Ser Pro Lys Trp Ser Asp Arg Ala Pro Lys Cys Leu Leu Glu 820 825 830 Gln Leu Lys Pro Cys His Gly Leu Ser Ala Pro Glu Asn Gly Ala Arg 835 840 845 Ser Pro Glu Lys Gln Leu His Pro Ala Gly Ala Thr Ile His Phe Ser 850 855 860 Cys Ala Pro Gly Tyr Val Leu Lys Gly Gln Ala Ser Ile Lys Cys Val 865 870 875 880 Pro Gly His Pro Ser His Trp Ser Asp Pro Pro Pro Ile Cys Arg Ala 885 890 895 Ala Ser Leu Asp Gly Phe Tyr Asn Ser Arg Ser Leu Asp Val Ala Lys 900 905 910 Ala Pro Ala Ala Ser Ser Thr Leu Asp Ala Ala His Ile Ala Ala Ala 915 920 925 Ile Phe Leu Pro Leu Val Ala Met Val Leu Leu Val Gly Gly Val Tyr 930 935 940 Phe Tyr Phe Ser Arg Leu Gln Gly Lys Ser Ser Leu Gln Leu Pro Arg 945 950 955 960 Pro Arg Pro Arg Pro Tyr Asn Arg Ile Thr Ile Glu Ser Ala Phe Asp 965 970 975 Asn Pro Thr Tyr Glu Thr Gly Ser Leu Ser Phe Ala Gly Asp Glu Arg 980 985 990 Ile <210> SEQ ID NO 10 <211> LENGTH: 276 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 10 Glu Lys Ala Leu Ala Leu Thr Gly Asn Gln Gly Ile Glu Ala Ala Met 1 5 10 15 Asp Trp Leu Met Glu His Glu Asp Asp Pro Asp Val Asp Glu Pro Leu 20 25 30 Glu Thr Pro Leu Val Thr Tyr Pro Gly Glu Pro Thr Ser Ser Glu Gln 35 40 45 Gly Gly Leu Glu Gly Ser Gly Ser Ala Ala Gly Glu Gly Lys Pro Ala 50 55 60 Leu Ser Glu Glu Glu Arg Gln Glu Gln Thr Lys Arg Met Leu Glu Leu 65 70 75 80 Val Ala Gln Lys Gln Arg Glu Arg Glu Glu Arg Glu Glu Arg Glu Ala 85 90 95 Leu Glu Arg Glu Arg Gln Arg Arg Arg Gln Gly Gln Glu Leu Ser Ala 100 105 110 Ala Arg Gln Arg Leu Gln Glu Asp Glu Met Arg Arg Ala Ala Glu Glu 115 120 125 Arg Arg Arg Glu Lys Ala Glu Glu Leu Ala Ala Arg Gln Arg Val Arg 130 135 140 Glu Lys Ile Glu Arg Asp Lys Ala Glu Arg Ala Lys Lys Tyr Gly Gly 145 150 155 160 Ser Val Gly Ser Gln Pro Pro Pro Val Ala Pro Glu Pro Gly Pro Val 165 170 175 Pro Ser Ser Pro Ser Gln Glu Pro Pro Pro Lys Arg Glu Tyr Asp Gln 180 185 190 Cys Arg Ile Gln Val Arg Leu Pro Asp Gly Thr Ser Leu Thr Gln Thr 195 200 205 Phe Arg Ala Arg Glu Gln Leu Ala Ala Val Arg Leu Tyr Val Glu Leu 210 215 220 His Arg Gly Glu Glu Leu Gly Gly Gly Gln Asp Pro Val Gln Leu Leu 225 230 235 240 Ser Gly Phe Pro Arg Arg Ala Phe Ser Glu Ala Asp Met Glu Arg Pro 245 250 255 Leu Gln Glu Leu Gly Leu Val Pro Ser Ala Val Leu Ile Val Ala Lys 260 265 270 Lys Cys Pro Ser 275 <210> SEQ ID NO 11 <211> LENGTH: 241 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 11 Ser Leu His Leu Ser Glu Arg Ala Asp Trp Gln Tyr Ser Gln Arg Glu 1 5 10 15 Leu Asp Ala Val Glu Val Phe Phe Ser Arg Thr Ala Arg Asp Asn Arg 20 25 30 Leu Gly Cys Met Phe Val Arg Cys Ala Pro Ser Ser Arg Tyr Thr Leu 35 40 45 Leu Phe Ser His Gly Asn Ala Val Asp Leu Gly Gln Met Cys Ser Phe 50 55 60 Tyr Ile Gly Leu Gly Ser Arg Ile Asn Cys Asn Ile Phe Ser Tyr Asp 65 70 75 80 Tyr Ser Gly Tyr Gly Val Ser Ser Gly Lys Pro Ser Glu Lys Asn Leu 85 90 95 Tyr Ala Asp Ile Asp Ala Ala Trp Gln Ala Leu Arg Thr Arg Tyr Gly 100 105 110 Val Ser Pro Glu Asn Ile Ile Leu Tyr Gly Gln Ser Ile Gly Thr Val 115 120 125 Pro Thr Val Asp Leu Ala Ser Arg Tyr Glu Cys Ala Ala Val Ile Leu 130 135 140 His Ser Pro Leu Met Ser Gly Leu Arg Val Ala Phe Pro Asp Thr Arg 145 150 155 160 Lys Thr Tyr Cys Phe Asp Ala Phe Pro Ser Ile Asp Lys Ile Ser Lys 165 170 175 Val Thr Ser Pro Val Leu Val Ile His Gly Thr Glu Asp Glu Val Ile 180 185 190 Asp Phe Ser His Gly Leu Ala Met Tyr Glu Arg Cys Pro Arg Ala Val 195 200 205 Glu Pro Leu Trp Val Glu Gly Ala Gly His Asn Asp Ile Glu Leu Tyr 210 215 220 Ala Gln Tyr Leu Glu Arg Leu Lys Gln Phe Ile His Glu Leu Pro Asn 225 230 235 240 Ser <210> SEQ ID NO 12 <211> LENGTH: 420 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 12 Met Thr Met Glu Lys Gly Met Ser Ser Gly Glu Gly Leu Pro Ser Arg 1 5 10 15 Ser Ser Gln Val Ser Ala Gly Lys Ile Thr Ala Lys Glu Leu Glu Thr 20 25 30 Lys Gln Ser Tyr Lys Glu Lys Arg Gly Gly Phe Val Leu Val His Ala 35 40 45 Gly Ala Gly Tyr His Ser Glu Ser Lys Ala Lys Glu Tyr Lys His Val 50 55 60 Cys Lys Arg Ala Cys Gln Lys Ala Ile Glu Lys Leu Gln Ala Gly Ala 65 70 75 80 Leu Ala Thr Asp Ala Val Thr Ala Ala Leu Val Glu Leu Glu Asp Ser 85 90 95 Pro Phe Thr Asn Ala Gly Met Gly Ser Asn Leu Asn Leu Leu Gly Glu 100 105 110 Ile Glu Cys Asp Ala Ser Ile Met Asp Gly Lys Ser Leu Asn Phe Gly 115 120 125 Ala Val Gly Ala Leu Ser Gly Ile Lys Asn Pro Val Ser Val Ala Asn 130 135 140 Arg Leu Leu Cys Glu Gly Gln Lys Gly Lys Leu Ser Ala Gly Arg Ile 145 150 155 160 Pro Pro Cys Phe Leu Val Gly Glu Gly Ala Tyr Arg Trp Ala Val Asp 165 170 175 His Gly Ile Pro Ser Cys Pro Pro Asn Ile Met Thr Thr Arg Phe Ser 180 185 190 Leu Ala Ala Phe Lys Arg Asn Lys Arg Lys Leu Glu Leu Ala Glu Arg 195 200 205 Val Asp Thr Asp Phe Met Gln Leu Lys Lys Arg Arg Gln Ser Ser Glu 210 215 220 Lys Glu Asn Asp Ser Gly Thr Leu Asp Thr Val Gly Ala Val Val Val 225 230 235 240 Asp His Glu Gly Asn Val Ala Ala Ala Val Ser Ser Gly Gly Leu Ala 245 250 255 Leu Lys His Pro Gly Arg Val Gly Gln Ala Ala Leu Tyr Gly Cys Gly 260 265 270 Cys Trp Ala Glu Asn Thr Gly Ala His Asn Pro Tyr Ser Thr Ala Val 275 280 285 Ser Thr Ser Gly Cys Gly Glu His Leu Val Arg Thr Ile Leu Ala Arg 290 295 300 Glu Cys Ser His Ala Leu Gln Ala Glu Asp Ala His Gln Ala Leu Leu 305 310 315 320 Glu Thr Met Gln Asn Lys Phe Ile Ser Ser Pro Phe Leu Ala Ser Glu 325 330 335 Asp Gly Val Leu Gly Gly Val Ile Val Leu Arg Ser Cys Arg Cys Ser 340 345 350 Ala Glu Pro Asp Ser Ser Gln Asn Lys Gln Thr Leu Leu Val Glu Phe 355 360 365 Leu Trp Ser His Thr Thr Glu Ser Met Cys Val Gly Tyr Met Ser Ala 370 375 380 Gln Asp Gly Lys Ala Lys Thr His Ile Ser Arg Leu Pro Pro Gly Ala 385 390 395 400 Val Ala Gly Gln Ser Val Ala Ile Glu Gly Gly Val Cys Arg Leu Glu 405 410 415 Ser Pro Val Asn 420 <210> SEQ ID NO 13 <211> LENGTH: 381 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 13 Lys Ile Lys Asp Cys Tyr Gly Leu Gly Ser Gly Gln Asn His Phe Ile 1 5 10 15 Lys Asp Ser Gln Trp Glu Gln Gln Ala Glu Ile Phe Asn Ala Ser Tyr 20 25 30 Lys Lys Tyr Leu Asp Arg Glu Trp Glu Glu Glu Pro Leu Ser Thr Ala 35 40 45 Thr Phe Tyr Phe Leu Leu Pro Ser Cys Leu Phe Ala Met Pro Pro Glu 50 55 60 Val Lys Gly Pro Ser Gly Met Ala Cys Val Leu Gly Ile His Trp Thr 65 70 75 80 Arg Ser His Asn Phe Phe Leu Tyr Ser Leu Asn Arg Thr Leu Lys Asp 85 90 95 Lys Ala Asp Pro Glu Gly Val Trp Pro Cys Ala Ala Pro Ile Ala Val 100 105 110 Ser Gln Leu Ser Cys Ser Ser Ser Tyr Leu Val Leu Ala Cys Glu Asp 115 120 125 Gly Val Leu Thr Leu Trp Asp Leu Ala Lys Gly Phe Pro Leu Gly Val 130 135 140 Ala Ala Leu Pro Gln Gly Cys Phe Cys Gln Ser Ile His Phe Leu Lys 145 150 155 160 Tyr Phe Ser Val His Lys Gly Gln Asn Met Tyr Pro Glu Gly Gln Val 165 170 175 Lys Ser Gln Met Lys Cys Val Val Leu Cys Thr Asp Ala Ser Leu His 180 185 190 Leu Val Glu Ala Ser Gly Thr Gln Gly Pro Thr Ile Ser Val Leu Val 195 200 205 Glu Arg Pro Val Lys His Leu Asp Lys Thr Ile Cys Ala Val Ala Pro 210 215 220 Val Pro Ala Leu Pro Gly Met Val Leu Ile Phe Ser Lys Asn Gly Ser 225 230 235 240 Val Cys Leu Met Asp Val Ala Lys Arg Glu Ile Ile Cys Ala Phe Ala 245 250 255 Pro Pro Gly Ala Phe Pro Leu Glu Val Pro Trp Lys Pro Val Phe Ala 260 265 270 Val Ser Pro Asp His Pro Cys Phe Leu Leu Arg Gly Asp Tyr Ser His 275 280 285 Glu Thr Ala Ser Thr Asp Asp Ala Gly Ile Gln Tyr Ser Val Phe Tyr 290 295 300 Phe Asn Phe Glu Ala Cys Pro Leu Leu Glu Asn Ile Ser Lys Asn Cys 305 310 315 320 Thr Ile Pro Gln Arg Asp Leu Asp Asn Met Ala Phe Pro Gln Ala Leu 325 330 335 Pro Leu Glu Lys Arg Cys Glu Arg Phe Leu Gln Lys Ser Tyr Arg Lys 340 345 350 Leu Glu Lys Asn Pro Glu Lys Glu Glu Glu His Trp Ala Arg Leu Gln 355 360 365 Arg Tyr Ser Leu Ser Leu Gln Arg Glu Asn Phe Lys Lys 370 375 380 <210> SEQ ID NO 14 <211> LENGTH: 108 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 14 Met Gly Lys Gly Tyr Tyr Leu Lys Gly Lys Ile Gly Lys Val Pro Val 1 5 10 15 Arg Phe Leu Val Asp Ser Gly Ala Gln Val Ser Val Val His Pro Asn 20 25 30 Leu Trp Glu Glu Val Thr Asp Gly Asp Leu Asp Thr Leu Gln Pro Phe 35 40 45 Glu Asn Val Val Lys Val Ala Asn Gly Ala Glu Met Lys Ile Leu Gly 50 55 60 Val Trp Asp Thr Ala Val Ser Leu Gly Lys Leu Lys Leu Lys Ala Gln 65 70 75 80 Phe Leu Val Ala Asn Ala Ser Ala Glu Glu Ala Ile Ile Gly Thr Asp 85 90 95 Leu Gln Asp His Asn Ala Ile Leu Asp Phe Glu His 100 105 <210> SEQ ID NO 15 <211> LENGTH: 522 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 15 Met Ser Phe Ile Cys Gly Leu Gln Ser Ala Ala Arg Asn His Val Phe 1 5 10 15 Phe Arg Phe Asn Ser Leu Ser Asn Trp Arg Lys Cys Asn Thr Leu Ala 20 25 30 Ser Thr Ser Arg Gly Cys His Gln Val Gln Val Asn His Ile Val Asn 35 40 45 Lys Tyr Gln Gly Leu Gly Val Asn Gln Cys Asp Arg Trp Ser Phe Leu 50 55 60 Pro Gly Asn Phe His Phe Tyr Ser Thr Phe Asn Asn Lys Arg Thr Gly 65 70 75 80 Gly Leu Ser Ser Thr Lys Ser Lys Glu Ile Trp Arg Ile Thr Ser Lys 85 90 95 Cys Thr Val Trp Asn Asp Ala Phe Ser Arg Gln Leu Leu Ile Lys Glu 100 105 110 Val Thr Ala Val Pro Ser Leu Ser Val Leu His Pro Leu Ser Pro Ala 115 120 125 Ser Ile Arg Ala Ile Arg Asn Phe His Thr Ser Pro Arg Phe Gln Ala 130 135 140 Ala Pro Val Pro Leu Leu Leu Met Ile Leu Lys Pro Val Gln Lys Leu 145 150 155 160 Phe Ala Ile Ile Val Gly Arg Gly Ile Arg Lys Trp Trp Gln Ala Leu 165 170 175 Pro Pro Asn Lys Lys Glu Val Val Lys Glu Asn Ile Arg Lys Asn Lys 180 185 190 Trp Lys Leu Phe Leu Gly Leu Ser Ser Phe Gly Leu Leu Phe Val Val 195 200 205 Phe Tyr Phe Thr His Leu Glu Val Ser Pro Ile Thr Gly Arg Ser Lys 210 215 220 Leu Leu Leu Leu Gly Lys Glu Gln Phe Arg Leu Leu Ser Glu Leu Glu 225 230 235 240 Tyr Glu Ala Trp Met Glu Glu Phe Lys Asn Asp Met Leu Thr Glu Lys 245 250 255 Asp Ala Arg Tyr Leu Ala Val Lys Glu Val Leu Cys His Leu Ile Glu 260 265 270 Cys Asn Lys Asp Val Pro Gly Ile Ser Gln Ile Asn Trp Val Ile His 275 280 285 Val Val Asp Ser Pro Ile Ile Asn Ala Phe Val Leu Pro Asn Gly Gln 290 295 300 Met Phe Val Phe Thr Gly Phe Leu Asn Ser Val Thr Asp Ile His Gln 305 310 315 320 Leu Ser Phe Leu Leu Gly His Glu Ile Ala His Ala Val Leu Gly His 325 330 335 Ala Ala Glu Lys Ala Gly Met Val His Leu Leu Asp Phe Leu Gly Met 340 345 350 Ile Phe Leu Thr Met Ile Trp Ala Ile Cys Pro Arg Asp Ser Leu Ala 355 360 365 Leu Leu Cys Gln Trp Ile Gln Ser Lys Leu Gln Glu Tyr Met Phe Asn 370 375 380 Arg Pro Tyr Ser Arg Lys Leu Glu Ala Glu Ala Asp Lys Ile Gly Leu 385 390 395 400 Leu Leu Ala Ala Lys Ala Cys Ala Asp Ile Arg Ala Ser Ser Val Phe 405 410 415 Trp Gln Gln Met Glu Phe Val Asp Ser Leu His Gly Gln Pro Lys Met 420 425 430 Pro Glu Trp Leu Ser Thr His Pro Ser His Gly Asn Arg Val Glu Tyr 435 440 445 Leu Asp Arg Leu Ile Pro Gln Ala Leu Lys Ile Arg Glu Met Cys Asn 450 455 460 Cys Pro Pro Leu Ser Asn Pro Asp Pro Arg Leu Leu Phe Lys Leu Ser 465 470 475 480 Thr Lys His Phe Leu Glu Glu Ser Glu Lys Glu Asp Leu Asn Ile Thr 485 490 495 Lys Lys Gln Lys Met Asp Thr Leu Pro Ile Gln Lys Gln Glu Gln Ile 500 505 510 Pro Leu Thr Tyr Ile Val Glu Lys Arg Thr 515 520 <210> SEQ ID NO 16 <211> LENGTH: 285 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 16 Met Asn Asn Leu Ser Phe Ser Glu Leu Cys Cys Leu Phe Cys Cys Pro 1 5 10 15 Pro Cys Pro Gly Lys Ile Ala Ser Lys Leu Ala Phe Leu Pro Pro Asp 20 25 30 Pro Thr Tyr Thr Leu Met Cys Asp Glu Ser Gly Ser Arg Trp Thr Leu 35 40 45 His Leu Ser Glu Arg Ala Asp Trp Gln Tyr Ser Ser Arg Glu Lys Asp 50 55 60 Ala Ile Glu Cys Phe Met Thr Arg Thr Ser Lys Gly Asn Arg Ile Ala 65 70 75 80 Cys Met Phe Val Arg Cys Ser Pro Asn Ala Lys Tyr Thr Leu Leu Phe 85 90 95 Ser His Gly Asn Ala Val Asp Leu Gly Gln Met Ser Ser Phe Tyr Ile 100 105 110 Gly Leu Gly Ser Arg Ile Asn Cys Asn Ile Phe Ser Tyr Asp Tyr Ser 115 120 125 Gly Tyr Gly Ala Ser Ser Gly Lys Pro Thr Glu Lys Asn Leu Tyr Ala 130 135 140 Asp Ile Glu Ala Ala Trp Leu Ala Leu Arg Thr Arg Tyr Ile Arg Pro 145 150 155 160 Glu Asn Val Ile Ile Tyr Gly Gln Ser Ile Gly Thr Val Pro Ser Val 165 170 175 Asp Leu Ala Ala Arg Tyr Glu Ser Ala Ala Val Ile Leu His Ser Pro 180 185 190 Leu Thr Ser Gly Met Arg Val Ala Phe Pro Asp Thr Lys Lys Thr Tyr 195 200 205 Cys Phe Asp Ala Phe Pro Asn Ile Asp Lys Ile Ser Lys Ile Thr Ser 210 215 220 Pro Val Leu Ile Ile His Gly Thr Glu Asp Glu Val Ile Asp Phe Ser 225 230 235 240 His Gly Leu Ala Leu Phe Glu Arg Cys Gln Arg Pro Val Glu Pro Leu 245 250 255 Trp Val Glu Gly Ala Gly His Asn Asp Val Glu Leu Tyr Gly Gln Tyr 260 265 270 Leu Glu Arg Leu Lys Gln Phe Val Ser Gln Glu Leu Val 275 280 285 <210> SEQ ID NO 17 <211> LENGTH: 1513 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 17 Gly Ser Gly Cys Leu Gly Ala Glu Lys Arg Glu Gly Lys Asn Arg Trp 1 5 10 15 Gln Gly Glu Ala Ser Met Glu Arg Leu Leu Ala Gln Leu Cys Gly Ser 20 25 30 Ser Ala Ala Trp Pro Leu Pro Leu Trp Glu Gly Asp Thr Thr Gly His 35 40 45 Cys Phe Thr Gln Leu Val Leu Ser Ala Leu Pro His Ala Leu Leu Ala 50 55 60 Val Leu Ser Ala Cys Tyr Leu Gly Thr Pro Arg Ser Pro Asp Tyr Ile 65 70 75 80 Leu Pro Cys Ser Pro Gly Trp Arg Leu Arg Leu Ala Ala Ser Phe Leu 85 90 95 Leu Ser Val Phe Pro Leu Leu Asp Leu Leu Pro Val Ala Leu Pro Pro 100 105 110 Gly Ala Gly Pro Gly Pro Ile Gly Leu Glu Val Leu Ala Gly Cys Val 115 120 125 Ala Ala Val Ala Trp Ile Ser His Ser Leu Ala Leu Trp Val Leu Ala 130 135 140 His Ser Pro His Gly His Ser Arg Gly Pro Leu Ala Leu Ala Leu Val 145 150 155 160 Ala Leu Leu Pro Ala Pro Ala Leu Val Leu Thr Val Leu Trp His Cys 165 170 175 Gln Arg Gly Thr Leu Leu Pro Pro Leu Leu Pro Gly Pro Met Ala Arg 180 185 190 Leu Cys Leu Leu Ile Leu Gln Leu Ala Ala Leu Leu Ala Tyr Ala Leu 195 200 205 Gly Trp Ala Ala Pro Gly Gly Pro Arg Glu Pro Trp Ala Gln Glu Pro 210 215 220 Leu Leu Pro Glu Asp Gln Glu Pro Glu Val Ala Glu Asp Gly Glu Ser 225 230 235 240 Trp Leu Ser Arg Phe Ser Tyr Ala Trp Leu Ala Pro Leu Leu Ala Arg 245 250 255 Gly Ala Cys Gly Glu Leu Arg Gln Pro Gln Asp Ile Cys Arg Leu Pro 260 265 270 His Arg Leu Gln Pro Thr Tyr Leu Ala Arg Val Phe Gln Ala His Trp 275 280 285 Gln Glu Gly Ala Arg Leu Trp Arg Ala Leu Tyr Gly Ala Phe Gly Arg 290 295 300 Cys Tyr Leu Ala Leu Gly Leu Leu Lys Leu Val Gly Thr Met Leu Gly 305 310 315 320 Phe Ser Gly Pro Leu Leu Leu Ser Leu Leu Val Gly Phe Leu Glu Glu 325 330 335 Gly Gln Glu Pro Leu Ser His Gly Leu Leu Tyr Ala Leu Gly Leu Ala 340 345 350 Gly Gly Ala Val Leu Gly Ala Val Leu Gln Asn Gln Tyr Gly Tyr Glu 355 360 365 Val Tyr Lys Val Thr Leu Gln Ala Arg Gly Ala Val Leu Asn Ile Leu 370 375 380 Tyr Cys Lys Ala Leu Gln Leu Gly Pro Ser Arg Pro Pro Thr Gly Glu 385 390 395 400 Ala Leu Asn Leu Leu Gly Thr Asp Ser Glu Arg Leu Leu Asn Phe Ala 405 410 415 Gly Ser Phe His Glu Ala Trp Gly Leu Pro Leu Gln Leu Ala Ile Thr 420 425 430 Leu Tyr Leu Leu Tyr Gln Gln Val Gly Val Ala Phe Val Gly Gly Leu 435 440 445 Ile Leu Ala Leu Leu Leu Val Pro Val Asn Lys Val Ile Ala Thr Arg 450 455 460 Ile Met Ala Ser Asn Gln Glu Met Leu Gln His Lys Asp Ala Arg Val 465 470 475 480 Lys Leu Val Thr Glu Leu Leu Ser Gly Ile Arg Val Ile Lys Phe Cys 485 490 495 Gly Trp Glu Gln Ala Leu Gly Ala Arg Val Glu Ala Cys Arg Ala Arg 500 505 510 Glu Leu Gly Arg Leu Arg Val Ile Lys Tyr Leu Asp Ala Ala Cys Val 515 520 525 Tyr Leu Trp Ala Ala Leu Pro Val Val Ile Ser Ile Val Ile Phe Ile 530 535 540 Thr Tyr Val Leu Met Gly His Gln Leu Thr Ala Thr Lys Val Phe Thr 545 550 555 560 Ala Leu Ala Leu Val Arg Met Leu Ile Leu Pro Leu Asn Asn Phe Pro 565 570 575 Trp Val Ile Asn Gly Leu Leu Glu Ala Lys Val Ser Leu Asp Arg Ile 580 585 590 Gln Leu Phe Leu Asp Leu Pro Asn His Asn Pro Gln Ala Tyr Tyr Ser 595 600 605 Pro Asp Pro Pro Ala Glu Pro Ser Thr Val Leu Glu Leu His Gly Ala 610 615 620 Leu Phe Ser Trp Asp Pro Val Gly Thr Ser Leu Glu Thr Phe Ile Ser 625 630 635 640 His Leu Glu Val Lys Lys Gly Met Leu Val Gly Ile Val Gly Lys Val 645 650 655 Gly Cys Gly Lys Ser Ser Leu Leu Ala Ala Ile Ala Gly Glu Leu His 660 665 670 Arg Leu Arg Gly His Val Ala Val Arg Gly Leu Ser Lys Gly Phe Gly 675 680 685 Leu Ala Thr Gln Glu Pro Trp Ile Gln Phe Ala Thr Ile Arg Asp Asn 690 695 700 Ile Leu Phe Gly Lys Thr Phe Asp Ala Gln Leu Tyr Lys Glu Val Leu 705 710 715 720 Glu Ala Cys Ala Leu Asn Asp Asp Leu Ser Ile Leu Pro Ala Gly Asp 725 730 735 Gln Thr Glu Val Gly Glu Lys Gly Val Thr Leu Ser Gly Gly Gln Arg 740 745 750 Ala Arg Ile Ala Leu Ala Arg Ala Val Tyr Gln Glu Lys Glu Leu Tyr 755 760 765 Leu Leu Asp Asp Pro Leu Ala Ala Val Asp Ala Asp Val Ala Asn His 770 775 780 Leu Leu His Arg Cys Ile Leu Gly Met Leu Ser Tyr Thr Thr Arg Leu 785 790 795 800 Leu Cys Thr His Arg Thr Glu Tyr Leu Glu Arg Ala Asp Ala Val Leu 805 810 815 Leu Met Glu Ala Gly Arg Leu Ile Arg Ala Gly Pro Pro Ser Glu Ile 820 825 830 Leu Pro Leu Val Gln Ala Val Pro Lys Ala Trp Ala Glu Asn Gly Gln 835 840 845 Glu Ser Asp Ser Ala Thr Ala Gln Ser Val Gln Asn Pro Glu Lys Thr 850 855 860 Lys Glu Gly Leu Glu Glu Glu Gln Ser Thr Ser Gly Arg Leu Leu Gln 865 870 875 880 Glu Glu Ser Lys Lys Glu Gly Ala Val Ala Leu His Val Tyr Gln Ala 885 890 895 Tyr Trp Lys Ala Val Gly Gln Gly Leu Ala Leu Ala Ile Leu Phe Ser 900 905 910 Leu Leu Leu Met Gln Ala Thr Arg Asn Ala Ala Asp Trp Trp Leu Ser 915 920 925 His Trp Ile Ser Gln Leu Lys Ala Glu Asn Ser Ser Gln Glu Ala Gln 930 935 940 Pro Ser Thr Ser Pro Ala Ser Met Gly Leu Phe Ser Pro Gln Leu Leu 945 950 955 960 Leu Phe Ser Pro Gly Asn Leu Tyr Ile Pro Val Phe Pro Leu Pro Lys 965 970 975 Ala Ala Pro Asn Gly Ser Ser Asp Ile Arg Phe Tyr Leu Thr Val Tyr 980 985 990 Ala Thr Ile Ala Gly Val Asn Ser Leu Cys Thr Leu Leu Arg Ala Val 995 1000 1005 Leu Phe Ala Ala Gly Thr Leu Gln Ala Ala Ala Thr Leu His Arg Arg 1010 1015 1020 Leu Leu His Arg Val Leu Met Ala Pro Val Thr Phe Phe Asn Ala Thr 1025 1030 1035 1040 Pro Thr Gly Arg Ile Leu Asn Arg Phe Ser Ser Asp Val Ala Cys Ala 1045 1050 1055 Asp Asp Ser Leu Pro Phe Ile Leu Asn Ile Leu Leu Ala Asn Ala Ala 1060 1065 1070 Gly Leu Leu Gly Leu Leu Ala Val Leu Gly Ser Gly Leu Pro Trp Leu 1075 1080 1085 Leu Leu Leu Leu Pro Pro Leu Ser Ile Met Tyr Tyr His Val Gln Arg 1090 1095 1100 His Tyr Arg Ala Ser Ser Arg Glu Leu Arg Arg Leu Gly Ser Leu Thr 1105 1110 1115 1120 Leu Ser Pro Leu Tyr Ser His Leu Ala Asp Thr Leu Ala Gly Leu Ser 1125 1130 1135 Val Leu Arg Ala Thr Gly Ala Thr Tyr Arg Phe Glu Glu Glu Asn Leu 1140 1145 1150 Arg Leu Leu Glu Leu Asn Gln Arg Cys Gln Phe Ala Thr Ser Ala Thr 1155 1160 1165 Met Gln Trp Leu Asp Ile Arg Leu Gln Leu Met Gly Ala Ala Val Val 1170 1175 1180 Ser Ala Ile Ala Gly Ile Ala Leu Val Gln His Gln Gln Gly Leu Ala 1185 1190 1195 1200 Asn Pro Gly Leu Val Gly Leu Ser Leu Ser Tyr Ala Leu Ser Leu Thr 1205 1210 1215 Gly Leu Leu Ser Gly Leu Val Ser Ser Phe Thr Gln Thr Glu Ala Met 1220 1225 1230 Leu Val Ser Val Glu Arg Leu Glu Glu Tyr Thr Cys Asp Leu Pro Gln 1235 1240 1245 Glu Pro Gln Gly Gln Pro Leu Gln Leu Gly Thr Gly Trp Leu Thr Gln 1250 1255 1260 Gly Gly Val Glu Phe Gln Asp Val Val Leu Ala Tyr Arg Pro Gly Leu 1265 1270 1275 1280 Pro Asn Ala Leu Asp Gly Val Thr Phe Cys Val Gln Pro Gly Glu Lys 1285 1290 1295 Leu Gly Ile Val Gly Arg Thr Gly Ser Gly Lys Ser Ser Leu Leu Leu 1300 1305 1310 Val Leu Phe Arg Leu Leu Glu Pro Ser Ser Gly Arg Val Leu Leu Asp 1315 1320 1325 Gly Val Asp Thr Ser Gln Leu Glu Leu Ala Gln Leu Arg Ser Gln Leu 1330 1335 1340 Ala Ile Ile Pro Gln Glu Pro Phe Leu Phe Ser Gly Thr Val Arg Glu 1345 1350 1355 1360 Asn Leu Asp Pro Gln Gly Leu His Lys Asp Arg Ala Leu Trp Gln Ala 1365 1370 1375 Leu Lys Gln Cys His Leu Ser Glu Val Ile Thr Ser Met Gly Gly Leu 1380 1385 1390 Asp Gly Glu Leu Gly Glu Gly Gly Arg Ser Leu Ser Leu Gly Gln Arg 1395 1400 1405 Gln Leu Leu Cys Leu Ala Arg Ala Leu Leu Thr Asp Ala Lys Ile Leu 1410 1415 1420 Cys Ile Asp Glu Ala Thr Ala Ser Val Asp Gln Lys Thr Asp Gln Leu 1425 1430 1435 1440 Leu Gln Gln Thr Ile Cys Lys Arg Phe Ala Asn Lys Thr Val Leu Thr 1445 1450 1455 Ile Ala His Arg Leu Asn Thr Ile Leu Asn Ser Asp Arg Val Leu Val 1460 1465 1470 Leu Gln Ala Gly Arg Val Val Glu Leu Asp Ser Pro Ala Thr Leu Arg 1475 1480 1485 Asn Gln Pro His Ser Leu Phe Gln Gln Leu Leu Gln Ser Ser Gln Gln 1490 1495 1500 Gly Val Pro Ala Ser Leu Gly Gly Pro 1505 1510 <210> SEQ ID NO 18 <211> LENGTH: 282 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 18 Met Ala Ala Val Arg Val Leu Val Ala Ser Arg Leu Ala Ala Ala Ser 1 5 10 15 Ala Phe Thr Ser Leu Ser Pro Gly Gly Arg Thr Pro Ser Gln Arg Ala 20 25 30 Ala Leu His Leu Ser Val Pro Arg Pro Ala Ala Arg Val Ala Leu Val 35 40 45 Leu Ser Gly Cys Gly Val Tyr Asp Gly Thr Glu Ile His Glu Ala Ser 50 55 60 Ala Ile Leu Val His Leu Ser Arg Gly Gly Ala Glu Val Gln Ile Phe 65 70 75 80 Ala Pro Asp Val Pro Gln Met His Val Ile Asp His Thr Lys Gly Gln 85 90 95 Pro Ser Glu Gly Glu Ser Arg Asn Val Leu Thr Glu Ser Ala Arg Ile 100 105 110 Ala Arg Gly Lys Ile Thr Asp Leu Ala Asn Leu Ser Ala Ala Asn His 115 120 125 Asp Ala Ala Ile Phe Pro Gly Gly Phe Gly Ala Ala Lys Asn Leu Ser 130 135 140 Thr Phe Ala Val Asp Gly Lys Asp Cys Lys Val Asn Lys Glu Val Glu 145 150 155 160 Arg Val Leu Lys Glu Phe His Gln Ala Gly Lys Pro Ile Gly Leu Cys 165 170 175 Cys Ile Ala Pro Val Leu Ala Ala Lys Val Leu Arg Gly Val Glu Val 180 185 190 Thr Val Gly His Glu Gln Glu Glu Gly Gly Lys Trp Pro Tyr Ala Gly 195 200 205 Thr Ala Glu Ala Ile Lys Ala Leu Gly Ala Lys His Cys Val Lys Glu 210 215 220 Val Ser Leu Arg Ser Val Leu Gly Gly Phe Phe Arg Asn Ser Ala His 225 230 235 240 Glu Ala His Val Asp Gln Lys Asn Lys Val Val Thr Thr Pro Ala Phe 245 250 255 Met Cys Glu Thr Ala Leu His Tyr Ile His Asp Gly Ile Gly Ala Met 260 265 270 Val Arg Lys Val Leu Glu Leu Thr Gly Lys 275 280 <210> SEQ ID NO 19 <211> LENGTH: 297 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 19 Met Ala Glu Leu Thr Ala Leu Glu Ser Leu Ile Glu Met Gly Phe Pro 1 5 10 15 Arg Gly Arg Ala Glu Lys Ala Leu Ala Leu Thr Gly Asn Gln Gly Ile 20 25 30 Glu Ala Ala Met Asp Trp Leu Met Glu His Glu Asp Asp Pro Asp Val 35 40 45 Asp Glu Pro Leu Glu Thr Pro Leu Gly His Ile Leu Gly Arg Glu Pro 50 55 60 Thr Ser Ser Glu Gln Gly Gly Leu Glu Gly Ser Gly Ser Ala Ala Gly 65 70 75 80 Glu Gly Lys Pro Ala Leu Ser Glu Glu Glu Arg Gln Glu Gln Thr Lys 85 90 95 Arg Met Leu Glu Leu Val Ala Gln Lys Gln Arg Glu Arg Glu Glu Arg 100 105 110 Glu Glu Arg Glu Ala Leu Glu Arg Glu Arg Gln Arg Arg Arg Gln Gly 115 120 125 Gln Glu Leu Ser Ala Ala Arg Gln Arg Leu Gln Glu Asp Glu Met Arg 130 135 140 Arg Ala Ala Glu Glu Arg Arg Arg Glu Lys Ala Glu Glu Leu Ala Ala 145 150 155 160 Arg Gln Arg Val Arg Glu Lys Ile Glu Arg Asp Lys Ala Glu Arg Ala 165 170 175 Lys Lys Tyr Gly Gly Ser Val Gly Ser Gln Pro Pro Pro Val Ala Pro 180 185 190 Glu Pro Gly Pro Val Pro Ser Ser Pro Ser Gln Glu Pro Pro Thr Lys 195 200 205 Arg Glu Tyr Asp Gln Cys Arg Ile Gln Val Arg Leu Pro Asp Gly Thr 210 215 220 Ser Leu Thr Gln Thr Phe Arg Ala Arg Glu Gln Leu Ala Ala Val Arg 225 230 235 240 Leu Tyr Val Glu Leu His Arg Gly Glu Glu Leu Gly Gly Gly Gln Asp 245 250 255 Pro Val Gln Leu Leu Ser Gly Phe Pro Arg Arg Ala Phe Ser Glu Ala 260 265 270 Asp Met Glu Arg Pro Leu Gln Glu Leu Gly Leu Val Pro Ser Ala Val 275 280 285 Leu Ile Val Ala Lys Lys Cys Pro Ser 290 295 <210> SEQ ID NO 20 <211> LENGTH: 221 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 20 Gln Val Lys Leu Lys Ile Pro Phe Gly Asn Lys Leu Leu Asp Ala Val 1 5 10 15 Cys Leu Val Pro Asn Lys Ser Leu Thr Tyr Gly Ile Ile Leu Thr His 20 25 30 Gly Ala Ser Gly Asp Met Asn Leu Pro His Leu Met Ser Leu Ala Ser 35 40 45 His Leu Ala Ser His Gly Phe Phe Cys Leu Arg Phe Thr Cys Lys Gly 50 55 60 Leu Asn Ile Val His Arg Ile Lys Ala Tyr Lys Ser Val Leu Asn Tyr 65 70 75 80 Leu Lys Thr Ser Gly Glu Tyr Lys Leu Ala Gly Val Phe Leu Gly Gly 85 90 95 Arg Ser Met Gly Ser Arg Ala Ala Ala Ser Val Met Cys His Ile Glu 100 105 110 Pro Asp Asp Gly Asp Asp Phe Val Arg Gly Leu Ile Cys Ile Ser Tyr 115 120 125 Pro Leu His His Pro Lys Gln Gln His Lys Leu Arg Asp Glu Asp Leu 130 135 140 Phe Arg Leu Lys Glu Pro Val Leu Phe Val Ser Gly Ser Ala Asp Glu 145 150 155 160 Met Cys Glu Lys Asn Leu Leu Glu Lys Val Ala Gln Lys Met Gln Ala 165 170 175 Pro His Lys Ile His Trp Ile Glu Lys Ala Asn His Ser Met Ala Val 180 185 190 Lys Gly Arg Ser Thr Asn Asp Val Phe Lys Glu Ile Asn Thr Gln Ile 195 200 205 Leu Phe Trp Ile Gln Glu Ile Thr Glu Met Asp Lys Lys 210 215 220 <210> SEQ ID NO 21 <211> LENGTH: 305 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 21 Met Asn Gly Leu Ser Leu Ser Glu Leu Cys Cys Leu Phe Cys Cys Pro 1 5 10 15 Pro Cys Pro Gly Arg Ile Ala Ala Lys Leu Ala Phe Leu Pro Pro Glu 20 25 30 Ala Thr Tyr Ser Leu Val Thr Glu Pro Glu Pro Gly Pro Gly Gly Ala 35 40 45 Gly Ala Ala Pro Leu Gly Thr Leu Arg Ala Ser Ser Gly Ala Pro Gly 50 55 60 Arg Trp Lys Leu His Leu Thr Glu Arg Ala Asp Phe Gln Tyr Ser Gln 65 70 75 80 Arg Glu Leu Asp Thr Ile Glu Val Phe Pro Thr Lys Ser Ala Arg Arg 85 90 95 Asn Arg Val Ser Cys Met Tyr Val Arg Cys Val Thr Gly Ala Arg Tyr 100 105 110 Thr Val Leu Phe Ser His Ser Asn Ala Val Asp Leu Gly Gln Met Ser 115 120 125 Ser Phe Tyr Ile Gly Leu Gly Ser Arg Leu His Cys Asn Ile Phe Ser 130 135 140 Tyr Asp Tyr Ser Gly Tyr Gly Ala Ser Ser Gly Arg Pro Ser Glu Arg 145 150 155 160 Asn Leu Tyr Ala Asp Ile Asp Ala Ala Trp Gln Ala Leu Arg Thr Arg 165 170 175 Tyr Gly Ile Ser Pro Asp Ser Ile Ile Leu Tyr Gly Gln Ser Ile Gly 180 185 190 Thr Val Pro Thr Val Asp Leu Ala Ser Arg Tyr Glu Cys Ala Ala Val 195 200 205 Val Leu His Ser Pro Leu Thr Ser Gly Met Arg Val Ala Phe Pro Asp 210 215 220 Thr Lys Lys Thr Tyr Cys Phe Asp Ala Phe Pro Asn Ile Glu Lys Val 225 230 235 240 Ser Lys Ile Thr Ser Pro Val Leu Ile Ile His Gly Thr Glu Asp Glu 245 250 255 Val Ile Asp Phe Ser His Gly Leu Ala Leu Tyr Glu Arg Cys Pro Lys 260 265 270 Ala Val Glu Pro Leu Trp Val Glu Gly Thr Arg His Asn Asp Ile Glu 275 280 285 Leu Tyr Ser Gln Tyr Leu Glu Gly Leu Arg Arg Phe Ile Ser Gln Glu 290 295 300 Leu 305 <210> SEQ ID NO 22 <211> LENGTH: 243 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 22 Ala Gln Gly Lys Asp Gln Met Trp Tyr Glu Asp Ala Leu Ala Ser Ser 1 5 10 15 His Pro Ile Ile Leu Tyr Leu His Gly Asn Ala Gly Thr Arg Cys Leu 20 25 30 Phe Phe Thr Leu Gln Val Leu Ser Ser Leu Gly Tyr His Val Val Thr 35 40 45 Phe Asp Tyr Arg Gly Trp Gly Asp Ser Val Gly Thr Pro Ser Glu Arg 50 55 60 Gly Met Thr Tyr Asp Ala Leu His Val Phe Asp Trp Ile Lys Ala Arg 65 70 75 80 Ser Gly Asp Asn Pro Val Tyr Ile Trp Gly His Ser Leu Gly Thr Gly 85 90 95 Val Ala Thr Asn Leu Val Arg Arg Leu Cys Glu Arg Glu Thr Pro Pro 100 105 110 Asp Ala Leu Ile Leu Glu Ser Pro Phe Thr Asn Ile Arg Glu Glu Ala 115 120 125 Lys Ser His Pro Phe Ser Ile Tyr Arg Tyr Phe Pro Gly Phe Asp Trp 130 135 140 Phe Phe Leu Asp Pro Ile Thr Ser Ser Gly Ile Lys Phe Ala Asn Asp 145 150 155 160 Glu Asn Val Lys His Ile Ser Cys Pro Leu Leu Ile Leu His Ala Glu 165 170 175 Asp Asp Pro Val Val Pro Phe Gln Leu Gly Arg Lys Leu Tyr Ser Ile 180 185 190 Ala Ala Pro Ala Arg Ser Phe Arg Asp Phe Lys Val Gln Phe Val Pro 195 200 205 Phe His Ser Asp Leu Gly Tyr Arg His Lys Tyr Ile Tyr Lys Ser Pro 210 215 220 Glu Leu Pro Arg Ile Leu Arg Glu Phe Leu Gly Lys Ser Glu Pro Glu 225 230 235 240 His Gln His <210> SEQ ID NO 23 <211> LENGTH: 233 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 23 Met Asp Ala Ser Ile Met Asp Gly Lys Asp Leu Ser Ala Gly Ala Val 1 5 10 15 Ser Ala Val Gln Cys Ile Ala Asn Pro Ile Lys Leu Ala Arg Leu Val 20 25 30 Met Glu Lys Thr Pro His Cys Phe Leu Thr Asp Gln Gly Ala Ala Gln 35 40 45 Phe Ala Ala Ala Met Gly Val Pro Glu Ile Pro Gly Glu Lys Leu Val 50 55 60 Thr Glu Arg Asn Lys Lys Arg Leu Glu Lys Glu Lys His Glu Lys Gly 65 70 75 80 Ala Gln Lys Thr Asp Cys Gln Lys Asn Leu Gly Thr Val Gly Ala Val 85 90 95 Ala Leu Asp Cys Lys Gly Asn Val Ala Tyr Ala Thr Ser Thr Gly Gly 100 105 110 Ile Val Asn Lys Met Val Gly Arg Val Gly Asp Ser Pro Cys Leu Ala 115 120 125 Gly Ala Gly Gly Tyr Ala Asp Asn Asp Ile Gly Ala Val Ser Thr Thr 130 135 140 Gly His Gly Glu Ser Ile Leu Lys Val Asn Leu Ala Arg Leu Thr Leu 145 150 155 160 Phe His Ile Glu Gln Gly Lys Thr Val Glu Glu Ala Ala Asp Leu Ser 165 170 175 Leu Gly Tyr Met Lys Ser Arg Val Lys Gly Leu Gly Gly Leu Ile Val 180 185 190 Val Ser Lys Thr Gly Asp Trp Val Ala Lys Trp Thr Ser Thr Ser Met 195 200 205 Pro Trp Ala Ala Ala Lys Asp Gly Lys Leu His Phe Gly Ile Asp Pro 210 215 220 Asp Asp Thr Thr Ile Thr Asp Leu Pro 225 230 <210> SEQ ID NO 24 <211> LENGTH: 166 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 24 Met Leu Arg Gly Val Leu Gly Lys Thr Phe Arg Leu Val Gly Tyr Thr 1 5 10 15 Ile Gln Tyr Gly Cys Ile Ala His Cys Ala Phe Glu Tyr Val Gly Gly 20 25 30 Val Val Met Cys Ser Gly Pro Ser Met Glu Pro Thr Ile Gln Asn Ser 35 40 45 Asp Ile Val Phe Ala Glu Asn Leu Ser Arg His Phe Tyr Gly Ile Gln 50 55 60 Arg Gly Asp Ile Val Ile Ala Lys Ser Pro Ser Asp Pro Lys Ser Asn 65 70 75 80 Ile Cys Lys Arg Val Ile Gly Leu Glu Gly Asp Lys Ile Leu Thr Thr 85 90 95 Ser Pro Ser Asp Phe Phe Lys Ser His Ser Tyr Val Pro Met Gly His 100 105 110 Val Trp Leu Glu Gly Asp Asn Leu Gln Asn Ser Thr Asp Ser Arg Cys 115 120 125 Tyr Gly Pro Ile Pro Tyr Gly Leu Ile Arg Gly Arg Ile Phe Phe Lys 130 135 140 Ile Trp Pro Leu Ser Asp Phe Gly Phe Leu Arg Ala Ser Pro Asn Gly 145 150 155 160 His Arg Phe Ser Asp Asp 165 <210> SEQ ID NO 25 <211> LENGTH: 1091 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 25 Met Met Asp Ser Pro Lys Ile Gly Asn Gly Leu Pro Val Ile Gly Pro 1 5 10 15 Gly Thr Asp Ile Gly Ile Ser Ser Leu His Met Val Gly Tyr Leu Gly 20 25 30 Lys Asn Phe Asp Ser Ala Lys Val Pro Ser Asp Glu Tyr Cys Pro Ala 35 40 45 Cys Arg Glu Lys Gly Lys Leu Lys Ala Leu Lys Thr Tyr Arg Ile Ser 50 55 60 Phe Gln Glu Ser Ile Phe Leu Cys Glu Asp Leu Gln Cys Ile Tyr Pro 65 70 75 80 Leu Gly Ser Lys Ser Leu Asn Asn Leu Ile Ser Pro Asp Leu Glu Glu 85 90 95 Cys His Thr Pro His Lys Pro Gln Lys Arg Lys Ser Leu Glu Ser Ser 100 105 110 Tyr Lys Asp Ser Leu Leu Leu Ala Asn Ser Lys Lys Thr Arg Asn Tyr 115 120 125 Ile Ala Ile Asp Gly Gly Lys Val Leu Asn Ser Lys His Asn Gly Glu 130 135 140 Val Tyr Asp Glu Thr Ser Ser Asn Leu Pro Asp Ser Ser Gly Gln Gln 145 150 155 160 Asn Pro Ile Arg Thr Ala Asp Ser Leu Glu Arg Asn Glu Ile Leu Glu 165 170 175 Ala Asp Thr Val Asp Met Ala Thr Thr Lys Asp Pro Ala Thr Val Asp 180 185 190 Val Ser Gly Thr Gly Arg Pro Ser Pro Gln Asn Glu Gly Cys Thr Ser 195 200 205 Lys Leu Glu Met Pro Leu Glu Ser Lys Cys Thr Ser Phe Pro Gln Ala 210 215 220 Leu Cys Val Gln Trp Lys Asn Ala Tyr Ala Leu Cys Trp Leu Asp Cys 225 230 235 240 Ile Leu Ser Ala Leu Val His Ser Glu Glu Leu Lys Asn Thr Val Thr 245 250 255 Gly Leu Cys Ser Lys Glu Glu Ser Ile Phe Trp Arg Leu Leu Thr Lys 260 265 270 Tyr Asn Gln Ala Asn Thr Leu Leu Tyr Thr Ser Gln Leu Ser Gly Val 275 280 285 Lys Asp Gly Asp Cys Lys Lys Leu Thr Ser Glu Ile Phe Ala Glu Ile 290 295 300 Glu Thr Cys Leu Asn Glu Val Arg Asp Glu Ile Phe Ile Ser Leu Gln 305 310 315 320 Pro Gln Leu Arg Cys Thr Leu Gly Asp Met Glu Ser Pro Val Phe Ala 325 330 335 Phe Pro Leu Leu Leu Lys Leu Glu Thr His Ile Glu Lys Leu Phe Leu 340 345 350 Tyr Ser Phe Ser Trp Asp Phe Glu Cys Ser Gln Cys Gly His Gln Tyr 355 360 365 Gln Asn Arg His Met Lys Ser Leu Val Thr Phe Thr Asn Val Ile Pro 370 375 380 Glu Trp His Pro Leu Asn Ala Ala His Phe Gly Pro Cys Asn Asn Cys 385 390 395 400 Asn Ser Lys Ser Gln Ile Arg Lys Met Val Leu Glu Lys Val Ser Pro 405 410 415 Ile Phe Met Leu His Phe Val Glu Gly Leu Pro Gln Asn Asp Leu Gln 420 425 430 His Tyr Ala Phe His Phe Glu Gly Cys Leu Tyr Gln Ile Thr Ser Val 435 440 445 Ile Gln Tyr Arg Ala Asn Asn His Phe Ile Thr Trp Ile Leu Asp Ala 450 455 460 Asp Gly Asn Trp Leu Glu Cys Asp Asp Leu Lys Gly Pro Cys Ser Glu 465 470 475 480 Arg His Lys Lys Phe Glu Val Pro Ala Ser Glu Ile His Ile Val Ile 485 490 495 Trp Glu Arg Lys Ile Ser Gln Val Thr Asp Lys Glu Ala Ala Cys Leu 500 505 510 Pro Leu Lys Lys Thr Asn Asp Gln His Ala Leu Ser Asn Glu Lys Pro 515 520 525 Val Ser Leu Thr Ser Cys Ser Val Gly Asp Ala Ala Ser Ala Glu Thr 530 535 540 Ala Ser Val Thr His Pro Lys Asp Ile Ser Val Ala Pro Arg Thr Leu 545 550 555 560 Ser Gln Asp Thr Ala Val Thr His Gly Asp His Leu Leu Ser Gly Pro 565 570 575 Lys Gly Leu Val Asp Asn Ile Leu Pro Leu Thr Leu Glu Glu Thr Ile 580 585 590 Gln Lys Thr Ala Ser Val Ser Gln Leu Asn Ser Glu Ala Phe Leu Leu 595 600 605 Glu Asn Lys Pro Val Ala Glu Asn Thr Gly Ile Leu Lys Thr Asn Thr 610 615 620 Leu Leu Ser Gln Glu Ser Leu Met Ala Ser Ser Val Ser Ala Pro Cys 625 630 635 640 Asn Glu Lys Leu Ile Gln Asp Gln Phe Val Asp Ile Ser Phe Pro Ser 645 650 655 Gln Val Val Asn Thr Asn Met Gln Ser Val Gln Leu Asn Thr Glu Asp 660 665 670 Thr Val Asn Thr Lys Ser Val Asn Asn Thr Asp Ala Thr Gly Leu Ile 675 680 685 Gln Gly Val Lys Ser Val Glu Ile Glu Lys Asp Ala Gln Leu Lys Gln 690 695 700 Phe Leu Thr Pro Lys Thr Glu Gln Leu Lys Pro Glu Arg Val Thr Ser 705 710 715 720 Gln Val Ser Asn Leu Lys Lys Lys Glu Thr Thr Ala Asp Ser Gln Thr 725 730 735 Thr Thr Ser Lys Ser Leu Gln Asn Gln Ser Leu Lys Glu Asn Gln Lys 740 745 750 Lys Pro Phe Val Gly Ser Trp Val Lys Gly Leu Ile Ser Arg Gly Ala 755 760 765 Ser Phe Met Pro Leu Cys Val Ser Ala His Asn Arg Asn Thr Ile Thr 770 775 780 Asp Leu Gln Pro Ser Val Lys Gly Val Asn Asn Phe Gly Gly Phe Lys 785 790 795 800 Thr Lys Gly Ile Asn Gln Lys Ala Ser His Val Ser Lys Lys Ala Arg 805 810 815 Lys Ser Ala Ser Lys Pro Pro Pro Ile Ser Lys Pro Pro Ala Gly Pro 820 825 830 Pro Ser Ser Asn Gly Thr Ala Ala His Pro His Ala His Ala Ala Ser 835 840 845 Glu Val Leu Glu Lys Ser Gly Ser Thr Ser Cys Gly Ala Gln Leu Asn 850 855 860 His Ser Ser Tyr Gly Asn Gly Ile Ser Ser Ala Asn His Glu Asp Leu 865 870 875 880 Val Glu Gly Gln Ile His Lys Leu Arg Leu Lys Leu Arg Lys Lys Leu 885 890 895 Lys Ala Glu Lys Lys Lys Leu Ala Ala Leu Met Ser Ser Pro Gln Ser 900 905 910 Arg Thr Val Arg Ser Glu Asn Leu Glu Gln Val Pro Gln Asp Gly Ser 915 920 925 Pro Asn Asp Cys Glu Ser Ile Glu Asp Leu Asn Glu Leu Pro Tyr Pro 930 935 940 Ile Asp Ile Ala Ser Glu Ser Ala Cys Thr Thr Val Pro Gly Val Ser 945 950 955 960 Leu Tyr Ser Ser Gln Thr His Glu Glu Ile Leu Ala Glu Leu Leu Ser 965 970 975 Pro Thr Pro Val Ser Thr Glu Leu Ser Glu Asn Gly Glu Gly Asp Phe 980 985 990 Arg Tyr Leu Gly Met Gly Asp Ser His Ile Pro Pro Pro Val Pro Ser 995 1000 1005 Glu Phe Asn Asp Val Ser Gln Asn Thr His Leu Arg Gln Asp His Asn 1010 1015 1020 Tyr Cys Ser Pro Thr Lys Lys Asn Pro Cys Glu Val Gln Pro Asp Ser 1025 1030 1035 1040 Leu Thr Asn Asn Ala Cys Val Arg Thr Leu Asn Leu Glu Ser Pro Met 1045 1050 1055 Lys Thr Asp Ile Phe Asp Glu Phe Phe Ser Ser Ser Ala Leu Asn Ala 1060 1065 1070 Leu Ala Asn Asp Thr Leu Asp Leu Pro His Phe Asp Glu Tyr Leu Phe 1075 1080 1085 Glu Asn Tyr 1090 <210> SEQ ID NO 26 <211> LENGTH: 439 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 26 Met Leu Thr Gly Val Thr Asp Gly Ile Phe Cys Cys Leu Leu Gly Thr 1 5 10 15 Pro Pro Asn Ala Val Gly Pro Leu Glu Ser Val Glu Ser Ser Asp Gly 20 25 30 Tyr Thr Phe Val Glu Val Lys Pro Gly Arg Val Leu Arg Val Lys His 35 40 45 Ala Gly Pro Ala Pro Ala Ala Ala Pro Pro Pro Pro Ser Ser Ala Ser 50 55 60 Ser Asp Ala Ala Gln Gly Asp Leu Ser Gly Leu Val Arg Cys Gln Arg 65 70 75 80 Arg Ile Thr Val Tyr Arg Asn Gly Arg Leu Leu Val Glu Asn Leu Gly 85 90 95 Arg Ala Pro Arg Ala Asp Leu Leu His Gly Gln Asn Gly Ser Gly Glu 100 105 110 Pro Pro Ala Ala Leu Glu Val Glu Leu Ala Asp Pro Ala Gly Ser Asp 115 120 125 Gly Arg Leu Ala Pro Gly Ser Ala Gly Ser Gly Ser Gly Ser Gly Ser 130 135 140 Gly Gly Arg Arg Arg Arg Ala Arg Arg Pro Lys Arg Thr Ile His Ile 145 150 155 160 Asp Cys Glu Lys Arg Ile Thr Ser Cys Lys Gly Ala Gln Ala Asp Val 165 170 175 Val Leu Phe Phe Ile His Gly Val Gly Gly Ser Leu Ala Ile Trp Lys 180 185 190 Glu Gln Leu Asp Phe Phe Val Arg Leu Gly Tyr Glu Val Val Ala Pro 195 200 205 Asp Leu Ala Gly His Gly Ala Ser Ser Ala Pro Gln Val Ala Ala Ala 210 215 220 Tyr Thr Phe Tyr Ala Leu Ala Glu Asp Met Arg Ala Ile Phe Lys Arg 225 230 235 240 Tyr Ala Lys Lys Arg Asn Val Leu Ile Gly His Ser Tyr Gly Val Ser 245 250 255 Phe Cys Thr Phe Leu Ala His Glu Tyr Pro Asp Leu Val His Lys Val 260 265 270 Ile Met Ile Asn Gly Gly Gly Pro Thr Ala Leu Glu Pro Ser Phe Cys 275 280 285 Ser Ile Phe Asn Met Pro Thr Cys Val Leu His Cys Leu Ser Pro Cys 290 295 300 Leu Ala Trp Ser Phe Leu Lys Ala Gly Phe Ala Arg Gln Gly Ala Lys 305 310 315 320 Glu Lys Gln Leu Leu Lys Glu Gly Asn Ala Phe Asn Val Ser Ser Phe 325 330 335 Val Leu Arg Ala Met Met Ser Gly Gln Tyr Trp Pro Glu Gly Asp Glu 340 345 350 Val Tyr His Ala Glu Leu Thr Val Pro Val Leu Leu Val His Gly Met 355 360 365 His Asp Lys Phe Val Pro Val Glu Glu Asp Gln Arg Met Ala Glu Ile 370 375 380 Leu Leu Leu Ala Phe Leu Lys Leu Ile Asp Glu Gly Ser His Met Val 385 390 395 400 Met Leu Glu Cys Pro Glu Thr Val Asn Thr Leu Leu His Glu Phe Leu 405 410 415 Leu Trp Glu Pro Glu Pro Ser Pro Lys Ala Leu Pro Glu Pro Leu Pro 420 425 430 Ala Pro Pro Glu Asp Lys Lys 435 <210> SEQ ID NO 27 <211> LENGTH: 514 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 27 Met Arg Arg Gln Trp Gly Ser Ala Met Arg Ala Ala Glu Gln Ala Gly 1 5 10 15 Cys Met Val Ser Ala Ser Arg Ala Gly Gln Pro Glu Ala Gly Pro Trp 20 25 30 Ser Cys Ser Gly Val Ile Leu Ser Arg Ser Pro Gly Leu Val Leu Cys 35 40 45 His Gly Gly Ile Phe Val Pro Phe Leu Arg Ala Gly Ser Glu Val Leu 50 55 60 Thr Ala Gly Ala Val Phe Leu Pro Gly Asp Ser Cys Arg Asp Asp Leu 65 70 75 80 Arg Leu His Val Gln Trp Ala Pro Thr Gly Ala Pro Arg Gly Gln Ala 85 90 95 Arg Thr Gly Pro Pro Arg Leu Ala Arg Pro Met Arg Asp Leu Ser Pro 100 105 110 Pro Pro Pro Ser Gln Ala Ser Leu Ser Gln Ser Cys Asp Trp Arg Ile 115 120 125 Thr Glu Thr Leu Gly Trp Phe Ala Leu Leu Gly Val Arg Leu Gly Gln 130 135 140 Glu Glu Trp Arg Arg Arg Gly Pro Met Ala Val Ser Pro Leu Gly Ala 145 150 155 160 Val Pro Lys Gly Ala Pro Leu Leu Val Cys Gly Ser Pro Phe Gly Ala 165 170 175 Phe Cys Pro Asp Ile Phe Leu Asn Thr Leu Ser Cys Gly Val Leu Ser 180 185 190 Asn Val Ala Gly Pro Leu Leu Leu Thr Asp Ala Arg Cys Leu Pro Gly 195 200 205 Thr Glu Gly Gly Gly Val Phe Thr Ala Arg Pro Ala Gly Ala Leu Val 210 215 220 Ala Leu Val Val Ala Pro Leu Cys Trp Lys Ala Gly Glu Trp Val Gly 225 230 235 240 Phe Thr Leu Leu Cys Ala Ala Ala Pro Leu Phe Arg Ala Ala Arg Asp 245 250 255 Ala Leu His Arg Leu Pro His Ser Thr Ala Ala Leu Ala Ala Leu Leu 260 265 270 Pro Pro Glu Val Gly Val Pro Trp Gly Leu Pro Leu Arg Asp Ser Gly 275 280 285 Pro Leu Trp Ala Ala Ala Ala Val Leu Val Glu Cys Gly Thr Val Trp 290 295 300 Gly Ser Gly Val Ala Val Ala Pro Arg Leu Val Val Thr Cys Arg His 305 310 315 320 Val Ser Pro Arg Glu Ala Ala Arg Val Leu Val Arg Ser Thr Thr Pro 325 330 335 Lys Ser Val Ala Ile Trp Gly Arg Val Val Phe Ala Thr Gln Glu Thr 340 345 350 Cys Pro Tyr Asp Ile Ala Val Val Ser Leu Glu Glu Asp Leu Asp Asp 355 360 365 Val Pro Ile Pro Val Pro Ala Glu His Phe His Glu Gly Glu Ala Val 370 375 380 Ser Val Val Gly Phe Gly Val Phe Gly Gln Ser Cys Gly Pro Ser Val 385 390 395 400 Thr Ser Gly Ile Leu Ser Ala Val Val Gln Val Asn Gly Thr Pro Val 405 410 415 Met Leu Gln Thr Thr Cys Ala Val His Ser Gly Ser Ser Gly Gly Pro 420 425 430 Leu Phe Ser Asn His Ser Gly Asn Leu Leu Gly Ile Ile Thr Ser Asn 435 440 445 Thr Arg Asp Asn Asn Thr Gly Ala Thr Tyr Pro His Leu Asn Phe Ser 450 455 460 Ile Pro Ile Thr Val Leu Gln Pro Ala Leu Gln Gln Tyr Ser Gln Thr 465 470 475 480 Gln Asp Leu Gly Gly Leu Arg Glu Leu Asp Arg Ala Ala Glu Pro Val 485 490 495 Arg Val Val Trp Arg Leu Gln Arg Pro Leu Ala Glu Ala Pro Arg Ser 500 505 510 Lys Leu <210> SEQ ID NO 28 <211> LENGTH: 305 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 28 Met Ala Val Ala Arg Leu Ala Ala Val Ala Ala Trp Val Pro Cys Arg 1 5 10 15 Ser Trp Gly Trp Ala Ala Val Pro Phe Gly Pro His Arg Gly Leu Ser 20 25 30 Val Leu Leu Ala Arg Ile Pro Gln Arg Ala Pro Arg Trp Leu Pro Ala 35 40 45 Cys Arg Gln Lys Thr Ser Leu Ser Phe Leu Asn Arg Pro Asp Leu Pro 50 55 60 Asn Leu Ala Tyr Lys Lys Leu Lys Gly Lys Ser Pro Gly Ile Ile Phe 65 70 75 80 Ile Pro Gly Tyr Leu Ser Tyr Met Asn Gly Thr Lys Ala Leu Ala Ile 85 90 95 Glu Glu Phe Cys Lys Ser Leu Gly His Ala Cys Ile Arg Phe Asp Tyr 100 105 110 Ser Gly Val Gly Ser Ser Asp Gly Asn Ser Glu Glu Ser Thr Leu Gly 115 120 125 Lys Trp Arg Lys Asp Val Leu Ser Ile Ile Asp Asp Leu Ala Asp Gly 130 135 140 Pro Gln Ile Leu Val Gly Ser Ser Leu Gly Gly Trp Leu Met Leu His 145 150 155 160 Ala Ala Ile Ala Arg Pro Glu Lys Val Val Ala Leu Ile Gly Val Ala 165 170 175 Thr Ala Asp Thr Leu Val Thr Lys Phe Asn Gln Leu Pro Val Glu Leu 180 185 190 Lys Lys Glu Val Glu Met Lys Gly Val Trp Ser Met Pro Ser Lys Tyr 195 200 205 Ser Glu Glu Gly Val Tyr Asn Val Gln Tyr Ser Phe Ile Lys Glu Ala 210 215 220 Glu His His Cys Leu Leu His Ser Pro Ile Pro Val Asn Cys Pro Ile 225 230 235 240 Arg Leu Leu His Gly Met Lys Asp Asp Ile Val Pro Trp His Thr Ser 245 250 255 Met Gln Val Ala Asp Arg Val Leu Ser Thr Asp Val Asp Val Ile Leu 260 265 270 Arg Lys His Ser Asp His Arg Met Arg Glu Lys Ala Asp Ile Gln Leu 275 280 285 Leu Val Tyr Thr Ile Asp Asp Leu Ile Asp Lys Leu Ser Thr Ile Val 290 295 300 Asn 305 <210> SEQ ID NO 29 <211> LENGTH: 728 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 29 Gln Gln Gly Ser Ile Thr Leu Ser Leu Trp Thr Leu Pro Asp Val Leu 1 5 10 15 Ile Ile His Leu Lys Arg Phe Arg Gln Glu Gly Asp Arg Arg Met Lys 20 25 30 Leu Gln Asn Met Val Lys Phe Pro Leu Thr Gly Leu Asp Met Thr Pro 35 40 45 His Val Val Lys Arg Ser Gln Ser Ser Trp Ser Leu Pro Ser His Trp 50 55 60 Ser Pro Trp Arg Arg Pro Tyr Gly Leu Gly Arg Asp Pro Glu Asp Tyr 65 70 75 80 Ile Tyr Asp Leu Tyr Ala Val Cys Asn His His Gly Thr Met Gln Gly 85 90 95 Gly His Tyr Thr Ala Tyr Cys Lys Asn Ser Val Asp Gly Leu Trp Tyr 100 105 110 Cys Phe Asp Asp Ser Asp Val Gln Gln Leu Ser Glu Asp Glu Val Cys 115 120 125 Thr Gln Thr Ala Tyr Ile Leu Phe Tyr Gln Arg Arg Thr Ala Ile Pro 130 135 140 Ser Trp Ser Ala Asn Ser Ser Val Ala Gly Ser Thr Ser Ser Ser Leu 145 150 155 160 Cys Glu His Trp Val Ser Arg Leu Pro Gly Ser Lys Pro Ala Ser Val 165 170 175 Thr Ser Ala Ala Ser Ser Arg Arg Thr Ser Leu Ala Ser Leu Ser Glu 180 185 190 Ser Val Glu Met Thr Gly Glu Arg Ser Glu Asp Asp Gly Gly Cys Phe 195 200 205 Ser Thr Arg Pro Phe Val Arg Ser Val Gln Arg Gln Ser Leu Ser Ser 210 215 220 Arg Ser Ser Val Thr Ser Pro Leu Ala Val Asn Glu Asn Cys Met Arg 225 230 235 240 Pro Ser Trp Ser Leu Ser Ala Lys Leu Gln Met Arg Ser Asn Ser Pro 245 250 255 Ser Arg Phe Ser Gly Asp Ser Pro Ile His Ser Ser Ala Ser Thr Leu 260 265 270 Glu Lys Ile Gly Glu Ala Ala Asp Asp Lys Val Ser Ile Ser Cys Phe 275 280 285 Gly Ser Leu Arg Asn Leu Ser Ser Ser Tyr Gln Glu Pro Ser Asp Ser 290 295 300 His Ser Leu Arg Glu His Lys Ala Val Gly Arg Ala Pro Leu Ala Val 305 310 315 320 Met Glu Gly Val Phe Lys Asp Glu Ser Asp Thr Arg Arg Leu Asn Ser 325 330 335 Ser Val Val Asp Thr Gln Ser Lys His Ser Ala Gln Gly Asp Arg Leu 340 345 350 Pro Pro Leu Ser Gly Pro Phe Asp Asn Asn Asn Gln Ile Ala Tyr Val 355 360 365 Asp Gln Ser Asp Ser Val Asp Ser Ser Pro Val Lys Glu Val Lys Ala 370 375 380 Pro Ser His Pro Gly Ser Leu Ala Lys Lys Pro Glu Ser Thr Thr Lys 385 390 395 400 Arg Ser Pro Ser Ser Lys Gly Thr Ser Glu Pro Glu Lys Ser Leu Arg 405 410 415 Lys Gly Arg Pro Ala Leu Ala Ser Gln Glu Ser Ser Leu Ser Ser Thr 420 425 430 Ser Pro Ser Ser Pro Leu Pro Val Lys Val Ser Leu Lys Pro Ser Arg 435 440 445 Ser Arg Ser Lys Ala Asp Ser Ser Ser Arg Gly Ser Gly Arg His Ser 450 455 460 Ser Pro Ala Pro Ala Gln Pro Lys Lys Glu Ser Ser Pro Lys Ser Gln 465 470 475 480 Asp Ser Val Ser Ser Pro Ser Pro Gln Lys Gln Lys Ser Ala Ser Ala 485 490 495 Leu Thr Tyr Thr Ala Ser Ser Thr Ser Ala Lys Lys Ala Ser Gly Pro 500 505 510 Ala Thr Arg Ser Pro Phe Pro Pro Gly Lys Ser Arg Thr Ser Asp His 515 520 525 Ser Leu Ser Arg Glu Gly Ser Arg Gln Ser Leu Gly Ser Asp Arg Ala 530 535 540 Ser Ala Thr Ser Thr Ser Lys Pro Asn Ser Pro Arg Val Ser Gln Ala 545 550 555 560 Arg Ala Gly Glu Gly Arg Gly Ala Gly Lys His Val Arg Ser Ser Ser 565 570 575 Met Ala Ser Leu Arg Ser Pro Ser Thr Ser Ile Lys Ser Gly Leu Lys 580 585 590 Arg Asp Ser Lys Ser Glu Asp Lys Gly Leu Ser Phe Phe Lys Ser Ala 595 600 605 Leu Arg Gln Lys Glu Thr Arg Arg Ser Thr Asp Leu Gly Lys Thr Ala 610 615 620 Leu Leu Ser Lys Lys Ala Gly Gly Ser Ser Val Lys Ser Val Cys Lys 625 630 635 640 Asn Thr Gly Asp Asp Glu Ala Glu Arg Gly His Gln Pro Pro Ala Ser 645 650 655 Gln Gln Pro Asn Ala Asn Thr Thr Gly Lys Glu Gln Leu Val Thr Lys 660 665 670 Asp Pro Ala Ser Ala Lys His Ser Leu Leu Ser Ala Arg Lys Ser Lys 675 680 685 Ser Ser Gln Leu Asp Ser Gly Val Pro Ser Ser Pro Gly Gly Arg Gln 690 695 700 Ser Ala Glu Lys Ser Ser Lys Lys Leu Ser Ser Ser Met Gln Thr Ser 705 710 715 720 Ala Arg Pro Ser Gln Lys Pro Gln 725 <210> SEQ ID NO 30 <211> LENGTH: 561 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 30 Met Cys Gly Ile Trp Ala Leu Phe Gly Ser Asp Asp Cys Leu Ser Val 1 5 10 15 Gln Cys Leu Ser Ala Met Lys Ile Ala His Arg Gly Pro Asp Ala Phe 20 25 30 Arg Phe Glu Asn Val Asn Gly Tyr Thr Asn Cys Cys Phe Gly Phe His 35 40 45 Arg Leu Ala Val Val Asp Pro Leu Phe Gly Met Gln Pro Ile Arg Val 50 55 60 Lys Lys Tyr Pro Tyr Leu Trp Leu Cys Tyr Asn Gly Glu Ile Tyr Asn 65 70 75 80 His Lys Lys Met Gln Gln His Phe Glu Phe Glu Tyr Gln Thr Lys Val 85 90 95 Asp Gly Glu Ile Ile Leu His Leu Tyr Asp Lys Gly Gly Ile Glu Gln 100 105 110 Thr Ile Cys Met Leu Asp Gly Val Phe Ala Phe Val Leu Leu Asp Thr 115 120 125 Ala Asn Lys Lys Val Phe Leu Gly Arg Asp Thr Tyr Gly Val Arg Pro 130 135 140 Leu Phe Lys Ala Met Thr Glu Asp Gly Phe Leu Ala Val Cys Ser Glu 145 150 155 160 Ala Lys Gly Leu Val Thr Leu Lys His Ser Ala Thr Pro Phe Leu Lys 165 170 175 Val Glu Pro Phe Leu Pro Gly His Tyr Glu Val Leu Asp Leu Lys Pro 180 185 190 Asn Gly Lys Val Ala Ser Val Glu Met Val Lys Tyr His His Cys Arg 195 200 205 Asp Val Pro Leu His Ala Leu Tyr Asp Asn Val Glu Lys Leu Phe Pro 210 215 220 Gly Phe Glu Ile Glu Thr Val Lys Asn Asn Leu Arg Ile Leu Phe Asn 225 230 235 240 Asn Ala Val Lys Lys Arg Leu Met Thr Asp Arg Arg Ile Gly Cys Leu 245 250 255 Leu Ser Gly Gly Leu Asp Ser Ser Leu Val Ala Ala Thr Leu Leu Lys 260 265 270 Gln Leu Lys Glu Ala Gln Val Gln Tyr Pro Leu Gln Thr Phe Ala Ile 275 280 285 Gly Met Glu Asp Ser Pro Asp Leu Leu Ala Ala Arg Lys Val Ala Asp 290 295 300 His Ile Gly Ser Glu His Tyr Glu Val Leu Phe Asn Ser Glu Glu Gly 305 310 315 320 Ile Gln Ala Leu Asp Glu Val Ile Phe Ser Leu Glu Thr Tyr Asp Ile 325 330 335 Thr Thr Val Arg Ala Ser Val Gly Met Tyr Leu Ile Ser Lys Tyr Ile 340 345 350 Arg Lys Asn Thr Asp Ser Val Val Ile Phe Ser Gly Glu Gly Ser Asp 355 360 365 Glu Leu Thr Gln Gly Tyr Ile Tyr Phe His Lys Ala Pro Ser Pro Glu 370 375 380 Lys Ala Glu Glu Glu Ser Glu Arg Leu Leu Arg Glu Leu Tyr Leu Phe 385 390 395 400 Asp Val Leu Arg Ala Asp Arg Thr Thr Ala Ala His Gly Leu Glu Leu 405 410 415 Arg Val Pro Phe Leu Asp His Arg Phe Ser Ser Tyr Tyr Leu Ser Leu 420 425 430 Pro Pro Glu Met Arg Ile Pro Lys Asn Gly Ile Glu Lys His Leu Leu 435 440 445 Arg Glu Thr Phe Glu Asp Ser Asn Leu Ile Pro Lys Glu Ile Leu Trp 450 455 460 Arg Pro Lys Glu Ala Phe Ser Asp Gly Ile Thr Ser Val Lys Asn Ser 465 470 475 480 Trp Phe Lys Ile Leu Gln Glu Tyr Val Glu His Gln Val Asp Asp Ala 485 490 495 Met Met Ala Asn Ala Ala Gln Lys Phe Pro Phe Asn Thr Pro Lys Thr 500 505 510 Lys Glu Gly Tyr Tyr Tyr Arg Gln Val Phe Glu Arg His Tyr Pro Gly 515 520 525 Arg Ala Asp Trp Leu Ser His Tyr Trp Met Pro Lys Trp Ile Asn Ala 530 535 540 Thr Asp Pro Ser Ala Arg Thr Leu Thr His Tyr Lys Ser Ala Val Lys 545 550 555 560 Ala <210> SEQ ID NO 31 <211> LENGTH: 830 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 31 Gln Ala Asn Cys Gln Ile Ala Ile Leu Tyr Gln Arg Phe Gln Arg Val 1 5 10 15 Val Phe Gly Ile Ser Gln Leu Leu Cys Phe Ser Ala Leu Ile Ser Glu 20 25 30 Leu Thr Asn Gln Lys Glu Val Ala Ala Trp Thr Tyr His Tyr Ser Thr 35 40 45 Lys Ala Tyr Ser Trp Asn Ile Ser Arg Lys Tyr Cys Gln Asn Arg Tyr 50 55 60 Thr Asp Leu Val Ala Ile Gln Asn Lys Asn Glu Ile Asp Tyr Leu Asn 65 70 75 80 Lys Val Leu Pro Tyr Tyr Ser Ser Tyr Tyr Trp Ile Gly Ile Arg Lys 85 90 95 Asn Asn Lys Thr Trp Thr Trp Val Gly Thr Lys Lys Ala Leu Thr Asn 100 105 110 Glu Ala Glu Asn Trp Ala Asp Asn Glu Pro Asn Asn Lys Arg Asn Asn 115 120 125 Glu Asp Cys Val Glu Ile Tyr Ile Lys Ser Pro Ser Ala Pro Gly Lys 130 135 140 Trp Asn Asp Glu His Cys Leu Lys Lys Lys His Ala Leu Cys Tyr Thr 145 150 155 160 Ala Ser Cys Gln Asp Met Ser Cys Ser Lys Gln Gly Glu Cys Leu Glu 165 170 175 Thr Ile Gly Asn Tyr Thr Cys Ser Cys Tyr Pro Gly Phe Tyr Gly Pro 180 185 190 Glu Cys Glu Tyr Val Arg Glu Cys Gly Glu Leu Glu Leu Pro Gln His 195 200 205 Val Leu Met Asn Cys Ser His Pro Leu Gly Asn Phe Ser Phe Asn Ser 210 215 220 Gln Cys Ser Phe His Cys Thr Asp Gly Tyr Gln Val Asn Gly Pro Ser 225 230 235 240 Lys Leu Glu Cys Leu Ala Ser Gly Ile Trp Thr Asn Lys Pro Pro Gln 245 250 255 Cys Leu Ala Ala Gln Cys Pro Pro Leu Lys Ile Pro Glu Arg Gly Asn 260 265 270 Met Thr Cys Leu His Ser Ala Lys Ala Phe Gln His Gln Ser Ser Cys 275 280 285 Ser Phe Ser Cys Glu Glu Gly Phe Ala Leu Val Gly Pro Glu Val Val 290 295 300 Gln Cys Thr Ala Ser Gly Val Trp Thr Ala Pro Ala Pro Val Cys Lys 305 310 315 320 Ala Val Gln Cys Gln His Leu Glu Ala Pro Ser Glu Gly Thr Met Asp 325 330 335 Cys Val His Pro Leu Thr Ala Phe Ala Tyr Gly Ser Ser Cys Lys Phe 340 345 350 Glu Cys Gln Pro Gly Tyr Arg Val Arg Gly Leu Asp Met Leu Arg Cys 355 360 365 Ile Asp Ser Gly His Trp Ser Ala Pro Leu Pro Thr Cys Glu Ala Ile 370 375 380 Ser Cys Glu Pro Leu Glu Ser Pro Val His Gly Ser Met Asp Cys Ser 385 390 395 400 Pro Ser Leu Arg Ala Phe Gln Tyr Asp Thr Asn Cys Ser Phe Arg Cys 405 410 415 Ala Glu Gly Phe Met Leu Arg Gly Ala Asp Ile Val Arg Cys Asp Asn 420 425 430 Leu Gly Gln Trp Thr Ala Pro Ala Pro Val Cys Gln Ala Leu Gln Cys 435 440 445 Gln Asp Leu Pro Val Pro Asn Glu Ala Arg Val Asn Cys Ser His Pro 450 455 460 Phe Gly Ala Phe Arg Tyr Gln Ser Val Cys Ser Phe Thr Cys Asn Glu 465 470 475 480 Gly Leu Leu Leu Val Gly Ala Ser Val Leu Gln Cys Leu Ala Thr Gly 485 490 495 Asn Trp Asn Ser Val Pro Pro Glu Cys Gln Ala Ile Pro Cys Thr Pro 500 505 510 Leu Leu Ser Pro Gln Asn Gly Thr Met Thr Cys Val Gln Pro Leu Gly 515 520 525 Ser Ser Ser Tyr Lys Ser Thr Cys Gln Phe Ile Cys Asp Glu Gly Tyr 530 535 540 Ser Leu Ser Gly Pro Glu Arg Leu Asp Cys Thr Arg Ser Gly Arg Trp 545 550 555 560 Thr Asp Ser Pro Pro Met Cys Glu Ala Ile Lys Cys Pro Glu Leu Phe 565 570 575 Ala Pro Glu Gln Gly Ser Leu Asp Cys Ser Asp Thr Arg Gly Glu Phe 580 585 590 Asn Val Gly Ser Thr Cys His Phe Ser Cys Asp Asn Gly Phe Lys Leu 595 600 605 Glu Gly Pro Asn Asn Val Glu Cys Thr Thr Ser Gly Arg Trp Ser Ala 610 615 620 Thr Pro Pro Thr Cys Lys Gly Ile Ala Ser Leu Pro Thr Pro Gly Val 625 630 635 640 Gln Cys Pro Ala Leu Thr Thr Pro Gly Gln Gly Thr Met Tyr Cys Arg 645 650 655 His His Pro Gly Thr Phe Gly Phe Asn Thr Thr Cys Tyr Phe Gly Cys 660 665 670 Asn Ala Gly Phe Thr Leu Ile Gly Asp Ser Thr Leu Ser Cys Arg Pro 675 680 685 Ser Gly Gln Trp Thr Ala Val Thr Pro Ala Cys Arg Ala Val Lys Cys 690 695 700 Ser Glu Leu His Val Asn Lys Pro Ile Ala Met Asn Cys Ser Asn Leu 705 710 715 720 Trp Gly Asn Phe Ser Tyr Gly Ser Ile Cys Ser Phe His Cys Leu Glu 725 730 735 Gly Gln Leu Leu Asn Gly Ser Ala Gln Thr Ala Cys Gln Glu Asn Gly 740 745 750 His Trp Ser Thr Thr Val Pro Thr Cys Gln Ala Gly Pro Leu Thr Ile 755 760 765 Gln Glu Ala Leu Thr Tyr Phe Gly Gly Ala Val Ala Ser Thr Ile Gly 770 775 780 Leu Ile Met Gly Gly Thr Leu Leu Ala Leu Leu Arg Lys Arg Phe Arg 785 790 795 800 Gln Lys Asp Asp Gly Lys Cys Pro Leu Asn Pro His Ser His Leu Gly 805 810 815 Thr Tyr Gly Val Phe Thr Asn Ala Ala Phe Asp Pro Ser Pro 820 825 830 <210> SEQ ID NO 32 <211> LENGTH: 2386 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 32 Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 1 5 10 15 Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 20 25 30 Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 35 40 45 Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 50 55 60 Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 65 70 75 80 Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 85 90 95 Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 100 105 110 Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 115 120 125 Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 130 135 140 Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 145 150 155 160 Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 165 170 175 Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 180 185 190 Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 195 200 205 Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 210 215 220 Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 225 230 235 240 Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 245 250 255 Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 260 265 270 His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 275 280 285 Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 290 295 300 Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 305 310 315 320 Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 325 330 335 Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 340 345 350 Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 355 360 365 Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 370 375 380 Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 385 390 395 400 Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 405 410 415 Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 420 425 430 Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 435 440 445 Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 450 455 460 Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 465 470 475 480 Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 485 490 495 Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 500 505 510 Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 515 520 525 Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 530 535 540 Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 545 550 555 560 Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 565 570 575 Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 580 585 590 Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 595 600 605 Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 610 615 620 Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 625 630 635 640 Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 645 650 655 Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 660 665 670 Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 675 680 685 His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 690 695 700 Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 705 710 715 720 Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 725 730 735 Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 740 745 750 Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 755 760 765 Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 770 775 780 Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 785 790 795 800 Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 805 810 815 Thr Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 820 825 830 Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 835 840 845 Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 850 855 860 Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 865 870 875 880 Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 885 890 895 Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 900 905 910 Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 915 920 925 Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 930 935 940 Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 945 950 955 960 Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 965 970 975 Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 980 985 990 Gln Thr Thr Lys Leu Asp Ala Pro Thr Asn Leu Gln Phe Val Asn Glu 995 1000 1005 Thr Asp Ser Thr Val Leu Val Arg Trp Thr Pro Pro Arg Ala Gln Ile 1010 1015 1020 Thr Gly Tyr Arg Leu Thr Val Gly Leu Thr Arg Arg Gly Gln Pro Arg 1025 1030 1035 1040 Gln Tyr Asn Val Gly Pro Ser Val Ser Lys Tyr Pro Leu Arg Asn Leu 1045 1050 1055 Gln Pro Ala Ser Glu Tyr Thr Val Ser Leu Val Ala Ile Lys Gly Asn 1060 1065 1070 Gln Glu Ser Pro Lys Ala Thr Gly Val Phe Thr Thr Leu Gln Pro Gly 1075 1080 1085 Ser Ser Ile Pro Pro Tyr Asn Thr Glu Val Thr Glu Thr Thr Ile Val 1090 1095 1100 Ile Thr Trp Thr Pro Ala Pro Arg Ile Gly Phe Lys Leu Gly Val Arg 1105 1110 1115 1120 Pro Ser Gln Gly Gly Glu Ala Pro Arg Glu Val Thr Ser Asp Ser Gly 1125 1130 1135 Ser Ile Val Val Ser Gly Leu Thr Pro Gly Val Glu Tyr Val Tyr Thr 1140 1145 1150 Ile Gln Val Leu Arg Asp Gly Gln Glu Arg Asp Ala Pro Ile Val Asn 1155 1160 1165 Lys Val Val Thr Pro Leu Ser Pro Pro Thr Asn Leu His Leu Glu Ala 1170 1175 1180 Asn Pro Asp Thr Gly Val Leu Thr Val Ser Trp Glu Arg Ser Thr Thr 1185 1190 1195 1200 Pro Asp Ile Thr Gly Tyr Arg Ile Thr Thr Thr Pro Thr Asn Gly Gln 1205 1210 1215 Gln Gly Asn Ser Leu Glu Glu Val Val His Ala Asp Gln Ser Ser Cys 1220 1225 1230 Thr Phe Asp Asn Leu Ser Pro Gly Leu Glu Tyr Asn Val Ser Val Tyr 1235 1240 1245 Thr Val Lys Asp Asp Lys Glu Ser Val Pro Ile Ser Asp Thr Ile Ile 1250 1255 1260 Pro Ala Val Pro Pro Pro Thr Asp Leu Arg Phe Thr Asn Ile Gly Pro 1265 1270 1275 1280 Asp Thr Met Arg Val Thr Trp Ala Pro Pro Pro Ser Ile Asp Leu Thr 1285 1290 1295 Asn Phe Leu Val Arg Tyr Ser Pro Val Lys Asn Glu Glu Asp Val Ala 1300 1305 1310 Glu Leu Ser Ile Ser Pro Ser Asp Asn Ala Val Val Leu Thr Asn Leu 1315 1320 1325 Leu Pro Gly Thr Glu Tyr Val Val Ser Val Ser Ser Val Tyr Glu Gln 1330 1335 1340 His Glu Ser Thr Pro Leu Arg Gly Arg Gln Lys Thr Gly Leu Asp Ser 1345 1350 1355 1360 Pro Thr Gly Ile Asp Phe Ser Asp Ile Thr Ala Asn Ser Phe Thr Val 1365 1370 1375 His Trp Ile Ala Pro Arg Ala Thr Ile Thr Gly Tyr Arg Ile Arg His 1380 1385 1390 His Pro Glu His Phe Ser Gly Arg Pro Arg Glu Asp Arg Val Pro His 1395 1400 1405 Ser Arg Asn Ser Ile Thr Leu Thr Asn Leu Thr Pro Gly Thr Glu Tyr 1410 1415 1420 Val Val Ser Ile Val Ala Leu Asn Gly Arg Glu Glu Ser Pro Leu Leu 1425 1430 1435 1440 Ile Gly Gln Gln Ser Thr Val Ser Asp Val Pro Arg Asp Leu Glu Val 1445 1450 1455 Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala 1460 1465 1470 Val Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn 1475 1480 1485 Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr 1490 1495 1500 Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala 1505 1510 1515 1520 Val Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile 1525 1530 1535 Asn Tyr Arg Thr Glu Ile Asp Lys Pro Ser Gln Met Gln Val Thr Asp 1540 1545 1550 Val Gln Asp Asn Ser Ile Ser Val Lys Trp Leu Pro Ser Ser Ser Pro 1555 1560 1565 Val Thr Gly Tyr Arg Val Thr Thr Thr Pro Lys Asn Gly Pro Gly Pro 1570 1575 1580 Thr Lys Thr Lys Thr Ala Gly Pro Asp Gln Thr Glu Met Thr Ile Glu 1585 1590 1595 1600 Gly Leu Gln Pro Thr Val Glu Tyr Val Val Ser Val Tyr Ala Gln Asn 1605 1610 1615 Pro Ser Gly Glu Ser Gln Pro Leu Val Gln Thr Ala Val Thr Asn Ile 1620 1625 1630 Asp Arg Pro Lys Gly Leu Ala Phe Thr Asp Val Asp Val Asp Ser Ile 1635 1640 1645 Lys Ile Ala Trp Glu Ser Pro Gln Gly Gln Val Ser Arg Tyr Arg Val 1650 1655 1660 Thr Tyr Ser Ser Pro Glu Asp Gly Ile His Glu Leu Phe Pro Ala Pro 1665 1670 1675 1680 Asp Gly Glu Glu Asp Thr Ala Glu Leu Gln Gly Leu Arg Pro Gly Ser 1685 1690 1695 Glu Tyr Thr Val Ser Val Val Ala Leu His Asp Asp Met Glu Ser Gln 1700 1705 1710 Pro Leu Ile Gly Thr Gln Ser Thr Ala Ile Pro Ala Pro Thr Asp Leu 1715 1720 1725 Lys Phe Thr Gln Val Thr Pro Thr Ser Leu Ser Ala Gln Trp Thr Pro 1730 1735 1740 Pro Asn Val Gln Leu Thr Gly Tyr Arg Val Arg Val Thr Pro Lys Glu 1745 1750 1755 1760 Lys Thr Gly Pro Met Lys Glu Ile Asn Leu Ala Pro Asp Ser Ser Ser 1765 1770 1775 Val Val Val Ser Gly Leu Met Val Ala Thr Lys Tyr Glu Val Ser Val 1780 1785 1790 Tyr Ala Leu Lys Asp Thr Leu Thr Ser Arg Pro Ala Gln Gly Val Val 1795 1800 1805 Thr Thr Leu Glu Asn Val Ser Pro Pro Arg Arg Ala Arg Val Thr Asp 1810 1815 1820 Ala Thr Glu Thr Thr Ile Thr Ile Ser Trp Arg Thr Lys Thr Glu Thr 1825 1830 1835 1840 Ile Thr Gly Phe Gln Val Asp Ala Val Pro Ala Asn Gly Gln Thr Pro 1845 1850 1855 Ile Gln Arg Thr Ile Lys Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly 1860 1865 1870 Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Asn Asp 1875 1880 1885 Asn Ala Arg Ser Ser Pro Val Val Ile Asp Ala Ser Thr Ala Ile Asp 1890 1895 1900 Ala Pro Ser Asn Leu Arg Phe Leu Ala Thr Thr Pro Asn Ser Leu Leu 1905 1910 1915 1920 Val Ser Trp Gln Pro Pro Arg Ala Arg Ile Thr Gly Tyr Ile Ile Lys 1925 1930 1935 Tyr Glu Lys Pro Gly Ser Pro Pro Arg Glu Val Val Pro Arg Pro Arg 1940 1945 1950 Pro Gly Val Thr Glu Ala Thr Ile Thr Gly Leu Glu Pro Gly Thr Glu 1955 1960 1965 Tyr Thr Ile Tyr Val Ile Ala Leu Lys Asn Asn Gln Lys Ser Glu Pro 1970 1975 1980 Leu Ile Gly Arg Lys Lys Thr Asp Glu Leu Pro Gln Leu Val Thr Leu 1985 1990 1995 2000 Pro His Pro Asn Leu His Gly Pro Glu Ile Leu Asp Val Pro Ser Thr 2005 2010 2015 Val Gln Lys Thr Pro Phe Val Thr His Pro Gly Tyr Asp Thr Gly Asn 2020 2025 2030 Gly Ile Gln Leu Pro Gly Thr Ser Gly Gln Gln Pro Ser Val Gly Gln 2035 2040 2045 Gln Met Ile Phe Glu Glu His Gly Phe Arg Arg Thr Thr Pro Pro Thr 2050 2055 2060 Thr Ala Thr Pro Ile Arg His Arg Pro Arg Pro Tyr Pro Pro Asn Val 2065 2070 2075 2080 Gly Glu Glu Ile Gln Ile Gly His Ile Pro Arg Glu Asp Val Asp Tyr 2085 2090 2095 His Leu Tyr Pro His Gly Pro Gly Leu Asn Pro Asn Ala Ser Thr Gly 2100 2105 2110 Gln Glu Ala Leu Ser Gln Thr Thr Ile Ser Trp Ala Pro Phe Gln Asp 2115 2120 2125 Thr Ser Glu Tyr Ile Ile Ser Cys His Pro Val Gly Thr Asp Glu Glu 2130 2135 2140 Pro Leu Gln Phe Arg Val Pro Gly Thr Ser Thr Ser Ala Thr Leu Thr 2145 2150 2155 2160 Gly Leu Thr Arg Gly Ala Thr Tyr Asn Val Ile Val Glu Ala Leu Lys 2165 2170 2175 Asp Gln Gln Arg His Lys Val Arg Glu Glu Val Val Thr Val Gly Asn 2180 2185 2190 Ser Val Asn Glu Gly Leu Asn Gln Pro Thr Asp Asp Ser Cys Phe Asp 2195 2200 2205 Pro Tyr Thr Val Ser His Tyr Ala Val Gly Asp Glu Trp Glu Arg Met 2210 2215 2220 Ser Glu Ser Gly Phe Lys Leu Leu Cys Gln Cys Leu Gly Phe Gly Ser 2225 2230 2235 2240 Gly His Phe Arg Cys Asp Ser Ser Arg Trp Cys His Asp Asn Gly Val 2245 2250 2255 Asn Tyr Lys Ile Gly Glu Lys Trp Asp Arg Gln Gly Glu Asn Gly Gln 2260 2265 2270 Met Met Ser Cys Thr Cys Leu Gly Asn Gly Lys Gly Glu Phe Lys Cys 2275 2280 2285 Asp Pro His Glu Ala Thr Cys Tyr Asp Asp Gly Lys Thr Tyr His Val 2290 2295 2300 Gly Glu Gln Trp Gln Lys Glu Tyr Leu Gly Ala Ile Cys Ser Cys Thr 2305 2310 2315 2320 Cys Phe Gly Gly Gln Arg Gly Trp Arg Cys Asp Asn Cys Arg Arg Pro 2325 2330 2335 Gly Gly Glu Pro Ser Pro Glu Gly Thr Thr Gly Gln Ser Tyr Asn Gln 2340 2345 2350 Tyr Ser Gln Arg Tyr His Gln Arg Thr Asn Thr Asn Val Asn Cys Pro 2355 2360 2365 Ile Glu Cys Phe Met Pro Leu Asp Val Gln Ala Asp Arg Glu Asp Ser 2370 2375 2380 Arg Glu 2385 <210> SEQ ID NO 33 <211> LENGTH: 953 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 33 Arg Tyr Asn Lys Asn Leu Glu Glu Ala Lys Arg Ile Gly Ile Lys Lys 1 5 10 15 Ala Ile Thr Ala Asn Ile Ser Ile Gly Ala Ala Phe Leu Leu Ile Tyr 20 25 30 Ala Ser Tyr Ala Leu Ala Phe Trp Tyr Gly Thr Thr Leu Val Leu Ser 35 40 45 Gly Glu Tyr Ser Ile Gly Gln Val Leu Thr Val Phe Phe Ser Val Leu 50 55 60 Ile Gly Ala Phe Ser Val Gly Gln Ala Ser Pro Ser Ile Glu Ala Phe 65 70 75 80 Ala Asn Ala Arg Gly Ala Ala Tyr Glu Ile Phe Lys Ile Ile Asp Asn 85 90 95 Lys Pro Ser Ile Asp Ser Tyr Ser Lys Ser Gly His Lys Pro Asp Asn 100 105 110 Ile Lys Gly Asn Leu Glu Phe Arg Asn Val His Phe Ser Tyr Pro Ser 115 120 125 Arg Lys Glu Val Lys Ile Leu Lys Gly Leu Asn Leu Lys Val Gln Ser 130 135 140 Gly Gln Thr Val Ala Leu Val Gly Asn Ser Gly Cys Gly Lys Ser Thr 145 150 155 160 Thr Val Gln Leu Met Gln Arg Leu Tyr Asp Pro Thr Glu Gly Met Val 165 170 175 Ser Val Asp Gly Gln Asp Ile Arg Thr Ile Asn Val Arg Phe Leu Arg 180 185 190 Glu Ile Ile Gly Val Val Ser Gln Glu Pro Val Leu Phe Ala Thr Thr 195 200 205 Ile Ala Glu Asn Ile Arg Tyr Gly Arg Glu Asn Val Thr Met Asp Glu 210 215 220 Ile Glu Lys Ala Val Lys Glu Ala Asn Ala Tyr Asp Phe Ile Met Lys 225 230 235 240 Leu Pro His Lys Phe Asp Thr Leu Val Gly Glu Arg Gly Ala Gln Leu 245 250 255 Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala Arg Ala Leu Val Arg 260 265 270 Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr Ser Ala Leu Asp Thr 275 280 285 Glu Ser Glu Ala Val Val Gln Val Ala Leu Asp Lys Ala Arg Lys Gly 290 295 300 Arg Thr Thr Ile Val Ile Ala His Arg Leu Ser Thr Val Arg Asn Ala 305 310 315 320 Asp Val Ile Ala Gly Phe Asp Asp Gly Val Ile Val Glu Lys Gly Asn 325 330 335 His Asp Glu Leu Met Lys Glu Lys Gly Ile Tyr Phe Lys Leu Val Thr 340 345 350 Met Gln Asp Glu Ser Ile Pro Pro Val Ser Phe Trp Arg Ile Met Lys 355 360 365 Leu Asn Leu Thr Glu Trp Pro Tyr Phe Val Val Gly Val Phe Cys Ala 370 375 380 Ile Ile Asn Gly Gly Leu Gln Pro Ala Phe Ala Ile Ile Phe Ser Lys 385 390 395 400 Ile Ile Gly Val Phe Thr Arg Ile Asp Asp Pro Glu Thr Lys Arg Gln 405 410 415 Asn Ser Asn Leu Phe Ser Leu Leu Phe Leu Ala Leu Gly Ile Ile Ser 420 425 430 Phe Ile Thr Phe Phe Leu Gln Gly Phe Thr Phe Gly Lys Ala Gly Glu 435 440 445 Ile Leu Thr Lys Arg Leu Arg Tyr Met Val Phe Arg Ser Met Leu Arg 450 455 460 Gln Asp Val Ser Trp Phe Asp Asp Pro Lys Asn Thr Thr Gly Ala Leu 465 470 475 480 Thr Thr Arg Leu Ala Asn Asp Ala Ala Gln Val Lys Gly Ala Ile Gly 485 490 495 Ser Arg Leu Ala Val Ile Thr Gln Asn Ile Ala Asn Leu Gly Thr Gly 500 505 510 Ile Ile Ile Ser Phe Ile Tyr Gly Trp Gln Leu Thr Leu Leu Leu Leu 515 520 525 Ala Ile Val Pro Ile Ile Ala Ile Ala Gly Val Val Glu Met Lys Met 530 535 540 Leu Ser Gly Gln Ala Leu Lys Asp Lys Lys Glu Leu Glu Gly Ser Gly 545 550 555 560 Lys Ile Ala Thr Glu Ala Ile Glu Asn Phe Arg Thr Val Val Ser Leu 565 570 575 Thr Gln Glu Gln Lys Phe Glu His Met Tyr Ala Gln Ser Leu Gln Val 580 585 590 Pro Tyr Arg Asn Ser Leu Arg Lys Ala His Ile Phe Gly Ile Thr Phe 595 600 605 Ser Phe Thr Gln Ala Met Met Tyr Phe Ser Tyr Ala Gly Cys Phe Arg 610 615 620 Phe Gly Ala Tyr Leu Val Ala His Lys Leu Met Ser Phe Glu Asp Val 625 630 635 640 Leu Leu Val Phe Ser Ala Val Val Phe Gly Ala Met Ala Val Gly Gln 645 650 655 Val Ser Ser Phe Ala Pro Asp Tyr Ala Lys Ala Lys Ile Ser Ala Ala 660 665 670 His Ile Ile Met Ile Ile Glu Lys Thr Pro Leu Ile Asp Ser Tyr Ser 675 680 685 Thr Glu Gly Leu Met Pro Asn Thr Leu Glu Gly Asn Val Thr Phe Gly 690 695 700 Glu Val Val Phe Asn Tyr Pro Thr Arg Pro Asp Ile Pro Val Leu Gln 705 710 715 720 Gly Leu Ser Leu Glu Val Lys Lys Gly Gln Thr Leu Ala Leu Val Gly 725 730 735 Ser Ser Gly Cys Gly Lys Ser Thr Val Val Gln Leu Leu Glu Arg Phe 740 745 750 Tyr Asp Pro Leu Ala Gly Lys Val Leu Ile Cys Glu Leu Phe Gln Leu 755 760 765 Leu Asp Gly Lys Glu Ile Lys Arg Leu Asn Val Gln Trp Leu Arg Ala 770 775 780 His Leu Gly Ile Val Ser Gln Glu Pro Ile Leu Phe Asp Cys Ser Ile 785 790 795 800 Ala Glu Asn Ile Ala Tyr Gly Asp Asn Ser Arg Val Val Ser Gln Glu 805 810 815 Glu Ile Val Arg Ala Ala Lys Glu Ala Asn Ile His Ala Phe Ile Glu 820 825 830 Ser Leu Pro Asn Lys Tyr Ser Thr Lys Val Gly Asp Lys Gly Thr Gln 835 840 845 Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala Arg Ala Leu Val 850 855 860 Arg Gln Pro His Ile Leu Leu Leu Asp Glu Ala Thr Ser Ala Leu Asp 865 870 875 880 Thr Glu Ser Glu Lys Val Val Gln Glu Ala Leu Asp Lys Ala Arg Glu 885 890 895 Gly Arg Thr Cys Ile Val Ile Ala His Arg Leu Ser Thr Ile Gln Asn 900 905 910 Ala Asp Leu Ile Val Val Phe Gln Asn Gly Arg Val Lys Glu His Gly 915 920 925 Thr His Gln Gln Leu Leu Ala Gln Lys Gly Ile Tyr Phe Ser Met Val 930 935 940 Ser Val Gln Ala Gly Thr Lys Arg Gln 945 950 <210> SEQ ID NO 34 <211> LENGTH: 1537 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 34 Met Ser Leu Ser Phe Cys Gly Asn Asn Ile Ser Ser Tyr Asn Ile Asn 1 5 10 15 Asp Gly Val Leu Gln Asn Ser Cys Phe Val Asp Ala Leu Asn Leu Val 20 25 30 Pro His Val Phe Leu Leu Phe Ile Thr Phe Pro Ile Leu Phe Ile Gly 35 40 45 Trp Gly Ser Gln Ser Ser Lys Val Gln Ile His His Asn Thr Trp Leu 50 55 60 His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Thr Phe Ala Leu Leu 65 70 75 80 Phe Val His Val Cys Glu Ile Ala Glu Gly Ile Val Ser Asp Ser Arg 85 90 95 Arg Glu Ser Arg His Leu His Leu Phe Met Pro Ala Val Met Gly Phe 100 105 110 Val Ala Thr Thr Thr Ser Ile Val Tyr Tyr His Asn Ile Glu Thr Ser 115 120 125 Asn Phe Pro Lys Leu Leu Leu Ala Leu Phe Leu Tyr Trp Val Met Ala 130 135 140 Phe Ile Thr Lys Thr Ile Lys Leu Val Lys Tyr Cys Gln Ser Gly Leu 145 150 155 160 Asp Ile Ser Asn Leu Arg Phe Cys Ile Thr Gly Met Met Val Ile Leu 165 170 175 Asn Gly Leu Leu Met Ala Val Glu Ile Asn Val Ile Arg Val Arg Arg 180 185 190 Tyr Val Phe Phe Met Asn Pro Gln Lys Val Lys Pro Pro Glu Asp Leu 195 200 205 Gln Asp Leu Gly Val Arg Phe Leu Gln Pro Phe Val Asn Leu Leu Ser 210 215 220 Lys Ala Thr Tyr Trp Trp Met Asn Thr Leu Ile Ile Ser Ala His Lys 225 230 235 240 Lys Pro Ile Asp Leu Lys Ala Ile Gly Lys Leu Pro Ile Ala Met Arg 245 250 255 Ala Val Thr Asn Tyr Val Cys Leu Lys Asp Ala Tyr Glu Glu Gln Lys 260 265 270 Lys Lys Val Ala Asp His Pro Asn Arg Thr Pro Ser Ile Trp Leu Ala 275 280 285 Met Tyr Arg Ala Phe Gly Arg Pro Ile Leu Leu Ser Ser Thr Phe Arg 290 295 300 Tyr Leu Ala Asp Leu Leu Gly Phe Ala Gly Pro Leu Cys Ile Ser Gly 305 310 315 320 Ile Val Gln Arg Val Asn Glu Thr Gln Asn Gly Thr Asn Asn Thr Thr 325 330 335 Gly Ile Ser Glu Thr Leu Ser Ser Lys Glu Phe Leu Glu Asn Ala Tyr 340 345 350 Val Leu Ala Val Leu Leu Phe Leu Ala Leu Ile Leu Gln Arg Thr Phe 355 360 365 Leu Gln Ala Ser Tyr Tyr Val Thr Ile Glu Thr Gly Ile Asn Leu Arg 370 375 380 Gly Ala Leu Leu Ala Met Ile Tyr Asn Lys Ile Leu Arg Leu Ser Thr 385 390 395 400 Ser Asn Leu Ser Met Gly Glu Met Thr Leu Gly Gln Ile Asn Asn Leu 405 410 415 Val Ala Ile Glu Thr Asn Gln Leu Met Trp Phe Leu Phe Leu Cys Pro 420 425 430 Asn Leu Trp Ala Met Pro Val Gln Ile Ile Met Gly Val Ile Leu Leu 435 440 445 Tyr Asn Leu Leu Gly Ser Ser Ala Leu Val Gly Ala Ala Val Ile Val 450 455 460 Leu Leu Ala Pro Ile Gln Tyr Phe Ile Ala Thr Lys Leu Ala Glu Ala 465 470 475 480 Gln Lys Ser Thr Leu Asp Tyr Ser Thr Glu Arg Leu Lys Lys Thr Asn 485 490 495 Glu Ile Leu Lys Gly Ile Lys Leu Leu Lys Leu Tyr Ala Trp Glu His 500 505 510 Ile Phe Cys Lys Ser Val Glu Glu Thr Arg Met Lys Glu Leu Ser Ser 515 520 525 Leu Lys Thr Phe Ala Leu Tyr Thr Ser Leu Ser Ser Lys Leu Leu Thr 530 535 540 Pro Phe Phe Ala Gln Thr Phe Val Thr His Ala Tyr Ala Ser Gly Asn 545 550 555 560 Asn Leu Lys Pro Ala Glu Ala Phe Ala Ser Leu Ser Leu Phe His Ile 565 570 575 Leu Val Thr Pro Leu Phe Leu Leu Ser Thr Val Val Arg Phe Ala Val 580 585 590 Lys Ala Ile Ile Ser Val Gln Lys Leu Asn Glu Phe Leu Leu Ser Asp 595 600 605 Glu Ile Gly Asp Asp Ser Trp Arg Thr Gly Glu Ser Ser Leu Pro Phe 610 615 620 Glu Ser Cys Lys Lys His Thr Gly Val Gln Pro Lys Thr Ile Asn Arg 625 630 635 640 Lys Gln Pro Gly Arg Tyr His Leu Asp Ser Tyr Glu Gln Ser Thr Arg 645 650 655 Arg Leu Arg Pro Ala Glu Thr Glu Asp Ile Ala Ile Lys Val Thr Asn 660 665 670 Gly Tyr Phe Ser Trp Gly Ser Gly Leu Ala Thr Leu Ser Asn Ile Asp 675 680 685 Ile Arg Ile Pro Thr Gly Gln Leu Thr Met Ile Val Gly Gln Val Gly 690 695 700 Cys Gly Lys Ser Ser Leu Leu Leu Ala Ile Leu Gly Glu Met Gln Thr 705 710 715 720 Leu Glu Gly Lys Val His Trp Ser Lys Tyr Val Tyr Phe Tyr Arg Asn 725 730 735 Arg Tyr Ser Val Ala Tyr Ala Ala Gln Lys Pro Trp Leu Leu Asn Ala 740 745 750 Thr Val Glu Glu Asn Ile Thr Phe Gly Ser Pro Phe Asn Lys Gln Arg 755 760 765 Tyr Lys Ala Val Thr Asp Ala Cys Ser Leu Gln Pro Asp Ile Asp Leu 770 775 780 Leu Pro Phe Gly Asp Gln Thr Glu Ile Gly Glu Arg Gly Ile Asn Leu 785 790 795 800 Ser Gly Gly Gln Arg Gln Arg Ile Cys Val Ala Arg Ala Leu Tyr Gln 805 810 815 Asn Thr Asn Ile Val Phe Leu Asp Asp Pro Phe Ser Ala Leu Asp Ile 820 825 830 His Leu Ser Asp His Leu Met Gln Glu Gly Ile Leu Lys Phe Leu Gln 835 840 845 Asp Asp Lys Arg Thr Leu Val Leu Val Thr His Lys Leu Gln Tyr Leu 850 855 860 Thr His Ala Asp Trp Ile Ile Ala Met Lys Asp Gly Ser Val Leu Arg 865 870 875 880 Glu Gly Thr Leu Lys Asp Ile Gln Thr Lys Asp Val Glu Leu Tyr Glu 885 890 895 His Trp Lys Thr Leu Met Asn Arg Gln Asp Gln Glu Leu Glu Lys Asp 900 905 910 Met Glu Ala Asp Gln Thr Thr Leu Glu Arg Lys Thr Leu Arg Arg Ala 915 920 925 Met Tyr Ser Arg Glu Ala Lys Ala Gln Met Glu Asp Glu Asp Glu Glu 930 935 940 Glu Glu Glu Glu Glu Asp Glu Asp Asp Asn Met Ser Thr Val Met Arg 945 950 955 960 Leu Arg Thr Lys Met Pro Trp Lys Thr Cys Trp Arg Tyr Leu Thr Ser 965 970 975 Gly Gly Phe Phe Leu Leu Ile Leu Met Ile Phe Ser Lys Leu Leu Lys 980 985 990 His Ser Val Ile Val Ala Ile Asp Tyr Trp Leu Ala Thr Trp Thr Ser 995 1000 1005 Glu Tyr Ser Ile Asn Asn Thr Gly Lys Ala Asp Gln Thr Tyr Tyr Val 1010 1015 1020 Ala Gly Phe Ser Ile Leu Cys Gly Ala Gly Ile Phe Leu Cys Leu Val 1025 1030 1035 1040 Thr Ser Leu Thr Val Glu Trp Met Gly Leu Thr Ala Ala Lys Asn Leu 1045 1050 1055 His His Asn Leu Leu Asn Lys Ile Ile Leu Gly Pro Ile Arg Phe Phe 1060 1065 1070 Asp Thr Thr Pro Leu Gly Leu Ile Leu Asn Arg Phe Ser Ala Asp Thr 1075 1080 1085 Asn Ile Ile Asp Gln His Ile Pro Pro Thr Leu Glu Ser Leu Thr Arg 1090 1095 1100 Ser Thr Leu Leu Cys Leu Ser Ala Ile Gly Met Ile Ser Tyr Ala Thr 1105 1110 1115 1120 Pro Val Phe Leu Val Ala Leu Leu Pro Leu Gly Val Ala Phe Tyr Phe 1125 1130 1135 Ile Gln Lys Tyr Phe Arg Val Ala Ser Lys Asp Leu Gln Glu Leu Asp 1140 1145 1150 Asp Ser Thr Gln Leu Pro Leu Leu Cys His Phe Ser Glu Thr Ala Glu 1155 1160 1165 Gly Leu Thr Thr Ile Arg Ala Phe Arg His Glu Thr Arg Phe Lys Gln 1170 1175 1180 Arg Met Leu Glu Leu Thr Asp Thr Asn Asn Ile Ala Tyr Leu Phe Leu 1185 1190 1195 1200 Ser Ala Ala Asn Arg Trp Leu Glu Val Arg Thr Asp Tyr Leu Gly Ala 1205 1210 1215 Cys Ile Val Leu Thr Ala Ser Ile Ala Ser Ile Ser Gly Ser Ser Asn 1220 1225 1230 Ser Gly Leu Val Gly Leu Gly Leu Leu Tyr Ala Leu Thr Ile Thr Asn 1235 1240 1245 Tyr Leu Asn Trp Val Val Arg Asn Leu Ala Asp Leu Glu Val Gln Met 1250 1255 1260 Gly Ala Val Lys Lys Val Asn Ser Phe Leu Thr Met Glu Ser Glu Asn 1265 1270 1275 1280 Tyr Glu Gly Thr Met Asp Pro Ser Gln Val Pro Glu His Trp Pro Gln 1285 1290 1295 Glu Gly Glu Ile Lys Ile His Asp Leu Cys Val Arg Tyr Glu Asn Asn 1300 1305 1310 Leu Lys Pro Val Leu Lys His Val Lys Ala Tyr Ile Lys Pro Gly Gln 1315 1320 1325 Lys Val Gly Ile Cys Gly Arg Thr Gly Ser Gly Lys Ser Ser Leu Ser 1330 1335 1340 Leu Ala Phe Phe Arg Met Val Asp Ile Phe Asp Gly Lys Ile Val Ile 1345 1350 1355 1360 Asp Gly Ile Asp Ile Ser Lys Leu Pro Leu His Thr Leu Arg Ser Arg 1365 1370 1375 Leu Ser Ile Ile Leu Gln Asp Pro Ile Leu Phe Ser Gly Ser Ile Arg 1380 1385 1390 Phe Asn Leu Asp Pro Glu Cys Lys Cys Thr Asp Asp Arg Leu Trp Glu 1395 1400 1405 Ala Leu Glu Ile Ala Gln Leu Lys Asn Met Val Lys Ser Leu Pro Gly 1410 1415 1420 Gly Leu Asp Ala Val Val Thr Glu Gly Gly Glu Asn Phe Ser Val Gly 1425 1430 1435 1440 Gln Arg Gln Leu Phe Cys Leu Ala Arg Ala Phe Val Arg Lys Ser Ser 1445 1450 1455 Ile Leu Ile Met Asp Glu Ala Thr Ala Ser Ile Asp Met Ala Thr Glu 1460 1465 1470 Asn Ile Leu Gln Lys Val Val Met Thr Ala Phe Ala Asp Arg Thr Val 1475 1480 1485 Val Thr Ile Ala His Arg Val His Thr Ile Leu Thr Ala Asp Leu Val 1490 1495 1500 Ile Val Met Lys Arg Gly Asn Ile Leu Glu Tyr Asp Thr Pro Glu Ser 1505 1510 1515 1520 Leu Leu Ala Gln Glu Asn Gly Val Phe Ala Ser Phe Val Arg Ala Asp 1525 1530 1535 Met <210> SEQ ID NO 35 <211> LENGTH: 676 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 35 Arg Ala Glu Leu Val Ala Leu Thr Ala Val Gln Ser Glu Gln Gly Glu 1 5 10 15 Ala Gly Gly Gly Gly Ser Pro Arg Arg Leu Gly Leu Leu Gly Ser Pro 20 25 30 Leu Pro Pro Gly Ala Pro Leu Pro Gly Pro Gly Ser Gly Ser Gly Ser 35 40 45 Ala Cys Gly Gln Arg Ser Ser Ala Ala His Lys Arg Tyr Arg Arg Leu 50 55 60 Gln Asn Trp Gly Tyr Asn Val Leu Glu Arg Pro Arg Gly Trp Ala Phe 65 70 75 80 Val Tyr His Val Phe Ile Phe Leu Leu Val Phe Ser Cys Leu Val Leu 85 90 95 Ser Val Leu Ser Thr Ile Gln Glu His Gln Glu Leu Ala Asn Glu Cys 100 105 110 Leu Leu Ile Leu Glu Phe Val Met Ile Val Val Phe Gly Leu Glu Tyr 115 120 125 Ile Val Arg Val Trp Ser Ala Gly Cys Cys Cys Arg Tyr Arg Gly Trp 130 135 140 Gln Gly Arg Phe Arg Phe Ala Arg Lys Pro Phe Cys Val Ile Asp Phe 145 150 155 160 Ile Val Phe Val Ala Ser Val Ala Val Ile Ala Ala Gly Thr Gln Gly 165 170 175 Asn Ile Phe Ala Thr Ser Ala Leu Arg Ser Met Arg Phe Leu Gln Ile 180 185 190 Leu Arg Met Val Arg Met Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu 195 200 205 Gly Ser Val Val Tyr Ala His Ser Lys Glu Leu Ile Thr Ala Trp Tyr 210 215 220 Ile Gly Phe Leu Val Leu Ile Phe Ala Ser Phe Leu Val Tyr Leu Ala 225 230 235 240 Glu Lys Asp Ala Asn Ser Asp Phe Ser Ser Tyr Ala Asp Ser Leu Trp 245 250 255 Trp Gly Thr Ile Thr Leu Thr Thr Ile Gly Tyr Gly Asp Lys Thr Pro 260 265 270 His Thr Trp Leu Gly Arg Val Leu Ala Ala Gly Phe Ala Leu Leu Gly 275 280 285 Ile Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala 290 295 300 Leu Lys Val Gln Glu Gln His Arg Gln Lys His Phe Glu Lys Arg Arg 305 310 315 320 Met Pro Ala Ala Asn Leu Ile Gln Ala Ala Trp Arg Leu Tyr Ser Thr 325 330 335 Asp Met Ser Arg Ala Tyr Leu Thr Ala Thr Trp Tyr Tyr Tyr Asp Ser 340 345 350 Ile Leu Pro Ser Phe Arg Glu Leu Ala Leu Leu Phe Glu His Val Gln 355 360 365 Arg Ala Arg Asn Gly Gly Leu Arg Pro Leu Glu Val Arg Arg Ala Pro 370 375 380 Val Pro Asp Gly Ala Pro Ser Arg Tyr Pro Pro Val Ala Thr Cys His 385 390 395 400 Arg Pro Gly Ser Thr Ser Phe Cys Pro Gly Glu Ser Ser Arg Met Gly 405 410 415 Ile Lys Asp Arg Ile Arg Met Gly Ser Ser Gln Arg Arg Thr Gly Pro 420 425 430 Ser Lys Gln His Leu Ala Pro Pro Thr Met Pro Thr Ser Pro Ser Ser 435 440 445 Glu Gln Val Gly Glu Ala Thr Ser Pro Thr Lys Val Gln Lys Ser Trp 450 455 460 Ser Phe Asn Asp Arg Thr Arg Phe Arg Ala Ser Leu Arg Leu Lys Pro 465 470 475 480 Arg Thr Ser Ala Glu Asp Ala Pro Ser Glu Glu Val Ala Glu Glu Lys 485 490 495 Ser Tyr Gln Cys Glu Leu Thr Val Asp Asp Ile Met Pro Ala Val Lys 500 505 510 Thr Val Ile Arg Ser Ile Arg Ile Leu Lys Phe Leu Val Ala Lys Arg 515 520 525 Lys Phe Lys Glu Thr Leu Arg Pro Tyr Asp Val Lys Asp Val Ile Glu 530 535 540 Gln Tyr Ser Ala Gly His Leu Asp Met Leu Gly Arg Ile Lys Ser Leu 545 550 555 560 Gln Thr Arg Val Asp Gln Ile Val Gly Arg Gly Pro Gly Asp Arg Lys 565 570 575 Ala Arg Glu Lys Gly Asp Lys Gly Pro Ser Asp Ala Glu Val Val Asp 580 585 590 Glu Ile Ser Met Met Gly Arg Val Val Lys Val Glu Lys Gln Val Gln 595 600 605 Ser Ile Glu His Lys Leu Asp Leu Leu Val Gly Phe Tyr Ser Arg Trp 610 615 620 Leu Arg Ser Gly Thr Ser Ala Ser Leu Gly Ala Val Gln Val Pro Leu 625 630 635 640 Phe Asp Pro Asp Ile Thr Ser Asp Tyr His Ser Pro Val Asp His Glu 645 650 655 Asp Ile Ser Val Ser Ala Gln Thr Leu Ser Ile Ser Arg Ser Val Ser 660 665 670 Thr Asn Met Asp 675 <210> SEQ ID NO 36 <211> LENGTH: 361 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 36 Gln Ile Phe Pro Trp Lys Cys Gln Ser Thr Gln Arg Asp Leu Trp Asn 1 5 10 15 Ile Phe Lys Leu Trp Gly Trp Thr Met Leu Cys Cys Asp Phe Leu Ala 20 25 30 His His Gly Thr Asp Cys Trp Thr Tyr His Tyr Ser Glu Lys Pro Met 35 40 45 Asn Trp Gln Arg Ala Arg Arg Phe Cys Arg Asp Asn Tyr Thr Asp Leu 50 55 60 Val Ala Ile Gln Asn Lys Ala Glu Ile Glu Tyr Leu Glu Lys Thr Leu 65 70 75 80 Pro Phe Ser Arg Ser Tyr Tyr Trp Ile Gly Ile Arg Lys Ile Gly Gly 85 90 95 Ile Trp Thr Trp Val Gly Thr Asn Lys Ser Leu Thr Glu Glu Ala Glu 100 105 110 Asn Trp Gly Asp Gly Glu Pro Asn Asn Lys Lys Asn Lys Glu Asp Cys 115 120 125 Val Glu Ile Tyr Ile Lys Arg Asn Lys Asp Ala Gly Lys Trp Asn Asp 130 135 140 Asp Ala Cys His Lys Leu Lys Ala Ala Leu Cys Tyr Thr Ala Ser Cys 145 150 155 160 Gln Pro Trp Ser Cys Ser Gly His Gly Glu Cys Val Glu Ile Ile Asn 165 170 175 Asn Tyr Thr Cys Asn Cys Asp Val Gly Tyr Tyr Gly Pro Gln Cys Gln 180 185 190 Phe Val Ile Gln Cys Glu Pro Leu Glu Ala Pro Glu Leu Gly Thr Met 195 200 205 Asp Cys Thr His Pro Leu Gly Asn Phe Ser Phe Ser Ser Gln Cys Ala 210 215 220 Phe Ser Cys Ser Glu Gly Thr Asn Leu Thr Gly Ile Glu Glu Thr Thr 225 230 235 240 Cys Gly Pro Phe Gly Asn Trp Ser Ser Pro Glu Pro Thr Cys Gln Val 245 250 255 Ile Gln Cys Glu Pro Leu Ser Ala Pro Asp Leu Gly Ile Met Asn Cys 260 265 270 Ser His Pro Leu Ala Ser Phe Ser Phe Thr Ser Ala Cys Thr Phe Ile 275 280 285 Cys Ser Glu Gly Thr Glu Leu Ile Gly Lys Lys Lys Thr Ile Cys Glu 290 295 300 Ser Ser Gly Ile Trp Ser Asn Pro Ser Pro Ile Cys Gln Lys Leu Asp 305 310 315 320 Lys Ser Phe Ser Met Ile Lys Glu Gly Asp Tyr Asn Pro Leu Phe Ile 325 330 335 Pro Val Ala Val Met Val Thr Ala Phe Ser Gly Leu Ala Phe Ile Ile 340 345 350 Trp Leu Ala Arg Arg Leu Lys Lys Gly 355 360 <210> SEQ ID NO 37 <211> LENGTH: 611 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 37 Gln Lys Glu Gly Lys Lys Glu Arg Ala Val Val Asp Lys Val Phe Phe 1 5 10 15 Ser Arg Leu Ile Gln Ile Leu Lys Ile Met Val Pro Arg Thr Phe Cys 20 25 30 Lys Glu Thr Gly Tyr Leu Val Leu Ile Ala Val Met Leu Val Ser Arg 35 40 45 Thr Tyr Cys Asp Val Trp Met Ile Gln Asn Gly Thr Leu Ile Glu Ser 50 55 60 Gly Ile Ile Gly Arg Ser Arg Lys Asp Phe Lys Arg Tyr Leu Leu Asn 65 70 75 80 Phe Ile Ala Ala Met Pro Leu Ile Ser Leu Val Asn Asn Phe Leu Lys 85 90 95 Tyr Gly Leu Asn Glu Leu Lys Leu Cys Phe Arg Val Arg Leu Thr Lys 100 105 110 Tyr Leu Tyr Glu Glu Tyr Leu Gln Ala Phe Thr Tyr Tyr Lys Met Gly 115 120 125 Asn Leu Asp Asn Arg Ile Ala Asn Pro Asp Gln Leu Leu Thr Gln Asp 130 135 140 Val Glu Lys Phe Cys Asn Ser Val Val Asp Leu Tyr Ser Asn Leu Ser 145 150 155 160 Lys Pro Phe Leu Asp Ile Val Leu Tyr Ile Phe Lys Leu Thr Ser Ala 165 170 175 Ile Gly Ala Gln Gly Pro Ala Ser Met Met Ala Tyr Leu Val Val Ser 180 185 190 Gly Leu Phe Leu Thr Arg Leu Arg Arg Pro Ile Gly Lys Met Thr Ile 195 200 205 Thr Glu Gln Lys Tyr Glu Gly Glu Tyr Arg Tyr Val Asn Ser Arg Leu 210 215 220 Ile Thr Asn Ser Glu Glu Ile Ala Phe Tyr Asn Gly Asn Lys Arg Glu 225 230 235 240 Lys Gln Thr Val His Ser Val Phe Arg Lys Leu Val Glu His Leu His 245 250 255 Asn Phe Ile Leu Phe Arg Phe Ser Met Gly Phe Ile Asp Ser Ile Ile 260 265 270 Ala Lys Tyr Leu Ala Thr Val Val Gly Tyr Leu Val Val Ser Arg Pro 275 280 285 Phe Leu Asp Leu Ser His Pro Arg His Leu Lys Ser Thr His Ser Glu 290 295 300 Leu Leu Glu Asp Tyr Tyr Gln Ser Gly Arg Met Leu Leu Arg Met Ser 305 310 315 320 Gln Ala Leu Gly Arg Ile Val Leu Ala Gly Arg Glu Met Thr Arg Leu 325 330 335 Ala Gly Phe Thr Ala Arg Ile Thr Glu Leu Met Gln Val Leu Lys Asp 340 345 350 Leu Asn His Gly Lys Tyr Glu Arg Thr Met Val Ser Gln Gln Glu Lys 355 360 365 Gly Ile Glu Gly Val Gln Val Ile Pro Leu Ile Pro Gly Ala Gly Glu 370 375 380 Ile Ile Ile Ala Asp Asn Ile Ile Lys Phe Asp His Val Pro Leu Ala 385 390 395 400 Thr Pro Asn Gly Asp Val Leu Ile Arg Asp Leu Asn Phe Glu Val Arg 405 410 415 Ser Gly Ala Asn Val Leu Ile Cys Gly Pro Asn Gly Cys Gly Lys Ser 420 425 430 Ser Leu Phe Arg Val Leu Gly Glu Leu Trp Pro Leu Phe Gly Gly Arg 435 440 445 Leu Thr Lys Pro Glu Arg Gly Lys Leu Phe Tyr Val Pro Gln Arg Pro 450 455 460 Tyr Met Thr Leu Gly Thr Leu Arg Asp Gln Val Ile Tyr Pro Asp Gly 465 470 475 480 Arg Glu Asp Gln Lys Arg Lys Gly Ile Ser Asp Leu Val Leu Lys Glu 485 490 495 Tyr Leu Asp Asn Val Gln Leu Gly His Ile Leu Glu Arg Glu Gly Gly 500 505 510 Trp Asp Ser Val Gln Asp Trp Met Asp Val Leu Ser Gly Gly Glu Lys 515 520 525 Gln Arg Met Ala Met Ala Arg Leu Phe Tyr His Lys Pro Gln Phe Ala 530 535 540 Ile Leu Asp Glu Cys Thr Ser Ala Val Ser Val Asp Val Glu Gly Tyr 545 550 555 560 Ile Tyr Ser His Cys Arg Lys Val Gly Ile Thr Leu Phe Thr Val Ser 565 570 575 His Arg Lys Ser Leu Trp Lys His His Glu Tyr Tyr Leu His Met Asp 580 585 590 Gly Arg Gly Asn Tyr Glu Phe Lys Gln Ile Thr Glu Asp Thr Val Glu 595 600 605 Phe Gly Ser 610 <210> SEQ ID NO 38 <211> LENGTH: 522 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 38 Met Gly His Leu Leu Thr Leu Val Phe Ile Leu Ala Leu Ala Gly Pro 1 5 10 15 Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp Cys Gln 20 25 30 Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys Leu Gln 35 40 45 Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp Ile Cys 50 55 60 Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn Ala Thr 65 70 75 80 Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp Leu Pro 85 90 95 Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser Tyr Leu 100 105 110 Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro Gly Glu 115 120 125 Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His Leu Ala 130 135 140 Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro Glu Leu 145 150 155 160 Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro Leu Leu 165 170 175 Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys Asp Asn 180 185 190 Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile Gln Thr 195 200 205 Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu His Val 210 215 220 Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile Cys Lys 225 230 235 240 Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met Met His 245 250 255 Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp Glu Val 260 265 270 Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala Ser Lys 275 280 285 Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys His Glu 290 295 300 Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe Leu Val 305 310 315 320 Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys Glu Ile 325 330 335 Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser Leu Ser 340 345 350 Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile Leu Ser 355 360 365 Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met Leu His 370 375 380 Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val Thr Gln 385 390 395 400 Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val Gly Tyr 405 410 415 Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile Leu Ala 420 425 430 Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln Lys Gln 435 440 445 Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu Ile Leu 450 455 460 Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly Ala Cys 465 470 475 480 Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile Trp Gly 485 490 495 Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys Asn Ala 500 505 510 Val Glu His Cys Lys Arg His Val Trp Asn 515 520 <210> SEQ ID NO 39 <211> LENGTH: 236 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 39 Leu Thr Glu Arg Ala Asp Phe Gln Tyr Ser Gln Arg Glu Leu Asp Thr 1 5 10 15 Ile Glu Val Phe Pro Thr Lys Ser Ala Arg Gly Asn Arg Val Ser Cys 20 25 30 Met Tyr Val Arg Cys Val Pro Gly Ala Arg Tyr Thr Val Phe Phe Ser 35 40 45 His Gly Asn Ala Val Asp Leu Ser Gln Met Ser Ser Phe Tyr Ile Gly 50 55 60 Leu Gly Ser Arg Leu His Cys Asn Ile Phe Tyr Asp Tyr Ser Gly Tyr 65 70 75 80 Gly Ala Ser Ala Gly Arg Pro Ser Glu Arg Asn Leu Tyr Ala Asp Ile 85 90 95 Asp Ala Ala Trp Gln Ala Leu His Thr Arg Tyr Gly Ile Ser Pro Asp 100 105 110 Ser Ile Ile Leu Tyr Gly Gln Ser Ile Gly Thr Val Pro Thr Val Asp 115 120 125 Leu Ala Ser Arg Tyr Glu Cys Ala Ala Val Val Leu His Ser Pro Leu 130 135 140 Thr Ser Gly Met Arg Val Ala Phe Pro Asp Thr Lys Thr Tyr Cys Phe 145 150 155 160 Asp Ala Phe Pro Asn Ile Glu Lys Val Ser Lys Ile Thr Ser Pro Val 165 170 175 Leu Ile Ile His Gly Met Glu Asp Glu Val Ile Asp Phe Ser His Gly 180 185 190 Leu Ala Leu Tyr Glu Arg Cys Pro Lys Ala Val Glu Pro Leu Trp Val 195 200 205 Glu Gly Ala Gly His Asn Asp Ile Glu Leu Tyr Ser Gln Tyr Leu Glu 210 215 220 Arg Leu Arg Arg Phe Ile Ser Gln Glu Leu Pro Ser 225 230 235 <210> SEQ ID NO 40 <211> LENGTH: 4647 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 40 Met Ser Glu Pro Gly Gly Gly Gly Gly Glu Asp Gly Ser Ala Gly Leu 1 5 10 15 Glu Val Ser Ala Val Gln Asn Val Ala Asp Val Ser Val Leu Gln Lys 20 25 30 His Leu Arg Lys Leu Val Pro Leu Leu Leu Glu Asp Gly Gly Glu Ala 35 40 45 Pro Ala Ala Leu Glu Ala Ala Leu Glu Glu Lys Ser Ala Leu Glu Gln 50 55 60 Met Arg Lys Phe Leu Ser Asp Pro Gln Val His Thr Val Leu Val Glu 65 70 75 80 Arg Ser Thr Leu Lys Glu Asp Val Gly Asp Glu Gly Glu Glu Glu Lys 85 90 95 Glu Phe Ile Ser Tyr Asn Ile Asn Ile Asp Ile His Tyr Gly Val Lys 100 105 110 Ser Asn Ser Leu Ala Phe Ile Lys Arg Thr Pro Val Ile Asp Ala Asp 115 120 125 Lys Pro Val Ser Ser Gln Leu Arg Val Leu Thr Leu Ser Glu Asp Ser 130 135 140 Pro Tyr Glu Thr Leu His Ser Phe Ile Ser Asn Ala Val Ala Pro Phe 145 150 155 160 Phe Lys Ser Tyr Ile Arg Glu Ser Gly Lys Ala Asp Arg Asp Gly Asp 165 170 175 Lys Met Ala Pro Ser Val Glu Lys Lys Ile Ala Glu Leu Glu Met Gly 180 185 190 Leu Leu His Leu Gln Gln Asn Ile Glu Ile Pro Glu Ile Ser Leu Pro 195 200 205 Ile His Pro Met Ile Thr Asn Val Ala Lys Gln Cys Tyr Glu Arg Gly 210 215 220 Glu Lys Pro Lys Val Thr Asp Phe Gly Asp Lys Val Glu Asp Pro Thr 225 230 235 240 Phe Leu Asn Gln Leu Gln Ser Gly Val Asn Arg Trp Ile Arg Glu Ile 245 250 255 Gln Lys Val Thr Lys Leu Asp Arg Asp Pro Ala Ser Gly Thr Ala Leu 260 265 270 Gln Glu Ile Ser Phe Trp Leu Asn Leu Glu Arg Ala Leu Tyr Arg Ile 275 280 285 Gln Glu Lys Arg Glu Ser Pro Glu Val Leu Leu Thr Leu Asp Ile Leu 290 295 300 Lys His Gly Lys Arg Phe His Ala Thr Val Ser Phe Asp Thr Asp Thr 305 310 315 320 Gly Leu Lys Gln Ala Leu Glu Thr Val Asn Asp Tyr Asn Pro Leu Met 325 330 335 Lys Asp Phe Pro Leu Asn Asp Leu Leu Ser Ala Thr Glu Leu Asp Lys 340 345 350 Ile Arg Gln Ala Leu Val Ala Ile Phe Thr His Leu Arg Lys Ile Arg 355 360 365 Asn Thr Lys Tyr Pro Ile Gln Arg Ala Leu Arg Leu Val Glu Ala Ile 370 375 380 Ser Arg Asp Leu Ser Ser Gln Leu Leu Lys Val Leu Gly Thr Arg Lys 385 390 395 400 Leu Met His Val Ala Tyr Glu Glu Phe Glu Lys Val Met Val Ala Cys 405 410 415 Phe Glu Val Phe Gln Thr Trp Asp Asp Glu Tyr Glu Lys Leu Gln Val 420 425 430 Leu Leu Arg Asp Ile Val Lys Arg Lys Arg Glu Glu Asn Leu Lys Met 435 440 445 Val Trp Arg Ile Asn Pro Ala His Arg Lys Leu Gln Ala Arg Leu Asp 450 455 460 Gln Met Arg Lys Phe Arg Arg Gln His Glu Gln Leu Arg Ala Val Ile 465 470 475 480 Val Arg Val Leu Arg Pro Gln Val Thr Ala Val Ala Gln Gln Asn Gln 485 490 495 Gly Glu Val Pro Glu Pro Gln Asp Met Lys Val Ala Glu Val Leu Phe 500 505 510 Asp Ala Ala Asp Ala Asn Ala Ile Glu Glu Val Asn Leu Ala Tyr Glu 515 520 525 Asn Val Lys Glu Val Asp Gly Leu Asp Val Ser Lys Glu Gly Thr Glu 530 535 540 Ala Trp Glu Ala Ala Met Lys Arg Tyr Asp Glu Arg Ile Asp Arg Val 545 550 555 560 Glu Thr Arg Ile Thr Ala Arg Leu Arg Asp Gln Leu Gly Thr Ala Lys 565 570 575 Asn Ala Asn Glu Met Phe Arg Ile Phe Ser Arg Phe Asn Ala Leu Phe 580 585 590 Val Arg Pro His Ile Arg Gly Ala Ile Arg Glu Tyr Gln Thr Gln Leu 595 600 605 Ile Gln Arg Val Lys Asp Asp Ile Glu Ser Leu His Asp Lys Phe Lys 610 615 620 Val Gln Tyr Pro Gln Ser Gln Ala Cys Lys Met Ser His Val Arg Asp 625 630 635 640 Leu Pro Pro Val Ser Gly Ser Ile Ile Trp Ala Lys Gln Ile Asp Arg 645 650 655 Gln Leu Thr Ala Tyr Met Lys Arg Val Glu Asp Val Leu Gly Lys Gly 660 665 670 Trp Glu Asn His Val Glu Gly Gln Lys Leu Lys Gln Asp Gly Asp Ser 675 680 685 Phe Arg Met Lys Leu Asn Thr Gln Glu Ile Phe Asp Asp Trp Ala Arg 690 695 700 Lys Val Gln Gln Arg Asn Leu Gly Val Ser Gly Arg Ile Phe Thr Ile 705 710 715 720 Glu Ser Thr Arg Val Arg Gly Arg Thr Gly Asn Val Leu Lys Leu Lys 725 730 735 Val Asn Phe Leu Pro Glu Ile Ile Thr Leu Ser Lys Glu Val Arg Asn 740 745 750 Leu Lys Trp Leu Gly Phe Arg Val Pro Leu Ala Ile Val Asn Lys Ala 755 760 765 His Gln Ala Asn Gln Leu Tyr Pro Phe Ala Ile Ser Leu Ile Glu Ser 770 775 780 Val Arg Thr Tyr Glu Arg Thr Cys Glu Lys Val Glu Glu Arg Asn Thr 785 790 795 800 Ile Ser Leu Leu Val Ala Gly Leu Lys Lys Glu Val Gln Ala Leu Ile 805 810 815 Ala Glu Gly Ile Ala Leu Val Trp Glu Ser Tyr Lys Leu Asp Pro Tyr 820 825 830 Val Gln Arg Leu Ala Glu Thr Val Phe Asn Phe Gln Glu Lys Val Asp 835 840 845 Asp Leu Leu Ile Ile Glu Glu Lys Ile Asp Leu Glu Val Arg Ser Leu 850 855 860 Glu Thr Cys Met Tyr Asp His Lys Thr Phe Ser Glu Ile Leu Asn Arg 865 870 875 880 Val Gln Lys Ala Val Asp Asp Leu Asn Leu His Ser Tyr Ser Asn Leu 885 890 895 Pro Ile Trp Val Asn Lys Leu Asp Met Glu Ile Glu Arg Ile Leu Gly 900 905 910 Val Arg Leu Gln Ala Gly Leu Arg Ala Trp Thr Gln Val Leu Leu Gly 915 920 925 Gln Ala Glu Asp Lys Ala Glu Val Asp Met Asp Thr Asp Ala Pro Gln 930 935 940 Val Ser His Lys Pro Gly Gly Glu Pro Lys Ile Lys Asn Val Val His 945 950 955 960 Glu Leu Arg Ile Thr Asn Gln Val Ile Tyr Leu Asn Pro Pro Ile Glu 965 970 975 Glu Cys Arg Tyr Lys Leu Tyr Gln Glu Met Phe Ala Trp Lys Met Val 980 985 990 Val Leu Ser Leu Pro Arg Ile Gln Ser Gln Arg Tyr Gln Val Gly Val 995 1000 1005 His Tyr Glu Leu Thr Glu Glu Glu Lys Phe Tyr Arg Asn Ala Leu Thr 1010 1015 1020 Arg Met Pro Asp Gly Pro Val Ala Leu Glu Glu Ser Tyr Ser Ala Val 1025 1030 1035 1040 Met Gly Ile Val Ser Glu Val Glu Gln Tyr Val Lys Val Trp Leu Gln 1045 1050 1055 Tyr Gln Cys Leu Trp Asp Met Gln Ala Glu Asn Ile Tyr Asn Arg Leu 1060 1065 1070 Gly Glu Asp Leu Asn Lys Trp Gln Ala Leu Leu Val Gln Ile Arg Lys 1075 1080 1085 Ala Arg Gly Thr Phe Asp Asn Ala Glu Thr Lys Lys Glu Phe Gly Pro 1090 1095 1100 Val Val Ile Asp Tyr Gly Lys Val Gln Ser Lys Val Asn Leu Lys Tyr 1105 1110 1115 1120 Asp Ser Trp His Lys Glu Val Leu Ser Lys Phe Gly Gln Met Leu Gly 1125 1130 1135 Ser Asn Met Thr Glu Phe His Ser Gln Ile Ser Lys Ser Arg Gln Glu 1140 1145 1150 Leu Glu Gln His Ser Val Asp Thr Ala Ser Thr Ser Asp Ala Val Thr 1155 1160 1165 Phe Ile Thr Tyr Val Gln Ser Leu Lys Arg Lys Ile Lys Gln Phe Glu 1170 1175 1180 Lys Gln Val Glu Leu Tyr Arg Asn Gly Gln Arg Leu Leu Glu Lys Gln 1185 1190 1195 1200 Arg Phe Gln Phe Pro Pro Ser Trp Leu Tyr Ile Asp Asn Ile Glu Gly 1205 1210 1215 Glu Trp Gly Ala Phe Asn Asp Ile Met Arg Arg Lys Asp Ser Ala Ile 1220 1225 1230 Gln Gln Gln Val Ala Asn Leu Gln Met Lys Ile Val Gln Glu Asp Arg 1235 1240 1245 Ala Val Glu Ser Arg Thr Thr Asp Leu Leu Thr Asp Trp Glu Lys Thr 1250 1255 1260 Lys Pro Val Thr Gly Asn Leu Arg Pro Glu Glu Ala Leu Gln Ala Leu 1265 1270 1275 1280 Thr Ile Tyr Glu Gly Lys Phe Gly Arg Leu Lys Asp Asp Arg Glu Lys 1285 1290 1295 Cys Ala Lys Ala Lys Glu Ala Leu Glu Leu Thr Asp Thr Gly Leu Leu 1300 1305 1310 Ser Gly Ser Glu Glu Arg Val Gln Val Ala Leu Glu Glu Leu Gln Asp 1315 1320 1325 Leu Lys Gly Val Trp Ser Glu Leu Ser Lys Val Trp Glu Gln Ile Asp 1330 1335 1340 Gln Met Lys Glu Gln Pro Trp Val Ser Val Gln Pro Arg Lys Leu Arg 1345 1350 1355 1360 Gln Asn Leu Asp Ala Leu Leu Asn Gln Leu Lys Ser Phe Pro Ala Arg 1365 1370 1375 Leu Arg Gln Tyr Ala Ser Tyr Glu Phe Val Gln Arg Leu Leu Lys Gly 1380 1385 1390 Tyr Met Lys Ile Asn Met Leu Val Ile Glu Leu Lys Ser Glu Ala Leu 1395 1400 1405 Lys Asp Arg His Trp Lys Gln Leu Met Lys Arg Leu His Val Asn Trp 1410 1415 1420 Val Val Ser Glu Leu Thr Leu Gly Gln Ile Trp Asp Val Asp Leu Gln 1425 1430 1435 1440 Lys Asn Glu Ala Ile Val Lys Asp Val Leu Leu Val Ala Gln Gly Glu 1445 1450 1455 Met Ala Leu Glu Glu Phe Leu Lys Gln Ala Lys Val Trp Asn Thr Tyr 1460 1465 1470 Glu Leu Asp Leu Val Asn Tyr Gln Asn Lys Cys Arg Leu Ile Arg Gly 1475 1480 1485 Trp Asp Asp Leu Phe Asn Lys Val Lys Glu His Ile Asn Ser Val Ser 1490 1495 1500 Ala Met Lys Leu Ser Pro Tyr Tyr Lys Val Phe Glu Glu Asp Ala Leu 1505 1510 1515 1520 Ser Trp Glu Asp Lys Leu Asn Arg Ile Met Ala Leu Phe Asp Val Trp 1525 1530 1535 Ile Asp Val Gln Arg Arg Trp Val Tyr Leu Glu Gly Ile Phe Thr Gly 1540 1545 1550 Ser Ala Asp Ile Lys His Leu Leu Pro Val Glu Thr Gln Arg Phe Gln 1555 1560 1565 Ser Ile Ser Thr Glu Phe Leu Ala Leu Met Lys Lys Val Ser Lys Ser 1570 1575 1580 Pro Leu Val Met Asp Val Leu Asn Ile Gln Gly Val Gln Arg Ser Leu 1585 1590 1595 1600 Glu Arg Leu Ala Asp Leu Leu Gly Lys Ile Gln Lys Ala Leu Gly Glu 1605 1610 1615 Tyr Leu Glu Arg Glu Arg Ser Ser Phe Pro Arg Phe Tyr Phe Val Gly 1620 1625 1630 Asp Glu Asp Leu Leu Glu Ile Ile Gly Asn Ser Lys Asn Val Ala Lys 1635 1640 1645 Leu Gln Lys His Phe Lys Lys Met Phe Ala Gly Val Ser Ser Ile Ile 1650 1655 1660 Leu Asn Glu Asp Asn Ser Val Val Leu Gly Ile Ser Ser Arg Glu Gly 1665 1670 1675 1680 Glu Glu Val Met Phe Lys Thr Pro Val Ser Ile Thr Glu His Pro Lys 1685 1690 1695 Ile Asn Glu Trp Leu Thr Leu Val Glu Lys Glu Met Arg Val Thr Leu 1700 1705 1710 Ala Lys Leu Leu Ala Glu Ser Val Thr Glu Val Glu Ile Phe Gly Lys 1715 1720 1725 Ala Thr Ser Ile Asp Pro Asn Thr Tyr Ile Thr Trp Ile Asp Lys Tyr 1730 1735 1740 Gln Ala Gln Leu Val Val Leu Ser Ala Gln Ile Ala Trp Ser Glu Asn 1745 1750 1755 1760 Val Glu Thr Ala Leu Ser Ser Met Gly Gly Gly Gly Asp Ala Ala Pro 1765 1770 1775 Leu His Ser Val Leu Ser Asn Val Glu Val Thr Leu Asn Val Leu Ala 1780 1785 1790 Asp Ser Val Leu Met Glu Gln Pro Pro Leu Arg Arg Arg Lys Leu Glu 1795 1800 1805 His Leu Ile Thr Glu Leu Val His Gln Arg Asp Val Thr Arg Ser Leu 1810 1815 1820 Ile Lys Ser Lys Ile Asp Asn Ala Lys Ser Phe Glu Trp Leu Ser Gln 1825 1830 1835 1840 Met Arg Phe Tyr Phe Asp Pro Lys Gln Thr Asp Val Leu Gln Gln Leu 1845 1850 1855 Ser Ile Gln Met Ala Asn Ala Lys Phe Asn Tyr Gly Phe Glu Tyr Leu 1860 1865 1870 Gly Val Gln Asp Lys Leu Val Gln Thr Pro Leu Thr Asp Arg Cys Tyr 1875 1880 1885 Leu Thr Met Thr Gln Ala Leu Glu Ala Arg Leu Gly Gly Ser Pro Phe 1890 1895 1900 Gly Pro Ala Gly Thr Gly Lys Thr Glu Ser Val Lys Ala Leu Gly His 1905 1910 1915 1920 Gln Leu Gly Arg Phe Val Leu Val Phe Asn Cys Asp Glu Thr Phe Asp 1925 1930 1935 Phe Gln Ala Met Gly Arg Ile Phe Val Gly Leu Cys Gln Val Gly Ala 1940 1945 1950 Trp Gly Cys Phe Asp Glu Phe Asn Arg Leu Glu Glu Arg Met Leu Ser 1955 1960 1965 Ala Val Ser Gln Gln Val Gln Cys Ile Gln Glu Ala Leu Arg Glu His 1970 1975 1980 Ser Asn Pro Asn Tyr Asp Lys Thr Ser Ala Pro Ile Thr Cys Glu Leu 1985 1990 1995 2000 Leu Asn Lys Gln Val Lys Val Ser Pro Asp Met Ala Ile Phe Ile Thr 2005 2010 2015 Met Asn Pro Ala Tyr Ala Gly Arg Ser Asn Leu Pro Asp Asn Leu Lys 2020 2025 2030 Lys Leu Phe Arg Ser Leu Ala Met Thr Lys Pro Asp Arg Gln Leu Ile 2035 2040 2045 Ala Gln Val Met Leu Tyr Ser Gln Gly Phe Arg Thr Ala Glu Val Leu 2050 2055 2060 Ala Asn Lys Ile Val Pro Phe Phe Lys Leu Cys Asp Glu Gln Leu Ser 2065 2070 2075 2080 Ser Gln Ser His Tyr Asp Phe Gly Leu Arg Ala Leu Lys Ser Val Leu 2085 2090 2095 Val Ser Ala Gly Asn Val Lys Arg Glu Arg Ile Gln Lys Ile Lys Arg 2100 2105 2110 Glu Lys Glu Glu Arg Gly Glu Ala Val Asp Glu Gly Glu Ile Ala Glu 2115 2120 2125 Asn Leu Pro Glu Gln Glu Ile Leu Ile Gln Ser Val Cys Glu Thr Met 2130 2135 2140 Val Pro Lys Leu Val Ala Glu Asp Ile Pro Leu Leu Phe Ser Leu Leu 2145 2150 2155 2160 Ser Asp Val Phe Pro Gly Val Gln Tyr His Arg Gly Glu Met Thr Ala 2165 2170 2175 Leu Arg Glu Glu Leu Lys Lys Val Cys Gln Glu Met Tyr Leu Thr Tyr 2180 2185 2190 Gly Asp Gly Glu Glu Val Gly Gly Met Trp Val Glu Lys Val Leu Gln 2195 2200 2205 Leu Tyr Gln Ile Thr Gln Ile Asn His Gly Leu Met Met Val Gly Pro 2210 2215 2220 Ser Gly Ser Gly Lys Ser Met Ala Trp Arg Val Leu Leu Lys Ala Leu 2225 2230 2235 2240 Glu Arg Leu Glu Gly Val Glu Gly Val Ala His Ile Ile Asp Pro Lys 2245 2250 2255 Ala Ile Ser Lys Asp His Leu Tyr Gly Thr Leu Asp Pro Asn Thr Arg 2260 2265 2270 Glu Trp Thr Asp Gly Leu Phe Thr His Val Leu Arg Lys Ile Ile Asp 2275 2280 2285 Ser Val Arg Gly Glu Leu Gln Lys Arg Gln Trp Ile Val Phe Asp Gly 2290 2295 2300 Asp Val Asp Pro Glu Trp Val Glu Asn Leu Asn Ser Val Leu Asp Asp 2305 2310 2315 2320 Asn Lys Leu Leu Thr Leu Pro Asn Gly Glu Arg Leu Ser Leu Pro Pro 2325 2330 2335 Asn Val Arg Ile Met Phe Glu Val Gln Asp Leu Lys Tyr Ala Thr Leu 2340 2345 2350 Ala Thr Val Ser Arg Cys Gly Met Val Trp Phe Ser Glu Asp Val Leu 2355 2360 2365 Ser Thr Asp Met Ile Phe Asn Asn Phe Leu Ala Arg Leu Arg Ser Ile 2370 2375 2380 Pro Leu Asp Glu Gly Glu Asp Glu Ala Gln Arg Arg Arg Lys Gly Lys 2385 2390 2395 2400 Glu Asp Glu Gly Glu Glu Ala Ala Ser Pro Met Leu Gln Ile Gln Arg 2405 2410 2415 Asp Ala Ala Thr Ile Met Gln Pro Tyr Phe Thr Ser Asn Gly Leu Val 2420 2425 2430 Thr Lys Ala Leu Glu His Ala Phe Gln Leu Glu His Ile Met Asp Leu 2435 2440 2445 Thr Arg Leu Arg Cys Leu Gly Ser Leu Phe Ser Met Leu His Gln Ala 2450 2455 2460 Cys Arg Asn Val Ala Gln Tyr Asn Ala Asn His Pro Asp Phe Pro Met 2465 2470 2475 2480 Gln Ile Glu Gln Leu Glu Arg Tyr Ile Gln Arg Tyr Leu Val Tyr Ala 2485 2490 2495 Ile Leu Trp Ser Leu Ser Gly Asp Ser Arg Leu Lys Met Arg Ala Glu 2500 2505 2510 Leu Gly Glu Tyr Ile Arg Arg Ile Thr Thr Val Pro Leu Pro Thr Ala 2515 2520 2525 Pro Asn Ile Pro Ile Ile Asp Tyr Glu Val Ser Ile Ser Gly Glu Trp 2530 2535 2540 Ser Pro Trp Gln Ala Lys Val Pro Gln Ile Glu Val Glu Thr His Lys 2545 2550 2555 2560 Val Ala Ala Pro Asp Val Val Val Pro Thr Leu Asp Thr Val Arg His 2565 2570 2575 Glu Ala Leu Leu Tyr Thr Trp Leu Ala Glu His Lys Pro Leu Val Leu 2580 2585 2590 Cys Gly Pro Pro Gly Ser Gly Lys Thr Met Thr Leu Phe Ser Ala Leu 2595 2600 2605 Arg Ala Leu Pro Asp Met Glu Val Val Gly Leu Asn Phe Ser Ser Ala 2610 2615 2620 Thr Thr Pro Glu Leu Leu Leu Lys Thr Phe Asp His Tyr Cys Glu Tyr 2625 2630 2635 2640 Arg Arg Thr Pro Asn Gly Val Val Leu Ala Pro Val Gln Leu Gly Lys 2645 2650 2655 Trp Leu Val Leu Phe Cys Asp Glu Ile Asn Leu Pro Asp Met Asp Lys 2660 2665 2670 Tyr Gly Thr Gln Arg Val Ile Ser Phe Ile Arg Gln Met Val Glu His 2675 2680 2685 Gly Gly Phe Tyr Arg Thr Ser Asp Gln Thr Trp Val Lys Leu Glu Arg 2690 2695 2700 Ile Gln Phe Val Gly Ala Cys Asn Pro Pro Thr Asp Pro Gly Arg Lys 2705 2710 2715 2720 Pro Leu Ser His Arg Phe Leu Arg His Val Pro Val Val Tyr Val Asp 2725 2730 2735 Tyr Pro Gly Pro Ala Ser Leu Thr Gln Ile Tyr Gly Thr Phe Asn Arg 2740 2745 2750 Ala Met Leu Arg Leu Ile Pro Ser Leu Arg Thr Tyr Ala Glu Pro Leu 2755 2760 2765 Thr Ala Ala Met Val Glu Phe Tyr Thr Met Ser Gln Glu Arg Phe Thr 2770 2775 2780 Gln Asp Thr Gln Pro His Tyr Ile Tyr Ser Pro Arg Glu Met Thr Arg 2785 2790 2795 2800 Trp Val Arg Gly Ile Phe Glu Ala Leu Arg Pro Leu Glu Thr Leu Pro 2805 2810 2815 Val Glu Gly Leu Ile Arg Ile Trp Ala His Glu Ala Leu Arg Leu Phe 2820 2825 2830 Gln Asp Arg Leu Val Glu Asp Glu Glu Arg Arg Trp Thr Asp Glu Asn 2835 2840 2845 Ile Asp Thr Val Ala Leu Lys His Phe Pro Asn Ile Asp Arg Glu Lys 2850 2855 2860 Ala Met Ser Arg Pro Ile Leu Tyr Ser Asn Trp Leu Ser Lys Asp Tyr 2865 2870 2875 2880 Ile Pro Val Asp Gln Glu Glu Leu Arg Asp Tyr Val Lys Ala Arg Leu 2885 2890 2895 Lys Val Phe Tyr Glu Glu Glu Leu Asp Val Pro Leu Val Leu Phe Asn 2900 2905 2910 Glu Val Leu Asp His Val Leu Arg Ile Asp Arg Ile Phe Arg Gln Pro 2915 2920 2925 Gln Gly His Leu Leu Leu Ile Gly Val Ser Gly Ala Gly Lys Thr Thr 2930 2935 2940 Leu Ser Arg Phe Val Ala Trp Met Asn Gly Leu Ser Val Tyr Gln Ile 2945 2950 2955 2960 Lys Val His Arg Lys Tyr Thr Gly Glu Asp Phe Asp Glu Asp Leu Arg 2965 2970 2975 Thr Val Leu Arg Arg Ser Gly Cys Lys Asn Glu Lys Ile Ala Phe Ile 2980 2985 2990 Met Asp Glu Ser Asn Val Leu Asp Ser Gly Phe Leu Glu Arg Met Asn 2995 3000 3005 Thr Leu Leu Ala Asn Gly Glu Val Pro Gly Leu Phe Glu Gly Asp Glu 3010 3015 3020 Tyr Ala Thr Leu Met Thr Gln Cys Lys Glu Gly Ala Gln Lys Glu Gly 3025 3030 3035 3040 Leu Met Leu Asp Ser His Glu Glu Leu Tyr Lys Trp Phe Thr Ser Gln 3045 3050 3055 Val Ile Arg Asn Leu His Val Val Phe Thr Met Asn Pro Ser Ser Glu 3060 3065 3070 Gly Leu Lys Asp Arg Ala Ala Thr Ser Pro Ala Leu Phe Asn Arg Cys 3075 3080 3085 Val Leu Asn Trp Phe Gly Asp Trp Ser Thr Glu Ala Leu Tyr Gln Val 3090 3095 3100 Gly Lys Glu Phe Thr Ser Lys Met Asp Leu Glu Lys Pro Asn Tyr Ile 3105 3110 3115 3120 Val Pro Asp Tyr Met Pro Val Val Tyr Asp Lys Leu Pro Gln Pro Pro 3125 3130 3135 Ser His Arg Glu Ala Ile Val Asn Ser Cys Val Phe Val His Gln Thr 3140 3145 3150 Leu His Gln Ala Asn Ala Arg Leu Ala Lys Arg Gly Gly Arg Thr Met 3155 3160 3165 Ala Ile Thr Pro Arg His Tyr Leu Asp Phe Ile Asn His Tyr Ala Asn 3170 3175 3180 Leu Phe His Glu Lys Arg Ser Glu Leu Glu Glu Gln Gln Met His Leu 3185 3190 3195 3200 Asn Val Gly Leu Arg Lys Ile Lys Glu Thr Val Asp Gln Val Glu Glu 3205 3210 3215 Leu Arg Arg Asp Leu Arg Ile Lys Ser Gln Glu Leu Glu Val Lys Asn 3220 3225 3230 Ala Ala Ala Asn Asp Lys Leu Lys Lys Met Val Lys Asp Gln Gln Glu 3235 3240 3245 Ala Glu Lys Lys Lys Val Met Ser Gln Glu Ile Gln Glu Gln Leu His 3250 3255 3260 Lys Gln Gln Glu Val Ile Ala Asp Lys Gln Met Ser Val Lys Glu Asp 3265 3270 3275 3280 Leu Asp Lys Val Glu Pro Ala Val Ile Glu Ala Gln Asn Ala Val Lys 3285 3290 3295 Ser Ile Lys Lys Gln His Leu Val Glu Val Arg Ser Met Ala Asn Pro 3300 3305 3310 Pro Ala Ala Val Lys Leu Ala Leu Glu Ser Ile Cys Leu Leu Leu Gly 3315 3320 3325 Glu Ser Thr Thr Asp Trp Lys Gln Ile Arg Ser Ile Ile Met Arg Glu 3330 3335 3340 Asn Phe Ile Pro Thr Ile Val Asn Phe Ser Ala Glu Glu Ile Ser Asp 3345 3350 3355 3360 Ala Ile Arg Glu Lys Met Lys Lys Asn Tyr Met Ser Asn Pro Ser Tyr 3365 3370 3375 Asn Tyr Glu Ile Val Asn Arg Ala Ser Leu Ala Cys Gly Pro Met Val 3380 3385 3390 Lys Trp Ala Ile Ala Gln Leu Asn Tyr Ala Asp Met Leu Lys Arg Val 3395 3400 3405 Glu Pro Leu Arg Asn Glu Leu Gln Lys Leu Glu Asp Asp Ala Lys Asp 3410 3415 3420 Asn Gln Gln Lys Ala Asn Glu Val Glu Gln Met Ile Arg Asp Leu Glu 3425 3430 3435 3440 Ala Ser Ile Ala Arg Tyr Lys Glu Glu Tyr Ala Val Leu Ile Ser Glu 3445 3450 3455 Ala Gln Ala Ile Lys Ala Asp Leu Ala Ala Val Glu Ala Lys Val Asn 3460 3465 3470 Arg Ser Thr Ala Leu Leu Lys Ser Leu Ser Ala Glu Arg Glu Arg Trp 3475 3480 3485 Glu Lys Thr Ser Glu Thr Phe Lys Asn Gln Met Ser Thr Ile Ala Gly 3490 3495 3500 Asp Cys Leu Leu Ser Ala Ala Phe Ile Ala Tyr Ala Gly Tyr Phe Asp 3505 3510 3515 3520 Gln Gln Met Arg Gln Asn Leu Phe Thr Thr Trp Ser His His Leu Gln 3525 3530 3535 Gln Ala Asn Ile Gln Phe Arg Thr Asp Ile Ala Arg Thr Glu Tyr Leu 3540 3545 3550 Ser Asn Ala Asp Glu Arg Leu Arg Trp Gln Ala Ser Ser Leu Pro Ala 3555 3560 3565 Asp Asp Leu Cys Thr Glu Asn Ala Ile Met Leu Lys Arg Phe Asn Arg 3570 3575 3580 Tyr Pro Leu Ile Ile Asp Pro Ser Gly Gln Ala Thr Glu Phe Ile Met 3585 3590 3595 3600 Asn Glu Tyr Lys Asp Arg Lys Ile Thr Arg Thr Ser Phe Leu Asp Asp 3605 3610 3615 Ala Phe Arg Lys Asn Leu Glu Ser Ala Leu Arg Phe Gly Asn Pro Leu 3620 3625 3630 Leu Val Gln Asp Val Glu Ser Tyr Asp Pro Val Leu Asn Pro Val Leu 3635 3640 3645 Asn Arg Glu Val Arg Arg Thr Gly Gly Arg Val Leu Ile Thr Leu Gly 3650 3655 3660 Asp Gln Asp Ile Asp Leu Ser Pro Ser Phe Val Ile Phe Leu Ser Thr 3665 3670 3675 3680 Arg Asp Pro Thr Val Glu Phe Pro Pro Asp Leu Cys Ser Arg Val Thr 3685 3690 3695 Phe Val Asn Phe Thr Val Thr Arg Ser Ser Leu Gln Ser Gln Cys Leu 3700 3705 3710 Asn Glu Val Leu Lys Ala Glu Arg Pro Asp Val Asp Glu Lys Arg Ser 3715 3720 3725 Asp Leu Leu Lys Leu Gln Gly Glu Phe Gln Leu Arg Leu Arg Gln Leu 3730 3735 3740 Glu Lys Ser Leu Leu Gln Ala Leu Asn Glu Val Lys Gly Arg Ile Leu 3745 3750 3755 3760 Asp Asp Asp Thr Ile Ile Thr Thr Leu Glu Asn Leu Lys Arg Glu Ala 3765 3770 3775 Ala Glu Val Thr Arg Lys Val Glu Glu Thr Asp Ile Val Met Gln Glu 3780 3785 3790 Val Glu Thr Val Ser Gln Gln Tyr Leu Pro Leu Ser Thr Ala Cys Ser 3795 3800 3805 Ser Ile Tyr Phe Thr Met Glu Ser Leu Lys Gln Ile His Phe Leu Tyr 3810 3815 3820 Gln Tyr Ser Leu Gln Phe Phe Leu Asp Ile Tyr His Asn Val Leu Tyr 3825 3830 3835 3840 Glu Asn Pro Asn Leu Lys Gly Val Thr Asp His Thr Gln Arg Leu Ser 3845 3850 3855 Ile Ile Thr Lys Asp Leu Phe Gln Val Ala Phe Asn Arg Val Ala Arg 3860 3865 3870 Gly Met Leu His Gln Asp His Ile Thr Phe Ala Met Leu Leu Ala Arg 3875 3880 3885 Ile Lys Leu Lys Gly Thr Val Gly Glu Pro Thr Tyr Asp Ala Glu Phe 3890 3895 3900 Gln His Phe Leu Arg Gly Asn Glu Ile Val Leu Ser Ala Gly Ser Thr 3905 3910 3915 3920 Pro Arg Ile Gln Gly Leu Thr Val Glu Gln Ala Glu Ala Val Val Arg 3925 3930 3935 Leu Ser Cys Leu Pro Ala Phe Lys Asp Leu Ile Ala Lys Val Gln Ala 3940 3945 3950 Asp Glu Gln Phe Gly Ile Trp Leu Asp Ser Ser Ser Pro Glu Gln Thr 3955 3960 3965 Val Pro Tyr Leu Trp Ser Glu Glu Thr Pro Ala Thr Pro Ile Gly Gln 3970 3975 3980 Ala Ile His Arg Leu Leu Leu Ile Gln Ala Phe Arg Pro Asp Arg Leu 3985 3990 3995 4000 Leu Ala Met Ala His Met Phe Val Ser Thr Asn Leu Gly Glu Ser Phe 4005 4010 4015 Met Ser Ile Met Glu Gln Pro Leu Asp Leu Thr His Ile Val Gly Thr 4020 4025 4030 Glu Val Lys Pro Asn Thr Pro Val Leu Met Cys Ser Val Pro Gly Tyr 4035 4040 4045 Asp Ala Ser Gly His Val Glu Asp Leu Ala Ala Glu Gln Asn Thr Gln 4050 4055 4060 Ile Thr Ser Ile Ala Ile Gly Ser Ala Glu Gly Phe Asn Gln Ala Asp 4065 4070 4075 4080 Lys Ala Ile Asn Thr Ala Val Lys Ser Gly Arg Trp Val Met Leu Lys 4085 4090 4095 Asn Val His Leu Ala Pro Gly Trp Leu Met Gln Leu Glu Lys Lys Leu 4100 4105 4110 His Ser Leu Gln Pro His Ala Cys Phe Arg Leu Phe Leu Thr Met Glu 4115 4120 4125 Ile Asn Pro Lys Val Pro Val Asn Leu Leu Arg Ala Gly Arg Ile Phe 4130 4135 4140 Val Phe Glu Pro Pro Pro Gly Val Lys Ala Asn Met Leu Arg Thr Phe 4145 4150 4155 4160 Ser Ser Ile Pro Val Ser Arg Ile Cys Lys Ser Pro Asn Glu Arg Ala 4165 4170 4175 Arg Leu Tyr Phe Leu Leu Ala Trp Phe His Ala Ile Ile Gln Glu Arg 4180 4185 4190 Leu Arg Tyr Ala Pro Leu Gly Trp Ser Lys Lys Tyr Glu Phe Gly Glu 4195 4200 4205 Ser Asp Leu Arg Ser Ala Cys Asp Thr Val Asp Thr Trp Leu Asp Asp 4210 4215 4220 Thr Ala Lys Ala Ser Gly Arg Gln Asn Ile Ser Pro Asp Lys Ile Pro 4225 4230 4235 4240 Trp Ser Ala Leu Lys Thr Leu Met Ala Gln Ser Ile Tyr Gly Gly Arg 4245 4250 4255 Val Asp Asn Glu Phe Asp Gln Arg Leu Leu Asn Thr Phe Leu Glu Arg 4260 4265 4270 Leu Phe Thr Thr Arg Ser Phe Asp Ser Glu Phe Lys Leu Ala Cys Lys 4275 4280 4285 Val Asp Gly His Lys Asp Ile Gln Met Pro Asp Gly Ile Arg Arg Glu 4290 4295 4300 Glu Phe Val Gln Trp Val Glu Leu Leu Pro Asp Thr Gln Thr Pro Ser 4305 4310 4315 4320 Trp Leu Gly Leu Pro Asn Asn Ala Glu Arg Val Leu Leu Thr Thr Gln 4325 4330 4335 Gly Val Asp Met Ile Ser Lys Met Leu Lys Met Gln Met Leu Glu Asp 4340 4345 4350 Glu Asp Asp Leu Ala Tyr Ala Glu Thr Glu Lys Lys Thr Arg Thr Asp 4355 4360 4365 Ser Thr Ser Asp Gly Arg Pro Ala Trp Met Arg Thr Leu His Thr Thr 4370 4375 4380 Ala Ser Asn Trp Leu His Leu Ile Pro Gln Thr Leu Ser His Leu Lys 4385 4390 4395 4400 Arg Thr Val Glu Asn Ile Lys Asp Pro Leu Phe Arg Phe Phe Glu Arg 4405 4410 4415 Glu Val Lys Met Gly Ala Lys Leu Leu Gln Asp Val Arg Gln Asp Leu 4420 4425 4430 Ala Asp Val Val Gln Val Cys Glu Gly Lys Lys Lys Gln Thr Asn Tyr 4435 4440 4445 Leu Arg Thr Leu Ile Asn Glu Leu Val Lys Gly Ile Leu Pro Arg Ser 4450 4455 4460 Trp Ser His Tyr Thr Val Pro Ala Gly Met Thr Val Ile Gln Trp Val 4465 4470 4475 4480 Ser Asp Phe Ser Glu Arg Ile Lys Gln Leu Gln Asn Ile Ser Leu Ala 4485 4490 4495 Ala Ala Ser Gly Gly Ala Lys Glu Leu Lys Asn Ile His Val Cys Leu 4500 4505 4510 Gly Gly Leu Phe Val Pro Glu Ala Tyr Ile Thr Ala Thr Arg Gln Tyr 4515 4520 4525 Val Ala Gln Ala Asn Ser Trp Ser Leu Glu Glu Leu Cys Leu Glu Val 4530 4535 4540 Asn Val Thr Thr Ser Gln Gly Ala Thr Leu Asp Ala Cys Ser Phe Gly 4545 4550 4555 4560 Val Thr Gly Leu Lys Leu Gln Gly Ala Thr Cys Asn Asn Asn Lys Leu 4565 4570 4575 Ser Leu Ser Asn Ala Ile Ser Thr Ala Leu Pro Leu Thr Gln Leu Arg 4580 4585 4590 Trp Val Lys Gln Thr Asn Thr Glu Lys Lys Ala Ser Val Val Thr Leu 4595 4600 4605 Pro Val Tyr Leu Asn Phe Thr Arg Ala Asp Leu Ile Phe Thr Val Asp 4610 4615 4620 Phe Glu Ile Ala Thr Lys Glu Asp Pro Arg Ser Phe Tyr Glu Arg Gly 4625 4630 4635 4640 Val Ala Val Leu Cys Thr Glu 4645 <210> SEQ ID NO 41 <211> LENGTH: 1232 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 41 Met Ala Asn Gly Val Ile Pro Pro Pro Gly Gly Ala Ser Pro Leu Pro 1 5 10 15 Gln Val Arg Val Pro Leu Glu Glu Pro Pro Leu Ser Pro Asp Val Glu 20 25 30 Glu Glu Asp Asp Asp Leu Gly Lys Thr Leu Ala Val Ser Arg Phe Gly 35 40 45 Asp Leu Ile Ser Lys Pro Pro Ala Trp Asp Pro Glu Lys Pro Ser Arg 50 55 60 Ser Tyr Ser Glu Arg Asp Phe Glu Phe His Arg His Thr Ser His His 65 70 75 80 Thr His His Pro Leu Ser Ala Arg Leu Pro Pro Pro His Lys Leu Arg 85 90 95 Arg Leu Pro Pro Thr Ser Ala Arg His Thr Arg Arg Lys Arg Lys Lys 100 105 110 Glu Lys Thr Ser Ala Pro Pro Ser Glu Gly Thr Pro Pro Ile Gln Glu 115 120 125 Glu Gly Gly Ala Gly Val Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu 130 135 140 Glu Gly Glu Ser Glu Ala Glu Pro Val Glu Pro Pro His Ser Gly Thr 145 150 155 160 Pro Gln Lys Ala Lys Phe Ser Ile Gly Ser Asp Glu Asp Asp Ser Pro 165 170 175 Gly Leu Pro Gly Arg Ala Ala Val Thr Lys Pro Leu Pro Ser Val Gly 180 185 190 Pro His Thr Asp Lys Ser Pro Gln His Ser Ser Ser Ser Pro Ser Pro 195 200 205 Arg Ala Arg Ala Ser Arg Leu Ala Gly Glu Lys Ser Arg Pro Trp Ser 210 215 220 Pro Ser Ala Ser Tyr Asp Leu Arg Glu Arg Leu Cys Pro Gly Ser Ala 225 230 235 240 Leu Gly Asn Pro Gly Gly Pro Glu Gln Gln Val Pro Thr Asp Glu Ala 245 250 255 Glu Ala Gln Met Leu Gly Ser Ala Asp Leu Asp Asp Met Lys Ser His 260 265 270 Arg Leu Glu Asp Asn Pro Gly Val Arg Arg His Leu Val Lys Lys Pro 275 280 285 Ser Arg Thr Gln Gly Gly Arg Gly Ser Pro Ser Gly Leu Ala Pro Ile 290 295 300 Leu Arg Arg Lys Lys Lys Lys Lys Lys Leu Asp Arg Arg Pro His Glu 305 310 315 320 Val Phe Val Glu Leu Asn Glu Leu Met Leu Asp Arg Ser Gln Glu Pro 325 330 335 His Trp Arg Glu Thr Ala Arg Trp Ile Lys Phe Glu Glu Asp Val Glu 340 345 350 Glu Glu Thr Glu Arg Trp Gly Lys Pro His Val Ala Ser Leu Ser Phe 355 360 365 Arg Ser Leu Leu Glu Leu Arg Arg Thr Ile Ala His Gly Ala Ala Leu 370 375 380 Leu Asp Leu Glu Gln Thr Thr Leu Pro Gly Ile Ala His Leu Val Val 385 390 395 400 Glu Thr Met Ile Val Ser Asp Gln Ile Arg Pro Glu Asp Arg Ala Ser 405 410 415 Val Leu Arg Thr Leu Leu Leu Lys His Ser His Pro Asn Asp Asp Lys 420 425 430 Asp Ser Gly Phe Phe Pro Arg Asn Pro Ser Ser Ser Ser Met Asn Ser 435 440 445 Val Leu Gly Asn His His Pro Thr Pro Ser His Gly Pro Asp Gly Ala 450 455 460 Val Pro Thr Met Ala Asp Asp Leu Gly Glu Pro Ala Pro Leu Trp Pro 465 470 475 480 His Asp Pro Asp Ala Lys Glu Lys Pro Leu His Met Pro Gly Gly Asp 485 490 495 Gly His Arg Gly Lys Ser Leu Lys Leu Leu Glu Lys Ile Pro Glu Asp 500 505 510 Ala Glu Ala Thr Val Val Leu Val Gly Cys Val Pro Phe Leu Glu Gln 515 520 525 Pro Ala Ala Ala Phe Val Arg Leu Asn Glu Ala Val Leu Leu Glu Ser 530 535 540 Val Leu Glu Val Pro Val Pro Val Arg Phe Leu Phe Val Met Leu Gly 545 550 555 560 Pro Ser His Thr Ser Thr Asp Tyr His Glu Leu Gly Arg Ser Ile Ala 565 570 575 Thr Leu Met Ser Asp Lys Leu Phe His Glu Ala Ala Tyr Gln Ala Asp 580 585 590 Asp Arg Gln Asp Leu Leu Ser Ala Ile Ser Glu Phe Leu Asp Gly Ser 595 600 605 Ile Val Ile Pro Pro Ser Glu Val Glu Gly Arg Asp Leu Leu Arg Ser 610 615 620 Val Ala Ala Phe Gln Arg Glu Leu Leu Arg Lys Arg Arg Glu Arg Glu 625 630 635 640 Gln Thr Lys Val Glu Met Thr Thr Arg Gly Gly Tyr Thr Ala Pro Gly 645 650 655 Lys Glu Leu Ser Leu Glu Leu Gly Gly Ser Glu Ala Thr Pro Glu Asp 660 665 670 Asp Pro Leu Leu Arg Thr Gly Ser Val Phe Gly Gly Leu Val Arg Asp 675 680 685 Val Arg Arg Arg Tyr Pro His Tyr Pro Ser Asp Leu Arg Asp Ala Leu 690 695 700 His Ser Gln Cys Val Ala Ala Val Leu Phe Ile Tyr Phe Ala Ala Leu 705 710 715 720 Ser Pro Ala Ile Thr Phe Gly Gly Leu Leu Gly Glu Lys Thr Glu Gly 725 730 735 Leu Met Gly Val Ser Glu Leu Ile Val Ser Thr Ala Val Leu Gly Val 740 745 750 Leu Phe Ser Leu Leu Gly Ala Gln Pro Leu Leu Val Val Gly Phe Ser 755 760 765 Gly Pro Leu Leu Val Phe Glu Glu Ala Phe Phe Lys Phe Cys Arg Ala 770 775 780 Gln Asp Leu Glu Tyr Leu Thr Gly Arg Val Trp Val Gly Leu Trp Leu 785 790 795 800 Val Val Phe Val Leu Ala Leu Val Ala Ala Glu Gly Ser Phe Leu Val 805 810 815 Arg Tyr Ile Ser Pro Phe Thr Gln Glu Ile Phe Ala Phe Leu Ile Ser 820 825 830 Leu Ile Phe Ile Tyr Glu Thr Phe Tyr Lys Leu Tyr Lys Val Phe Thr 835 840 845 Glu His Pro Leu Leu Pro Phe Tyr Pro Pro Glu Gly Ala Leu Glu Gly 850 855 860 Ser Leu Asp Ala Gly Leu Glu Pro Asn Gly Ser Ala Leu Pro Pro Thr 865 870 875 880 Glu Gly Pro Pro Ser Pro Arg Asn Gln Pro Asn Thr Ala Leu Leu Ser 885 890 895 Leu Ile Leu Met Leu Gly Thr Phe Phe Ile Ala Phe Phe Leu Arg Lys 900 905 910 Phe Arg Asn Ser Arg Phe Leu Gly Gly Lys Ala Arg Arg Ile Ile Gly 915 920 925 Asp Phe Gly Ile Pro Ile Ser Ile Leu Val Met Val Leu Val Asp Tyr 930 935 940 Ser Ile Thr Asp Thr Tyr Thr Gln Lys Leu Thr Val Pro Thr Gly Leu 945 950 955 960 Ser Val Thr Ser Pro Asp Lys Arg Ser Trp Phe Ile Pro Pro Leu Gly 965 970 975 Ser Ala Arg Pro Phe Pro Pro Trp Met Met Val Ala Ala Ala Val Pro 980 985 990 Ala Leu Leu Val Leu Ile Leu Ile Phe Met Glu Thr Gln Ile Thr Ala 995 1000 1005 Leu Ile Val Ser Gln Lys Ala Arg Arg Leu Leu Lys Gly Ser Gly Phe 1010 1015 1020 His Leu Asp Leu Leu Leu Ile Gly Ser Leu Gly Gly Leu Cys Gly Leu 1025 1030 1035 1040 Phe Gly Leu Pro Trp Leu Thr Ala Ala Thr Val Arg Ser Val Thr His 1045 1050 1055 Val Asn Ala Leu Thr Val Met Arg Thr Ala Ile Ala Pro Gly Asp Lys 1060 1065 1070 Pro Gln Ile Gln Glu Val Arg Glu Gln Arg Val Thr Gly Val Leu Ile 1075 1080 1085 Ala Ser Leu Val Gly Leu Ser Ile Val Met Gly Ala Val Leu Arg Arg 1090 1095 1100 Ile Pro Leu Ala Val Leu Phe Gly Ile Phe Leu Tyr Met Gly Val Thr 1105 1110 1115 1120 Ser Leu Ser Gly Ile Gln Leu Ser Gln Arg Leu Leu Leu Ile Leu Met 1125 1130 1135 Pro Ala Lys His His Pro Glu Gln Pro Tyr Val Thr Lys Val Lys Thr 1140 1145 1150 Trp Arg Met His Leu Phe Thr Cys Ile Gln Leu Gly Cys Ile Ala Leu 1155 1160 1165 Leu Trp Val Val Lys Ser Thr Ala Ala Ser Leu Ala Phe Pro Phe Leu 1170 1175 1180 Leu Leu Leu Thr Val Pro Leu Arg His Cys Leu Leu Pro Arg Leu Phe 1185 1190 1195 1200 Gln Asp Arg Glu Leu Gln Ala Leu Asp Ser Glu Asp Ala Glu Pro Asn 1205 1210 1215 Phe Asp Glu Asp Gly Gln Asp Glu Tyr Asn Glu Leu His Met Pro Val 1220 1225 1230 <210> SEQ ID NO 42 <211> LENGTH: 1515 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 42 Asp Trp Asn Val Thr Trp Asn Thr Ser Asn Pro Asp Phe Thr Lys Cys 1 5 10 15 Phe Gln Asn Thr Val Leu Val Trp Val Pro Cys Phe Tyr Leu Trp Ala 20 25 30 Cys Phe Pro Phe Tyr Phe Leu Tyr Leu Ser Arg His Asp Arg Gly Tyr 35 40 45 Ile Gln Met Thr Pro Leu Asn Lys Thr Lys Thr Ala Leu Gly Phe Leu 50 55 60 Leu Trp Ile Val Cys Trp Ala Asp Leu Phe Tyr Ser Phe Trp Glu Arg 65 70 75 80 Ser Arg Gly Ile Phe Leu Ala Pro Val Phe Leu Val Ser Pro Thr Leu 85 90 95 Leu Gly Ile Thr Met Leu Leu Ala Thr Phe Leu Ile Gln Leu Glu Arg 100 105 110 Arg Lys Gly Val Gln Ser Ser Gly Ile Met Leu Thr Phe Trp Leu Val 115 120 125 Ala Leu Val Cys Ala Leu Ala Ile Leu Arg Ser Lys Ile Met Thr Ala 130 135 140 Leu Lys Glu Asp Ala Gln Val Asp Leu Phe Arg Asp Ile Thr Phe Tyr 145 150 155 160 Val Tyr Phe Ser Leu Leu Leu Ile Gln Leu Val Leu Ser Cys Phe Ser 165 170 175 Asp Arg Ser Pro Leu Phe Ser Glu Thr Ile His Asp Pro Asn Pro Cys 180 185 190 Pro Glu Ser Ser Ala Ser Phe Leu Ser Arg Ile Thr Phe Trp Trp Ile 195 200 205 Thr Gly Leu Ile Val Arg Gly Tyr Arg Gln Pro Leu Glu Gly Ser Asp 210 215 220 Leu Trp Ser Leu Asn Lys Glu Asp Thr Ser Glu Gln Val Val Pro Val 225 230 235 240 Leu Val Lys Asn Trp Lys Lys Glu Cys Ala Lys Thr Arg Lys Gln Pro 245 250 255 Val Lys Val Val Tyr Ser Ser Lys Asp Pro Ala Gln Pro Lys Glu Ser 260 265 270 Ser Lys Val Asp Ala Asn Glu Glu Val Glu Ala Leu Ile Val Lys Ser 275 280 285 Pro Gln Lys Glu Trp Asn Pro Ser Leu Phe Lys Val Leu Tyr Lys Thr 290 295 300 Phe Gly Pro Tyr Phe Leu Met Ser Phe Phe Phe Lys Ala Ile His Asp 305 310 315 320 Leu Met Met Phe Ser Gly Pro Gln Ile Leu Lys Leu Leu Ile Lys Phe 325 330 335 Val Asn Asp Thr Lys Ala Pro Asp Trp Gln Gly Tyr Phe Tyr Thr Val 340 345 350 Leu Leu Phe Val Thr Ala Cys Leu Gln Thr Leu Val Leu His Gln Tyr 355 360 365 Phe His Ile Cys Phe Val Ser Gly Met Arg Ile Lys Thr Ala Val Ile 370 375 380 Gly Ala Val Tyr Arg Lys Ala Leu Val Ile Thr Asn Ser Ala Arg Lys 385 390 395 400 Ser Ser Thr Val Gly Glu Ile Val Asn Leu Met Ser Val Asp Ala Gln 405 410 415 Arg Phe Met Asp Leu Ala Thr Tyr Ile Asn Met Ile Trp Ser Ala Pro 420 425 430 Leu Gln Val Ile Leu Ala Leu Tyr Leu Leu Trp Leu Asn Leu Gly Pro 435 440 445 Ser Val Leu Ala Gly Val Ala Val Met Val Leu Met Val Pro Val Asn 450 455 460 Ala Val Met Ala Met Lys Thr Lys Thr Tyr Gln Val Ala His Met Lys 465 470 475 480 Ser Lys Asp Asn Arg Ile Lys Leu Met Asn Glu Ile Leu Asn Gly Ile 485 490 495 Lys Val Leu Lys Leu Tyr Ala Trp Glu Leu Ala Phe Lys Asp Lys Val 500 505 510 Leu Ala Ile Arg Gln Glu Glu Leu Lys Val Leu Lys Lys Ser Ala Tyr 515 520 525 Leu Ser Ala Val Gly Thr Phe Thr Trp Val Cys Thr Pro Phe Leu Val 530 535 540 Ala Leu Cys Thr Phe Ala Val Tyr Val Thr Ile Asp Glu Asn Asn Ile 545 550 555 560 Leu Asp Ala Gln Thr Ala Phe Val Ser Leu Ala Leu Phe Asn Ile Leu 565 570 575 Arg Phe Pro Leu Asn Ile Leu Pro Met Val Ile Ser Ser Ile Val Gln 580 585 590 Ala Ser Val Ser Leu Lys Arg Leu Arg Ile Phe Leu Ser His Glu Glu 595 600 605 Leu Glu Pro Asp Ser Ile Glu Arg Arg Pro Val Lys Asp Gly Gly Gly 610 615 620 Thr Asn Ser Ile Thr Val Arg Asn Ala Thr Phe Thr Trp Ala Arg Ser 625 630 635 640 Asp Pro Pro Thr Leu Asn Gly Ile Thr Phe Ser Ile Pro Glu Gly Ala 645 650 655 Leu Val Ala Val Val Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu 660 665 670 Ser Ala Leu Leu Ala Glu Met Asp Lys Val Glu Gly His Val Ala Ile 675 680 685 Lys Gly Ser Val Ala Tyr Val Pro Gln Gln Ala Trp Ile Gln Asn Asp 690 695 700 Ser Leu Arg Glu Asn Ile Leu Phe Gly Cys Gln Leu Glu Glu Pro Tyr 705 710 715 720 Tyr Arg Ser Val Ile Gln Ala Cys Ala Leu Leu Pro Asp Leu Glu Ile 725 730 735 Leu Pro Ser Gly Asp Arg Thr Glu Ile Gly Glu Lys Gly Val Asn Leu 740 745 750 Ser Gly Gly Gln Lys Gln Arg Val Ser Leu Ala Arg Ala Val Tyr Ser 755 760 765 Asn Ala Asp Ile Tyr Leu Phe Asp Asp Pro Leu Ser Ala Val Asp Ala 770 775 780 His Val Gly Lys His Ile Phe Glu Asn Val Ile Gly Pro Lys Gly Met 785 790 795 800 Leu Lys Asn Lys Thr Arg Ile Leu Val Thr His Ser Met Ser Tyr Leu 805 810 815 Pro Gln Val Asp Val Ile Ile Val Met Ser Gly Gly Lys Ile Ser Glu 820 825 830 Met Gly Ser Tyr Gln Glu Leu Leu Ala Arg Asp Gly Ala Phe Ala Glu 835 840 845 Phe Leu Arg Thr Tyr Ala Ser Thr Glu Gln Glu Gln Asp Ala Glu Glu 850 855 860 Asn Gly Val Thr Gly Val Ser Gly Pro Gly Lys Glu Ala Lys Gln Met 865 870 875 880 Glu Asn Gly Met Leu Val Thr Asp Ser Ala Gly Lys Gln Leu Gln Arg 885 890 895 Gln Leu Ser Ser Ser Ser Ser Tyr Ser Gly Asp Ile Ser Arg His His 900 905 910 Asn Ser Thr Ala Glu Leu Gln Lys Ala Glu Ala Lys Lys Glu Glu Thr 915 920 925 Trp Lys Leu Met Glu Ala Asp Lys Ala Gln Thr Gly Gln Val Lys Leu 930 935 940 Ser Val Tyr Trp Asp Tyr Met Lys Ala Ile Gly Leu Phe Ile Ser Phe 945 950 955 960 Leu Ser Ile Phe Leu Phe Met Cys Asn His Val Ser Ala Leu Ala Ser 965 970 975 Asn Tyr Trp Leu Ser Leu Trp Thr Asp Asp Pro Ile Val Asn Gly Thr 980 985 990 Gln Glu His Thr Lys Val Arg Leu Ser Val Tyr Gly Ala Leu Gly Ile 995 1000 1005 Ser Gln Gly Ile Ala Val Phe Gly Tyr Ser Met Ala Val Ser Ile Gly 1010 1015 1020 Gly Ile Leu Ala Ser Arg Cys Leu His Val Asp Leu Leu His Ser Ile 1025 1030 1035 1040 Leu Arg Ser Pro Met Ser Phe Phe Glu Arg Thr Pro Ser Gly Asn Leu 1045 1050 1055 Val Asn Arg Phe Ser Lys Glu Leu Asp Thr Val Asp Ser Met Ile Pro 1060 1065 1070 Glu Val Ile Lys Met Phe Met Gly Ser Leu Phe Asn Val Ile Gly Ala 1075 1080 1085 Cys Ile Val Ile Leu Leu Ala Thr Pro Ile Ala Ala Ile Ile Ile Pro 1090 1095 1100 Pro Leu Gly Leu Ile Tyr Phe Phe Val Gln Arg Phe Tyr Val Ala Ser 1105 1110 1115 1120 Ser Arg Gln Leu Lys Arg Leu Glu Ser Val Ser Arg Ser Pro Val Tyr 1125 1130 1135 Ser His Phe Asn Glu Thr Leu Leu Gly Val Ser Val Ile Arg Ala Phe 1140 1145 1150 Glu Glu Gln Glu Arg Phe Ile His Gln Ser Asp Leu Lys Val Asp Glu 1155 1160 1165 Asn Gln Lys Ala Tyr Tyr Pro Ser Ile Val Ala Asn Arg Trp Leu Ala 1170 1175 1180 Val Arg Leu Glu Cys Val Gly Asn Cys Ile Val Leu Phe Ala Ala Leu 1185 1190 1195 1200 Phe Ala Val Ile Ser Arg His Ser Leu Ser Ala Gly Leu Val Gly Leu 1205 1210 1215 Ser Val Ser Tyr Ser Leu Gln Val Thr Thr Tyr Leu Asn Trp Leu Val 1220 1225 1230 Arg Met Ser Ser Glu Met Glu Thr Asn Ile Val Ala Val Glu Arg Leu 1235 1240 1245 Lys Glu Tyr Ser Glu Thr Glu Lys Glu Ala Pro Trp Gln Ile Gln Glu 1250 1255 1260 Thr Ala Pro Pro Ser Ser Trp Pro Gln Val Gly Arg Val Glu Phe Arg 1265 1270 1275 1280 Asn Tyr Cys Leu Arg Tyr Arg Glu Asp Leu Asp Phe Val Leu Arg His 1285 1290 1295 Ile Asn Val Thr Ile Asn Gly Gly Glu Lys Val Gly Ile Val Gly Arg 1300 1305 1310 Thr Gly Ala Gly Lys Ser Ser Leu Thr Leu Gly Leu Phe Arg Ile Asn 1315 1320 1325 Glu Ser Ala Glu Gly Glu Ile Ile Ile Asp Gly Ile Asn Ile Ala Lys 1330 1335 1340 Ile Gly Leu His Asp Leu Arg Phe Lys Ile Thr Ile Ile Pro Gln Asp 1345 1350 1355 1360 Pro Val Leu Phe Ser Gly Ser Leu Arg Met Asn Leu Asp Pro Phe Ser 1365 1370 1375 Gln Tyr Ser Asp Glu Glu Val Trp Thr Ser Leu Glu Leu Ala His Leu 1380 1385 1390 Lys Asp Phe Val Ser Ala Leu Pro Asp Lys Leu Asp His Glu Cys Ala 1395 1400 1405 Glu Gly Gly Glu Asn Leu Ser Val Gly Gln Arg Gln Leu Val Cys Leu 1410 1415 1420 Ala Arg Ala Leu Leu Arg Lys Thr Lys Ile Leu Val Leu Asp Glu Ala 1425 1430 1435 1440 Thr Ala Ala Val Asp Leu Glu Thr Asp Asp Leu Ile Gln Ser Thr Ile 1445 1450 1455 Arg Thr Gln Phe Glu Asp Cys Thr Val Leu Thr Ile Ala His Arg Leu 1460 1465 1470 Asn Thr Ile Met Asp Tyr Thr Arg Val Ile Val Leu Asp Lys Gly Glu 1475 1480 1485 Ile Gln Glu Tyr Gly Ala Pro Ser Asp Leu Leu Gln Gln Arg Gly Leu 1490 1495 1500 Phe Tyr Ser Met Ala Lys Asp Ala Gly Leu Val 1505 1510 1515 <210> SEQ ID NO 43 <211> LENGTH: 357 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 43 Phe Cys Arg Ala Gln Asp Leu Glu Tyr Leu Thr Gly Arg Val Trp Val 1 5 10 15 Gly Leu Trp Leu Val Val Phe Val Leu Ala Leu Val Ala Ala Glu Gly 20 25 30 Ser Phe Leu Val Arg Tyr Ile Ser Pro Phe Thr Gln Glu Ile Phe Ala 35 40 45 Phe Leu Ile Ser Leu Ile Phe Ile Tyr Glu Thr Phe Tyr Lys Leu Tyr 50 55 60 Lys Val Phe Thr Glu His Pro Leu Leu Pro Phe Tyr Pro Pro Glu Pro 65 70 75 80 Gly Gly Val Pro Gly Cys Trp Ser Gly Ala Lys Trp Gln Leu Pro Pro 85 90 95 Thr Glu Gly Pro Pro Ser Pro Arg Asn Gln Pro Asn Thr Ala Leu Leu 100 105 110 Ser Leu Ile Leu Met Leu Gly Thr Phe Phe Ile Ala Phe Phe Leu Arg 115 120 125 Lys Phe Arg Asn Ser Arg Phe Leu Gly Gly Lys Ala Arg Arg Ile Ile 130 135 140 Gly Asp Phe Gly Ile Pro Ile Ser Ile Leu Val Met Val Leu Val Asp 145 150 155 160 Tyr Ser Ile Thr Asp Thr Tyr Thr Gln Lys Leu Thr Val Pro Thr Gly 165 170 175 Leu Ser Val Thr Ser Pro Asp Lys Arg Ser Trp Phe Ile Pro Pro Leu 180 185 190 Gly Ser Ala Arg Pro Phe Pro Pro Trp Met Met Val Ala Ala Ala Val 195 200 205 Pro Ala Leu Leu Val Leu Ile Leu Ile Phe Met Glu Thr Gln Ile Thr 210 215 220 Ala Leu Ile Val Ser Gln Lys Ala Arg Arg Leu Leu Lys Gly Ser Gly 225 230 235 240 Phe His Leu Asp Leu Leu Leu Ile Gly Ser Leu Gly Gly Leu Cys Gly 245 250 255 Leu Phe Gly Leu Pro Trp Leu Thr Ala Ala Thr Val Arg Ser Val Thr 260 265 270 His Val Asn Ala Leu Thr Val Met Arg Thr Ala Ile Ala Pro Gly Asp 275 280 285 Lys Pro Gln Ile Gln Glu Val Arg Glu Gln Arg Val Thr Gly Val Leu 290 295 300 Ile Ala Ser Leu Val Gly Leu Ser Ile Val Met Gly Ala Val Leu Arg 305 310 315 320 Arg Ile Pro Leu Ala Val Leu Phe Gly Ile Phe Leu Tyr Met Gly Val 325 330 335 Thr Ser Leu Ser Gly Ile Gln Leu Ser Gln Arg Leu Leu Leu Ile Leu 340 345 350 Met Pro Ala Lys His 355 <210> SEQ ID NO 44 <211> LENGTH: 2147 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 44 Met Ala Phe Trp Thr Gln Leu Met Leu Leu Leu Trp Lys Asn Phe Met 1 5 10 15 Tyr Arg Arg Arg Gln Pro Val Gln Leu Leu Val Glu Leu Leu Trp Pro 20 25 30 Leu Phe Leu Phe Phe Ile Leu Val Ala Val Arg His Ser His Pro Pro 35 40 45 Leu Glu His His Glu Cys His Phe Pro Asn Lys Pro Leu Pro Ser Ala 50 55 60 Gly Thr Val Pro Trp Leu Gln Gly Leu Ile Cys Asn Val Asn Asn Thr 65 70 75 80 Cys Phe Pro Gln Leu Thr Pro Gly Glu Glu Pro Gly Arg Leu Ser Asn 85 90 95 Phe Asn Asp Ser Leu Val Ser Arg Leu Leu Ala Asp Ala Arg Thr Val 100 105 110 Leu Gly Gly Ala Ser Ala His Arg Thr Leu Ala Gly Leu Gly Lys Leu 115 120 125 Ile Ala Thr Leu Arg Ala Ala Arg Ser Thr Ala Gln Pro Gln Pro Thr 130 135 140 Lys Gln Ser Pro Leu Glu Pro Pro Met Leu Asp Val Ala Glu Leu Leu 145 150 155 160 Thr Ser Leu Leu Arg Thr Glu Ser Leu Gly Leu Ala Leu Gly Gln Ala 165 170 175 Gln Glu Pro Leu His Ser Leu Leu Glu Ala Ala Glu Asp Leu Ala Gln 180 185 190 Glu Leu Leu Ala Leu Arg Ser Leu Val Glu Leu Arg Ala Leu Leu Gln 195 200 205 Arg Pro Arg Gly Thr Ser Gly Pro Leu Glu Leu Leu Ser Glu Ala Leu 210 215 220 Cys Ser Val Arg Gly Pro Ser Ser Thr Val Gly Pro Ser Leu Asn Trp 225 230 235 240 Tyr Glu Ala Ser Asp Leu Met Glu Leu Val Gly Gln Glu Pro Glu Ser 245 250 255 Ala Leu Pro Asp Ser Ser Leu Ser Pro Ala Cys Ser Glu Leu Ile Gly 260 265 270 Ala Leu Asp Ser His Pro Leu Ser Arg Leu Leu Trp Arg Arg Leu Lys 275 280 285 Pro Leu Ile Leu Gly Lys Leu Leu Phe Ala Pro Asp Thr Pro Phe Thr 290 295 300 Arg Lys Leu Met Ala Gln Val Asn Arg Thr Phe Glu Glu Leu Thr Leu 305 310 315 320 Leu Arg Asp Val Arg Glu Val Trp Glu Met Leu Gly Pro Arg Ile Phe 325 330 335 Thr Phe Met Asn Asp Ser Ser Asn Val Ala Met Leu Gln Arg Leu Leu 340 345 350 Gln Met Gln Asp Glu Gly Arg Arg Gln Pro Arg Pro Gly Gly Arg Asp 355 360 365 His Met Glu Ala Leu Arg Ser Phe Leu Asp Pro Gly Ser Gly Gly Tyr 370 375 380 Ser Trp Gln Asp Ala His Ala Asp Val Gly His Leu Val Gly Thr Leu 385 390 395 400 Gly Arg Val Thr Glu Cys Leu Ser Leu Asp Lys Leu Glu Ala Ala Pro 405 410 415 Ser Glu Ala Ala Leu Val Ser Arg Ala Leu Gln Leu Leu Ala Glu His 420 425 430 Arg Phe Trp Ala Gly Val Val Phe Leu Gly Pro Glu Asp Ser Ser Asp 435 440 445 Pro Thr Glu His Pro Thr Pro Asp Leu Gly Pro Gly His Val Arg Ile 450 455 460 Lys Ile Arg Met Asp Ile Asp Val Val Thr Arg Thr Asn Lys Ile Arg 465 470 475 480 Asp Arg Phe Trp Asp Pro Gly Pro Ala Ala Asp Pro Leu Thr Asp Leu 485 490 495 Arg Tyr Val Trp Gly Gly Phe Val Tyr Leu Gln Asp Leu Val Glu Arg 500 505 510 Ala Ala Val Arg Val Leu Ser Gly Ala Asn Pro Arg Ala Gly Leu Tyr 515 520 525 Leu Gln Gln Met Pro Tyr Pro Cys Tyr Val Asp Asp Val Phe Leu Arg 530 535 540 Val Leu Ser Arg Ser Leu Pro Leu Phe Leu Thr Leu Ala Trp Ile Tyr 545 550 555 560 Ser Val Thr Leu Thr Val Lys Ala Val Val Arg Glu Lys Glu Thr Arg 565 570 575 Leu Arg Asp Thr Met Arg Ala Met Gly Leu Ser Arg Ala Val Leu Trp 580 585 590 Leu Gly Trp Phe Leu Ser Cys Leu Gly Pro Phe Leu Leu Ser Ala Ala 595 600 605 Leu Leu Val Leu Val Leu Lys Leu Gly Asp Ile Leu Pro Tyr Ser His 610 615 620 Pro Gly Val Val Phe Leu Phe Leu Ala Ala Phe Ala Val Ala Thr Val 625 630 635 640 Thr Gln Ser Phe Leu Leu Ser Ala Phe Phe Ser Arg Ala Asn Leu Ala 645 650 655 Ala Ala Cys Gly Gly Leu Ala Tyr Phe Ser Leu Tyr Leu Pro Tyr Val 660 665 670 Leu Cys Val Ala Trp Arg Asp Arg Leu Pro Ala Gly Gly Arg Val Ala 675 680 685 Ala Ser Leu Leu Ser Pro Val Ala Phe Gly Phe Gly Cys Glu Ser Leu 690 695 700 Ala Leu Leu Glu Glu Gln Gly Glu Gly Ala Gln Trp His Asn Val Gly 705 710 715 720 Thr Arg Pro Thr Ala Asp Val Phe Ser Leu Ala Gln Val Ser Gly Leu 725 730 735 Leu Leu Leu Asp Ala Ala Leu Tyr Gly Leu Ala Thr Trp Tyr Leu Glu 740 745 750 Ala Val Cys Pro Gly Gln Tyr Gly Ile Pro Glu Pro Trp Asn Phe Pro 755 760 765 Phe Arg Arg Ser Tyr Trp Cys Gly Pro Arg Pro Pro Lys Ser Pro Ala 770 775 780 Pro Cys Pro Thr Pro Leu Asp Pro Lys Val Leu Val Glu Glu Ala Pro 785 790 795 800 Pro Gly Leu Ser Pro Gly Val Ser Val Arg Ser Leu Glu Lys Arg Phe 805 810 815 Pro Gly Ser Pro Gln Pro Ala Leu Arg Gly Leu Ser Leu Asp Phe Tyr 820 825 830 Gln Gly His Ile Thr Ala Phe Leu Gly His Asn Gly Ala Gly Lys Thr 835 840 845 Thr Thr Leu Ser Ile Leu Ser Gly Leu Phe Pro Pro Ser Gly Gly Ser 850 855 860 Ala Phe Ile Leu Gly His Asp Val Arg Ser Ser Met Ala Ala Ile Arg 865 870 875 880 Pro His Leu Gly Val Cys Pro Gln Tyr Asn Val Leu Phe Asp Met Leu 885 890 895 Thr Val Asp Glu His Val Trp Phe Tyr Gly Arg Leu Lys Gly Leu Ser 900 905 910 Ala Ala Val Val Gly Pro Glu Gln Asp Arg Leu Leu Gln Asp Val Gly 915 920 925 Leu Val Ser Lys Gln Ser Val Gln Thr Arg His Leu Ser Gly Gly Met 930 935 940 Gln Arg Lys Leu Ser Val Ala Ile Ala Phe Val Gly Gly Ser Gln Val 945 950 955 960 Val Ile Leu Asp Glu Pro Thr Ala Gly Val Asp Pro Ala Ser Arg Arg 965 970 975 Gly Ile Trp Glu Leu Leu Leu Lys Tyr Arg Glu Gly Arg Thr Leu Ile 980 985 990 Leu Ser Thr His His Leu Asp Glu Ala Glu Leu Leu Gly Asp Arg Val 995 1000 1005 Ala Val Val Ala Gly Gly Arg Leu Cys Cys Cys Gly Ser Pro Leu Phe 1010 1015 1020 Leu Arg Arg His Leu Gly Ser Gly Tyr Tyr Leu Thr Leu Val Lys Ala 1025 1030 1035 1040 Arg Leu Pro Leu Thr Thr Asn Glu Lys Ala Asp Thr Asp Met Glu Gly 1045 1050 1055 Ser Val Asp Thr Arg Gln Glu Lys Lys Asn Gly Ser Gln Gly Ser Arg 1060 1065 1070 Val Gly Thr Pro Gln Leu Leu Ala Leu Val Gln His Trp Val Pro Gly 1075 1080 1085 Ala Arg Leu Val Glu Glu Leu Pro His Glu Leu Val Leu Val Leu Pro 1090 1095 1100 Tyr Thr Gly Ala His Asp Gly Ser Phe Ala Thr Leu Phe Arg Glu Leu 1105 1110 1115 1120 Asp Thr Arg Leu Ala Glu Leu Arg Leu Thr Gly Tyr Gly Ile Ser Asp 1125 1130 1135 Thr Ser Leu Glu Glu Ile Phe Leu Lys Val Val Glu Glu Cys Ala Ala 1140 1145 1150 Asp Thr Asp Met Glu Asp Gly Ser Cys Gly Gln His Leu Cys Thr Gly 1155 1160 1165 Ile Ala Gly Leu Asp Val Thr Leu Arg Leu Lys Met Pro Pro Gln Glu 1170 1175 1180 Thr Ala Leu Glu Asn Gly Glu Pro Ala Gly Ser Ala Pro Glu Thr Asp 1185 1190 1195 1200 Gln Gly Ser Gly Pro Asp Ala Val Gly Arg Val Gln Gly Trp Ala Leu 1205 1210 1215 Thr Arg Gln Gln Leu Gln Ala Leu Leu Leu Lys Arg Phe Leu Leu Ala 1220 1225 1230 Arg Arg Ser Arg Arg Gly Leu Phe Ala Gln Ile Val Leu Pro Ala Leu 1235 1240 1245 Phe Val Gly Leu Ala Leu Val Phe Ser Leu Ile Val Pro Pro Phe Gly 1250 1255 1260 His Tyr Pro Ala Leu Arg Leu Ser Pro Thr Met Tyr Gly Ala Gln Val 1265 1270 1275 1280 Ser Phe Phe Ser Glu Asp Ala Pro Gly Asp Pro Gly Arg Ala Arg Leu 1285 1290 1295 Leu Glu Ala Leu Leu Gln Glu Ala Gly Leu Glu Glu Pro Pro Val Gln 1300 1305 1310 His Ser Ser His Arg Phe Ser Ala Pro Glu Val Pro Ala Glu Val Ala 1315 1320 1325 Lys Val Leu Ala Ser Gly Asn Trp Thr Pro Glu Ser Pro Ser Pro Ala 1330 1335 1340 Cys Gln Cys Ser Arg Pro Gly Ala Arg Arg Leu Leu Pro Asp Cys Pro 1345 1350 1355 1360 Ala Ala Ala Gly Gly Pro Pro Pro Pro Gln Ala Val Thr Gly Ser Gly 1365 1370 1375 Glu Val Val Gln Asn Leu Thr Gly Arg Asn Leu Ser Asp Phe Leu Val 1380 1385 1390 Lys Thr Tyr Pro Arg Leu Val Arg Gln Gly Leu Lys Thr Lys Lys Trp 1395 1400 1405 Val Asn Glu Val Arg Tyr Gly Gly Phe Ser Leu Gly Gly Arg Asp Pro 1410 1415 1420 Gly Leu Pro Ser Gly Gln Glu Leu Gly Arg Ser Val Glu Glu Leu Trp 1425 1430 1435 1440 Ala Leu Leu Ser Pro Leu Pro Gly Gly Ala Leu Asp Arg Val Leu Lys 1445 1450 1455 Asn Leu Thr Ala Trp Ala His Ser Leu Asp Ala Gln Asp Ser Leu Lys 1460 1465 1470 Ile Trp Phe Asn Asn Lys Gly Trp His Ser Met Val Ala Phe Val Asn 1475 1480 1485 Arg Ala Ser Asn Ala Ile Leu Arg Ala His Leu Pro Pro Gly Pro Ala 1490 1495 1500 Arg His Ala His Ser Ile Thr Thr Leu Asn His Pro Leu Asn Leu Thr 1505 1510 1515 1520 Lys Glu Gln Leu Ser Glu Gly Ala Leu Met Ala Ser Ser Val Asp Val 1525 1530 1535 Leu Val Ser Ile Cys Val Val Phe Ala Met Ser Phe Val Pro Ala Ser 1540 1545 1550 Phe Thr Leu Val Leu Ile Glu Glu Arg Val Thr Arg Ala Lys His Leu 1555 1560 1565 Gln Leu Met Gly Gly Leu Ser Pro Thr Leu Tyr Trp Leu Gly Asn Phe 1570 1575 1580 Leu Trp Asp Met Cys Asn Tyr Leu Val Pro Ala Cys Ile Val Val Leu 1585 1590 1595 1600 Ile Phe Leu Ala Phe Gln Gln Arg Ala Tyr Val Ala Pro Ala Asn Leu 1605 1610 1615 Pro Ala Leu Leu Leu Leu Leu Leu Leu Tyr Gly Trp Ser Ile Thr Pro 1620 1625 1630 Leu Met Tyr Pro Ala Ser Phe Phe Phe Ser Val Pro Ser Thr Ala Tyr 1635 1640 1645 Val Val Leu Thr Cys Ile Asn Leu Phe Ile Gly Ile Asn Gly Ser Met 1650 1655 1660 Ala Thr Phe Val Leu Glu Leu Phe Ser Asp Gln Gln Lys Leu Gln Glu 1665 1670 1675 1680 Val Ser Arg Ile Leu Lys Gln Val Phe Leu Ile Phe Pro His Phe Cys 1685 1690 1695 Leu Gly Arg Gly Leu Ile Asp Met Val Arg Asn Gln Ala Met Ala Asp 1700 1705 1710 Ala Phe Glu Arg Leu Gly Asp Arg Gln Phe Gln Ser Pro Leu Arg Trp 1715 1720 1725 Glu Val Val Gly Lys Asn Leu Leu Ala Met Val Ile Gln Gly Pro Leu 1730 1735 1740 Phe Leu Leu Phe Thr Leu Leu Leu Gln His Arg Ser Gln Leu Leu Pro 1745 1750 1755 1760 Gln Pro Arg Val Arg Ser Leu Pro Leu Leu Gly Glu Glu Asp Glu Asp 1765 1770 1775 Val Ala Arg Glu Arg Glu Arg Val Val Gln Gly Ala Thr Gln Gly Asp 1780 1785 1790 Val Leu Val Leu Arg Asn Leu Thr Lys Val Tyr Arg Gly Gln Arg Met 1795 1800 1805 Pro Ala Val Asp Arg Leu Cys Leu Gly Ile Pro Pro Gly Glu Cys Phe 1810 1815 1820 Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Ser Thr Phe Arg Met 1825 1830 1835 1840 Val Thr Gly Asp Thr Leu Ala Ser Arg Gly Glu Ala Val Leu Ala Gly 1845 1850 1855 His Ser Val Ala Arg Glu Pro Ser Ala Ala His Leu Ser Met Gly Tyr 1860 1865 1870 Cys Pro Gln Ser Asp Ala Ile Phe Glu Leu Leu Thr Gly Arg Glu His 1875 1880 1885 Leu Glu Leu Leu Ala Arg Leu Arg Gly Val Pro Glu Ala Gln Val Ala 1890 1895 1900 Gln Thr Ala Gly Ser Gly Leu Ala Arg Leu Gly Leu Ser Trp Tyr Ala 1905 1910 1915 1920 Asp Arg Pro Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ala 1925 1930 1935 Thr Ala Leu Ala Leu Val Gly Asp Pro Ala Val Val Phe Leu Asp Glu 1940 1945 1950 Pro Thr Thr Gly Met Asp Pro Ser Ala Arg Arg Phe Leu Trp Asn Ser 1955 1960 1965 Leu Leu Ala Val Val Arg Glu Gly Arg Ser Val Met Leu Thr Ser His 1970 1975 1980 Ser Met Glu Glu Cys Glu Ala Leu Cys Ser Arg Leu Ala Ile Met Val 1985 1990 1995 2000 Asn Gly Arg Phe Arg Cys Leu Gly Ser Pro Gln His Leu Lys Gly Arg 2005 2010 2015 Phe Ala Ala Gly His Thr Leu Thr Leu Arg Val Pro Ala Ala Arg Ser 2020 2025 2030 Gln Pro Ala Ala Ala Phe Val Ala Ala Glu Phe Pro Gly Ala Glu Leu 2035 2040 2045 Arg Glu Ala His Gly Gly Arg Leu Arg Phe Gln Leu Pro Pro Gly Gly 2050 2055 2060 Arg Cys Ala Leu Ala Arg Val Phe Gly Glu Leu Ala Val His Gly Ala 2065 2070 2075 2080 Glu His Gly Val Glu Asp Phe Ser Val Ser Gln Thr Met Leu Glu Glu 2085 2090 2095 Val Phe Leu Tyr Phe Ser Lys Asp Gln Gly Lys Asp Glu Asp Thr Glu 2100 2105 2110 Glu Gln Lys Glu Ala Gly Val Gly Val Asp Pro Ala Pro Gly Leu Gln 2115 2120 2125 His Pro Lys Arg Val Ser Gln Phe Leu Asp Asp Pro Ser Thr Ala Glu 2130 2135 2140 Thr Val Leu 2145 <210> SEQ ID NO 45 <211> LENGTH: 650 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 45 Met Arg Leu Lys Asn Leu Thr Phe Ile Ile Ile Leu Ile Ile Ser Gly 1 5 10 15 Glu Leu Tyr Ala Glu Glu Lys Pro Cys Gly Phe Pro His Val Glu Asn 20 25 30 Gly Arg Ile Ala Gln Tyr Tyr Tyr Thr Phe Lys Ser Phe Tyr Phe Pro 35 40 45 Met Ser Ile Asp Lys Lys Leu Ser Phe Phe Cys Leu Ala Gly Tyr Thr 50 55 60 Thr Glu Ser Gly Arg Gln Glu Glu Gln Thr Thr Cys Thr Thr Glu Gly 65 70 75 80 Trp Ser Pro Glu Pro Arg Cys Phe Lys Lys Cys Thr Lys Pro Asp Leu 85 90 95 Ser Asn Gly Tyr Ile Ser Asp Val Lys Leu Leu Tyr Lys Ile Gln Glu 100 105 110 Asn Met His Tyr Gly Cys Ala Ser Gly Tyr Lys Thr Thr Gly Gly Lys 115 120 125 Asp Glu Glu Val Val Gln Cys Leu Ser Asp Gly Trp Ser Ser Gln Pro 130 135 140 Thr Cys Arg Lys Glu His Glu Thr Cys Leu Ala Pro Glu Leu Tyr Asn 145 150 155 160 Gly Asn Tyr Ser Thr Thr Gln Lys Thr Phe Lys Val Lys Asp Lys Val 165 170 175 Gln Tyr Glu Cys Ala Thr Gly Tyr Tyr Thr Ala Gly Gly Lys Lys Thr 180 185 190 Glu Glu Val Glu Cys Leu Thr Tyr Gly Trp Ser Leu Thr Pro Lys Cys 195 200 205 Thr Lys Leu Lys Cys Ser Ser Leu Arg Leu Ile Glu Asn Gly Tyr Phe 210 215 220 His Pro Val Lys Gln Thr Tyr Glu Glu Gly Asp Val Val Gln Phe Phe 225 230 235 240 Cys His Glu Asn Tyr Tyr Leu Ser Gly Ser Asp Leu Ile Gln Cys Tyr 245 250 255 Asn Phe Gly Trp Tyr Pro Glu Ser Pro Val Cys Glu Gly Arg Arg Asn 260 265 270 Arg Cys Pro Pro Pro Pro Leu Pro Ile Asn Ser Lys Ile Gln Thr His 275 280 285 Ser Thr Thr Tyr Arg His Gly Glu Ile Val His Ile Glu Cys Glu Leu 290 295 300 Asn Phe Glu Ile His Gly Ser Ala Glu Ile Arg Cys Glu Asp Gly Lys 305 310 315 320 Ser Thr Glu Pro Pro Lys Cys Ile Glu Gly Gln Glu Lys Val Ala Cys 325 330 335 Glu Glu Pro Pro Phe Ile Glu Asn Gly Ala Ala Asn Leu His Ser Lys 340 345 350 Ile Tyr Tyr Asn Gly Asp Lys Val Thr Tyr Ala Cys Lys Ser Gly Tyr 355 360 365 Leu Leu His Gly Ser Asn Glu Ile Thr Cys Asn Arg Gly Lys Trp Thr 370 375 380 Leu Pro Pro Glu Cys Val Glu Asn Asn Glu Asn Cys Lys His Pro Pro 385 390 395 400 Val Val Met Asn Gly Ala Val Ala Asp Gly Ile Leu Ala Ser Tyr Ala 405 410 415 Thr Gly Ser Ser Val Glu Tyr Arg Cys Asn Glu Tyr Tyr Leu Leu Arg 420 425 430 Gly Ser Lys Ile Ser Arg Cys Glu Gln Gly Lys Trp Ser Ser Pro Pro 435 440 445 Val Cys Leu Glu Pro Cys Thr Val Asn Val Asp Tyr Met Asn Arg Asn 450 455 460 Asn Ile Glu Met Lys Trp Lys Tyr Glu Gly Lys Val Leu His Gly Asp 465 470 475 480 Leu Ile Asp Phe Val Cys Lys Gln Gly Tyr Asp Leu Ser Pro Leu Thr 485 490 495 Pro Leu Ser Glu Leu Ser Val Gln Cys Asn Arg Gly Glu Val Lys Tyr 500 505 510 Pro Leu Cys Thr Arg Lys Glu Ser Lys Gly Met Cys Thr Ser Pro Pro 515 520 525 Leu Ile Lys His Gly Val Ile Ile Ser Ser Thr Val Asp Thr Tyr Glu 530 535 540 Asn Gly Ser Ser Val Glu Tyr Arg Cys Phe Asp His His Phe Leu Glu 545 550 555 560 Gly Ser Arg Glu Ala Tyr Cys Leu Asp Gly Met Trp Thr Thr Pro Pro 565 570 575 Leu Cys Leu Glu Pro Cys Thr Leu Ser Phe Thr Glu Met Glu Lys Asn 580 585 590 Asn Leu Leu Leu Lys Trp Asp Phe Asp Asn Arg Pro His Ile Leu His 595 600 605 Gly Glu Tyr Ile Glu Phe Ile Cys Arg Gly Asp Thr Tyr Pro Ala Glu 610 615 620 Leu Tyr Ile Thr Gly Ser Ile Leu Arg Met Gln Cys Asp Arg Gly Gln 625 630 635 640 Leu Lys Tyr Pro Arg Cys Ile Pro Arg Gln 645 650 <210> SEQ ID NO 46 <211> LENGTH: 2496 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 46 Met Gly Ala Ala Ala Gly Arg Ser Pro His Leu Gly Pro Ala Pro Ala 1 5 10 15 Arg Arg Pro Gln Arg Ser Leu Leu Leu Leu Gln Leu Leu Leu Leu Val 20 25 30 Ala Ala Pro Gly Ser Thr Gln Ala Gln Ala Ala Pro Phe Pro Glu Leu 35 40 45 Cys Ser Tyr Thr Trp Glu Ala Val Asp Thr Lys Asn Asn Val Leu Tyr 50 55 60 Lys Ile Asn Ile Cys Gly Ser Val Asp Ile Val Gln Cys Gly Pro Ser 65 70 75 80 Ser Ala Val Cys Met His Asp Leu Lys Thr Arg Thr Tyr His Ser Val 85 90 95 Gly Asp Ser Val Leu Arg Ser Ala Thr Arg Ser Leu Leu Glu Phe Asn 100 105 110 Thr Thr Val Ser Cys Asp Gln Gln Gly Thr Asn His Arg Val Gln Ser 115 120 125 Ser Ile Ala Phe Leu Cys Gly Lys Thr Leu Gly Thr Pro Glu Phe Val 130 135 140 Thr Ala Thr Glu Cys Val His Tyr Phe Glu Trp Arg Thr Thr Ala Ala 145 150 155 160 Cys Lys Lys Asp Ile Phe Lys Ala Asn Lys Glu Val Pro Cys Tyr Val 165 170 175 Phe Asp Glu Glu Leu Arg Lys His Asp Leu Asn Pro Leu Ile Lys Leu 180 185 190 Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp Pro Asp Thr Ser Leu Phe 195 200 205 Ile Asn Val Cys Arg Asp Ile Asp Thr Leu Arg Asp Pro Gly Ser Gln 210 215 220 Leu Arg Ala Cys Pro Pro Gly Thr Ala Ala Cys Leu Val Arg Gly His 225 230 235 240 Gln Ala Phe Asp Val Gly Gln Pro Arg Asp Gly Leu Lys Leu Val Arg 245 250 255 Lys Asp Arg Leu Val Leu Ser Tyr Val Arg Glu Glu Ala Gly Lys Leu 260 265 270 Asp Phe Cys Asp Gly His Ser Pro Ala Val Thr Ile Thr Phe Val Cys 275 280 285 Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro Lys Leu Thr Ala Lys Ser 290 295 300 Asn Cys Arg Tyr Glu Ile Glu Trp Ile Thr Glu Tyr Ala Cys His Arg 305 310 315 320 Asp Tyr Leu Glu Ser Lys Thr Cys Ser Leu Ser Gly Glu Gln Gln Asp 325 330 335 Val Ser Ile Asp Leu Thr Pro Leu Ala Gln Ser Gly Gly Ser Ser Tyr 340 345 350 Ile Ser Asp Gly Lys Glu Tyr Leu Phe Tyr Leu Asn Val Cys Gly Glu 355 360 365 Thr Glu Ile Gln Phe Cys Asn Lys Lys Gln Ala Ala Val Cys Gln Val 370 375 380 Lys Lys Ser Asp Thr Ser Gln Val Lys Ala Ala Gly Arg Tyr His Asn 385 390 395 400 Gln Thr Leu Arg Tyr Ser Asp Gly Asp Leu Thr Leu Ile Tyr Phe Gly 405 410 415 Gly Asp Glu Cys Ser Ser Gly Phe Gln Arg Met Ser Val Ile Asn Phe 420 425 430 Glu Cys Asn Lys Thr Ala Gly Asn Asp Gly Lys Gly Thr Pro Val Phe 435 440 445 Thr Gly Glu Val Asp Cys Thr Tyr Phe Phe Thr Trp Asp Thr Glu Tyr 450 455 460 Ala Cys Val Lys Glu Lys Glu Asp Leu Leu Cys Gly Ala Thr Asp Gly 465 470 475 480 Lys Lys Arg Tyr Asp Leu Ser Ala Leu Val Arg His Ala Glu Pro Glu 485 490 495 Gln Asn Trp Glu Ala Val Asp Gly Ser Gln Thr Glu Thr Glu Lys Lys 500 505 510 His Phe Phe Ile Asn Ile Cys His Arg Val Leu Gln Glu Gly Lys Ala 515 520 525 Arg Gly Cys Pro Glu Asp Ala Ala Val Cys Ala Val Asp Lys Asn Gly 530 535 540 Ser Lys Asn Leu Gly Lys Phe Ile Ser Ser Pro Met Lys Glu Lys Gly 545 550 555 560 Asn Ile Gln Leu Ser Tyr Ser Asp Gly Asp Asp Cys Gly His Gly Lys 565 570 575 Lys Ile Lys Thr Asn Ile Thr Leu Val Cys Lys Pro Gly Asp Leu Glu 580 585 590 Ser Ala Pro Val Leu Arg Thr Ser Gly Glu Gly Gly Cys Phe Tyr Glu 595 600 605 Phe Glu Trp His Thr Ala Ala Ala Cys Val Leu Ser Lys Thr Glu Gly 610 615 620 Glu Asn Cys Thr Val Phe Asp Ser Gln Ala Gly Phe Ser Phe Asp Leu 625 630 635 640 Ser Pro Leu Thr Lys Lys Asn Gly Ala Tyr Lys Val Glu Thr Lys Lys 645 650 655 Tyr Asp Phe Tyr Ile Asn Val Cys Gly Pro Val Ser Val Ser Pro Cys 660 665 670 Gln Pro Asp Ser Gly Ala Cys Gln Val Ala Lys Arg Gln Val Ala Ser 675 680 685 His Asp Glu Lys Thr Trp Asn Leu Gly Leu Ser Asn Ala Lys Leu Ser 690 695 700 Tyr Tyr Asp Gly Met Ile Gln Leu Asn Tyr Arg Gly Gly Thr Pro Tyr 705 710 715 720 Asn Asn Glu Arg His Thr Pro Arg Ala Thr Leu Ile Thr Phe Leu Cys 725 730 735 Asp Arg Asp Ala Gly Val Gly Phe Pro Glu Tyr Gln Glu Glu Asp Asn 740 745 750 Ser Thr Tyr Asn Phe Arg Trp Tyr Thr Ser Tyr Ala Cys Pro Glu Glu 755 760 765 Pro Leu Glu Cys Val Val Thr Asp Pro Ser Thr Leu Glu Gln Tyr Asp 770 775 780 Leu Ser Ser Leu Ala Lys Ser Glu Gly Gly Leu Gly Gly Asn Trp Tyr 785 790 795 800 Ala Met Asp Asn Ser Gly Glu His Val Thr Trp Arg Lys Tyr Tyr Ile 805 810 815 Asn Val Cys Arg Pro Leu Asn Pro Val Pro Gly Cys Asn Arg Tyr Ala 820 825 830 Ser Ala Cys Gln Met Lys Tyr Glu Lys Asp Gln Gly Ser Phe Thr Glu 835 840 845 Val Val Ser Ile Ser Asn Leu Gly Met Ala Lys Thr Gly Pro Val Val 850 855 860 Glu Asp Ser Gly Ser Leu Leu Leu Glu Tyr Val Asn Gly Ser Ala Cys 865 870 875 880 Thr Thr Ser Asp Gly Arg Gln Thr Thr Tyr Thr Thr Arg Ile His Leu 885 890 895 Val Cys Ser Arg Gly Arg Leu Asn Ser His Pro Ile Phe Ser Leu Asn 900 905 910 Trp Glu Cys Val Val Ser Phe Leu Trp Asn Thr Glu Ala Ala Cys Pro 915 920 925 Ile Gln Thr Thr Thr Asp Thr Asp Gln Ala Cys Ser Ile Arg Asp Pro 930 935 940 Asn Ser Gly Phe Val Phe Asn Leu Asn Pro Leu Asn Ser Ser Gln Gly 945 950 955 960 Tyr Asn Val Ser Gly Ile Gly Lys Ile Phe Met Phe Asn Val Cys Gly 965 970 975 Thr Met Pro Val Cys Gly Thr Ile Leu Gly Lys Pro Ala Ser Gly Cys 980 985 990 Glu Ala Glu Thr Gln Thr Glu Glu Leu Lys Asn Trp Lys Pro Ala Arg 995 1000 1005 Pro Val Gly Ile Glu Lys Ser Leu Gln Leu Ser Thr Glu Gly Phe Ile 1010 1015 1020 Thr Leu Thr Tyr Lys Gly Pro Leu Ser Ala Lys Gly Thr Ala Asp Ala 1025 1030 1035 1040 Phe Ile Val Arg Phe Val Cys Asn Asp Asp Val Tyr Ser Gly Pro Leu 1045 1050 1055 Lys Phe Leu His Gln Asp Ile Asp Ser Gly Gln Gly Ile Arg Asn Thr 1060 1065 1070 Tyr Phe Glu Phe Glu Thr Ala Leu Ala Cys Val Pro Ser Pro Val Asp 1075 1080 1085 Cys Gln Val Thr Asp Leu Ala Gly Asn Glu Tyr Asp Leu Thr Gly Leu 1090 1095 1100 Ser Thr Val Arg Lys Pro Trp Thr Ala Val Asp Thr Ser Val Asp Gly 1105 1110 1115 1120 Arg Lys Arg Thr Phe Tyr Leu Ser Val Cys Asn Pro Leu Pro Tyr Ile 1125 1130 1135 Pro Gly Cys Gln Gly Asp Ala Val Gly Ser Cys Leu Val Ser Glu Gly 1140 1145 1150 Asn Ser Trp Asn Leu Gly Val Val Gln Met Ser Pro Gln Ala Ala Ala 1155 1160 1165 Asn Gly Ser Leu Ser Ile Met Tyr Val Asn Gly Asp Lys Cys Gly Asn 1170 1175 1180 Gln Arg Phe Ser Thr Arg Ile Thr Phe Glu Cys Ala Gln Ile Ser Gly 1185 1190 1195 1200 Ser Pro Ala Phe Gln Leu Gln Asp Gly Cys Glu Tyr Val Phe Ile Trp 1205 1210 1215 Arg Thr Val Glu Ala Cys Pro Val Val Arg Val Glu Gly Asp Asn Cys 1220 1225 1230 Glu Val Lys Asp Pro Arg His Gly Asn Leu Tyr Asp Leu Lys Pro Leu 1235 1240 1245 Gly Leu Asn Asp Thr Ile Val Ser Ala Gly Glu Tyr Thr Tyr Tyr Phe 1250 1255 1260 Arg Val Cys Gly Lys Leu Ser Ser Asp Val Cys Pro Thr Ser Asp Lys 1265 1270 1275 1280 Ser Lys Val Val Ser Ser Cys Gln Glu Lys Arg Glu Pro Gln Gly Phe 1285 1290 1295 His Lys Val Ala Gly Leu Leu Thr Gln Lys Leu Thr Tyr Glu Asn Gly 1300 1305 1310 Leu Leu Lys Met Asn Phe Thr Gly Gly Asp Thr Cys His Lys Val Tyr 1315 1320 1325 Gln Arg Ser Thr Ala Ile Phe Phe Tyr Cys Asp Arg Gly Thr Gln Arg 1330 1335 1340 Pro Val Phe Leu Lys Glu Thr Ser Asp Cys Ser Tyr Leu Phe Glu Trp 1345 1350 1355 1360 Arg Thr Gln Tyr Ala Cys Pro Pro Phe Asp Leu Thr Glu Cys Ser Phe 1365 1370 1375 Lys Asp Gly Ala Gly Asn Ser Phe Asp Leu Ser Ser Leu Ser Arg Tyr 1380 1385 1390 Ser Asp Asn Trp Glu Ala Ile Thr Gly Thr Gly Asp Pro Glu His Tyr 1395 1400 1405 Leu Ile Asn Val Cys Lys Ser Leu Ala Pro Gln Ala Gly Thr Glu Pro 1410 1415 1420 Cys Pro Pro Glu Ala Ala Ala Cys Leu Leu Gly Gly Ser Lys Pro Val 1425 1430 1435 1440 Asn Leu Gly Arg Val Arg Asp Gly Pro Gln Trp Arg Asp Gly Ile Ile 1445 1450 1455 Val Leu Lys Tyr Val Asp Gly Asp Leu Cys Pro Asp Gly Ile Arg Lys 1460 1465 1470 Lys Ser Thr Thr Ile Arg Phe Thr Cys Ser Glu Ser Gln Val Asn Ser 1475 1480 1485 Arg Pro Met Phe Ile Ser Ala Val Glu Asp Cys Glu Tyr Thr Phe Ala 1490 1495 1500 Trp Pro Thr Ala Thr Ala Cys Pro Met Lys Ser Asn Glu His Asp Asp 1505 1510 1515 1520 Cys Gln Val Thr Asn Pro Ser Thr Gly His Leu Phe Asp Leu Ser Ser 1525 1530 1535 Leu Ser Gly Arg Ala Gly Phe Thr Ala Ala Tyr Ser Glu Lys Gly Leu 1540 1545 1550 Val Tyr Met Ser Ile Cys Gly Glu Asn Glu Asn Cys Pro Pro Gly Val 1555 1560 1565 Gly Ala Cys Phe Gly Gln Thr Arg Ile Ser Val Gly Lys Ala Asn Lys 1570 1575 1580 Arg Leu Arg Tyr Val Asp Gln Val Leu Gln Leu Val Tyr Lys Asp Gly 1585 1590 1595 1600 Ser Pro Cys Pro Ser Lys Ser Gly Leu Ser Tyr Lys Ser Val Ile Ser 1605 1610 1615 Phe Val Cys Arg Pro Glu Ala Arg Pro Thr Asn Arg Pro Met Leu Ile 1620 1625 1630 Ser Leu Asp Lys Gln Thr Cys Thr Leu Phe Phe Ser Trp His Thr Pro 1635 1640 1645 Leu Ala Cys Glu Gln Ala Thr Glu Cys Ser Val Arg Asn Gly Ser Ser 1650 1655 1660 Ile Val Asp Leu Ser Pro Leu Ile His Arg Thr Gly Gly Tyr Glu Ala 1665 1670 1675 1680 Tyr Asp Glu Ser Glu Asp Asp Ala Ser Asp Thr Asn Pro Asp Phe Tyr 1685 1690 1695 Ile Asn Ile Cys Gln Pro Leu Asn Pro Met His Gly Val Pro Cys Pro 1700 1705 1710 Ala Gly Ala Ala Val Cys Lys Val Pro Ile Asp Gly Pro Pro Ile Asp 1715 1720 1725 Ile Gly Arg Val Ala Gly Pro Pro Ile Leu Asn Pro Ile Ala Asn Glu 1730 1735 1740 Ile Tyr Leu Asn Phe Glu Ser Ser Thr Pro Cys Leu Ala Asp Lys His 1745 1750 1755 1760 Phe Asn Tyr Thr Ser Leu Ile Ala Phe His Cys Lys Arg Gly Val Ser 1765 1770 1775 Met Gly Thr Pro Lys Leu Leu Arg Thr Ser Glu Cys Asp Phe Val Phe 1780 1785 1790 Glu Trp Glu Thr Pro Val Val Cys Pro Asp Glu Val Arg Met Asp Gly 1795 1800 1805 Cys Thr Leu Thr Asp Glu Gln Leu Leu Tyr Ser Phe Asn Leu Ser Ser 1810 1815 1820 Leu Ser Thr Ser Thr Phe Lys Val Thr Arg Asp Ser Arg Thr Tyr Ser 1825 1830 1835 1840 Val Gly Val Cys Thr Phe Ala Val Gly Pro Glu Gln Gly Gly Cys Lys 1845 1850 1855 Asp Gly Gly Val Cys Leu Leu Ser Gly Thr Lys Gly Ala Ser Phe Gly 1860 1865 1870 Arg Leu Gln Ser Met Lys Leu Asp Tyr Arg His Gln Asp Glu Ala Val 1875 1880 1885 Val Leu Ser Tyr Val Asn Gly Asp Arg Cys Pro Pro Glu Thr Asp Asp 1890 1895 1900 Gly Val Pro Cys Val Phe Pro Phe Ile Phe Asn Gly Lys Ser Tyr Glu 1905 1910 1915 1920 Glu Cys Ile Ile Glu Ser Arg Ala Lys Leu Trp Cys Ser Thr Thr Ala 1925 1930 1935 Asp Tyr Asp Arg Asp His Glu Trp Gly Phe Cys Arg His Ser Asn Ser 1940 1945 1950 Tyr Arg Thr Ser Ser Ile Ile Phe Lys Cys Asp Glu Asp Glu Asp Ile 1955 1960 1965 Gly Arg Pro Gln Val Phe Ser Glu Val Arg Gly Cys Asp Val Thr Phe 1970 1975 1980 Glu Trp Lys Thr Lys Val Val Cys Pro Pro Lys Lys Leu Glu Cys Lys 1985 1990 1995 2000 Phe Val Gln Lys His Lys Thr Tyr Asp Leu Arg Leu Leu Ser Ser Leu 2005 2010 2015 Thr Gly Ser Trp Ser Leu Val His Asn Gly Val Ser Tyr Tyr Ile Asn 2020 2025 2030 Leu Cys Gln Lys Ile Tyr Lys Gly Pro Leu Gly Cys Ser Glu Arg Ala 2035 2040 2045 Ser Ile Cys Arg Arg Thr Thr Thr Gly Asp Val Gln Val Leu Gly Leu 2050 2055 2060 Val His Thr Gln Lys Leu Gly Val Ile Gly Asp Lys Val Val Val Thr 2065 2070 2075 2080 Tyr Ser Lys Gly Tyr Pro Cys Gly Gly Asn Lys Thr Ala Ser Ser Val 2085 2090 2095 Ile Glu Leu Thr Cys Thr Lys Thr Val Gly Arg Pro Ala Phe Lys Arg 2100 2105 2110 Phe Asp Ile Asp Ser Cys Thr Tyr Tyr Phe Ser Trp Asp Ser Arg Ala 2115 2120 2125 Ala Cys Ala Val Lys Pro Gln Glu Val Gln Met Val Asn Gly Thr Ile 2130 2135 2140 Thr Asn Pro Ile Asn Gly Lys Ser Phe Ser Leu Gly Asp Ile Tyr Phe 2145 2150 2155 2160 Lys Leu Phe Arg Ala Ser Gly Asp Met Arg Thr Asn Gly Asp Asn Tyr 2165 2170 2175 Leu Tyr Glu Ile Gln Leu Ser Ser Ile Thr Ser Ser Arg Asn Pro Ala 2180 2185 2190 Cys Ser Gly Ala Asn Ile Cys Gln Val Lys Pro Asn Asp Gln His Phe 2195 2200 2205 Ser Arg Lys Val Gly Thr Ser Asp Lys Thr Lys Tyr Tyr Leu Gln Asp 2210 2215 2220 Gly Asp Leu Asp Val Val Phe Ala Ser Ser Ser Lys Cys Gly Lys Asp 2225 2230 2235 2240 Lys Thr Lys Ser Val Ser Ser Thr Ile Phe Phe His Cys Asp Pro Leu 2245 2250 2255 Val Glu Asp Gly Ile Pro Glu Phe Ser His Glu Thr Ala Asp Cys Gln 2260 2265 2270 Tyr Leu Phe Ser Trp Tyr Thr Ser Ala Val Cys Pro Leu Gly Val Gly 2275 2280 2285 Phe Asp Ser Glu Asn Pro Gly Asp Asp Gly Gln Met His Lys Gly Leu 2290 2295 2300 Ser Glu Arg Ser Gln Ala Val Gly Ala Val Leu Ser Leu Leu Leu Val 2305 2310 2315 2320 Ala Leu Thr Cys Cys Leu Leu Ala Leu Leu Leu Tyr Lys Lys Glu Arg 2325 2330 2335 Arg Glu Thr Val Ile Ser Lys Leu Thr Thr Cys Cys Arg Arg Ser Ser 2340 2345 2350 Asn Val Ser Tyr Lys Tyr Ser Lys Val Asn Lys Glu Glu Glu Thr Asp 2355 2360 2365 Glu Asn Glu Thr Glu Trp Leu Met Glu Glu Ile Gln Leu Pro Pro Pro 2370 2375 2380 Arg Gln Gly Lys Glu Gly Gln Glu Asn Gly His Ile Thr Thr Lys Ser 2385 2390 2395 2400 Val Lys Ala Leu Ser Ser Leu His Gly Asp Asp Gln Asp Ser Glu Asp 2405 2410 2415 Glu Val Leu Thr Ile Pro Glu Val Lys Val His Ser Gly Arg Gly Ala 2420 2425 2430 Gly Ala Glu Ser Ser His Pro Val Arg Asn Ala Gln Ser Asn Ala Leu 2435 2440 2445 Gln Glu Arg Glu Asp Asp Arg Val Gly Leu Val Arg Gly Glu Lys Ala 2450 2455 2460 Arg Lys Gly Lys Ser Ser Ser Ala Gln Gln Lys Thr Val Ser Ser Thr 2465 2470 2475 2480 Lys Leu Val Ser Phe His Asp Asp Ser Asp Glu Asp Leu Leu His Ile 2485 2490 2495 <210> SEQ ID NO 47 <211> LENGTH: 561 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 47 Leu Gly Phe Ser Leu Pro Pro His Leu Leu Phe Arg Pro Arg Leu Asp 1 5 10 15 Leu Gln Phe Leu Gln Arg Phe Leu Gln Ile Leu Lys Val Leu Phe Pro 20 25 30 Ser Trp Ser Ser Gln Asn Ala Leu Met Phe Leu Thr Leu Leu Cys Leu 35 40 45 Thr Leu Leu Gly Asp Phe Asp Gln Phe Thr Cys Asn Leu Leu Tyr Val 50 55 60 Ser Trp Arg Lys Asp Leu Thr Glu His Leu His Arg Leu Tyr Phe Arg 65 70 75 80 Gly Arg Ala Tyr Tyr Thr Leu Asn Val Leu Arg Asp Asp Ile Asp Asn 85 90 95 Pro Asp Gln Arg Ile Ser Gln Asp Val Glu Arg Phe Cys Arg Gln Leu 100 105 110 Ser Ser Met Ala Ser Lys Leu Ile Ile Ser Pro Phe Thr Leu Val Tyr 115 120 125 Tyr Thr Tyr Gln Cys Phe Gln Ser Thr Gly Trp Leu Gly Pro Val Ser 130 135 140 Ile Phe Gly Tyr Phe Ile Leu Gly Thr Val Val Asn Lys Thr Leu Met 145 150 155 160 Gly Pro Ile Val Met Lys Leu Val His Gln Glu Lys Leu Glu Gly Asp 165 170 175 Phe Arg Phe Lys His Met Gln Ile Arg Val Asn Ala Glu Pro Ala Ala 180 185 190 Phe Tyr Arg Ala Gly His Val Glu His Met Arg Thr Asp Arg Arg Leu 195 200 205 Gln Arg Leu Leu Gln Thr Gln Arg Glu Leu Met Ser Lys Glu Leu Trp 210 215 220 Leu Tyr Ile Gly Ile Asn Thr Phe Asp Tyr Leu Gly Ser Ile Leu Ser 225 230 235 240 Tyr Val Val Ile Ala Ile Pro Ile Phe Ser Gly Val Tyr Gly Asp Leu 245 250 255 Ser Pro Ala Glu Leu Ser Thr Leu Val Ser Lys Asn Ala Phe Val Cys 260 265 270 Ile Tyr Leu Ile Ser Cys Phe Thr Gln Leu Ile Asp Leu Ser Thr Thr 275 280 285 Leu Ser Asp Val Ala Gly Tyr Thr His Arg Ile Gly Gln Leu Arg Glu 290 295 300 Thr Leu Leu Asp Met Ser Leu Lys Ser Gln Asp Cys Glu Ile Leu Gly 305 310 315 320 Glu Ser Glu Trp Gly Leu Asp Thr Pro Pro Gly Trp Pro Ala Ala Glu 325 330 335 Pro Ala Asp Thr Ala Phe Leu Leu Glu Arg Val Ser Ile Ser Ala Pro 340 345 350 Ser Ser Asp Lys Pro Leu Ile Lys Asp Leu Ser Leu Lys Ile Ser Glu 355 360 365 Gly Gln Ser Leu Leu Ile Thr Gly Asn Thr Gly Thr Gly Lys Thr Ser 370 375 380 Leu Leu Arg Val Leu Gly Gly Leu Trp Thr Ser Thr Arg Gly Ser Val 385 390 395 400 Gln Met Leu Thr Asp Phe Gly Pro His Gly Val Leu Phe Leu Pro Gln 405 410 415 Lys Pro Phe Phe Thr Asp Gly Thr Leu Arg Glu Gln Val Ile Tyr Pro 420 425 430 Leu Lys Glu Val Tyr Pro Asp Ser Gly Ser Ala Asp Asp Glu Arg Ile 435 440 445 Leu Arg Phe Leu Glu Leu Ala Gly Leu Ser Asn Leu Val Ala Arg Thr 450 455 460 Glu Gly Leu Asp Gln Gln Val Asp Trp Asn Trp Tyr Asp Val Leu Ser 465 470 475 480 Pro Gly Glu Met Gln Arg Leu Ser Phe Ala Arg Leu Phe Tyr Leu Gln 485 490 495 Pro Lys Tyr Ala Val Leu Asp Glu Ala Thr Ser Ala Leu Thr Glu Glu 500 505 510 Val Glu Ser Glu Leu Tyr Arg Ile Gly Gln Gln Leu Gly Met Thr Phe 515 520 525 Ile Ser Val Gly His Arg Gln Ser Leu Glu Lys Phe His Ser Leu Val 530 535 540 Leu Lys Leu Cys Gly Gly Gly Arg Trp Glu Leu Met Arg Ile Lys Val 545 550 555 560 Glu <210> SEQ ID NO 48 <211> LENGTH: 421 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 48 Met Ala Ala Thr Leu Ile Leu Glu Pro Ala Gly Arg Cys Cys Trp Asp 1 5 10 15 Glu Pro Val Arg Ile Ala Val Arg Gly Leu Ala Pro Glu Gln Pro Val 20 25 30 Thr Leu Arg Ala Ser Leu Arg Asp Glu Lys Gly Ala Leu Phe Gln Ala 35 40 45 His Ala Arg Tyr Arg Ala Asp Thr Leu Gly Glu Leu Asp Leu Glu Arg 50 55 60 Ala Pro Ala Leu Gly Gly Ser Phe Ala Gly Leu Glu Pro Met Gly Leu 65 70 75 80 Leu Trp Ala Leu Glu Pro Glu Lys Pro Leu Val Arg Leu Val Lys Arg 85 90 95 Asp Val Arg Thr Pro Leu Ala Val Glu Leu Glu Val Leu Asp Gly His 100 105 110 Asp Pro Asp Pro Gly Arg Leu Leu Cys Arg Val Arg His Glu Arg Tyr 115 120 125 Phe Leu Pro Pro Gly Val Arg Arg Glu Pro Val Arg Ala Gly Arg Val 130 135 140 Arg Gly Thr Leu Phe Leu Pro Pro Glu Pro Gly Pro Phe Pro Gly Ile 145 150 155 160 Val Asp Met Phe Gly Thr Gly Gly Gly Leu Leu Glu Tyr Arg Ala Ser 165 170 175 Leu Leu Ala Gly Lys Gly Phe Ala Val Met Ala Leu Ala Tyr Tyr Asn 180 185 190 Tyr Glu Asp Leu Pro Lys Thr Met Glu Thr Leu His Leu Glu Tyr Phe 195 200 205 Glu Glu Ala Val Asn Tyr Leu Leu Ser His Pro Glu Val Lys Gly Pro 210 215 220 Gly Val Gly Leu Leu Gly Ile Ser Lys Gly Gly Glu Leu Cys Leu Ser 225 230 235 240 Met Ala Ser Phe Leu Lys Gly Ile Thr Ala Ala Val Val Ile Asn Gly 245 250 255 Ser Val Ala Asn Val Gly Gly Thr Leu Arg Tyr Lys Gly Glu Thr Leu 260 265 270 Pro Pro Val Gly Val Asn Arg Asn Arg Ile Lys Val Thr Lys Asp Gly 275 280 285 Tyr Ala Asp Ile Val Asp Val Leu Asn Ser Pro Leu Glu Gly Pro Asp 290 295 300 Gln Lys Ser Phe Ile Pro Val Glu Arg Ala Glu Ser Thr Phe Leu Phe 305 310 315 320 Leu Val Gly Gln Asp Asp His Asn Trp Lys Ser Glu Phe Tyr Ala Asn 325 330 335 Glu Ala Cys Lys Arg Leu Gln Ala His Gly Arg Arg Lys Pro Gln Ile 340 345 350 Ile Cys Tyr Pro Glu Thr Gly His Tyr Ile Glu Pro Pro Tyr Phe Pro 355 360 365 Leu Cys Arg Ala Ser Leu His Ala Leu Val Gly Ser Pro Ile Ile Trp 370 375 380 Gly Gly Glu Pro Arg Ala His Ala Met Ala Gln Val Asp Ala Trp Lys 385 390 395 400 Gln Leu Gln Thr Phe Phe His Lys His Leu Gly Gly His Glu Gly Thr 405 410 415 Ile Pro Ser Lys Val 420 <210> SEQ ID NO 49 <211> LENGTH: 785 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION: (196)...(198) <223> OTHER INFORMATION: Xaa = Any Amino Acid <400> SEQUENCE: 49 Met Pro Lys Ala Pro Lys Gln Gln Pro Pro Glu Pro Glu Trp Ile Gly 1 5 10 15 Asp Gly Glu Ser Thr Ser Pro Ser Gly Glu Ala Gly Arg Gln Gly Arg 20 25 30 Asn Glu Gln Arg Gly Lys Arg Glu Glu Thr Ala Arg Phe Phe Glu Glu 35 40 45 Leu Ala Val Glu Asp Lys Gln Ala Gly Glu Glu Glu Lys Val Leu Lys 50 55 60 Glu Lys Glu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Lys Lys 65 70 75 80 Lys Arg Asp Thr Arg Lys Gly Arg Arg Lys Lys Asp Val Asp Asp Asp 85 90 95 Gly Glu Glu Lys Glu Leu Met Glu Arg Leu Lys Lys Leu Ser Val Pro 100 105 110 Thr Ser Asp Glu Glu Asp Glu Val Pro Ala Pro Lys Pro Arg Gly Gly 115 120 125 Lys Lys Thr Lys Gly Gly Asn Val Phe Ala Ala Leu Ile Gln Asp Gln 130 135 140 Ser Glu Glu Glu Glu Glu Glu Glu Lys His Pro Pro Lys Pro Ala Lys 145 150 155 160 Pro Glu Lys Asn Arg Ile Asn Lys Ala Val Ser Glu Glu Gln Gln Pro 165 170 175 Ala Leu Lys Gly Lys Lys Gly Lys Glu Glu Lys Ser Lys Gly Lys Ala 180 185 190 Lys Val Arg Xaa Xaa Xaa Phe Phe Leu Pro Ser Gln Met Glu Tyr Glu 195 200 205 Arg Gln Val Ala Ser Leu Lys Ala Ala Asn Ala Ala Glu Asn Asp Phe 210 215 220 Ser Val Ser Gln Ala Glu Met Ser Ser Arg Gln Ala Met Leu Glu Asn 225 230 235 240 Ala Ser Asp Ile Lys Leu Glu Lys Phe Ser Ile Ser Ala His Gly Lys 245 250 255 Glu Leu Phe Val Asn Ala Asp Leu Tyr Ile Val Ala Gly Arg Arg Tyr 260 265 270 Gly Leu Val Gly Pro Asn Gly Lys Gly Lys Thr Thr Leu Leu Lys His 275 280 285 Ile Ala Asn Arg Ala Leu Ser Ile Pro Pro Asn Ile Asp Val Leu Leu 290 295 300 Cys Glu Gln Glu Val Val Ala Asp Glu Thr Pro Ala Val Gln Ala Val 305 310 315 320 Leu Arg Ala Asp Thr Lys Arg Leu Lys Leu Leu Glu Glu Glu Arg Arg 325 330 335 Leu Gln Gly Gln Leu Glu Gln Gly Asp Asp Thr Ala Ala Glu Arg Leu 340 345 350 Glu Lys Val Tyr Glu Glu Leu Arg Ala Thr Gly Ala Ala Ala Ala Glu 355 360 365 Ala Lys Ala Arg Arg Ile Leu Ala Gly Leu Gly Phe Asp Pro Glu Met 370 375 380 Gln Asn Arg Pro Thr Gln Lys Phe Ser Gly Gly Trp Arg Met Arg Val 385 390 395 400 Ser Leu Ala Arg Ala Leu Phe Met Glu Pro Thr Leu Leu Met Leu Asp 405 410 415 Glu Pro Thr Asn His Leu Asp Leu Asn Ala Val Ile Trp Leu Asn Asn 420 425 430 Tyr Leu Gln Gly Trp Arg Lys Thr Leu Leu Ile Val Ser His Asp Gln 435 440 445 Gly Phe Leu Asp Asp Val Cys Thr Asp Ile Ile His Leu Asp Ala Gln 450 455 460 Arg Leu His Tyr Tyr Arg Gly Asn Tyr Met Thr Phe Lys Lys Met Tyr 465 470 475 480 Gln Gln Lys Gln Lys Glu Leu Leu Lys Gln Tyr Glu Lys Gln Glu Lys 485 490 495 Lys Leu Lys Glu Leu Lys Ala Gly Gly Lys Ser Thr Lys Gln Ala Glu 500 505 510 Lys Gln Thr Lys Glu Ala Leu Thr Arg Lys Gln Gln Lys Cys Arg Arg 515 520 525 Lys Asn Gln Asp Glu Glu Ser Gln Glu Ala Pro Glu Leu Leu Lys Arg 530 535 540 Pro Lys Glu Tyr Thr Val Arg Phe Thr Phe Pro Asp Pro Pro Pro Leu 545 550 555 560 Ser Pro Pro Val Leu Gly Leu His Gly Val Thr Phe Gly Tyr Gln Gly 565 570 575 Gln Lys Pro Leu Phe Lys Asn Leu Asp Phe Gly Ile Asp Met Asp Ser 580 585 590 Arg Ile Cys Ile Val Gly Pro Asn Gly Val Gly Lys Ser Thr Leu Leu 595 600 605 Leu Leu Leu Thr Gly Lys Leu Thr Pro Thr His Gly Glu Met Arg Lys 610 615 620 Asn His Arg Leu Lys Ile Gly Phe Phe Asn Gln Gln Tyr Ala Glu Gln 625 630 635 640 Leu Arg Met Glu Glu Thr Pro Thr Glu Tyr Leu Gln Arg Gly Phe Asn 645 650 655 Leu Pro Tyr Gln Asp Ala Arg Lys Cys Leu Gly Arg Phe Gly Leu Glu 660 665 670 Ser His Ala His Thr Ile Gln Ile Cys Lys Leu Ser Gly Gly Gln Lys 675 680 685 Ala Arg Val Val Phe Ala Glu Leu Ala Cys Arg Glu Pro Asp Val Leu 690 695 700 Ile Leu Asp Glu Pro Thr Asn Asn Leu Asp Ile Glu Ser Ile Asp Ala 705 710 715 720 Leu Gly Glu Ala Ile Asn Glu Tyr Lys Gly Ala Val Ile Val Val Ser 725 730 735 His Asp Ala Arg Leu Ile Thr Glu Thr Asn Cys Gln Leu Trp Val Val 740 745 750 Glu Glu Gln Ser Val Ser Gln Ile Asp Gly Asp Phe Glu Asp Tyr Lys 755 760 765 Arg Glu Val Leu Glu Ala Leu Gly Glu Val Met Val Ser Arg Pro Arg 770 775 780 Glu 785 <210> SEQ ID NO 50 <211> LENGTH: 405 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 50 Lys Met Leu Ser Ser Phe Leu Ser Pro Gln Asn Gly Thr Trp Ala Asp 1 5 10 15 Thr Phe Ser Leu Leu Leu Ala Leu Ala Val Ala Leu Tyr Leu Gly Tyr 20 25 30 Tyr Trp Ala Cys Val Leu Gln Arg Pro Arg Leu Val Ala Gly Pro Gln 35 40 45 Phe Leu Ala Phe Leu Glu Pro His Cys Ser Ile Thr Thr Glu Thr Phe 50 55 60 Tyr Pro Thr Leu Trp Cys Phe Glu Gly Arg Leu Gln Ser Ile Phe Gln 65 70 75 80 Val Leu Leu Gln Ser Gln Pro Leu Val Leu Tyr Gln Ser Asp Ile Leu 85 90 95 Gln Thr Pro Asp Gly Gly Gln Leu Leu Leu Asp Trp Ala Lys Gln Pro 100 105 110 Asp Ser Ser Gln Asp Pro Asp Pro Thr Thr Gln Pro Ile Val Leu Leu 115 120 125 Leu Pro Gly Ile Thr Gly Ser Ser Gln Asp Thr Tyr Val Leu His Leu 130 135 140 Val Asn Gln Ala Leu Arg Asp Gly Tyr Gln Ala Val Val Phe Asn Asn 145 150 155 160 Arg Gly Cys Arg Gly Glu Glu Leu Arg Thr His Arg Ala Phe Cys Ala 165 170 175 Ser Asn Thr Glu Asp Leu Glu Thr Val Val Asn His Ile Lys His Arg 180 185 190 Tyr Pro Gln Ala Pro Leu Leu Ala Val Gly Ile Ser Phe Gly Gly Ile 195 200 205 Leu Val Leu Asn His Leu Ala Gln Ala Arg Gln Ala Ala Gly Leu Val 210 215 220 Ala Ala Leu Thr Leu Ser Ala Cys Trp Asp Ser Phe Glu Thr Thr Arg 225 230 235 240 Ser Leu Glu Thr Pro Leu Asn Ser Leu Leu Phe Asn Gln Pro Leu Thr 245 250 255 Ala Gly Leu Cys Gln Leu Val Glu Arg Asn Arg Lys Val Ile Glu Lys 260 265 270 Val Val Asp Ile Asp Phe Val Leu Gln Ala Arg Thr Ile Arg Gln Phe 275 280 285 Asp Glu Arg Tyr Thr Ser Val Ala Phe Gly Tyr Gln Asp Cys Val Thr 290 295 300 Tyr Tyr Lys Ala Ala Ser Pro Arg Thr Lys Ile Asp Ala Ile Arg Ile 305 310 315 320 Pro Val Leu Tyr Leu Ser Ala Ala Asp Asp Pro Phe Ser Pro Val Cys 325 330 335 Ala Leu Pro Ile Gln Ala Ala Gln His Ser Pro Tyr Val Ala Leu Leu 340 345 350 Ile Thr Ala Arg Gly Gly His Ile Gly Phe Leu Glu Gly Leu Leu Pro 355 360 365 Trp Gln His Trp Tyr Met Ser Arg Leu Leu His Gln Tyr Ala Lys Ala 370 375 380 Ile Phe Gln Asp Pro Glu Gly Leu Pro Asp Leu Arg Ala Leu Leu Pro 385 390 395 400 Ser Glu Asp Arg Asn 405 <210> SEQ ID NO 51 <400> SEQUENCE: 51 000 <210> SEQ ID NO 52 <211> LENGTH: 284 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 52 Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 1 5 10 15 Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 20 25 30 Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 35 40 45 Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 50 55 60 Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 65 70 75 80 Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 85 90 95 Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 100 105 110 Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 115 120 125 Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 130 135 140 Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 145 150 155 160 Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 165 170 175 Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 180 185 190 Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His Ile Phe Ile 195 200 205 Pro Phe Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val Ile Ala Leu 210 215 220 Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp Val Ser Ile 225 230 235 240 His Cys Ala Lys Val Thr Leu Leu Val Pro Ile Pro Thr Gln Thr Thr 245 250 255 Val Leu Gln Asp Tyr Ser Ser Tyr Gly Ser Pro Thr His Ala Leu Ser 260 265 270 Leu Val Pro Lys Gln Asp Pro Tyr Gly Leu Met Arg 275 280 <210> SEQ ID NO 53 <211> LENGTH: 442 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 53 Met Ala Arg Gly Tyr Gly Ala Thr Val Ser Leu Val Leu Leu Gly Leu 1 5 10 15 Gly Leu Ala Leu Ala Val Ile Val Leu Ala Val Val Leu Ser Arg His 20 25 30 Gln Ala Pro Cys Gly Pro Gln Ala Phe Ala His Ala Ala Val Ala Ala 35 40 45 Asp Ser Lys Val Cys Ser Asp Ile Gly Arg Ala Ile Leu Gln Gln Gln 50 55 60 Gly Ser Pro Val Asp Ala Thr Ile Ala Ala Leu Val Cys Thr Ser Val 65 70 75 80 Val Asn Pro Gln Ser Met Gly Leu Gly Gly Gly Val Ile Phe Thr Ile 85 90 95 Tyr Asn Val Thr Thr Gly Ala Gln Trp Ile Gly Val Pro Gly Glu Leu 100 105 110 Arg Gly Tyr Ala Glu Ala His Arg Arg His Gly Arg Leu Pro Trp Ala 115 120 125 Gln Leu Phe Gln Pro Thr Ile Ala Leu Leu Arg Gly Gly His Val Val 130 135 140 Ala Pro Val Leu Ser Arg Phe Leu His Asn Ser Ile Leu Arg Pro Ser 145 150 155 160 Leu Gln Ala Ser Thr Leu Arg Gln Leu Phe Phe Asn Gly Thr Glu Pro 165 170 175 Leu Arg Pro Gln Asp Pro Leu Pro Trp Pro Ala Leu Ala Thr Thr Leu 180 185 190 Glu Thr Val Ala Thr Glu Gly Val Glu Val Phe Tyr Thr Gly Arg Leu 195 200 205 Gly Gln Met Leu Val Glu Asp Ile Ala Lys Glu Gly Ser Gln Leu Thr 210 215 220 Leu Gln Asp Leu Ala Lys Phe Gln Pro Glu Val Val Asp Ala Leu Glu 225 230 235 240 Val Pro Leu Gly Asp Tyr Thr Leu Tyr Ser Pro Pro Pro Pro Ala Gly 245 250 255 Gly Ala Ile Leu Ser Phe Ile Leu Asn Val Leu Arg Gly Phe Asn Phe 260 265 270 Ser Thr Glu Ser Met Ala Arg Pro Glu Gly Arg Val Asn Val Tyr His 275 280 285 His Leu Val Glu Thr Leu Lys Phe Ala Lys Gly Gln Arg Trp Arg Leu 290 295 300 Gly Asp Pro Arg Ser His Pro Lys Leu Gln Asn Ala Ser Arg Asp Leu 305 310 315 320 Leu Gly Glu Thr Leu Ala Gln Leu Ile Arg Gln Gln Ile Asp Gly Arg 325 330 335 Gly Asp His Gln Leu Ser His Tyr Ser Leu Ala Glu Ala Trp Gly His 340 345 350 Gly Thr Gly Thr Ser His Val Ser Val Leu Gly Glu Asp Gly Ser Ala 355 360 365 Val Ala Ala Thr Ser Thr Ile Asn Thr Pro Phe Gly Ala Met Val Tyr 370 375 380 Ser Pro Arg Thr Gly Ile Ile Leu Asn Asn Glu Leu Leu Asp Leu Cys 385 390 395 400 Glu Arg Cys Pro Arg Gly Ser Gly Thr Thr Pro Ser Pro Val Glu Thr 405 410 415 Gly Trp Val Glu Leu Pro Glu Gly Ala Gly Pro Gln Phe Gln Ala Ser 420 425 430 Val Pro His Pro Pro Trp Cys Pro Pro Ser 435 440 <210> SEQ ID NO 54 <211> LENGTH: 1047 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 54 Met Ala Val Thr Leu Asp Lys Asp Ala Tyr Tyr Arg Arg Val Lys Arg 1 5 10 15 Leu Tyr Ser Asn Trp Arg Lys Gly Glu Asp Glu Tyr Ala Asn Val Asp 20 25 30 Ala Ile Val Val Ser Val Gly Val Asp Glu Glu Ile Val Tyr Ala Lys 35 40 45 Ser Thr Ala Leu Gln Thr Trp Leu Phe Gly Tyr Glu Leu Thr Asp Thr 50 55 60 Ile Met Val Phe Cys Asp Asp Lys Ile Ile Phe Met Ala Ser Lys Lys 65 70 75 80 Lys Val Glu Phe Leu Lys Gln Ile Ala Asn Thr Lys Gly Asn Glu Asn 85 90 95 Ala Asn Gly Ala Pro Ala Ile Thr Leu Leu Ile Arg Glu Lys Asn Glu 100 105 110 Ser Asn Lys Ser Ser Phe Asp Lys Met Ile Glu Ala Ile Lys Glu Ser 115 120 125 Lys Asn Gly Lys Lys Ile Gly Val Phe Ser Lys Asp Lys Phe Pro Gly 130 135 140 Glu Phe Met Lys Ser Trp Asn Asp Cys Leu Asn Lys Glu Gly Phe Asp 145 150 155 160 Lys Ile Asp Ile Ser Ala Val Val Ala Tyr Thr Ile Ala Val Lys Glu 165 170 175 Asp Gly Glu Leu Asn Leu Met Lys Lys Ala Ala Ser Ile Thr Ser Glu 180 185 190 Val Phe Asn Lys Phe Phe Lys Glu Arg Val Met Glu Ile Val Asp Ala 195 200 205 Asp Glu Lys Val Arg His Ser Lys Leu Ala Glu Ser Val Glu Lys Ala 210 215 220 Ile Glu Glu Lys Lys Tyr Leu Ala Gly Ala Asp Pro Ser Thr Val Glu 225 230 235 240 Met Cys Tyr Pro Pro Ile Ile Gln Ser Gly Gly Asn Tyr Asn Leu Lys 245 250 255 Phe Ser Val Val Ser Asp Lys Asn His Met His Phe Gly Ala Ile Thr 260 265 270 Cys Ala Met Gly Ile Arg Phe Lys Ser Tyr Cys Ser Asn Leu Val Arg 275 280 285 Thr Leu Met Val Asp Pro Ser Gln Glu Val Gln Glu Asn Tyr Asn Phe 290 295 300 Leu Leu Gln Leu Gln Glu Glu Leu Leu Lys Glu Leu Arg His Gly Val 305 310 315 320 Lys Ile Cys Asp Val Tyr Asn Ala Val Met Asp Val Val Lys Lys Gln 325 330 335 Lys Pro Glu Leu Leu Asn Lys Ile Thr Lys Asn Leu Gly Phe Gly Met 340 345 350 Gly Ile Glu Phe Arg Glu Gly Ser Leu Val Ile Asn Ser Lys Asn Gln 355 360 365 Tyr Lys Leu Lys Lys Gly Met Val Phe Ser Ile Asn Leu Gly Phe Ser 370 375 380 Asp Leu Thr Asn Lys Glu Gly Lys Lys Pro Glu Glu Lys Thr Tyr Ala 385 390 395 400 Leu Phe Ile Gly Asp Thr Val Leu Val Asp Glu Asp Gly Pro Ala Thr 405 410 415 Val Leu Thr Ser Val Lys Lys Lys Val Lys Asn Val Gly Ile Phe Leu 420 425 430 Lys Asn Glu Asp Glu Glu Glu Glu Glu Glu Glu Lys Asp Glu Ala Glu 435 440 445 Asp Leu Leu Gly Arg Gly Ser Arg Ala Ala Leu Leu Thr Glu Arg Thr 450 455 460 Arg Asn Glu Met Thr Ala Glu Glu Lys Arg Arg Ala His Gln Lys Glu 465 470 475 480 Leu Ala Ala Gln Leu Asn Glu Glu Ala Lys Arg Arg Leu Thr Glu Gln 485 490 495 Lys Gly Glu Gln Gln Ile Gln Lys Ala Arg Lys Ser Asn Val Ser Tyr 500 505 510 Lys Asn Pro Ser Leu Met Pro Lys Glu Pro His Ile Arg Glu Met Lys 515 520 525 Ile Tyr Ile Asp Lys Lys Tyr Glu Thr Val Ile Met Pro Val Phe Gly 530 535 540 Ile Ala Thr Pro Phe His Ile Ala Thr Ile Lys Asn Ile Ser Met Ser 545 550 555 560 Val Glu Gly Asp Tyr Thr Tyr Leu Arg Ile Asn Phe Tyr Cys Pro Gly 565 570 575 Ser Ala Leu Gly Arg Asn Glu Gly Asn Ile Phe Pro Asn Pro Glu Ala 580 585 590 Thr Phe Val Lys Glu Ile Thr Tyr Arg Ala Ser Asn Ile Lys Ala Pro 595 600 605 Gly Glu Gln Thr Val Pro Ala Leu Asn Leu Gln Asn Ala Phe Arg Ile 610 615 620 Ile Lys Glu Val Gln Lys Arg Tyr Lys Thr Arg Glu Ala Glu Glu Lys 625 630 635 640 Glu Lys Glu Gly Ile Val Lys Gln Asp Ser Leu Val Ile Asn Leu Asn 645 650 655 Arg Ser Asn Pro Lys Leu Lys Asp Leu Tyr Ile Arg Pro Asn Ile Ala 660 665 670 Gln Lys Arg Met Gln Gly Ser Leu Glu Ala His Val Asn Gly Phe Arg 675 680 685 Phe Thr Ser Val Arg Gly Asp Lys Val Asp Ile Leu Tyr Asn Asn Ile 690 695 700 Lys His Ala Leu Phe Gln Pro Cys Asp Gly Glu Met Ile Ile Val Leu 705 710 715 720 His Phe His Leu Lys Asn Ala Ile Met Phe Gly Lys Lys Arg His Thr 725 730 735 Asp Val Gln Phe Tyr Thr Glu Val Gly Glu Ile Thr Thr Asp Leu Gly 740 745 750 Lys His Gln His Met His Asp Arg Asp Asp Leu Tyr Ala Glu Gln Met 755 760 765 Glu Arg Glu Met Arg His Lys Leu Lys Thr Ala Phe Lys Asn Phe Ile 770 775 780 Glu Lys Val Glu Ala Leu Thr Lys Glu Glu Leu Glu Phe Glu Val Pro 785 790 795 800 Phe Arg Asp Leu Gly Phe Asn Gly Ala Pro Tyr Arg Ser Thr Cys Leu 805 810 815 Leu Gln Pro Thr Ser Ser Ala Leu Val Asn Ala Thr Glu Trp Pro Pro 820 825 830 Phe Val Val Thr Leu Asp Glu Val Glu Leu Ile His Phe Glu Arg Val 835 840 845 Gln Phe His Leu Lys Asn Phe Asp Met Val Ile Val Tyr Lys Asp Tyr 850 855 860 Ser Lys Lys Val Thr Met Ile Asn Ala Ile Pro Val Ala Ser Leu Asp 865 870 875 880 Pro Ile Lys Glu Trp Leu Asn Ser Cys Asp Leu Lys Tyr Thr Glu Gly 885 890 895 Val Gln Ser Leu Asn Trp Thr Lys Ile Met Lys Thr Ile Val Asp Asp 900 905 910 Pro Glu Gly Phe Phe Glu Gln Gly Gly Trp Ser Phe Leu Glu Pro Glu 915 920 925 Gly Glu Gly Ser Asp Ala Glu Glu Gly Asp Ser Glu Ser Glu Ile Glu 930 935 940 Asp Glu Thr Phe Asn Pro Ser Glu Asp Asp Tyr Glu Glu Glu Glu Glu 945 950 955 960 Asp Ser Asp Glu Asp Tyr Ser Ser Glu Ala Glu Glu Ser Asp Tyr Ser 965 970 975 Lys Glu Ser Leu Gly Ser Glu Glu Glu Ser Gly Lys Asp Trp Asp Glu 980 985 990 Leu Glu Glu Glu Ala Arg Lys Ala Asp Arg Glu Ser Arg Tyr Glu Glu 995 1000 1005 Glu Glu Glu Gln Ser Arg Ser Met Ser Arg Lys Arg Lys Ala Ser Val 1010 1015 1020 His Ser Ser Gly Arg Gly Ser Asn Arg Gly Ser Arg His Ser Ser Ala 1025 1030 1035 1040 Pro Pro Lys Lys Lys Arg Lys 1045 <210> SEQ ID NO 55 <211> LENGTH: 1530 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 55 Ser Pro Ile Leu Cys Gly Ala Ala Thr Ala Leu Asn Cys Ser Leu Cys 1 5 10 15 Pro Gln Asp Ser Asn Leu Ser Val His Thr Glu Asn Pro Asp Leu Thr 20 25 30 Pro Cys Phe Gln Asn Ser Leu Leu Ala Trp Val Pro Cys Ile Tyr Leu 35 40 45 Trp Val Ala Leu Pro Cys Tyr Leu Leu Tyr Leu Arg His His Cys Arg 50 55 60 Gly Tyr Ile Ile Leu Ser His Leu Ser Lys Leu Lys Met Val Leu Gly 65 70 75 80 Val Leu Leu Trp Cys Val Ser Trp Ala Asp Leu Phe Tyr Ser Phe His 85 90 95 Gly Leu Val His Gly Arg Ala Pro Ala Pro Val Phe Phe Val Thr Pro 100 105 110 Leu Val Val Gly Val Thr Met Leu Leu Ala Thr Leu Leu Ile Gln Tyr 115 120 125 Glu Arg Leu Gln Gly Val Gln Ser Ser Gly Val Leu Ile Ile Phe Trp 130 135 140 Phe Leu Cys Val Val Cys Ala Ile Val Pro Phe Arg Ser Lys Ile Leu 145 150 155 160 Leu Ala Lys Ala Glu Gly Glu Ile Ser Asp Pro Phe Arg Phe Thr Thr 165 170 175 Phe Tyr Ile His Phe Ala Leu Val Leu Ser Ala Leu Ile Leu Ala Cys 180 185 190 Phe Arg Glu Lys Pro Pro Phe Phe Ser Ala Lys Asn Val Asp Pro Asn 195 200 205 Pro Tyr Pro Glu Thr Ser Ala Gly Phe Leu Ser Arg Leu Phe Phe Trp 210 215 220 Trp Phe Thr Lys Met Ala Ile Tyr Gly Tyr Arg His Pro Leu Glu Glu 225 230 235 240 Lys Asp Leu Trp Ser Leu Lys Glu Glu Asp Arg Ser Gln Met Val Val 245 250 255 Gln Gln Leu Leu Glu Ala Trp Arg Lys Gln Glu Lys Gln Thr Ala Arg 260 265 270 His Lys Ala Ser Ala Ala Pro Gly Lys Asn Ala Ser Gly Glu Asp Glu 275 280 285 Val Leu Leu Gly Ala Arg Pro Arg Pro Arg Lys Pro Ser Phe Leu Lys 290 295 300 Ala Leu Leu Ala Thr Phe Gly Ser Ser Phe Leu Ile Ser Ala Cys Phe 305 310 315 320 Lys Leu Ile Gln Asp Leu Leu Ser Phe Ile Asn Pro Gln Leu Leu Ser 325 330 335 Ile Leu Ile Arg Phe Ile Ser Asn Pro Met Ala Pro Ser Trp Trp Gly 340 345 350 Phe Leu Val Ala Gly Leu Met Phe Leu Cys Ser Met Met Gln Ser Leu 355 360 365 Ile Leu Gln His Tyr Tyr His Tyr Ile Phe Val Thr Gly Val Lys Phe 370 375 380 Arg Thr Gly Ile Met Gly Val Ile Tyr Arg Lys Ala Leu Val Ile Thr 385 390 395 400 Asn Ser Val Lys Arg Ala Ser Thr Val Gly Glu Ile Val Asn Leu Met 405 410 415 Ser Val Asp Ala Gln Arg Phe Met Asp Leu Ala Pro Phe Leu Asn Leu 420 425 430 Leu Trp Ser Ala Pro Leu Gln Ile Ile Leu Ala Ile Tyr Phe Leu Trp 435 440 445 Gln Asn Leu Gly Pro Ser Val Leu Ala Gly Val Ala Phe Met Val Leu 450 455 460 Leu Ile Pro Leu Asn Gly Ala Val Ala Val Lys Met Arg Ala Phe Gln 465 470 475 480 Val Lys Gln Met Lys Leu Lys Asp Ser Arg Ile Lys Leu Met Ser Glu 485 490 495 Ile Leu Asn Gly Ile Lys Val Leu Lys Leu Tyr Ala Trp Glu Pro Ser 500 505 510 Phe Leu Lys Gln Val Glu Gly Ile Arg Gln Gly Glu Leu Gln Leu Leu 515 520 525 Arg Thr Ala Ala Tyr Leu His Thr Thr Thr Thr Phe Thr Trp Met Cys 530 535 540 Ser Pro Phe Leu Val Thr Leu Ile Thr Leu Trp Val Tyr Val Tyr Val 545 550 555 560 Asp Pro Asn Asn Val Leu Asp Ala Glu Lys Ala Phe Val Ser Val Ser 565 570 575 Leu Phe Asn Ile Leu Arg Leu Pro Leu Asn Met Leu Pro Gln Leu Ile 580 585 590 Ser Asn Leu Thr Gln Ala Ser Val Ser Leu Lys Arg Ile Gln Gln Phe 595 600 605 Leu Ser Gln Glu Glu Leu Asp Pro Gln Ser Val Glu Arg Lys Thr Ile 610 615 620 Ser Pro Gly Tyr Ala Ile Thr Ile His Ser Gly Thr Phe Thr Trp Ala 625 630 635 640 Gln Asp Leu Pro Pro Thr Leu His Ser Leu Asp Ile Gln Val Pro Lys 645 650 655 Gly Ala Leu Val Ala Val Val Gly Pro Val Gly Cys Gly Lys Ser Ser 660 665 670 Leu Val Ser Ala Leu Leu Gly Glu Met Glu Lys Leu Glu Gly Lys Val 675 680 685 His Met Lys Gly Ser Val Ala Tyr Val Pro Gln Gln Ala Trp Ile Gln 690 695 700 Asn Cys Thr Leu Gln Glu Asn Val Leu Phe Gly Lys Ala Leu Asn Pro 705 710 715 720 Lys Arg Tyr Gln Gln Thr Leu Glu Ala Cys Ala Leu Leu Ala Asp Leu 725 730 735 Glu Met Leu Pro Gly Gly Asp Gln Thr Glu Ile Gly Glu Lys Gly Ile 740 745 750 Asn Leu Ser Gly Gly Gln Arg Gln Arg Val Ser Leu Ala Arg Ala Val 755 760 765 Tyr Ser Asp Ala Asp Ile Phe Leu Leu Asp Asp Pro Leu Ser Ala Val 770 775 780 Asp Ser His Val Ala Lys His Ile Phe Asp His Val Ile Gly Pro Glu 785 790 795 800 Gly Val Leu Ala Gly Lys Thr Arg Val Leu Val Thr His Gly Ile Ser 805 810 815 Phe Leu Pro Gln Thr Asp Phe Ile Ile Val Leu Ala Asp Gly Gln Val 820 825 830 Ser Glu Met Gly Pro Tyr Pro Ala Leu Leu Gln Arg Asn Gly Ser Phe 835 840 845 Ala Asn Phe Leu Cys Asn Tyr Ala Pro Asp Glu Asp Gln Gly His Leu 850 855 860 Glu Asp Ser Trp Thr Ala Leu Glu Gly Ala Glu Asp Lys Glu Ala Leu 865 870 875 880 Leu Ile Glu Asp Thr Leu Ser Asn His Thr Asp Leu Thr Asp Asn Asp 885 890 895 Pro Val Thr Tyr Val Val Gln Lys Gln Phe Met Arg Gln Leu Ser Ala 900 905 910 Leu Ser Ser Asp Gly Glu Gly Gln Gly Arg Pro Val Pro Arg Arg His 915 920 925 Leu Gly Pro Ser Glu Lys Val Gln Val Thr Glu Ala Lys Ala Asp Gly 930 935 940 Ala Leu Thr Gln Glu Glu Lys Ala Ala Ile Gly Thr Val Glu Leu Ser 945 950 955 960 Val Phe Trp Asp Tyr Ala Lys Ala Val Gly Leu Cys Thr Thr Leu Ala 965 970 975 Ile Cys Leu Leu Tyr Val Gly Gln Ser Ala Ala Ala Ile Gly Ala Asn 980 985 990 Val Trp Leu Ser Ala Trp Thr Asn Asp Ala Met Ala Asp Ser Arg Gln 995 1000 1005 Asn Asn Thr Ser Leu Arg Leu Gly Val Tyr Ala Ala Leu Gly Ile Leu 1010 1015 1020 Gln Gly Phe Leu Val Met Leu Ala Ala Met Ala Met Ala Ala Gly Gly 1025 1030 1035 1040 Ile Gln Ala Ala Arg Val Leu His Gln Ala Leu Leu His Asn Lys Ile 1045 1050 1055 Arg Ser Pro Gln Ser Phe Phe Asp Thr Thr Pro Ser Gly Arg Ile Leu 1060 1065 1070 Asn Cys Phe Ser Lys Asp Ile Tyr Val Val Asp Glu Val Leu Ala Pro 1075 1080 1085 Val Ile Leu Met Leu Leu Asn Ser Phe Phe Asn Ala Ile Ser Thr Leu 1090 1095 1100 Val Val Ile Met Ala Ser Thr Pro Leu Phe Thr Val Val Ile Leu Pro 1105 1110 1115 1120 Leu Ala Val Leu Tyr Thr Leu Val Gln Arg Phe Tyr Ala Ala Thr Ser 1125 1130 1135 Arg Gln Leu Lys Arg Leu Glu Ser Val Ser Arg Ser Pro Ile Tyr Ser 1140 1145 1150 His Phe Ser Glu Thr Val Thr Gly Ala Ser Val Ile Arg Ala Tyr Asn 1155 1160 1165 Arg Ser Arg Asp Phe Glu Ile Ile Ser Asp Thr Lys Val Asp Ala Asn 1170 1175 1180 Gln Arg Ser Cys Tyr Pro Tyr Ile Ile Ser Asn Arg Trp Leu Ser Ile 1185 1190 1195 1200 Gly Val Glu Phe Val Gly Asn Cys Val Val Leu Phe Ala Ala Leu Phe 1205 1210 1215 Ala Val Ile Gly Arg Ser Ser Leu Asn Pro Gly Leu Val Gly Leu Ser 1220 1225 1230 Val Ser Tyr Ser Leu Gln Val Thr Phe Ala Leu Asn Trp Met Ile Arg 1235 1240 1245 Met Met Ser Asp Leu Glu Ser Asn Ile Val Ala Val Glu Arg Val Lys 1250 1255 1260 Glu Tyr Ser Lys Thr Glu Thr Glu Ala Pro Trp Val Val Glu Gly Ser 1265 1270 1275 1280 Arg Pro Pro Glu Gly Trp Pro Pro Arg Gly Glu Val Glu Phe Arg Asn 1285 1290 1295 Tyr Ser Val Arg Tyr Arg Pro Gly Leu Asp Leu Val Leu Arg Asp Leu 1300 1305 1310 Ser Leu His Val His Gly Gly Glu Lys Val Gly Ile Val Gly Arg Thr 1315 1320 1325 Gly Ala Gly Lys Ser Ser Met Thr Leu Cys Leu Phe Arg Ile Leu Glu 1330 1335 1340 Ala Ala Lys Gly Glu Ile Arg Ile Asp Gly Leu Asn Val Ala Asp Ile 1345 1350 1355 1360 Gly Leu His Asp Leu Arg Ser Gln Leu Thr Ile Ile Pro Gln Asp Pro 1365 1370 1375 Ile Leu Phe Ser Gly Thr Leu Arg Met Asn Leu Asp Pro Phe Gly Ser 1380 1385 1390 Tyr Ser Glu Glu Asp Ile Trp Trp Ala Leu Glu Leu Ser His Leu His 1395 1400 1405 Thr Phe Val Ser Ser Gln Pro Ala Gly Leu Asp Phe Gln Cys Ser Glu 1410 1415 1420 Gly Gly Glu Asn Leu Ser Val Gly Gln Arg Gln Leu Val Cys Leu Ala 1425 1430 1435 1440 Arg Ala Leu Leu Arg Lys Ser Arg Ile Leu Val Leu Asp Glu Ala Thr 1445 1450 1455 Ala Ala Ile Asp Leu Glu Thr Asp Asn Leu Ile Gln Ala Thr Ile Arg 1460 1465 1470 Thr Gln Phe Asp Thr Cys Thr Val Leu Thr Ile Ala His Arg Leu Asn 1475 1480 1485 Thr Ile Met Asp Tyr Thr Arg Val Leu Val Leu Asp Lys Gly Val Val 1490 1495 1500 Ala Glu Phe Asp Ser Pro Ala Asn Leu Ile Ala Ala Arg Gly Ile Phe 1505 1510 1515 1520 Tyr Gly Met Ala Arg Asp Ala Gly Leu Ala 1525 1530 <210> SEQ ID NO 56 <211> LENGTH: 533 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 56 Pro Tyr Cys Ser Leu Pro Arg Ala Pro Leu His Gly Phe Ile Leu Gly 1 5 10 15 Gln Thr Ser Thr Gln Pro Gly Gly Ser Ile His Phe Gly Cys Asn Ala 20 25 30 Gly Tyr Arg Leu Val Gly His Ser Met Ala Ile Cys Thr Arg His Pro 35 40 45 Gln Gly Tyr His Leu Trp Ser Glu Ala Ile Pro Leu Cys Gln Ala Leu 50 55 60 Ser Cys Gly Leu Pro Glu Ala Pro Lys Asn Gly Met Val Phe Gly Lys 65 70 75 80 Glu Tyr Thr Val Gly Thr Lys Ala Met Tyr Ser Cys Ser Glu Gly Tyr 85 90 95 His Leu Gln Ala Gly Ala Glu Ala Thr Ala Glu Cys Leu Asp Thr Gly 100 105 110 Leu Trp Ser Asn Arg Asn Val Pro Pro Gln Cys Val Pro Val Thr Cys 115 120 125 Pro Asp Val Ser Ser Ile Ser Val Glu His Gly Arg Trp Arg Leu Ile 130 135 140 Phe Glu Thr Gln Tyr Gln Phe Gln Ala Gln Leu Met Leu Ile Cys Asp 145 150 155 160 Pro Gly Tyr Tyr Tyr Thr Gly Gln Arg Val Ile Arg Cys Gln Ala Asn 165 170 175 Gly Lys Trp Ser Leu Gly Asp Ser Thr Pro Thr Cys Arg Ile Leu Ala 180 185 190 Lys Gln Lys Gln Pro Cys Pro Ser Ser Trp Gly Trp Leu Thr Glu His 195 200 205 Leu Val Ile Ile Leu Val Ile Ser Cys Gly Glu Leu Pro Ile Pro Pro 210 215 220 Asn Gly His Arg Ile Gly Thr Leu Ser Val Tyr Gly Ala Thr Ala Ile 225 230 235 240 Phe Ser Cys Asn Ser Gly Tyr Thr Leu Val Gly Ser Arg Val Arg Glu 245 250 255 Cys Met Ala Asn Gly Leu Trp Ser Gly Ser Glu Val Arg Cys Leu Ala 260 265 270 Thr Gln Thr Lys Leu His Ser Ile Phe Tyr Lys Leu Leu Phe Asp Val 275 280 285 Leu Ser Ser Pro Ser Leu Thr Lys Ala Gly His Cys Gly Thr Pro Glu 290 295 300 Pro Ile Val Asn Gly His Ile Asn Gly Glu Asn Tyr Ser Tyr Arg Gly 305 310 315 320 Ser Val Val Tyr Gln Cys Asn Ala Gly Phe Arg Leu Ile Gly Met Ser 325 330 335 Val Arg Ile Cys Gln Gln Asp His His Trp Ser Gly Lys Thr Pro Phe 340 345 350 Cys Val Pro Ile Thr Cys Gly His Pro Gly Asn Pro Val Asn Gly Leu 355 360 365 Thr Gln Gly Asn Gln Phe Asn Leu Asn Asp Val Val Lys Phe Val Cys 370 375 380 Asn Pro Gly Tyr Met Ala Glu Gly Ala Ala Arg Ser Gln Cys Leu Ala 385 390 395 400 Ser Gly Gln Trp Ser Asp Met Leu Pro Thr Cys Arg Ile Ile Asn Cys 405 410 415 Thr Asp Pro Gly His Gln Glu Asn Ser Val Arg Gln Val His Ala Ser 420 425 430 Gly Pro His Arg Phe Ser Phe Gly Thr Thr Val Ser Tyr Arg Cys Asn 435 440 445 His Gly Phe Tyr Leu Leu Gly Thr Pro Val Leu Ser Cys Gln Gly Asp 450 455 460 Gly Thr Trp Asp Arg Pro Arg Pro Gln Cys Leu Leu Val Ser Cys Gly 465 470 475 480 His Pro Gly Ser Pro Pro His Ser Gln Met Ser Gly Asp Ser Tyr Thr 485 490 495 Val Gly Ala Val Val Arg Tyr Ser Cys Ile Gly Lys Arg Thr Leu Val 500 505 510 Gly Asn Ser Thr Arg Met Cys Gly Leu Asp Gly His Trp Thr Gly Ser 515 520 525 Leu Pro His Cys Ser 530 <210> SEQ ID NO 57 <211> LENGTH: 1584 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 57 Pro Leu Ala Phe Cys Gly Ser Glu Asn His Ser Ala Ala Tyr Arg Val 1 5 10 15 Asp Gln Gly Val Leu Asn Asn Gly Cys Phe Val Asp Ala Leu Asn Val 20 25 30 Val Pro His Val Phe Leu Leu Phe Ile Thr Phe Pro Ile Leu Phe Ile 35 40 45 Gly Trp Gly Ser Gln Ser Ser Lys Val His Ile His His Ser Thr Trp 50 55 60 Leu His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Thr Phe Met Leu 65 70 75 80 Leu Phe Val Leu Val Cys Glu Ile Ala Glu Gly Ile Leu Ser Asp Gly 85 90 95 Val Thr Glu Ser His His Leu His Leu Tyr Met Pro Ala Gly Met Ala 100 105 110 Phe Met Ala Ala Val Thr Ser Val Val Tyr Tyr His Asn Ile Glu Thr 115 120 125 Ser Asn Phe Pro Lys Leu Leu Ile Ala Leu Leu Val Tyr Trp Thr Leu 130 135 140 Ala Phe Ile Thr Lys Thr Ile Lys Phe Val Lys Phe Leu Asp His Ala 145 150 155 160 Ile Gly Phe Ser Gln Leu Arg Phe Cys Leu Thr Gly Leu Leu Val Ile 165 170 175 Leu Tyr Gly Met Leu Leu Leu Val Glu Val Asn Val Ile Arg Val Arg 180 185 190 Arg Tyr Ile Phe Phe Lys Thr Pro Arg Glu Val Lys Pro Pro Glu Asp 195 200 205 Leu Gln Asp Leu Gly Val Arg Phe Leu Gln Pro Phe Val Asn Leu Leu 210 215 220 Ser Lys Gly Thr Tyr Trp Trp Met Asn Ala Phe Ile Lys Thr Ala His 225 230 235 240 Lys Lys Pro Ile Asp Leu Arg Ala Ile Gly Lys Leu Pro Ile Ala Met 245 250 255 Arg Ala Leu Thr Asn Tyr Gln Arg Leu Cys Glu Ala Phe Asp Ala Gln 260 265 270 Val Arg Lys Asp Ile Gln Gly Thr Gln Gly Ala Arg Ala Ile Trp Gln 275 280 285 Ala Leu Ser His Ala Phe Gly Arg Arg Leu Val Leu Ser Ser Thr Phe 290 295 300 Arg Ile Leu Ala Asp Leu Leu Gly Phe Ala Gly Pro Leu Cys Ile Phe 305 310 315 320 Gly Ile Val Asp His Leu Gly Lys Glu Asn Asp Val Phe Gln Pro Lys 325 330 335 Thr Gln Phe Leu Gly Val Tyr Phe Val Ser Ser Gln Glu Phe Leu Ala 340 345 350 Asn Ala Tyr Val Leu Ala Val Leu Leu Phe Leu Ala Leu Leu Leu Gln 355 360 365 Arg Thr Phe Leu Gln Ala Ser Tyr Tyr Val Ala Ile Glu Thr Gly Ile 370 375 380 Asn Leu Arg Gly Ala Ile Gln Thr Lys Ile Tyr Asn Lys Ile Met His 385 390 395 400 Leu Ser Thr Ser Asn Leu Ser Met Gly Glu Met Thr Ala Gly Gln Ile 405 410 415 Cys Asn Leu Val Ala Ile Asp Thr Asn Gln Leu Met Trp Phe Phe Phe 420 425 430 Leu Cys Pro Asn Leu Trp Ala Met Pro Val Gln Ile Ile Val Gly Val 435 440 445 Ile Leu Leu Tyr Tyr Ile Leu Gly Val Ser Ala Leu Ile Gly Ala Ala 450 455 460 Val Ile Ile Leu Leu Ala Pro Val Gln Tyr Phe Val Ala Thr Lys Leu 465 470 475 480 Ser Gln Ala Gln Arg Ser Thr Leu Glu Tyr Ser Asn Glu Arg Leu Lys 485 490 495 Gln Thr Asn Glu Met Leu Arg Gly Ile Lys Leu Leu Lys Leu Tyr Ala 500 505 510 Trp Glu Asn Ile Phe Arg Thr Arg Val Glu Thr Thr Arg Arg Lys Glu 515 520 525 Met Thr Ser Leu Arg Ala Phe Ala Ile Tyr Thr Ser Ile Ser Ile Phe 530 535 540 Met Asn Thr Ala Ile Pro Ile Ala Ala Val Leu Ile Thr Phe Val Gly 545 550 555 560 His Val Ser Phe Phe Lys Glu Ala Asp Phe Ser Pro Ser Val Ala Phe 565 570 575 Ala Ser Leu Ser Leu Phe His Ile Leu Val Thr Pro Leu Phe Leu Leu 580 585 590 Ser Ser Val Val Arg Ser Thr Val Lys Ala Leu Val Ser Val Gln Lys 595 600 605 Leu Ser Glu Phe Leu Ser Ser Ala Glu Ile Arg Glu Glu Gln Cys Ala 610 615 620 Pro His Glu Pro Thr Pro Gln Gly Pro Ala Ser Lys Tyr Gln Ala Val 625 630 635 640 Pro Leu Arg Val Val Asn Arg Lys Arg Pro Ala Arg Glu Asp Cys Arg 645 650 655 Gly Leu Thr Gly Pro Leu Gln Ser Leu Val Pro Ser Ala Asp Gly Asp 660 665 670 Ala Asp Asn Cys Cys Val Gln Ile Met Gly Gly Tyr Phe Thr Trp Thr 675 680 685 Pro Asp Gly Ile Pro Thr Leu Ser Asn Ile Thr Ile Arg Ile Pro Arg 690 695 700 Gly Gln Leu Thr Met Ile Val Gly Gln Val Gly Cys Gly Lys Ser Ser 705 710 715 720 Leu Leu Leu Ala Ala Leu Gly Glu Met Gln Lys Val Ser Gly Ala Val 725 730 735 Phe Trp Ser Ser Met Pro Phe Leu Pro Cys Cys Ser Pro Glu Arg Glu 740 745 750 Thr Ala Thr Asp Leu Asp Ile Arg Lys Arg Gly Pro Val Ala Tyr Ala 755 760 765 Ser Gln Lys Pro Trp Leu Leu Asn Ala Thr Val Glu Glu Asn Ile Ile 770 775 780 Phe Glu Ser Pro Phe Asn Lys Gln Arg Tyr Lys Met Val Ile Glu Ala 785 790 795 800 Cys Ser Leu Gln Pro Asp Ile Asp Ile Leu Pro His Gly Asp Gln Thr 805 810 815 Gln Ile Gly Glu Arg Gly Ile Asn Leu Ser Gly Gly Gln Arg Gln Arg 820 825 830 Ile Ser Val Ala Arg Ala Leu Tyr Gln His Ala Asn Val Val Phe Leu 835 840 845 Asp Asp Pro Phe Ser Ala Leu Asp Ile His Leu Ser Asp His Leu Met 850 855 860 Gln Ala Gly Ile Leu Glu Leu Leu Arg Asp Asp Lys Arg Thr Val Val 865 870 875 880 Leu Val Thr His Lys Leu Gln Tyr Leu Pro His Ala Asp Trp Ile Ile 885 890 895 Ala Met Lys Asp Gly Thr Ile Gln Arg Glu Gly Thr Leu Lys Asp Phe 900 905 910 Gln Arg Ser Glu Cys Gln Leu Phe Glu His Trp Lys Thr Leu Met Asn 915 920 925 Arg Gln Asp Gln Glu Leu Glu Lys Glu Thr Val Thr Glu Arg Lys Ala 930 935 940 Thr Glu Pro Pro Gln Gly Leu Ser Arg Ala Met Ser Ser Arg Asp Gly 945 950 955 960 Leu Leu Gln Asp Glu Glu Glu Glu Glu Glu Glu Ala Ala Glu Ser Glu 965 970 975 Glu Asp Asp Asn Leu Ser Ser Met Leu His Gln Arg Ala Glu Ile Pro 980 985 990 Trp Arg Ala Cys Ala Lys Tyr Leu Ser Ser Ala Gly Ile Leu Leu Leu 995 1000 1005 Ser Leu Leu Val Phe Ser Gln Leu Leu Lys His Met Val Leu Val Ala 1010 1015 1020 Ile Asp Tyr Trp Leu Ala Lys Trp Thr Asp Ser Ala Leu Thr Leu Thr 1025 1030 1035 1040 Pro Ala Ala Arg Asn Cys Ser Leu Ser Gln Glu Cys Thr Leu Asp Gln 1045 1050 1055 Thr Val Tyr Ala Met Val Phe Thr Val Leu Cys Ser Leu Gly Ile Val 1060 1065 1070 Leu Cys Leu Val Thr Ser Val Thr Val Glu Trp Thr Gly Leu Lys Val 1075 1080 1085 Ala Lys Arg Leu His Arg Ser Leu Leu Asn Arg Ile Ile Leu Ala Pro 1090 1095 1100 Met Arg Phe Phe Glu Thr Thr Pro Leu Gly Ser Ile Leu Asn Arg Phe 1105 1110 1115 1120 Ser Ser Asp Cys Asn Thr Ile Asp Gln His Ile Pro Ser Thr Leu Glu 1125 1130 1135 Cys Leu Ser Arg Ser Thr Leu Leu Cys Val Ser Ala Leu Ala Val Ile 1140 1145 1150 Ser Tyr Val Thr Pro Val Phe Leu Val Ala Leu Leu Pro Leu Ala Ile 1155 1160 1165 Val Cys Tyr Phe Ile Gln Lys Tyr Phe Arg Val Ala Ser Arg Asp Leu 1170 1175 1180 Gln Gln Leu Asp Asp Thr Thr Gln Leu Pro Leu Leu Ser His Phe Ala 1185 1190 1195 1200 Glu Thr Val Glu Gly Leu Thr Thr Ile Arg Ala Phe Arg Tyr Glu Ala 1205 1210 1215 Arg Phe Gln Gln Lys Leu Leu Glu Tyr Thr Asp Ser Asn Asn Ile Ala 1220 1225 1230 Ser Leu Phe Leu Thr Ala Ala Asn Arg Trp Leu Glu Val Arg Met Ala 1235 1240 1245 Thr Pro Leu Pro Pro Gln Glu Tyr Ile Gly Ala Cys Val Val Leu Ile 1250 1255 1260 Ala Ala Val Thr Ser Ile Ser Asn Ser Leu His Arg Glu Leu Ser Ala 1265 1270 1275 1280 Gly Leu Val Gly Leu Gly Leu Thr Tyr Ala Leu Met Val Ser Asn Tyr 1285 1290 1295 Leu Asn Trp Met Val Arg Asn Leu Ala Asp Met Glu Leu Gln Leu Gly 1300 1305 1310 Ala Val Lys Arg Ile His Gly Leu Leu Lys Thr Glu Ala Glu Ser Tyr 1315 1320 1325 Glu Gly Leu Leu Ala Pro Ser Leu Ile Pro Lys Asn Trp Pro Asp Gln 1330 1335 1340 Gly Lys Ile Gln Ile Gln Asn Leu Ser Val Arg Tyr Asp Ser Ser Leu 1345 1350 1355 1360 Lys Pro Val Leu Lys His Val Asn Ala Leu Ile Ala Pro Gly Gln Lys 1365 1370 1375 Ile Gly Ile Cys Gly Arg Thr Gly Ser Gly Lys Ser Ser Phe Ser Leu 1380 1385 1390 Ala Phe Phe Arg Met Val Asp Thr Phe Glu Gly His Ile Ile Ile Asp 1395 1400 1405 Gly Ile Asp Ile Ala Lys Leu Pro Leu His Thr Leu Arg Ser Arg Leu 1410 1415 1420 Ser Ile Ile Leu Gln Asp Pro Val Leu Phe Ser Gly Thr Ile Arg Phe 1425 1430 1435 1440 Asn Leu Asp Pro Glu Arg Lys Cys Ser Asp Ser Thr Leu Trp Glu Ala 1445 1450 1455 Leu Glu Ile Ala Gln Leu Lys Leu Val Val Lys Ala Leu Pro Gly Gly 1460 1465 1470 Leu Asp Ala Ile Ile Thr Glu Gly Gly Glu Asn Phe Ser Gln Gly Gln 1475 1480 1485 Arg Gln Leu Phe Cys Leu Ala Arg Ala Phe Val Arg Lys Thr Ser Ile 1490 1495 1500 Phe Ile Met Asp Glu Ala Thr Ala Ser Ile Asp Met Ala Thr Glu Asn 1505 1510 1515 1520 Ile Leu Gln Lys Val Val Met Thr Ala Phe Ala Asp Arg Thr Val Val 1525 1530 1535 Thr Ile Ala His Arg Val His Thr Ile Leu Ser Ala Asp Leu Val Ile 1540 1545 1550 Val Leu Lys Arg Gly Ala Ile Leu Glu Phe Asp Lys Pro Glu Lys Leu 1555 1560 1565 Leu Ser Arg Lys Asp Ser Val Phe Ala Ser Phe Val Arg Ala Asp Lys 1570 1575 1580 <210> SEQ ID NO 58 <211> LENGTH: 274 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 58 Met Pro Arg Asn Leu Leu Tyr Ser Leu Leu Ser Ser His Leu Ser Pro 1 5 10 15 His Phe Ser Thr Ser Val Thr Ser Ala Lys Val Ala Val Asn Gly Val 20 25 30 Gln Leu His Tyr Gln Gln Thr Gly Glu Gly Asp His Ala Val Leu Leu 35 40 45 Leu Pro Gly Met Leu Gly Ser Gly Glu Thr Asp Phe Gly Pro Gln Leu 50 55 60 Lys Asn Leu Asn Lys Lys Leu Phe Thr Val Val Ala Trp Asp Pro Arg 65 70 75 80 Gly Tyr Gly His Ser Arg Pro Pro Asp Arg Asp Phe Pro Ala Asp Phe 85 90 95 Phe Glu Arg Asp Ala Lys Asp Ala Val Asp Leu Met Lys Ala Leu Lys 100 105 110 Phe Lys Lys Val Ser Leu Leu Gly Trp Ser Asp Gly Gly Ile Thr Ala 115 120 125 Leu Ile Ala Ala Ala Lys Tyr Pro Ser Tyr Ile His Lys Met Val Ile 130 135 140 Trp Gly Ala Asn Ala Tyr Val Thr Asp Glu Asp Ser Met Ile Tyr Glu 145 150 155 160 Gly Ile Arg Asp Val Ser Lys Trp Ser Glu Arg Thr Arg Lys Pro Leu 165 170 175 Glu Ala Leu Tyr Gly Tyr Asp Tyr Phe Ala Arg Thr Cys Glu Lys Trp 180 185 190 Val Asp Gly Ile Arg Gln Phe Lys His Leu Pro Asp Gly Asn Ile Cys 195 200 205 Arg His Leu Leu Pro Arg Val Gln Cys Pro Ala Leu Ile Val His Gly 210 215 220 Glu Lys Asp Pro Leu Val Pro Arg Phe His Ala Asp Phe Ile His Lys 225 230 235 240 His Val Lys Gly Ser Arg Leu His Leu Met Pro Glu Gly Lys His Asn 245 250 255 Leu His Leu Arg Phe Ala Asp Glu Phe Asn Lys Leu Ala Glu Asp Phe 260 265 270 Leu Gln <210> SEQ ID NO 59 <211> LENGTH: 1247 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 59 Met Met Arg Glu Trp Val Leu Leu Met Ser Val Leu Leu Cys Gly Leu 1 5 10 15 Ala Gly Pro Thr His Leu Phe Gln Pro Ser Leu Val Leu Asp Met Ala 20 25 30 Lys Val Leu Leu Asp Asn Tyr Cys Phe Pro Glu Asn Leu Leu Gly Met 35 40 45 Gln Glu Ala Ile Gln Gln Ala Ile Lys Ser His Glu Ile Leu Ser Ile 50 55 60 Ser Asp Pro Gln Thr Leu Ala Ser Val Leu Thr Ala Gly Val Gln Ser 65 70 75 80 Ser Leu Asn Asp Pro Arg Leu Val Ile Ser Tyr Glu Pro Ser Thr Pro 85 90 95 Glu Pro Pro Pro Gln Val Pro Ala Leu Thr Ser Leu Ser Glu Glu Glu 100 105 110 Leu Leu Ala Trp Leu Gln Arg Gly Leu Arg His Glu Val Leu Glu Gly 115 120 125 Asn Val Gly Tyr Leu Arg Val Asp Ser Val Pro Gly Gln Glu Val Leu 130 135 140 Ser Met Met Gly Glu Phe Leu Val Ala His Val Trp Gly Asn Leu Met 145 150 155 160 Gly Thr Ser Ala Leu Val Leu Asp Leu Arg His Cys Thr Gly Gly Gln 165 170 175 Val Ser Gly Ile Pro Tyr Ile Ile Ser Tyr Leu His Pro Gly Asn Thr 180 185 190 Ile Leu His Val Asp Thr Ile Tyr Asn Arg Pro Ser Asn Thr Thr Thr 195 200 205 Glu Ile Trp Thr Leu Pro Gln Val Leu Gly Glu Arg Tyr Gly Ala Asp 210 215 220 Lys Asp Val Val Val Leu Thr Ser Ser Gln Thr Arg Gly Val Ala Glu 225 230 235 240 Asp Ile Ala His Ile Leu Lys Gln Met Arg Arg Ala Ile Val Val Gly 245 250 255 Glu Arg Thr Gly Gly Gly Ala Leu Asp Leu Arg Lys Leu Arg Ile Gly 260 265 270 Glu Ser Asp Phe Phe Phe Thr Val Pro Val Ser Arg Ser Leu Gly Pro 275 280 285 Leu Gly Gly Gly Ser Gln Thr Trp Glu Gly Ser Gly Val Leu Pro Cys 290 295 300 Val Gly Thr Pro Ala Glu Gln Ala Leu Glu Lys Ala Leu Ala Ile Leu 305 310 315 320 Thr Leu Arg Ser Ala Leu Pro Gly Val Val His Cys Leu Gln Glu Val 325 330 335 Leu Lys Asp Tyr Tyr Thr Leu Val Asp Arg Val Pro Thr Leu Leu Gln 340 345 350 His Leu Ala Ser Met Asp Phe Ser Thr Val Val Ser Glu Glu Asp Leu 355 360 365 Val Thr Lys Leu Asn Ala Gly Leu Gln Ala Ala Ser Glu Asp Pro Arg 370 375 380 Leu Leu Val Arg Ala Ile Gly Pro Thr Glu Thr Pro Ser Trp Pro Ala 385 390 395 400 Pro Asp Ala Ala Ala Glu Asp Ser Pro Gly Val Ala Pro Glu Leu Pro 405 410 415 Glu Asp Glu Ala Ile Arg Gln Ala Leu Val Asp Ser Val Phe Gln Val 420 425 430 Ser Val Leu Pro Gly Asn Val Gly Tyr Leu Arg Phe Asp Ser Phe Ala 435 440 445 Asp Ala Ser Val Leu Gly Val Leu Ala Pro Tyr Val Leu Arg Gln Val 450 455 460 Trp Glu Pro Leu Gln Asp Thr Glu His Leu Ile Met Asp Leu Arg His 465 470 475 480 Asn Pro Gly Gly Pro Ser Ser Ala Val Pro Leu Leu Leu Ser Tyr Phe 485 490 495 Gln Gly Pro Glu Ala Gly Pro Val His Leu Phe Thr Thr Tyr Asp Arg 500 505 510 Arg Thr Asn Ile Thr Gln Glu His Phe Ser His Met Glu Leu Pro Gly 515 520 525 Pro Arg Tyr Ser Thr Gln Arg Gly Val Tyr Leu Leu Thr Ser His Arg 530 535 540 Thr Ala Thr Ala Ala Glu Glu Phe Ala Phe Leu Met Gln Ser Leu Gly 545 550 555 560 Trp Ala Thr Leu Val Gly Glu Ile Thr Ala Gly Asn Leu Leu His Thr 565 570 575 Arg Thr Val Pro Leu Leu Asp Thr Pro Glu Gly Ser Leu Ala Leu Thr 580 585 590 Val Pro Val Leu Thr Phe Ile Asp Asn His Gly Glu Ala Trp Leu Gly 595 600 605 Gly Gly Val Val Pro Asp Ala Ile Val Leu Ala Glu Glu Ala Leu Asp 610 615 620 Lys Ala Gln Glu Val Leu Glu Phe His Gln Ser Leu Gly Ala Leu Val 625 630 635 640 Glu Gly Thr Gly His Leu Leu Glu Ala His Tyr Ala Arg Pro Glu Val 645 650 655 Val Gly Gln Thr Ser Ala Leu Leu Arg Ala Lys Leu Ala Gln Gly Ala 660 665 670 Tyr Arg Thr Ala Val Asp Leu Glu Ser Leu Ala Ser Gln Leu Thr Ala 675 680 685 Asp Leu Gln Glu Val Ser Gly Asp His Arg Leu Leu Val Phe His Ser 690 695 700 Pro Gly Glu Leu Val Val Glu Glu Ala Pro Pro Pro Pro Pro Ala Val 705 710 715 720 Pro Ser Pro Glu Glu Leu Thr Tyr Leu Ile Glu Ala Leu Phe Lys Thr 725 730 735 Glu Val Leu Pro Gly Gln Leu Gly Tyr Leu Arg Phe Asp Ala Met Ala 740 745 750 Glu Leu Glu Thr Val Lys Ala Val Gly Pro Gln Leu Val Arg Leu Val 755 760 765 Trp Gln Gln Leu Val Asp Thr Ala Ala Leu Val Ile Asp Leu Arg Tyr 770 775 780 Asn Pro Gly Ser Tyr Ser Thr Ala Ile Pro Leu Leu Cys Ser Tyr Phe 785 790 795 800 Phe Glu Ala Glu Pro Arg Gln His Leu Tyr Ser Val Phe Asp Arg Ala 805 810 815 Thr Ser Lys Val Thr Glu Val Trp Thr Leu Pro Gln Val Ala Gly Gln 820 825 830 Arg Tyr Gly Ser His Lys Asp Leu Tyr Ile Leu Met Ser His Thr Ser 835 840 845 Gly Ser Ala Ala Glu Ala Phe Ala His Thr Met Gln Asp Leu Gln Arg 850 855 860 Ala Thr Val Ile Gly Glu Pro Thr Ala Gly Gly Ala Leu Ser Val Gly 865 870 875 880 Ile Tyr Gln Val Gly Ser Ser Pro Leu Tyr Ala Ser Met Pro Thr Gln 885 890 895 Met Ala Met Ser Ala Thr Thr Gly Lys Ala Trp Asp Leu Ala Gly Val 900 905 910 Glu Pro Asp Ile Thr Val Pro Met Ser Glu Ala Leu Ser Ile Ala Gln 915 920 925 Asp Ile Val Ala Leu Arg Ala Lys Val Pro Thr Val Leu Gln Thr Ala 930 935 940 Gly Lys Leu Val Ala Asp Asn Tyr Ala Ser Ala Glu Leu Gly Ala Lys 945 950 955 960 Met Ala Thr Lys Leu Ser Gly Leu Gln Ser Arg Tyr Ser Arg Val Thr 965 970 975 Ser Glu Val Ala Leu Ala Glu Ile Leu Gly Ala Asp Leu Gln Met Leu 980 985 990 Ser Gly Asp Pro His Leu Lys Ala Ala His Ile Pro Glu Asn Ala Lys 995 1000 1005 Asp Arg Ile Pro Gly Ile Val Pro Met Gln Ile Pro Ser Pro Glu Val 1010 1015 1020 Phe Glu Glu Leu Ile Lys Phe Ser Phe His Thr Asn Val Leu Glu Asp 1025 1030 1035 1040 Asn Ile Gly Tyr Leu Arg Phe Asp Met Phe Gly Asp Gly Glu Leu Leu 1045 1050 1055 Thr Gln Val Ser Arg Leu Leu Val Glu His Ile Trp Lys Lys Ile Met 1060 1065 1070 His Thr Asp Ala Met Ile Ile Asp Met Arg Phe Asn Ile Gly Gly Pro 1075 1080 1085 Thr Ser Ser Ile Pro Ile Leu Cys Ser Tyr Phe Phe Asp Glu Gly Pro 1090 1095 1100 Pro Val Leu Leu Asp Lys Ile Tyr Ser Arg Pro Asp Asp Ser Val Ser 1105 1110 1115 1120 Glu Leu Trp Thr His Ala Gln Val Val Gly Glu Arg Tyr Gly Ser Lys 1125 1130 1135 Lys Ser Met Val Ile Leu Thr Ser Ser Val Thr Ala Gly Thr Ala Glu 1140 1145 1150 Glu Phe Thr Tyr Ile Met Lys Arg Leu Gly Arg Ala Leu Val Ile Gly 1155 1160 1165 Glu Val Thr Ser Gly Gly Cys Gln Pro Pro Gln Thr Tyr His Val Asp 1170 1175 1180 Asp Thr Asn Leu Tyr Leu Thr Ile Pro Thr Ala Arg Ser Val Gly Ala 1185 1190 1195 1200 Ser Asp Gly Ser Ser Trp Glu Gly Val Gly Val Thr Pro His Val Val 1205 1210 1215 Val Pro Ala Glu Glu Ala Leu Ala Arg Ala Lys Glu Met Leu Gln His 1220 1225 1230 Asn Gln Leu Arg Val Lys Arg Ser Pro Gly Leu Gln Asp His Leu 1235 1240 1245 <210> SEQ ID NO 60 <211> LENGTH: 300 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 60 Met Ala Glu Val Asn Ile Ile Tyr Val Thr Val Phe Ile Leu Lys Gly 1 5 10 15 Ile Thr Asn Arg Pro Glu Leu Gln Ala Pro Cys Phe Gly Val Phe Leu 20 25 30 Val Ile Tyr Leu Val Thr Val Leu Gly Asn Leu Gly Leu Ile Thr Leu 35 40 45 Ile Lys Ile Asp Thr Arg Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60 His Leu Ala Phe Val Asp Leu Cys Tyr Ser Ser Ala Ile Thr Pro Lys 65 70 75 80 Met Met Val Asn Phe Val Val Glu Arg Asn Thr Ile Pro Phe His Ala 85 90 95 Cys Ala Thr Gln Leu Gly Cys Phe Leu Thr Phe Met Ile Thr Glu Cys 100 105 110 Phe Leu Leu Ala Ser Met Ala Tyr Asp Cys Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu His Tyr Ser Thr Leu Met Ser Arg Arg Val Cys Ile Gln Leu 130 135 140 Val Ala Val Pro Tyr Ile Tyr Ser Phe Leu Val Ala Leu Phe His Thr 145 150 155 160 Val Ile Thr Phe Arg Leu Thr Tyr Cys Gly Pro Asn Leu Ile Asn His 165 170 175 Phe Tyr Cys Asp Asp Leu Pro Phe Leu Ala Leu Ser Cys Ser Asp Thr 180 185 190 His Met Lys Glu Ile Leu Ile Phe Ala Phe Ala Gly Phe Asp Met Ile 195 200 205 Ser Ser Ser Ser Ile Val Leu Thr Ser Tyr Ile Phe Ile Ile Ala Ala 210 215 220 Ile Leu Arg Ile Arg Ser Thr Gln Gly Gln His Lys Ala Ile Ser Thr 225 230 235 240 Cys Gly Ser His Met Val Thr Val Thr Ile Phe Tyr Gly Thr Leu Ile 245 250 255 Phe Met Tyr Leu Gln Pro Lys Ser Asn His Ser Leu Asp Thr Asp Lys 260 265 270 Met Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Asp Ala 290 295 300 <210> SEQ ID NO 61 <211> LENGTH: 418 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 61 Met Ile Gln Leu Thr Ala Thr Pro Val Ser Ala Leu Val Asp Glu Pro 1 5 10 15 Val His Ile Arg Ala Thr Gly Leu Ile Pro Phe Gln Met Val Ser Phe 20 25 30 Gln Ala Ser Leu Glu Asp Glu Asn Gly Asp Met Phe Tyr Ser Gln Ala 35 40 45 His Tyr Arg Ala Asn Glu Phe Gly Glu Val Asp Leu Asn His Ala Ser 50 55 60 Ser Leu Gly Gly Asp Tyr Met Gly Val His Pro Met Gly Leu Phe Trp 65 70 75 80 Ser Leu Lys Pro Glu Lys Leu Leu Thr Arg Leu Leu Lys Arg Asp Val 85 90 95 Met Asn Arg Pro Phe Gln Val Gln Val Lys Leu Tyr Asp Leu Glu Leu 100 105 110 Ile Val Asn Asn Lys Val Ala Ser Ala Pro Lys Ala Ser Leu Thr Leu 115 120 125 Glu Arg Trp Tyr Val Ala Pro Gly Val Thr Arg Ile Lys Val Arg Glu 130 135 140 Gly Arg Leu Arg Gly Ala Leu Phe Leu Pro Pro Gly Glu Gly Leu Phe 145 150 155 160 Pro Gly Val Ile Asp Leu Phe Gly Gly Leu Gly Gly Leu Leu Glu Phe 165 170 175 Arg Ala Ser Leu Leu Ala Ser Arg Gly Phe Ala Ser Leu Ala Leu Ala 180 185 190 Tyr His Asn Tyr Glu Asp Leu Pro Arg Lys Pro Glu Val Thr Asp Leu 195 200 205 Glu Tyr Phe Glu Glu Ala Ala Asn Phe Leu Leu Arg His Pro Lys Val 210 215 220 Phe Gly Ser Gly Val Gly Val Val Ser Val Cys Gln Gly Val Gln Ile 225 230 235 240 Gly Leu Ser Met Ala Ile Tyr Leu Lys Gln Val Thr Ala Thr Val Leu 245 250 255 Ile Asn Gly Thr Asn Phe Pro Phe Gly Ile Pro Gln Val Tyr His Gly 260 265 270 Gln Ile His Gln Pro Leu Pro His Ser Ala Gln Leu Ile Ser Thr Asn 275 280 285 Ala Leu Gly Leu Leu Glu Leu Tyr Arg Thr Phe Glu Thr Thr Gln Val 290 295 300 Gly Ala Ser Gln Tyr Leu Phe Pro Ile Glu Glu Ala Gln Gly Gln Phe 305 310 315 320 Leu Phe Ile Val Gly Glu Gly Asp Lys Thr Ile Asn Ser Lys Ala His 325 330 335 Ala Glu Gln Ala Ile Gly Gln Leu Lys Arg His Gly Lys Asn Asn Trp 340 345 350 Thr Leu Leu Ser Tyr Pro Gly Ala Gly His Leu Ile Glu Pro Pro Tyr 355 360 365 Ser Pro Leu Cys Cys Ala Ser Thr Thr His Asp Leu Arg Leu His Trp 370 375 380 Gly Gly Glu Val Ile Pro His Ala Ala Ala Gln Glu His Ala Trp Lys 385 390 395 400 Glu Ile Gln Arg Phe Leu Arg Lys His Leu Ile Pro Asp Val Thr Ser 405 410 415 Gln Leu <210> SEQ ID NO 62 <211> LENGTH: 262 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 62 Ile Ser Pro Gln Ser Arg Asp Ala Lys Pro Asn Pro Glu Glu Pro Ile 1 5 10 15 Asp Glu Asp Glu Asp Ile Gln Thr Glu Arg Ile Arg Thr Ala Thr Ala 20 25 30 Leu Thr Thr Ser Ile Leu Asp Glu Val Glu Leu Lys Gly Cys Ser Ser 35 40 45 Val Leu Gly His Leu Gly Tyr Cys Pro Gln Glu Asn Val Leu Trp Pro 50 55 60 Met Leu Thr Leu Arg Glu His Leu Glu Val Tyr Ala Ala Val Lys Gly 65 70 75 80 Leu Arg Lys Ala Asp Ala Arg Leu Ala Ile Ala Arg Leu Val Ser Ala 85 90 95 Phe Lys Leu His Glu Gln Leu Asn Val Pro Val Gln Lys Leu Thr Ala 100 105 110 Gly Ile Thr Arg Lys Leu Cys Phe Val Leu Ser Leu Leu Gly Asn Ser 115 120 125 Pro Val Leu Leu Leu Asp Glu Pro Ser Thr Gly Ile Asp Pro Thr Gly 130 135 140 Gln Gln Gln Met Trp Gln Ala Ile Gln Ala Val Val Lys Asn Thr Glu 145 150 155 160 Arg Gly Val Leu Leu Thr Thr His Asn Leu Ala Glu Ala Glu Ala Leu 165 170 175 Cys Asp Arg Val Ala Ile Met Val Ser Gly Arg Leu Arg Cys Ile Gly 180 185 190 Ser Ile Gln His Leu Lys Asn Lys Leu Gly Lys Asp Tyr Ile Leu Glu 195 200 205 Leu Lys Val Lys Glu Thr Ser Gln Val Thr Leu Val His Thr Glu Ile 210 215 220 Leu Lys Leu Phe Pro Gln Ala Ala Gly Gln Glu Arg Tyr Ser Ser Leu 225 230 235 240 Leu Thr Tyr Lys Leu Pro Val Ala Asp Val Tyr Pro Leu Ser Gln Thr 245 250 255 Phe His Lys Leu Glu Ala 260 <210> SEQ ID NO 63 <211> LENGTH: 1303 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 63 Trp Asn Thr Ser Asn Pro Asp Phe Thr Lys Cys Phe Gln Asn Thr Val 1 5 10 15 Leu Val Trp Val Pro Cys Phe Tyr Leu Trp Ala Cys Phe Pro Phe Tyr 20 25 30 Phe Leu Tyr Leu Ser Arg His Asp Arg Gly Tyr Ile Gln Met Thr Pro 35 40 45 Leu Asn Lys Thr Lys Thr Ala Leu Gly Phe Leu Leu Trp Ile Val Cys 50 55 60 Trp Ala Asp Leu Phe Tyr Ser Phe Trp Glu Arg Ser Arg Gly Ile Phe 65 70 75 80 Leu Ala Pro Val Phe Leu Val Ser Pro Thr Leu Leu Gly Ile Thr Met 85 90 95 Leu Leu Ala Thr Phe Leu Ile Gln Leu Glu Arg Arg Lys Gly Val Gln 100 105 110 Ser Ser Gly Ile Met Leu Thr Phe Trp Leu Val Ala Leu Val Cys Ala 115 120 125 Leu Ala Ile Leu Arg Ser Lys Ile Met Thr Ala Leu Lys Glu Val Asp 130 135 140 Leu Phe Arg Asp Ile Thr Phe Tyr Val Tyr Phe Ser Leu Leu Leu Ile 145 150 155 160 Gln Leu Val Leu Ser Cys Phe Ser Asp Arg Ser Pro Leu Phe Ser Glu 165 170 175 Thr Ile His Asp Pro Asn Pro Cys Pro Glu Ser Ser Ala Ser Phe Leu 180 185 190 Ser Arg Ile Thr Phe Trp Trp Ile Thr Gly Leu Ile Val Arg Gly Tyr 195 200 205 Arg Gln Pro Leu Glu Gly Ser Asp Leu Trp Ser Leu Asn Lys Glu Asp 210 215 220 Thr Ser Glu Gln Val Val Pro Val Leu Val Lys Asn Trp Lys Lys Glu 225 230 235 240 Cys Ala Lys Thr Arg Asn Ser Ser Gly Ser Gly Glu Ser Cys Ser Ala 245 250 255 Asn Thr Glu Ala Leu Phe Pro Ala Pro Thr Cys His Lys Ser Phe Gln 260 265 270 Ala Leu Ser Leu Leu Leu Cys Arg Leu Leu Ile Lys Phe Val Asn Asp 275 280 285 Thr Lys Ala Pro Asp Trp Gln Gly Tyr Phe Tyr Thr Val Leu Leu Phe 290 295 300 Val Thr Ala Cys Leu Gln Thr Leu Val Leu His Gln Tyr Phe His Ile 305 310 315 320 Cys Phe Val Ser Gly Met Arg Ile Lys Thr Ala Val Ile Gly Ala Val 325 330 335 Tyr Arg Lys Ala Leu Val Ile Thr Asn Ser Ala Arg Lys Ser Ser Thr 340 345 350 Val Gly Glu Ile Val Asn Leu Met Ser Val Asp Ala Gln Arg Phe Met 355 360 365 Asp Leu Ala Thr Tyr Ile Asn Met Ile Trp Ser Ala Pro Leu Gln Val 370 375 380 Ile Leu Ala Leu Tyr Leu Leu Trp Leu Val Val Ala Pro Asp Val Leu 385 390 395 400 Thr Ala Val Ser Ser Lys Val Ala His Met Lys Ser Lys Asp Asn Arg 405 410 415 Ile Lys Leu Met Asn Glu Ile Leu Asn Gly Ile Lys Val Leu Lys Leu 420 425 430 Tyr Ala Trp Glu Leu Ala Phe Lys Asp Lys Val Leu Ala Ile Arg Gln 435 440 445 Glu Glu Leu Lys Val Leu Lys Lys Ser Ala Tyr Leu Ser Ala Val Gly 450 455 460 Thr Phe Thr Trp Val Cys Thr Pro Phe Leu Val Ala Leu Cys Thr Phe 465 470 475 480 Ala Val Tyr Val Thr Ile Asp Glu Asn Asn Ile Leu Asp Ala Gln Thr 485 490 495 Ala Phe Val Ser Leu Ala Leu Phe Asn Ile Leu Arg Phe Pro Leu Asn 500 505 510 Ile Leu Pro Met Val Ile Ser Ser Ile Val Gln Val Gln Gly Glu Ala 515 520 525 Gly Ala Thr Ser Glu Arg Gly Pro Trp Gly Ser Arg Pro Arg Lys His 530 535 540 Gly Thr Arg Gln Ala Ser Phe Ser Val Ala Glu Pro Gly Val Leu Cys 545 550 555 560 Arg Phe Ser Ile Thr Phe Ser Ile Pro Glu Gly Ala Leu Val Ala Val 565 570 575 Val Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu Ser Ala Leu Leu 580 585 590 Ala Glu Met Asp Lys Val Glu Gly His Val Ala Ile Lys Gly Ser Val 595 600 605 Ala Tyr Val Pro Gln Gln Ala Trp Ile Gln Asn Asp Ser Leu Arg Glu 610 615 620 Asn Ile Leu Phe Gly Cys Gln Leu Glu Glu Pro Tyr Tyr Arg Ser Val 625 630 635 640 Ile Gln Ala Cys Ala Leu Leu Pro Asp Leu Glu Ile Leu Pro Ser Gly 645 650 655 Asp Arg Thr Glu Ile Gly Glu Lys Gly Val Asn Leu Ser Gly Gly Gln 660 665 670 Lys Gln Arg Val Ser Leu Ala Arg Ala Val Tyr Ser Asn Ala Asp Ile 675 680 685 Tyr Leu Phe Asp Asp Pro Leu Ser Ala Val Asp Ala His Val Gly Lys 690 695 700 His Ile Phe Glu Asn Val Ile Gly Pro Lys Gly Met Leu Lys Asn Lys 705 710 715 720 Ser Cys Leu Ile Ser Cys Asp Leu Gln Val Lys Leu Ser Val Tyr Trp 725 730 735 Asp Tyr Met Lys Ala Ile Gly Leu Phe Ile Ser Phe Leu Ser Ile Phe 740 745 750 Leu Phe Met Cys Asn His Val Ser Ala Leu Ala Ser Asn Tyr Trp Leu 755 760 765 Ser Leu Trp Thr Asp Asp Pro Ile Val Asn Gly Thr Gln Glu His Thr 770 775 780 Lys Val Arg Leu Ser Val Tyr Gly Ala Leu Gly Ile Ser Gln Gly Ile 785 790 795 800 Ala Val Phe Gly Tyr Ser Met Ala Val Ser Ile Gly Gly Ile Leu Ala 805 810 815 Ser Arg Cys Leu His Val Asp Leu Leu His Ser Ile Leu Arg Ser Pro 820 825 830 Met Ser Phe Phe Glu Arg Thr Pro Ser Gly Asn Leu Val Asn Arg Phe 835 840 845 Ser Lys Glu Leu Asp Thr Val Asp Ser Met Ile Pro Glu Val Ile Lys 850 855 860 Met Phe Met Gly Ser Leu Phe Asn Val Ile Gly Ala Cys Ile Val Ile 865 870 875 880 Leu Leu Ala Thr Pro Ile Ala Ala Ile Ile Ile Pro Pro Leu Gly Leu 885 890 895 Ile Tyr Phe Phe Val Gln Arg Phe Tyr Val Ala Ser Ser Arg Gln Leu 900 905 910 Lys Arg Leu Glu Ser Val Ser Arg Ser Pro Val Tyr Ser His Phe Asn 915 920 925 Glu Thr Leu Leu Gly Val Ser Val Ile Arg Ala Phe Glu Glu Gln Glu 930 935 940 Arg Phe Ile His Gln Ser Asp Leu Lys Val Asp Glu Asn Gln Lys Ala 945 950 955 960 Tyr Tyr Pro Ser Ile Val Ala Asn Arg Trp Leu Ala Val Arg Leu Glu 965 970 975 Cys Val Gly Asn Cys Ile Val Leu Phe Ala Ala Leu Phe Ala Val Ile 980 985 990 Ser Arg His Ser Leu Ser Ala Gly Leu Val Gly Leu Ser Val Ser Tyr 995 1000 1005 Ser Leu Gln Val Thr Thr Tyr Leu Asn Trp Leu Val Arg Met Ser Ser 1010 1015 1020 Glu Met Glu Thr Asn Ile Val Ala Val Glu Arg Leu Lys Glu Tyr Ser 1025 1030 1035 1040 Glu Thr Glu Lys Glu Ala Pro Trp Gln Ile Gln Glu Thr Ala Pro Pro 1045 1050 1055 Ser Ser Trp Pro Gln Val Gly Arg Val Glu Phe Arg Asn Tyr Cys Leu 1060 1065 1070 Arg Tyr Arg Glu Asp Leu Asp Phe Val Leu Arg His Ile Asn Val Thr 1075 1080 1085 Ile Asn Gly Gly Glu Lys Val Gly Ile Val Gly Arg Thr Gly Ala Gly 1090 1095 1100 Lys Ser Ser Leu Thr Leu Gly Leu Phe Arg Ile Asn Glu Ser Ala Glu 1105 1110 1115 1120 Gly Glu Ile Ile Ile Asp Gly Ile Asn Ile Ala Lys Ile Gly Leu His 1125 1130 1135 Asp Leu Arg Phe Lys Ile Thr Ile Ile Pro Gln Asp Pro Val Leu Phe 1140 1145 1150 Ser Gly Ser Leu Arg Met Asn Leu Asp Pro Phe Ser Gln Tyr Ser Asp 1155 1160 1165 Glu Glu Val Trp Thr Ser Leu Glu Leu Ala His Leu Lys Asp Phe Val 1170 1175 1180 Ser Ala Leu Pro Asp Lys Leu Asp His Glu Cys Ala Glu Gly Gly Glu 1185 1190 1195 1200 Asn Leu Ser Val Gly Gln Arg Gln Leu Val Cys Leu Ala Arg Ala Leu 1205 1210 1215 Leu Arg Lys Thr Lys Ile Leu Val Leu Asp Glu Ala Thr Ala Ala Val 1220 1225 1230 Asp Leu Glu Thr Asp Asp Leu Ile Gln Ser Thr Ile Arg Thr Gln Phe 1235 1240 1245 Glu Asp Cys Thr Val Leu Thr Ile Ala His Arg Leu Asn Thr Ile Met 1250 1255 1260 Asp Tyr Thr Arg Val Ile Val Leu Asp Lys Gly Glu Ile Gln Glu Tyr 1265 1270 1275 1280 Gly Ala Pro Ser Asp Leu Leu Gln Gln Arg Gly Leu Phe Tyr Ser Met 1285 1290 1295 Ala Lys Asp Ala Gly Leu Val 1300 <210> SEQ ID NO 64 <211> LENGTH: 736 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 64 His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn 1 5 10 15 Thr Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys 20 25 30 Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg 35 40 45 Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Leu Gly 50 55 60 Ser Arg Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr 65 70 75 80 Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro 85 90 95 Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly 100 105 110 Ile Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val 115 120 125 Glu Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val 130 135 140 Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser 145 150 155 160 Arg Val Cys Gln Pro Pro Pro Glu Ile Leu His Gly Glu His Thr Pro 165 170 175 Ser His Gln Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys 180 185 190 Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Leu His Cys Thr Pro 195 200 205 Gln Gly Asp Trp Ser Pro Glu Ala Pro Arg Cys Ala Val Lys Ser Cys 210 215 220 Asp Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val Leu Phe Pro Leu 225 230 235 240 Asn Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys Asp Glu Gly Phe 245 250 255 Arg Leu Lys Gly Ser Ser Val Ser His Cys Val Leu Val Gly Met Arg 260 265 270 Ser Leu Trp Asn Asn Ser Val Pro Val Cys Glu His Ile Phe Cys Pro 275 280 285 Asn Pro Pro Ala Ile Leu Asn Gly Arg His Thr Gly Thr Pro Ser Gly 290 295 300 Asp Ile Pro Tyr Gly Lys Glu Ile Ser Tyr Thr Cys Asp Pro His Pro 305 310 315 320 Asp Arg Gly Met Thr Phe Asn Leu Ile Gly Glu Ser Thr Ile Arg Cys 325 330 335 Thr Ser Asp Pro His Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg 340 345 350 Cys Glu Leu Ser Val Arg Ala Gly His Cys Lys Thr Pro Glu Gln Phe 355 360 365 Pro Phe Ala Ser Pro Thr Ile Pro Ile Asn Asp Phe Glu Phe Pro Val 370 375 380 Gly Thr Ser Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Phe Gly Lys Met 385 390 395 400 Phe Ser Ile Ser Cys Leu Glu Asn Leu Val Trp Ser Ser Val Glu Asp 405 410 415 Asn Cys Arg Arg Lys Ser Cys Gly Pro Pro Pro Glu Pro Phe Asn Gly 420 425 430 Met Val His Ile Asn Thr Asp Thr Gln Phe Gly Ser Thr Val Asn Tyr 435 440 445 Ser Cys Asn Glu Gly Phe Arg Leu Ile Gly Ser Pro Ser Thr Thr Cys 450 455 460 Leu Val Ser Gly Asn Asn Val Thr Trp Asp Lys Lys Ala Pro Ile Cys 465 470 475 480 Glu Ile Ile Ser Cys Glu Pro Pro Pro Thr Ile Ser Asn Gly Asp Phe 485 490 495 Tyr Ser Asn Asn Arg Thr Ser Phe His Asn Gly Thr Val Val Thr Tyr 500 505 510 Gln Cys His Thr Gly Pro Asp Gly Glu Gln Leu Phe Glu Leu Val Gly 515 520 525 Glu Arg Ser Ile Tyr Cys Thr Ser Lys Asp Asp Gln Val Gly Val Trp 530 535 540 Ser Ser Pro Pro Pro Arg Cys Ile Ser Thr Asn Lys Cys Thr Ala Pro 545 550 555 560 Glu Val Glu Asn Ala Ile Arg Val Pro Gly Asn Arg Ser Phe Phe Thr 565 570 575 Leu Thr Glu Ile Ile Arg Phe Arg Cys Gln Pro Gly Phe Val Met Val 580 585 590 Gly Ser His Thr Val Gln Cys Gln Thr Asn Gly Arg Trp Gly Pro Lys 595 600 605 Leu Pro His Cys Ser Arg Val Cys Gln Pro Pro His Ile Leu His Gly 610 615 620 Glu His Thr Leu Ser His Gln Asp Asn Phe Ser Pro Gly Gln Glu Val 625 630 635 640 Phe Tyr Ser Cys Glu Pro Ser Tyr Asp Leu Arg Gly Ala Ala Ser Leu 645 650 655 His Cys Thr Pro Gln Gly Asp Trp Ser Pro Glu Ala Pro Arg Cys Thr 660 665 670 Val Lys Ser Cys Asp Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val 675 680 685 Leu Leu Pro Leu Asn Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys 690 695 700 Asp Glu Gly Phe Arg Leu Lys Gly Arg Ser Ala Ser His Cys Val Leu 705 710 715 720 Ala Gly Met Lys Ala Leu Trp Asn Ser Ser Val Pro Val Cys Glu Arg 725 730 735 <210> SEQ ID NO 65 <211> LENGTH: 738 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 65 Met Arg Gly Pro Pro Ala Trp Pro Leu Arg Leu Leu Glu Pro Pro Ser 1 5 10 15 Pro Ala Glu Pro Gly Arg Leu Leu Pro Val Ala Cys Val Trp Ala Ala 20 25 30 Ala Ser Arg Val Pro Gly Ser Leu Ser Pro Phe Thr Gly Leu Arg Pro 35 40 45 Ala Arg Leu Trp Gly Ala Gly Pro Ala Leu Leu Trp Gly Val Gly Ala 50 55 60 Ala Arg Arg Trp Arg Ser Gly Cys Arg Gly Gly Gly Pro Gly Ala Ser 65 70 75 80 Arg Gly Val Leu Gly Leu Ala Arg Leu Leu Gly Leu Trp Ala Arg Gly 85 90 95 Pro Gly Ser Cys Arg Cys Gly Ala Phe Ala Gly Pro Gly Ala Pro Arg 100 105 110 Leu Pro Arg Ala Arg Phe Pro Gly Gly Pro Ala Ala Ala Ala Trp Ala 115 120 125 Gly Asp Glu Ala Trp Arg Arg Gly Pro Ala Ala Pro Pro Gly Asp Lys 130 135 140 Gly Arg Leu Arg Pro Ala Ala Ala Gly Leu Pro Glu Ala Arg Lys Leu 145 150 155 160 Leu Gly Leu Ala Tyr Pro Glu Arg Arg Arg Leu Ala Ala Ala Val Gly 165 170 175 Phe Leu Thr Met Ser Ser Val Ile Ser Met Ser Ala Pro Phe Phe Leu 180 185 190 Gly Lys Ile Ile Asp Val Ile Tyr Thr Asn Pro Thr Val Asp Tyr Ser 195 200 205 Asp Asn Leu Thr Arg Leu Cys Leu Gly Leu Ser Ala Val Phe Leu Cys 210 215 220 Gly Ala Ala Ala Asn Ala Ile Arg Val Tyr Leu Met Gln Thr Ser Gly 225 230 235 240 Gln Arg Ile Val Asn Arg Leu Arg Thr Ser Leu Phe Ser Ser Ile Leu 245 250 255 Arg Gln Glu Val Ala Phe Phe Asp Lys Thr Arg Thr Gly Glu Leu Ile 260 265 270 Asn Arg Leu Ser Ser Asp Thr Ala Leu Leu Gly Arg Ser Val Thr Glu 275 280 285 Asn Leu Ser Asp Gly Leu Arg Ala Gly Ala Gln Ala Ser Val Gly Ile 290 295 300 Ser Met Met Phe Phe Val Ser Pro Asn Leu Ala Thr Phe Val Leu Ser 305 310 315 320 Val Val Pro Pro Val Ser Ile Ile Ala Val Ile Tyr Gly Arg Tyr Leu 325 330 335 Arg Lys Leu Thr Lys Val Thr Gln Asp Ser Leu Ala Gln Ala Thr Gln 340 345 350 Leu Ala Glu Glu Arg Ile Gly Asn Val Arg Thr Val Arg Ala Phe Gly 355 360 365 Lys Glu Met Thr Glu Ile Glu Lys Tyr Ala Ser Lys Val Asp His Val 370 375 380 Met Gln Leu Ala Arg Lys Glu Ala Phe Ala Arg Ala Gly Phe Phe Gly 385 390 395 400 Ala Thr Gly Leu Ser Gly Asn Leu Ile Val Leu Ser Val Leu Tyr Lys 405 410 415 Gly Gly Leu Leu Met Gly Ser Ala His Met Thr Val Gly Glu Leu Ser 420 425 430 Ser Phe Leu Met Tyr Ala Phe Trp Val Gly Ile Ser Ile Gly Gly Leu 435 440 445 Ser Ser Phe Tyr Ser Glu Leu Met Lys Gly Leu Gly Ala Gly Gly Arg 450 455 460 Leu Trp Glu Leu Leu Glu Arg Glu Pro Lys Leu Pro Phe Asn Glu Gly 465 470 475 480 Val Ile Leu Asn Glu Lys Ser Phe Gln Gly Ala Leu Glu Phe Lys Asn 485 490 495 Val His Phe Ala Tyr Pro Ala Arg Pro Glu Val Pro Ile Phe Gln Asp 500 505 510 Phe Ser Leu Ser Ile Pro Ser Gly Ser Val Thr Ala Leu Val Gly Pro 515 520 525 Ser Gly Ser Gly Lys Ser Thr Val Leu Ser Leu Leu Leu Arg Leu Tyr 530 535 540 Asp Pro Ala Ser Gly Thr Ile Ser Leu Asp Gly His Asp Ile Arg Gln 545 550 555 560 Leu Asn Pro Val Trp Leu Arg Ser Lys Ile Gly Thr Val Ser Gln Glu 565 570 575 Pro Ile Leu Phe Ser Cys Ser Ile Ala Glu Asn Ile Ala Tyr Gly Ala 580 585 590 Asp Asp Pro Ser Ser Val Thr Ala Glu Glu Ile Gln Arg Val Ala Glu 595 600 605 Val Ala Asn Ala Val Ala Phe Ile Arg Asn Phe Pro Gln Gly Phe Asn 610 615 620 Thr Val Val Gly Glu Lys Gly Val Leu Leu Ser Gly Gly Gln Lys Gln 625 630 635 640 Arg Ile Ala Ile Ala Arg Ala Leu Leu Lys Asn Pro Lys Ile Leu Leu 645 650 655 Leu Asp Glu Ala Thr Ser Ala Leu Asp Ala Glu Asn Glu Tyr Leu Val 660 665 670 Gln Glu Ala Leu Asp Arg Leu Met Asp Gly Arg Thr Val Leu Val Ile 675 680 685 Ala His Arg Leu Ser Thr Ile Lys Asn Ala Asn Met Val Ala Val Leu 690 695 700 Asp Gln Gly Lys Ile Thr Glu Tyr Gly Lys His Glu Glu Leu Leu Ser 705 710 715 720 Lys Pro Asn Gly Ile Tyr Arg Lys Leu Met Asn Lys Gln Ser Phe Ile 725 730 735 Ser Ala <210> SEQ ID NO 66 <211> LENGTH: 1273 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 66 Gly Ile Leu Thr Trp Tyr Ile Glu Ala Val His Pro Gly Met Tyr Gly 1 5 10 15 Leu Pro Arg Pro Trp Tyr Phe Pro Leu Gln Lys Ser Tyr Trp Leu Gly 20 25 30 Ser Gly Arg Thr Glu Ala Trp Glu Trp Ser Trp Pro Trp Ala Arg Thr 35 40 45 Pro Arg Leu Ser Val Met Glu Glu Asp Gln Ala Cys Ala Met Glu Ser 50 55 60 Arg Arg Phe Glu Glu Thr Arg Gly Met Glu Glu Glu Pro Thr His Leu 65 70 75 80 Pro Leu Val Val Cys Val Asp Lys Leu Thr Lys Val Tyr Lys Asp Asp 85 90 95 Lys Lys Leu Ala Leu Asn Lys Leu Ser Leu Asn Leu Tyr Glu Asn Gln 100 105 110 Val Val Ser Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr His His 115 120 125 Asn Val Leu Phe Asp Arg Leu Thr Val Glu Glu His Leu Trp Phe Tyr 130 135 140 Ser Arg Leu Lys Ser Met Ala Gln Glu Glu Ile Arg Arg Glu Met Asp 145 150 155 160 Lys Met Ile Glu Asp Leu Glu Leu Ser Asn Lys Arg His Ser Leu Val 165 170 175 Gln Thr Leu Ser Gly Gly Met Lys Arg Lys Leu Ser Val Ala Ile Ala 180 185 190 Phe Val Gly Gly Ser Arg Ala Ile Ile Leu Asp Glu Pro Thr Ala Gly 195 200 205 Val Asp Pro Tyr Ala Arg Arg Ala Ile Trp Asp Leu Ile Leu Lys Tyr 210 215 220 Lys Pro Gly Arg Thr Ile Leu Leu Ser Thr His His Met Asp Glu Ala 225 230 235 240 Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ser His Gly Lys Leu Lys 245 250 255 Cys Cys Gly Ser Pro Leu Phe Leu Lys Gly Thr Tyr Gly Asp Gly Tyr 260 265 270 Arg Leu Thr Leu Val Lys Arg Pro Ala Glu Pro Gly Gly Pro Gln Glu 275 280 285 Pro Gly Leu Ala Ser Ser Pro Pro Gly Arg Ala Pro Leu Ser Ser Cys 290 295 300 Ser Glu Leu Gln Val Ser Gln Phe Ile Arg Lys His Val Ala Ser Cys 305 310 315 320 Leu Leu Val Ser Asp Thr Ser Thr Glu Leu Ser Tyr Ile Leu Pro Ser 325 330 335 Glu Ala Ala Lys Lys Gly Ala Phe Glu Arg Leu Phe Gln His Leu Glu 340 345 350 Arg Ser Leu Asp Ala Leu His Leu Ser Ser Phe Gly Leu Met Asp Thr 355 360 365 Thr Leu Glu Glu Val Phe Leu Lys Val Ser Glu Glu Asp Gln Ser Leu 370 375 380 Glu Asn Ser Glu Ala Asp Val Lys Glu Ser Arg Lys Asp Val Leu Pro 385 390 395 400 Gly Ala Glu Gly Pro Ala Ser Gly Glu Gly His Ala Gly Asn Leu Ala 405 410 415 Arg Cys Ser Glu Leu Thr Gln Ser Gln Ala Ser Leu Gln Ser Ala Ser 420 425 430 Ser Val Gly Ser Ala Arg Gly Asp Glu Gly Ala Gly Tyr Thr Asp Val 435 440 445 Tyr Gly Asp Tyr Arg Pro Leu Phe Asp Asn Pro Gln Asp Pro Asp Asn 450 455 460 Val Ser Leu Gln Glu Val Glu Ala Glu Ala Leu Ser Arg Val Gly Gln 465 470 475 480 Gly Ser Arg Lys Leu Asp Gly Gly Trp Leu Lys Val Arg Gln Phe His 485 490 495 Gly Leu Leu Val Lys Arg Phe His Cys Ala Arg Arg Asn Ser Lys Ala 500 505 510 Leu Phe Ser Gln Ile Leu Leu Pro Ala Phe Phe Val Cys Val Ala Met 515 520 525 Thr Val Ala Leu Ser Val Pro Glu Ile Gly Asp Leu Pro Pro Leu Val 530 535 540 Leu Ser Pro Ser Gln Tyr His Asn Tyr Thr Gln Pro Arg Gly Asn Phe 545 550 555 560 Ile Pro Tyr Ala Asn Glu Glu Arg Arg Glu Tyr Arg Arg His Pro Ala 565 570 575 Gly Ala Ser Leu Val Gly Gly Ala Ser Glu Gly Ala Gly Thr Ala Leu 580 585 590 Val Gly Gln Ala Gly Glu Gly Ala Gly Leu Ala Arg Gly Gly Asp Trp 595 600 605 Gln Pro His Leu Thr Leu Ile Trp Gly Arg Gly Gly Glu Asp Leu Gly 610 615 620 Pro Glu Ser Ala Ala Pro Ala Pro Pro Cys Ala Gly Ile Thr Val Thr 625 630 635 640 Asn His Pro Met Asn Lys Thr Ser Ala Ser Leu Ser Leu Asp Tyr Leu 645 650 655 Leu Gln Gly Thr Asp Val Val Ile Ala Ile Phe Ile Ile Val Ala Met 660 665 670 Ser Phe Val Pro Ala Ser Phe Val Val Phe Leu Val Ala Glu Lys Ser 675 680 685 Thr Lys Ala Lys His Leu Gln Phe Val Ser Gly Cys Asn Pro Ile Ile 690 695 700 Tyr Trp Leu Ala Asn Tyr Val Trp Asp Met Leu Asn Tyr Leu Val Pro 705 710 715 720 Ala Thr Cys Cys Val Ile Ile Leu Phe Val Phe Asp Leu Pro Ala Tyr 725 730 735 Thr Ser Pro Thr Asn Phe Pro Ala Val Leu Ser Leu Phe Leu Leu Tyr 740 745 750 Gly Trp Ser Ile Thr Pro Ile Met Tyr Pro Ala Ser Phe Trp Phe Glu 755 760 765 Val Pro Ser Ser Ala Tyr Val Phe Leu Ile Val Ile Asn Leu Phe Ile 770 775 780 Gly Ile Thr Ala Thr Val Ala Thr Phe Leu Leu Gln Leu Phe Glu His 785 790 795 800 Asp Lys Asp Leu Lys Val Val Asn Ser Tyr Leu Lys Ser Cys Phe Leu 805 810 815 Ile Phe Pro Asn Tyr Asn Leu Gly His Gly Leu Met Glu Met Ala Tyr 820 825 830 Asn Glu Tyr Ile Asn Glu Tyr Tyr Ala Lys Ile Gly Gln Phe Asp Lys 835 840 845 Met Lys Ser Pro Phe Glu Trp Asp Ile Val Thr Arg Gly Leu Val Ala 850 855 860 Met Ala Val Glu Gly Val Val Gly Phe Leu Leu Thr Ile Met Cys Gln 865 870 875 880 Tyr Asn Phe Leu Arg Arg Pro Gln Arg Met Pro Val Ser Thr Lys Pro 885 890 895 Val Glu Asp Asp Val Asp Val Ala Ser Glu Arg Gln Arg Val Leu Arg 900 905 910 Gly Asp Ser Asp Asn Asp Met Cys Phe Gly Leu Leu Gly Val Asn Gly 915 920 925 Ala Gly Lys Thr Ser Thr Phe Lys Met Leu Thr Gly Asp Glu Ser Thr 930 935 940 Thr Gly Gly Glu Ala Phe Val Asn Gly His Ser Val Leu Lys Glu Leu 945 950 955 960 Leu Gln Val Gln Gln Ser Leu Gly Tyr Cys Pro Gln Cys Asp Ala Leu 965 970 975 Phe Asp Glu Leu Thr Ala Arg Glu His Leu Gln Leu Tyr Thr Arg Leu 980 985 990 Arg Gly Ile Ser Trp Lys Asp Glu Ala Arg Val Val Lys Trp Ala Leu 995 1000 1005 Glu Lys Leu Glu Leu Thr Lys Tyr Ala Asp Lys Pro Ala Gly Thr Tyr 1010 1015 1020 Ser Gly Gly Asn Lys Arg Lys Leu Ser Thr Ala Ile Ala Leu Ile Gly 1025 1030 1035 1040 Tyr Pro Ala Phe Ile Phe Leu Asp Glu Pro Thr Thr Gly Met Asp Pro 1045 1050 1055 Lys Ala Arg Arg Phe Leu Trp Asn Leu Ile Leu Asp Leu Ile Lys Thr 1060 1065 1070 Gly Arg Ser Val Val Leu Thr Ser His Ser Met Glu Glu Cys Glu Ala 1075 1080 1085 Leu Cys Thr Arg Leu Ala Ile Met Val Asn Gly Arg Leu Arg Cys Leu 1090 1095 1100 Gly Ser Ile Gln His Leu Lys Asn Arg Phe Gly Asp Gly Tyr Met Ile 1105 1110 1115 1120 Thr Val Arg Thr Lys Ser Ser Gln Ser Val Lys Asp Val Val Arg Phe 1125 1130 1135 Phe Asn Arg Asn Phe Pro Glu Ala Met Leu Lys Glu Arg His His Thr 1140 1145 1150 Lys Val Gln Tyr Gln Leu Lys Ser Glu His Ile Ser Leu Ala Gln Val 1155 1160 1165 Phe Ser Lys Met Glu Gln Val Ser Gly Val Leu Gly Ile Glu Asp Tyr 1170 1175 1180 Ser Val Ser Gln Thr Thr Leu Asp Asn Val Phe Val Asn Phe Ala Lys 1185 1190 1195 1200 Lys Gln Ser Asp Asn Leu Glu Gln Gln Glu Thr Glu Pro Pro Ser Ala 1205 1210 1215 Leu Gln Ser Pro Leu Gly Cys Leu Leu Ser Leu Leu Arg Pro Arg Ser 1220 1225 1230 Ala Pro Thr Glu Leu Arg Ala Leu Val Ala Asp Glu Pro Glu Asp Leu 1235 1240 1245 Asp Thr Glu Asp Glu Gly Leu Ile Ser Phe Glu Glu Glu Arg Ala Gln 1250 1255 1260 Leu Ser Phe Asn Thr Asp Thr Leu Cys 1265 1270 <210> SEQ ID NO 67 <211> LENGTH: 1479 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 67 Met Gly Pro Gly Arg Pro Ala Pro Ala Pro Trp Pro Arg His Leu Leu 1 5 10 15 Arg Cys Val Leu Leu Leu Gly Cys Leu His Leu Gly Arg Pro Gly Ala 20 25 30 Pro Gly Asp Ala Ala Leu Pro Glu Pro Asn Ile Phe Leu Ile Phe Ser 35 40 45 His Gly Leu Gln Gly Cys Leu Glu Ala Gln Gly Gly Gln Val Arg Val 50 55 60 Thr Pro Ala Cys Asn Thr Ser Leu Pro Ala Gln Arg Trp Lys Trp Val 65 70 75 80 Ser Arg Asn Arg Leu Phe Asn Leu Gly Thr Met Gln Cys Leu Gly Thr 85 90 95 Gly Trp Pro Gly Thr Asn Thr Thr Ala Ser Leu Gly Met Tyr Glu Cys 100 105 110 Asp Arg Glu Ala Leu Asn Leu Arg Trp His Cys Arg Thr Leu Gly Asp 115 120 125 Gln Leu Ser Leu Leu Leu Gly Ala Arg Thr Ser Asn Ile Ser Lys Pro 130 135 140 Gly Thr Leu Glu Arg Gly Asp Gln Thr Arg Ser Gly Gln Trp Arg Ile 145 150 155 160 Tyr Gly Ser Glu Glu Asp Leu Cys Ala Leu Pro Tyr His Glu Val Tyr 165 170 175 Thr Ile Gln Gly Asn Ser His Gly Lys Pro Cys Thr Ile Pro Phe Lys 180 185 190 Tyr Asp Asn Gln Trp Phe His Gly Cys Thr Ser Thr Gly Arg Glu Asp 195 200 205 Gly His Leu Trp Cys Ala Thr Thr Gln Asp Tyr Gly Lys Asp Glu Arg 210 215 220 Trp Gly Phe Cys Pro Ile Lys Ser Asn Asp Cys Glu Thr Phe Trp Asp 225 230 235 240 Lys Asp Gln Leu Thr Asp Ser Cys Tyr Gln Phe Asn Phe Gln Ser Thr 245 250 255 Leu Ser Trp Arg Glu Ala Trp Ala Ser Cys Glu Gln Gln Gly Ala Asp 260 265 270 Leu Leu Ser Ile Thr Glu Ile His Glu Gln Thr Tyr Ile Asn Gly Leu 275 280 285 Leu Thr Gly Tyr Ser Ser Thr Leu Trp Ile Gly Leu Asn Asp Leu Asp 290 295 300 Thr Ser Gly Gly Trp Gln Trp Ser Asp Asn Ser Pro Leu Lys Tyr Leu 305 310 315 320 Asn Trp Glu Ser Asp Gln Pro Asp Asn Pro Ser Glu Glu Asn Cys Gly 325 330 335 Val Ile Arg Thr Glu Ser Ser Gly Gly Trp Gln Asn Arg Asp Cys Ser 340 345 350 Ile Ala Leu Pro Tyr Val Cys Lys Lys Lys Pro Asn Ala Thr Ala Glu 355 360 365 Pro Thr Pro Pro Asp Arg Trp Ala Asn Val Lys Val Glu Cys Glu Pro 370 375 380 Ser Trp Gln Pro Phe Gln Gly His Cys Tyr Arg Leu Gln Ala Glu Lys 385 390 395 400 Arg Ser Trp Gln Glu Ser Lys Lys Ala Cys Leu Arg Gly Gly Gly Asp 405 410 415 Leu Val Ser Ile His Ser Met Ala Glu Leu Glu Phe Ile Thr Lys Gln 420 425 430 Ile Lys Gln Glu Val Glu Glu Leu Trp Ile Gly Leu Asn Asp Leu Lys 435 440 445 Leu Gln Met Asn Phe Glu Trp Ser Asp Gly Ser Leu Val Ser Phe Thr 450 455 460 His Trp His Pro Phe Glu Pro Asn Asn Phe Arg Asp Ser Leu Glu Asp 465 470 475 480 Cys Val Thr Ile Trp Gly Pro Glu Gly Arg Trp Asn Asp Ser Pro Cys 485 490 495 Asn Gln Ser Leu Pro Ser Ile Cys Lys Lys Ala Gly Gln Leu Ser Gln 500 505 510 Gly Ala Ala Glu Glu Asp His Gly Cys Arg Lys Gly Trp Thr Trp His 515 520 525 Ser Pro Ser Cys Tyr Trp Leu Gly Glu Asp Gln Val Thr Tyr Ser Glu 530 535 540 Ala Arg Arg Leu Cys Thr Asp His Gly Ser Gln Leu Val Thr Ile Thr 545 550 555 560 Asn Arg Phe Glu Gln Ala Phe Val Ser Ser Leu Ile Tyr Asn Trp Glu 565 570 575 Gly Glu Tyr Phe Trp Thr Ala Leu Gln Asp Leu Asn Ser Thr Gly Ser 580 585 590 Phe Phe Trp Leu Ser Gly Asp Glu Val Met Tyr Thr His Trp Asn Arg 595 600 605 Asp Gln Pro Gly Tyr Ser Arg Gly Gly Cys Val Ala Leu Ala Thr Gly 610 615 620 Ser Ala Met Gly Leu Trp Glu Val Lys Asn Cys Thr Ser Phe Arg Ala 625 630 635 640 Arg Tyr Ile Cys Arg Gln Ser Leu Gly Thr Pro Val Thr Pro Glu Leu 645 650 655 Pro Gly Pro Asp Pro Thr Pro Ser Leu Thr Gly Ser Cys Pro Gln Gly 660 665 670 Trp Ala Ser Asp Thr Lys Leu Arg Tyr Cys Tyr Lys Val Phe Ser Ser 675 680 685 Glu Arg Leu Gln Asp Lys Lys Ser Trp Val Gln Ala Gln Gly Ala Cys 690 695 700 Gln Glu Leu Gly Ala Gln Leu Leu Ser Leu Ala Ser Tyr Glu Glu Glu 705 710 715 720 His Phe Val Ala Asn Met Leu Asn Lys Ile Phe Gly Glu Ser Glu Pro 725 730 735 Glu Ile His Glu Gln His Trp Phe Trp Ile Gly Leu Asn Arg Arg Asp 740 745 750 Pro Arg Gly Gly Gln Ser Trp Arg Trp Ser Asp Gly Val Gly Phe Ser 755 760 765 Tyr His Asn Phe Asp Arg Ser Arg His Asp Asp Asp Asp Ile Arg Gly 770 775 780 Cys Ala Val Leu Asp Leu Ala Ser Leu Gln Trp Val Ala Met Gln Cys 785 790 795 800 Asp Thr Gln Leu Asp Trp Ile Cys Lys Ile Pro Arg Gly Thr Asp Val 805 810 815 Arg Glu Pro Asp Asp Ser Pro Gln Gly Arg Arg Glu Trp Leu Arg Phe 820 825 830 Gln Glu Ala Glu Tyr Lys Phe Phe Glu His His Ser Thr Trp Ala Gln 835 840 845 Ala Gln Arg Ile Cys Thr Trp Phe Gln Ala Glu Leu Thr Ser Val His 850 855 860 Ser Gln Ala Glu Leu Asp Phe Leu Ser His Asn Leu Gln Lys Phe Ser 865 870 875 880 Arg Ala Gln Glu Gln His Trp Trp Ile Gly Leu His Thr Ser Glu Ser 885 890 895 Asp Gly Arg Phe Arg Trp Thr Asp Gly Ser Ile Ile Asn Phe Ile Ser 900 905 910 Trp Ala Pro Gly Lys Pro Arg Pro Val Gly Lys Asp Lys Lys Cys Val 915 920 925 Tyr Met Thr Ala Ser Arg Glu Asp Trp Gly Asp Gln Arg Cys Leu Thr 930 935 940 Ala Leu Pro Tyr Ile Cys Lys Arg Ser Asn Val Thr Lys Glu Thr Gln 945 950 955 960 Pro Pro Asp Leu Pro Thr Thr Ala Leu Gly Gly Cys Pro Ser Asp Trp 965 970 975 Ile Gln Phe Leu Asn Lys Cys Phe Gln Val Gln Gly Gln Glu Pro Gln 980 985 990 Ser Arg Val Lys Trp Ser Glu Ala Gln Phe Ser Cys Glu Gln Gln Glu 995 1000 1005 Ala Gln Leu Val Thr Ile Thr Asn Pro Leu Glu Gln Ala Phe Ile Thr 1010 1015 1020 Ala Ser Leu Pro Asn Val Thr Phe Asp Leu Trp Ile Gly Leu His Ala 1025 1030 1035 1040 Ser Gln Arg Asp Phe Gln Trp Val Glu Gln Glu Pro Leu Met Tyr Ala 1045 1050 1055 Asn Trp Ala Pro Gly Glu Pro Ser Gly Pro Ser Pro Ala Pro Ser Gly 1060 1065 1070 Asn Lys Pro Thr Ser Cys Ala Val Val Leu His Ser Pro Ser Ala His 1075 1080 1085 Phe Thr Gly Arg Trp Asp Asp Arg Ser Cys Thr Glu Glu Thr His Gly 1090 1095 1100 Phe Ile Cys Gln Lys Gly Thr Asp Pro Ser Leu Ser Pro Ser Pro Ala 1105 1110 1115 1120 Ala Leu Pro Pro Ala Pro Gly Thr Glu Leu Ser Tyr Leu Asn Gly Thr 1125 1130 1135 Phe Arg Leu Leu Gln Lys Pro Leu Arg Trp His Asp Ala Leu Leu Leu 1140 1145 1150 Cys Glu Ser His Asn Ala Ser Leu Ala Tyr Val Pro Asp Pro Tyr Thr 1155 1160 1165 Gln Ala Phe Leu Thr Gln Ala Ala Arg Gly Leu Arg Thr Pro Leu Trp 1170 1175 1180 Ile Gly Leu Ala Gly Glu Glu Gly Ser Arg Arg Tyr Ser Trp Val Ser 1185 1190 1195 1200 Glu Glu Pro Leu Asn Tyr Val Gly Trp Gln Asp Gly Glu Pro Gln Gln 1205 1210 1215 Pro Gly Gly Cys Thr Tyr Val Asp Val Asp Gly Ala Trp Arg Thr Thr 1220 1225 1230 Ser Cys Asp Thr Lys Leu Gln Gly Ala Val Cys Gly Val Ser Ser Gly 1235 1240 1245 Pro Pro Pro Pro Arg Arg Ile Ser Tyr His Gly Ser Cys Pro Gln Gly 1250 1255 1260 Leu Ala Asp Ser Ala Trp Ile Pro Phe Arg Glu His Cys Tyr Ser Phe 1265 1270 1275 1280 His Met Glu Leu Leu Leu Gly His Lys Glu Ala Arg Gln Arg Cys Gln 1285 1290 1295 Arg Ala Gly Gly Ala Val Leu Ser Ile Leu Asp Glu Met Glu Asn Val 1300 1305 1310 Phe Val Trp Glu His Leu Gln Ser Tyr Glu Gly Gln Ser Arg Gly Ala 1315 1320 1325 Trp Leu Gly Met Asn Phe Asn Pro Lys Gly Gly Thr Leu Val Trp Gln 1330 1335 1340 Asp Asn Thr Ala Val Asn Tyr Ser Asn Trp Gly Pro Pro Gly Leu Gly 1345 1350 1355 1360 Pro Ser Met Leu Ser His Asn Ser Cys Tyr Trp Ile Gln Ser Asn Ser 1365 1370 1375 Gly Leu Trp Arg Pro Gly Ala Cys Thr Asn Ile Thr Met Gly Val Val 1380 1385 1390 Cys Lys Leu Pro Arg Ala Glu Gln Ser Ser Phe Ser Pro Ser Ala Leu 1395 1400 1405 Pro Glu Asn Pro Ala Ala Leu Val Val Val Leu Met Ala Val Leu Leu 1410 1415 1420 Leu Leu Ala Leu Leu Thr Ala Ala Leu Ile Leu Tyr Arg Arg Arg Gln 1425 1430 1435 1440 Ser Ile Glu Arg Gly Ala Phe Glu Gly Ala Arg Tyr Ser Arg Ser Ser 1445 1450 1455 Ser Ser Pro Thr Glu Ala Thr Glu Lys Asn Ile Leu Val Ser Asp Met 1460 1465 1470 Glu Met Asn Glu Gln Gln Glu 1475 <210> SEQ ID NO 68 <211> LENGTH: 583 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 68 Met Lys Tyr Ile Leu Val Thr Gly Gly Val Ile Ser Gly Ile Gly Lys 1 5 10 15 Gly Ile Ile Ala Ser Ser Ile Gly Thr Ile Leu Lys Ser Cys Gly Leu 20 25 30 Arg Val Thr Ala Ile Lys Ile Asp Pro Tyr Ile Asn Ile Asp Ala Gly 35 40 45 Thr Phe Ser Pro Tyr Glu His Gly Glu Val Phe Val Leu Asn Asp Gly 50 55 60 Gly Glu Val Asp Leu Asp Leu Gly Asn Tyr Glu Arg Phe Leu Asp Ile 65 70 75 80 Asn Leu Tyr Lys Asp Asn Asn Ile Thr Thr Gly Lys Ile Tyr Gln His 85 90 95 Val Ile Asn Lys Glu Arg Arg Gly Asp Tyr Leu Gly Lys Thr Val Gln 100 105 110 Val Val Pro His Ile Thr Asp Ala Val Gln Glu Trp Val Met Asn Gln 115 120 125 Ala Lys Val Pro Val Asp Gly Asn Lys Glu Glu Pro Gln Ile Cys Leu 130 135 140 Gly Gly Thr Ile Gly Asp Ile Glu Gly Met Pro Phe Val Glu Ala Phe 145 150 155 160 Arg Gln Phe Gln Phe Lys Ala Lys Arg Glu Asn Phe Cys Asn Ile His 165 170 175 Val Ser Leu Val Pro Gln Leu Ser Ala Thr Gly Glu Gln Lys Thr Lys 180 185 190 Pro Thr Gln Asn Ser Val Arg Ala Leu Arg Gly Leu Gly Leu Ser Pro 195 200 205 Asp Leu Ile Val Cys Arg Ser Ser Thr Pro Ile Glu Met Ala Val Lys 210 215 220 Glu Lys Ile Ser Met Phe Cys His Val Asn Pro Glu Gln Val Ile Cys 225 230 235 240 Ile His Asp Val Ser Ser Thr Tyr Arg Val Pro Val Leu Leu Glu Glu 245 250 255 Gln Ser Ile Val Lys Tyr Phe Lys Glu Arg Leu His Leu Pro Ile Gly 260 265 270 Asp Ser Ala Ser Asn Leu Leu Phe Lys Trp Arg Asn Met Ala Asp Arg 275 280 285 Tyr Glu Arg Leu Gln Lys Ile Cys Ser Ile Ala Leu Val Gly Lys Tyr 290 295 300 Thr Lys Leu Arg Asp Cys Tyr Ala Ser Val Phe Lys Ala Leu Glu His 305 310 315 320 Ser Ala Leu Ala Ile Asn His Lys Leu Asn Leu Met Tyr Ile Asp Ser 325 330 335 Ile Asp Leu Glu Lys Ile Thr Glu Thr Glu Asp Pro Val Lys Phe His 340 345 350 Glu Ala Trp Gln Lys Leu Cys Lys Ala Asp Gly Ile Leu Val Pro Gly 355 360 365 Gly Phe Gly Ile Arg Gly Thr Leu Gly Lys Leu Gln Ala Ile Ser Trp 370 375 380 Ala Arg Thr Lys Lys Ile Pro Phe Leu Gly Val Cys Leu Gly Met Gln 385 390 395 400 Leu Ala Val Ile Glu Phe Ala Arg Asn Cys Leu Asn Leu Lys Asp Ala 405 410 415 Asp Ser Thr Glu Phe Arg Pro Asn Ala Pro Val Pro Leu Val Ile Asp 420 425 430 Met Pro Glu His Asn Pro Gly Asn Leu Gly Gly Thr Met Arg Leu Gly 435 440 445 Ile Arg Arg Thr Val Phe Lys Thr Glu Asn Ser Ile Leu Arg Lys Leu 450 455 460 Tyr Gly Asp Val Pro Phe Ile Glu Glu Arg His Arg His Arg Phe Glu 465 470 475 480 Val Asn Pro Asn Leu Ile Lys Gln Phe Glu Gln Asn Asp Leu Ser Phe 485 490 495 Val Gly Gln Asp Val Asp Gly Asp Arg Met Glu Ile Ile Glu Leu Ala 500 505 510 Asn His Pro Tyr Phe Val Gly Val Gln Phe His Pro Glu Phe Ser Ser 515 520 525 Arg Pro Met Lys Pro Ser Pro Pro Tyr Leu Gly Leu Leu Leu Ala Ala 530 535 540 Thr Gly Asn Leu Asn Ala Tyr Leu Gln Gln Gly Cys Lys Leu Ser Ser 545 550 555 560 Ser Asp Arg Tyr Ser Asp Ala Ser Asp Asp Ser Phe Ser Glu Pro Arg 565 570 575 Ile Ala Glu Leu Glu Ile Ser 580 <210> SEQ ID NO 69 <211> LENGTH: 1241 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 69 Ser Pro Ile Leu Cys Gly Ala Ala Thr Ala Leu Asn Cys Ser Leu Cys 1 5 10 15 Pro Gln Asp Ser Asn Leu Ser Val His Thr Glu Asn Pro Asp Leu Thr 20 25 30 Pro Cys Phe Gln Asn Ser Leu Leu Ala Trp Val Pro Cys Ile Tyr Leu 35 40 45 Trp Val Ala Leu Pro Cys Tyr Leu Leu Tyr Leu Arg His His Cys Arg 50 55 60 Gly Tyr Ile Ile Leu Ser His Leu Ser Lys Leu Lys Met Val Leu Gly 65 70 75 80 Val Leu Leu Trp Cys Val Ser Trp Ala Asp Leu Phe Tyr Ser Phe His 85 90 95 Gly Leu Val His Gly Arg Ala Pro Ala Pro Val Phe Phe Val Thr Pro 100 105 110 Leu Val Val Gly Val Thr Met Leu Leu Ala Thr Leu Leu Ile Gln Tyr 115 120 125 Glu Arg Leu Gln Gly Val Gln Ser Ser Gly Val Leu Ile Ile Phe Trp 130 135 140 Phe Leu Cys Val Val Cys Ala Ile Val Pro Phe Arg Ser Lys Ile Leu 145 150 155 160 Leu Ala Lys Ala Glu Gly Glu Ile Ser Asp Pro Phe Arg Phe Thr Thr 165 170 175 Phe Tyr Ile His Phe Ala Leu Val Leu Ser Ala Leu Ile Leu Ala Cys 180 185 190 Phe Arg Glu Lys Pro Pro Phe Phe Ser Ala Lys Asn Val Asp Pro Asn 195 200 205 Pro Tyr Pro Glu Thr Ser Ala Gly Phe Leu Ser Arg Leu Phe Phe Trp 210 215 220 Trp Phe Thr Lys Met Ala Ile Tyr Gly Tyr Arg His Pro Leu Glu Glu 225 230 235 240 Lys Asp Leu Trp Ser Leu Lys Glu Glu Asp Arg Ser Gln Met Val Val 245 250 255 Gln Gln Leu Leu Glu Ala Trp Arg Lys Gln Glu Lys Gln Thr Ala Arg 260 265 270 His Lys Ala Ser Ala Ala Pro Gly Lys Asn Ala Ser Gly Glu Asp Glu 275 280 285 Val Leu Leu Gly Ala Arg Pro Arg Pro Arg Lys Pro Ser Phe Leu Lys 290 295 300 Ala Leu Leu Ala Thr Phe Gly Ser Ser Phe Leu Ile Ser Ala Cys Phe 305 310 315 320 Lys Leu Ile Gln Asp Leu Leu Ser Phe Ile Asn Pro Gln Leu Leu Ser 325 330 335 Ile Leu Ile Arg Phe Ile Ser Asn Pro Met Ala Pro Ser Trp Trp Gly 340 345 350 Phe Leu Val Ala Gly Leu Met Phe Leu Cys Ser Met Met Gln Ser Leu 355 360 365 Ile Leu Gln His Tyr Tyr His Tyr Ile Phe Val Thr Gly Val Lys Phe 370 375 380 Arg Thr Gly Ile Met Gly Val Ile Tyr Arg Lys Ala Leu Val Ile Thr 385 390 395 400 Asn Ser Val Lys Arg Ala Ser Thr Val Gly Glu Ile Val Asn Leu Met 405 410 415 Ser Val Asp Ala Gln Arg Phe Met Asp Leu Ala Pro Phe Leu Asn Leu 420 425 430 Leu Trp Ser Ala Pro Leu Gln Ile Ile Leu Ala Ile Tyr Phe Leu Trp 435 440 445 Gln Asn Leu Gly Pro Ser Val Leu Ala Gly Val Ala Phe Met Val Leu 450 455 460 Leu Ile Pro Leu Asn Gly Ala Val Ala Val Lys Met Arg Ala Phe Gln 465 470 475 480 Val Lys Gln Met Lys Leu Lys Asp Ser Arg Ile Lys Leu Met Ser Glu 485 490 495 Ile Leu Asn Gly Ile Lys Val Leu Lys Leu Tyr Ala Trp Glu Pro Ser 500 505 510 Phe Leu Lys Gln Val Glu Gly Ile Arg Gln Gly Glu Leu Gln Leu Leu 515 520 525 Arg Thr Ala Ala Tyr Leu His Thr Thr Thr Thr Phe Thr Trp Met Cys 530 535 540 Ser Pro Phe Leu Val Thr Leu Ile Thr Leu Trp Val Tyr Val Tyr Val 545 550 555 560 Asp Pro Asn Asn Val Leu Asp Ala Glu Lys Ala Phe Val Ser Val Ser 565 570 575 Leu Phe Asn Ile Leu Arg Leu Pro Leu Asn Met Leu Pro Gln Leu Ile 580 585 590 Ser Asn Leu Thr Gln Ala Ser Val Ser Leu Lys Arg Ile Gln Gln Phe 595 600 605 Leu Ser Gln Glu Glu Leu Asp Pro Gln Ser Val Glu Arg Lys Thr Ile 610 615 620 Ser Pro Gly Tyr Ala Ile Thr Ile His Ser Gly Thr Phe Thr Trp Ala 625 630 635 640 Gln Asp Leu Pro Pro Thr Leu His Ser Leu Asp Ile Gln Val Pro Lys 645 650 655 Gly Ala Leu Val Ala Val Val Gly Pro Val Gly Cys Gly Lys Ser Ser 660 665 670 Leu Val Ser Ala Leu Leu Gly Glu Met Glu Lys Leu Glu Gly Lys Val 675 680 685 His Met Lys Gly Ser Val Ala Tyr Val Pro Gln Gln Ala Trp Ile Gln 690 695 700 Asn Cys Thr Leu Gln Glu Asn Val Leu Phe Gly Lys Ala Leu Asn Pro 705 710 715 720 Lys Arg Tyr Gln Gln Thr Leu Glu Ala Cys Ala Leu Leu Ala Asp Leu 725 730 735 Glu Met Leu Pro Gly Gly Asp Gln Thr Glu Ile Gly Glu Lys Gly Ile 740 745 750 Asn Leu Ser Gly Gly Gln Arg Gln Arg Val Ser Leu Ala Arg Ala Val 755 760 765 Tyr Ser Asp Ala Asp Ile Phe Leu Leu Asp Asp Pro Leu Ser Ala Val 770 775 780 Asp Ser His Val Ala Lys His Ile Phe Asp His Val Ile Gly Pro Glu 785 790 795 800 Gly Val Leu Ala Gly Lys Thr Arg Val Leu Val Thr His Gly Ile Ser 805 810 815 Phe Leu Pro Gln Thr Asp Phe Ile Ile Val Leu Ala Asp Gly Gln Val 820 825 830 Ser Glu Met Gly Pro Tyr Pro Ala Leu Leu Gln Arg Asn Gly Ser Phe 835 840 845 Ala Asn Phe Leu Cys Asn Tyr Ala Pro Asp Glu Asp Gln Gly His Leu 850 855 860 Glu Asp Ser Trp Thr Ala Leu Glu Gly Ala Glu Asp Lys Glu Ala Leu 865 870 875 880 Leu Ile Glu Asp Thr Leu Ser Asn His Thr Asp Leu Thr Asp Asn Asp 885 890 895 Pro Val Thr Tyr Val Val Gln Lys Gln Phe Met Arg Gln Leu Ser Ala 900 905 910 Leu Ser Ser Asp Gly Glu Gly Gln Gly Arg Pro Val Pro Arg Arg His 915 920 925 Leu Gly Pro Ser Glu Lys Val Gln Val Thr Glu Ala Lys Ala Asp Gly 930 935 940 Ala Leu Thr Gln Glu Glu Lys Ala Ala Ile Gly Thr Val Glu Leu Ser 945 950 955 960 Val Phe Trp Asp Tyr Ala Lys Ala Val Gly Leu Cys Thr Thr Leu Ala 965 970 975 Ile Cys Leu Leu Tyr Val Gly Gln Ser Ala Ala Ala Ile Gly Ala Asn 980 985 990 Val Trp Leu Ser Ala Trp Thr Asn Asp Ala Met Ala Asp Ser Arg Gln 995 1000 1005 Asn Asn Thr Ser Leu Arg Leu Gly Val Tyr Ala Ala Leu Gly Ile Leu 1010 1015 1020 Gln Gly Phe Leu Val Met Leu Ala Ala Met Ala Met Ala Ala Gly Gly 1025 1030 1035 1040 Ile Gln Ala Ala Arg Val Leu His Gln Ala Leu Leu His Asn Lys Ile 1045 1050 1055 Arg Ser Pro Gln Ser Phe Phe Asp Thr Thr Pro Ser Gly Arg Ile Leu 1060 1065 1070 Asn Cys Phe Ser Lys Asp Ile Tyr Val Val Asp Glu Val Leu Ala Pro 1075 1080 1085 Val Ile Leu Met Leu Leu Asn Ser Phe Phe Asn Ala Ile Ser Thr Leu 1090 1095 1100 Val Val Ile Met Ala Ser Thr Pro Leu Phe Thr Val Val Ile Leu Pro 1105 1110 1115 1120 Leu Ala Val Leu Tyr Thr Leu Val Gln Arg Phe Tyr Ala Ala Thr Ser 1125 1130 1135 Arg Gln Leu Lys Arg Leu Glu Ser Val Ser Arg Ser Pro Ile Tyr Ser 1140 1145 1150 His Phe Ser Glu Thr Val Thr Gly Ala Ser Val Ile Arg Ala Tyr Asn 1155 1160 1165 Arg Ser Arg Asp Phe Glu Ile Ile Ser Asp Thr Lys Val Asp Ala Asn 1170 1175 1180 Gln Arg Ser Cys Tyr Pro Tyr Ile Ile Ser Asn Arg Ser Glu Ala Ala 1185 1190 1195 1200 Ser Leu Ala Pro Cys Ser Ser Arg Asn Ser Gln Gln Ala Leu Trp Cys 1205 1210 1215 Ser Gly Ser Leu Ser Leu Leu Ser Pro Lys Gln Lys Thr Gly Pro Ala 1220 1225 1230 Leu Pro Leu Pro His Phe Leu Leu Ile 1235 1240 <210> SEQ ID NO 70 <211> LENGTH: 573 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 70 Ala Phe His Gln Gly Ser Leu Ile Leu Cys Leu Ala Leu Gln Ser Asp 1 5 10 15 Arg Leu Leu Ile Lys Gly Gly Arg Ile Ile Asn Asp Asp Gln Ser Leu 20 25 30 Tyr Ala Asp Val Tyr Leu Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu 35 40 45 Asn Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala Asn Gly Arg 50 55 60 Met Val Ile Pro Gly Gly Ile Asp Val Asn Thr Tyr Leu Gln Lys Pro 65 70 75 80 Ser Gln Gly Met Thr Ala Ala Asp Asp Phe Phe Gln Gly Thr Arg Ala 85 90 95 Ala Leu Val Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro Glu 100 105 110 Pro Gly Ser Ser Leu Leu Thr Ser Phe Glu Lys Trp His Glu Ala Ala 115 120 125 Asp Thr Lys Ser Cys Cys Asp Tyr Ser Leu His Val Asp Ile Thr Ser 130 135 140 Trp Tyr Asp Gly Val Arg Glu Glu Leu Glu Val Leu Val Gln Asp Lys 145 150 155 160 Gly Val Asn Ser Phe Gln Val Tyr Met Ala Tyr Lys Asp Val Tyr Gln 165 170 175 Met Ser Asp Ser Gln Leu Tyr Glu Ala Phe Thr Phe Leu Lys Gly Leu 180 185 190 Gly Ala Val Ile Leu Val His Ala Glu Asn Gly Asp Leu Ile Ala Gln 195 200 205 Glu Gln Lys Arg Ile Leu Glu Met Gly Ile Thr Gly Pro Glu Gly His 210 215 220 Ala Leu Ser Arg Pro Glu Glu Leu Glu Ala Glu Ala Val Phe Arg Ala 225 230 235 240 Ile Thr Ile Ala Gly Arg Ile Asn Cys Pro Val Tyr Ile Thr Lys Val 245 250 255 Met Ser Lys Ser Ala Ala Asp Ile Ile Ala Leu Ala Arg Lys Lys Gly 260 265 270 Pro Leu Val Phe Gly Glu Pro Ile Ala Ala Ser Leu Gly Thr Asp Gly 275 280 285 Thr His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr 290 295 300 Ser Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Tyr Leu Thr Ser 305 310 315 320 Leu Leu Ala Cys Gly Asp Leu Gln Val Thr Gly Ser Gly His Cys Pro 325 330 335 Tyr Ser Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile 340 345 350 Pro Glu Gly Val Asn Gly Ile Glu Glu Arg Met Thr Val Val Trp Asp 355 360 365 Lys Ala Val Ala Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val 370 375 380 Thr Ser Thr Asn Ala Ala Lys Ile Phe Asn Leu Tyr Pro Arg Lys Gly 385 390 395 400 Arg Ile Ala Val Gly Ser Asp Ala Asp Val Val Ile Trp Asp Pro Asp 405 410 415 Lys Leu Lys Thr Ile Thr Ala Lys Ser His Lys Ser Ala Val Glu Tyr 420 425 430 Asn Ile Phe Glu Gly Met Glu Cys His Gly Ser Pro Leu Val Val Ile 435 440 445 Ser Gln Gly Lys Ile Val Phe Glu Asp Gly Asn Ile Asn Val Asn Lys 450 455 460 Gly Met Gly Arg Phe Ile Pro Arg Lys Ala Phe Pro Glu His Leu Tyr 465 470 475 480 Gln Arg Val Lys Ile Arg Asn Lys Val Phe Gly Leu Gln Gly Val Ser 485 490 495 Arg Gly Met Tyr Asp Gly Pro Val Tyr Glu Val Pro Ala Thr Pro Lys 500 505 510 Tyr Ala Thr Pro Ala Pro Ser Ala Lys Ser Ser Pro Ser Lys His Gln 515 520 525 Pro Pro Pro Ile Arg Asn Leu His Gln Ser Asn Phe Ser Leu Ser Gly 530 535 540 Ala Gln Ile Asp Asp Asn Asn Pro Arg Arg Thr Gly His Arg Ile Val 545 550 555 560 Ala Pro Pro Gly Gly Arg Ser Asn Ile Thr Ser Leu Gly 565 570 <210> SEQ ID NO 71 <211> LENGTH: 351 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 71 Met Gln Arg Ala Leu Pro Gly Ala Arg Gln His Leu Gly Ala Ile Leu 1 5 10 15 Ala Ser Ala Ser Val Val Val Lys Ala Leu Cys Ala Ala Val Leu Phe 20 25 30 Leu Tyr Leu Leu Ser Phe Ala Val Asp Thr Gly Cys Leu Ala Val Thr 35 40 45 Pro Gly Tyr Leu Phe Pro Pro Asn Phe Trp Ile Trp Thr Leu Ala Thr 50 55 60 His Gly Leu Met Glu Gln His Val Trp Asp Val Ala Ile Ser Leu Thr 65 70 75 80 Thr Val Val Val Ala Gly Arg Leu Leu Glu Pro Leu Trp Gly Ala Leu 85 90 95 Glu Leu Leu Ile Phe Phe Ser Val Val Asn Val Ser Val Gly Leu Leu 100 105 110 Gly Ala Phe Ala Tyr Leu Leu Thr Tyr Met Ala Ser Phe Asn Leu Val 115 120 125 Tyr Leu Phe Thr Val Arg Ile His Gly Ala Leu Gly Phe Leu Gly Gly 130 135 140 Val Leu Val Ala Leu Lys Gln Thr Met Gly Asp Cys Val Val Leu Arg 145 150 155 160 Val Pro Gln Val Arg Val Ser Val Met Pro Met Leu Leu Leu Ala Leu 165 170 175 Leu Leu Leu Leu Arg Leu Ala Thr Leu Leu Gln Ser Pro Ala Leu Ala 180 185 190 Ser Tyr Gly Phe Gly Leu Leu Ser Ser Trp Val Tyr Leu Arg Phe Tyr 195 200 205 Gln Arg His Ser Arg Gly Arg Gly Asp Met Ala Asp His Phe Ala Phe 210 215 220 Ala Thr Phe Phe Pro Glu Ile Leu Gln Pro Val Val Gly Leu Leu Ala 225 230 235 240 Asn Leu Val His Ser Leu Leu Val Lys Val Lys Ile Cys Gln Lys Thr 245 250 255 Val Lys Arg Tyr Asp Val Gly Ala Pro Ser Ser Ile Thr Ile Ser Leu 260 265 270 Pro Gly Thr Asp Pro Gln Asp Ala Glu Arg Arg Arg Gln Leu Ala Leu 275 280 285 Lys Ala Leu Asn Glu Arg Leu Lys Arg Val Glu Asp Gln Ser Ile Trp 290 295 300 Pro Ser Met Asp Asp Asp Glu Glu Glu Ser Gly Ala Lys Val Asp Ser 305 310 315 320 Pro Leu Pro Ser Asp Lys Ala Pro Thr Pro Pro Gly Lys Gly Ala Ala 325 330 335 Pro Glu Ser Ser Leu Ile Thr Phe Glu Ala Ala Pro Pro Thr Leu 340 345 350 <210> SEQ ID NO 72 <211> LENGTH: 745 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 72 Met Pro Val Leu Ser Arg Pro Arg Pro Trp Arg Gly Asn Thr Leu Lys 1 5 10 15 Arg Thr Ala Val Leu Leu Ala Leu Ala Ala Tyr Gly Ala His Lys Val 20 25 30 Tyr Pro Leu Val Arg Gln Cys Leu Ala Pro Ala Arg Gly Leu Gln Ala 35 40 45 Pro Ala Gly Glu Pro Thr Gln Glu Ala Ser Gly Val Ala Ala Ala Lys 50 55 60 Ala Gly Met Asn Arg Val Phe Leu Gln Arg Leu Leu Trp Leu Leu Arg 65 70 75 80 Leu Leu Phe Pro Arg Val Leu Cys Arg Glu Thr Gly Leu Leu Ala Leu 85 90 95 His Ser Ala Ala Leu Val Ser Arg Thr Phe Leu Ser Val Tyr Val Ala 100 105 110 Arg Leu Asp Gly Arg Leu Ala Arg Cys Ile Val Arg Lys Asp Pro Arg 115 120 125 Ala Phe Gly Trp Gln Leu Leu Gln Trp Leu Leu Ile Ala Leu Pro Ala 130 135 140 Thr Phe Val Asn Ser Ala Ile Arg Tyr Leu Glu Gly Gln Leu Ala Leu 145 150 155 160 Ser Phe Arg Ser Arg Leu Val Ala His Ala Tyr Arg Leu Tyr Phe Ser 165 170 175 Gln Gln Thr Tyr Tyr Arg Val Ser Asn Met Asp Gly Arg Leu Arg Asn 180 185 190 Pro Asp Gln Ser Leu Thr Glu Asp Val Val Ala Phe Ala Ala Ser Val 195 200 205 Ala His Leu Tyr Ser Asn Leu Thr Lys Pro Leu Leu Asp Val Ala Val 210 215 220 Thr Ser Tyr Thr Leu Leu Arg Ala Ala Arg Ser Arg Gly Ala Gly Thr 225 230 235 240 Ala Trp Pro Ser Ala Ile Ala Gly Leu Val Val Phe Leu Thr Ala Asn 245 250 255 Val Leu Arg Ala Phe Ser Pro Lys Phe Gly Glu Leu Val Ala Glu Glu 260 265 270 Ala Arg Arg Lys Gly Glu Leu Arg Tyr Met His Ser Arg Val Val Ala 275 280 285 Asn Ser Glu Glu Ile Ala Phe Tyr Gly Gly His Glu Val Glu Leu Ala 290 295 300 Leu Leu Gln Arg Ser Tyr Gln Asp Leu Ala Ser Gln Ile Asn Leu Ile 305 310 315 320 Leu Leu Glu Arg Leu Trp Tyr Val Met Leu Glu Gln Phe Leu Met Lys 325 330 335 Tyr Val Trp Ser Ala Ser Gly Leu Leu Met Val Ala Val Pro Ile Ile 340 345 350 Thr Ala Thr Gly Tyr Ser Glu Ser Asp Ala Glu Ala Val Lys Lys Ala 355 360 365 Ala Leu Glu Lys Lys Glu Glu Glu Leu Val Ser Glu Arg Thr Glu Ala 370 375 380 Phe Thr Ile Ala Arg Asn Leu Leu Thr Ala Ala Ala Asp Ala Ile Glu 385 390 395 400 Arg Ile Met Ser Ser Tyr Lys Glu Val Thr Glu Leu Ala Gly Tyr Thr 405 410 415 Ala Arg Val His Glu Met Phe Gln Val Phe Glu Asp Val Gln Arg Cys 420 425 430 His Phe Lys Arg Pro Arg Glu Leu Glu Asp Ala Gln Ala Gly Ser Gly 435 440 445 Thr Ile Gly Arg Ser Gly Val Arg Val Glu Gly Pro Leu Lys Ile Arg 450 455 460 Gly Gln Val Val Asp Val Glu Gln Gly Ile Ile Cys Glu Asn Ile Pro 465 470 475 480 Ile Val Thr Pro Ser Gly Glu Val Val Val Ala Ser Leu Asn Ile Arg 485 490 495 Val Glu Glu Gly Met His Leu Leu Ile Thr Gly Pro Asn Gly Cys Gly 500 505 510 Lys Ser Ser Leu Phe Arg Ile Leu Gly Gly Leu Trp Pro Thr Tyr Gly 515 520 525 Gly Val Leu Tyr Lys Pro Pro Pro Gln Arg Met Phe Tyr Ile Pro Gln 530 535 540 Arg Pro Tyr Met Ser Val Gly Ser Leu Arg Asp Gln Val Ile Tyr Pro 545 550 555 560 Asp Ser Val Glu Asp Met Gln Arg Lys Gly Tyr Ser Glu Gln Asp Leu 565 570 575 Glu Ala Ile Leu Asp Val Val His Leu His His Ile Leu Gln Arg Glu 580 585 590 Gly Gly Trp Glu Ala Met Cys Asp Trp Lys Asp Val Leu Ser Gly Gly 595 600 605 Glu Lys Gln Arg Ile Gly Met Ala Arg Met Phe Tyr His Arg Pro Lys 610 615 620 Tyr Ala Leu Leu Asp Glu Cys Thr Ser Ala Val Ser Ile Asp Val Glu 625 630 635 640 Gly Lys Ile Phe Gln Ala Ala Lys Asp Ala Gly Ile Ala Leu Leu Ser 645 650 655 Ile Thr His Arg Pro Ser Leu Trp Lys Tyr His Thr His Leu Leu Gln 660 665 670 Phe Asp Gly Glu Gly Gly Trp Lys Phe Glu Lys Leu Asp Ser Ala Ala 675 680 685 Arg Leu Ser Leu Thr Glu Glu Lys Gln Arg Leu Glu Gln Gln Leu Ala 690 695 700 Gly Ile Pro Lys Met Gln Arg Arg Leu Gln Glu Leu Cys Gln Ile Leu 705 710 715 720 Gly Glu Ala Val Ala Pro Ala His Val Pro Ala Pro Ser Pro Gln Gly 725 730 735 Pro Gly Gly Leu Gln Gly Ala Ser Thr 740 745 <210> SEQ ID NO 73 <211> LENGTH: 334 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 73 Met Asp Leu Asp Val Val Asn Met Phe Val Ile Ala Gly Gly Thr Leu 1 5 10 15 Ala Ile Pro Ile Leu Ala Phe Val Ala Ser Phe Leu Leu Trp Pro Ser 20 25 30 Ala Leu Ile Arg Ile Tyr Tyr Trp Tyr Trp Arg Arg Thr Leu Gly Met 35 40 45 Gln Val Arg Tyr Val His His Glu Asp Tyr Gln Phe Cys Tyr Ser Phe 50 55 60 Arg Gly Arg Pro Gly His Lys Pro Ser Ile Leu Met Leu His Gly Phe 65 70 75 80 Ser Ala His Lys Asp Met Trp Leu Ser Val Val Lys Phe Leu Pro Lys 85 90 95 Asn Leu His Leu Val Cys Val Asp Met Pro Gly His Glu Gly Thr Thr 100 105 110 Arg Ser Ser Leu Asp Asp Leu Ser Ile Asp Gly Gln Val Lys Arg Ile 115 120 125 His Gln Phe Val Glu Cys Leu Lys Leu Asn Lys Lys Pro Phe His Leu 130 135 140 Val Gly Thr Ser Met Gly Gly Gln Val Ala Gly Val Tyr Ala Ala Tyr 145 150 155 160 Tyr Pro Ser Asp Val Ser Ser Leu Cys Leu Val Cys Pro Ala Gly Leu 165 170 175 Gln Tyr Ser Thr Asp Asn Gln Phe Val Gln Arg Leu Lys Glu Leu Gln 180 185 190 Gly Ser Ala Ala Val Glu Lys Ile Pro Leu Ile Pro Ser Thr Pro Glu 195 200 205 Glu Met Ser Glu Met Leu Gln Leu Cys Ser Tyr Val Arg Phe Lys Val 210 215 220 Pro Gln Gln Ile Leu Gln Gly Leu Val Asp Val Arg Ile Pro His Asn 225 230 235 240 Asn Phe Tyr Arg Lys Leu Phe Leu Glu Ile Val Ser Glu Lys Ser Arg 245 250 255 Tyr Ser Leu His Gln Asn Met Asp Lys Ile Lys Val Pro Thr Gln Ile 260 265 270 Ile Trp Gly Lys Gln Asp Gln Val Leu Asp Val Ser Gly Ala Asp Met 275 280 285 Leu Ala Lys Ser Ile Ala Asn Cys Gln Val Glu Leu Leu Glu Asn Cys 290 295 300 Gly His Ser Val Val Met Glu Arg Pro Arg Lys Thr Ala Lys Leu Ile 305 310 315 320 Ile Asp Phe Leu Ala Ser Val His Asn Thr Asp Asn Asn Lys 325 330 <210> SEQ ID NO 74 <211> LENGTH: 559 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 74 Ser Asp Arg Leu Leu Ile Arg Gly Gly Arg Ile Val Asn Asp Asp Gln 1 5 10 15 Ser Phe Tyr Ala Asp Val His Val Glu Asp Gly Leu Ile Lys Gln Ile 20 25 30 Gly Glu Asn Leu Ile Val Pro Gly Gly Ile Lys Thr Ile Asp Ala His 35 40 45 Gly Leu Met Val Leu Pro Gly Gly Val Asp Val His Thr Arg Leu Gln 50 55 60 Met Pro Val Leu Gly Met Thr Pro Ala Asp Asp Phe Cys Gln Gly Thr 65 70 75 80 Lys Ala Ala Leu Ala Gly Gly Thr Thr Met Ile Leu Asp His Val Phe 85 90 95 Pro Asp Thr Gly Val Ser Leu Leu Ala Ala Tyr Glu Gln Trp Arg Glu 100 105 110 Arg Ala Asp Ser Ala Ala Cys Cys Asp Tyr Ser Leu His Val Asp Ile 115 120 125 Thr Arg Trp His Glu Ser Ile Lys Glu Glu Leu Glu Ala Leu Val Lys 130 135 140 Glu Lys Gly Val Asn Ser Phe Leu Val Phe Met Ala Tyr Lys Asp Arg 145 150 155 160 Cys Gln Cys Ser Asp Ser Gln Met Tyr Glu Ile Phe Ser Ile Ile Arg 165 170 175 Asp Leu Gly Ala Leu Ala Gln Val His Ala Glu Asn Gly Asp Ile Val 180 185 190 Glu Glu Glu Gln Lys Arg Leu Leu Glu Leu Gly Ile Thr Gly Pro Glu 195 200 205 Gly His Val Leu Ser His Pro Glu Glu Val Glu Ala Glu Ala Val Tyr 210 215 220 Arg Ala Val Thr Ile Ala Lys Gln Ala Asn Cys Pro Leu Tyr Val Thr 225 230 235 240 Lys Val Met Ser Lys Gly Ala Ala Asp Ala Ile Ala Gln Ala Lys Arg 245 250 255 Arg Gly Val Val Val Phe Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr 260 265 270 Asp Gly Ser His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe 275 280 285 Val Thr Ser Pro Pro Val Asn Pro Asp Pro Thr Thr Ala Asp His Leu 290 295 300 Thr Cys Leu Leu Ser Ser Gly Asp Leu Gln Val Thr Gly Ser Ala His 305 310 315 320 Cys Thr Phe Thr Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Ala 325 330 335 Leu Ile Pro Glu Gly Thr Asn Gly Ile Glu Glu Arg Met Ser Met Val 340 345 350 Trp Glu Lys Cys Val Ala Ser Gly Lys Met Asp Glu Asn Glu Phe Val 355 360 365 Ala Val Thr Ser Thr Asn Ala Ala Lys Ile Phe Asn Phe Tyr Pro Arg 370 375 380 Lys Gly Arg Val Ala Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asn 385 390 395 400 Pro Lys Ala Thr Lys Ile Ile Ser Ala Lys Thr His Asn Leu Asn Val 405 410 415 Glu Tyr Asn Ile Phe Glu Gly Val Glu Cys Arg Gly Ala Pro Ala Val 420 425 430 Val Ile Ser Gln Gly Arg Val Ala Leu Glu Asp Gly Lys Met Phe Val 435 440 445 Thr Pro Gly Ala Gly Arg Phe Val Pro Arg Lys Thr Phe Pro Asp Phe 450 455 460 Val Tyr Lys Arg Ile Lys Ala Arg Asn Arg Leu Ala Glu Ile His Gly 465 470 475 480 Val Pro Arg Gly Leu Tyr Asp Gly Pro Val His Glu Val Met Val Pro 485 490 495 Ala Lys Pro Gly Ser Gly Ala Pro Ala Arg Ala Ser Cys Pro Gly Lys 500 505 510 Ile Ser Val Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu 515 520 525 Ser Gly Ser Gln Ala Asp Asp His Ile Ala Arg Arg Thr Ala Gln Lys 530 535 540 Ile Met Ala Pro Pro Gly Gly Arg Ser Asn Ile Thr Ser Leu Ser 545 550 555 <210> SEQ ID NO 75 <211> LENGTH: 743 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 75 Met Ala Arg Arg Ser Val Leu Tyr Phe Ile Leu Leu Asn Ala Leu Ile 1 5 10 15 Asn Lys Gly Gln Ala Cys Phe Cys Asp His Tyr Ala Trp Thr Gln Trp 20 25 30 Thr Ser Cys Ser Lys Thr Cys Asn Ser Gly Thr Gln Ser Arg His Arg 35 40 45 Gln Ile Val Val Asp Lys Tyr Tyr Gln Glu Asn Phe Cys Glu Gln Ile 50 55 60 Cys Ser Lys Gln Glu Thr Arg Glu Cys Asn Trp Gln Arg Cys Pro Ile 65 70 75 80 Asn Cys Leu Leu Gly Asp Phe Gly Pro Trp Ser Asp Cys Asp Pro Cys 85 90 95 Ile Glu Lys Gln Gly Thr Ser Asn Phe His Tyr Leu Asn His Leu Phe 100 105 110 Thr Ser Phe Phe His Leu Asp Ser Ser Phe Ile Arg Ile His Lys Val 115 120 125 Met Lys Val Leu Asn Phe Thr Thr Lys Ala Lys Asp Leu His Leu Ser 130 135 140 Asp Val Phe Leu Lys Ala Leu Asn His Leu Pro Leu Glu Tyr Asn Ser 145 150 155 160 Ala Leu Tyr Ser Arg Ile Phe Asp Asp Phe Gly Thr His Tyr Phe Thr 165 170 175 Ser Gly Ser Leu Gly Gly Val Tyr Asp Leu Leu Tyr Gln Phe Ser Ser 180 185 190 Glu Glu Leu Lys Asn Ser Gly Leu Thr Glu Glu Glu Ala Lys His Cys 195 200 205 Val Arg Ile Glu Thr Lys Lys Arg Val Leu Phe Ala Lys Lys Thr Lys 210 215 220 Val Glu His Arg Cys Thr Thr Asn Lys Leu Ser Glu Lys His Glu Gly 225 230 235 240 Ser Phe Ile Gln Gly Ala Glu Lys Ser Ile Ser Leu Ile Arg Gly Gly 245 250 255 Arg Ser Glu Tyr Gly Ala Ala Leu Ala Trp Glu Lys Gly Ser Ser Gly 260 265 270 Leu Glu Glu Lys Thr Phe Ser Glu Trp Leu Glu Ser Val Lys Glu Asn 275 280 285 Pro Ala Val Ile Asp Phe Glu Leu Ala Pro Ile Val Asp Leu Val Arg 290 295 300 Asn Ile Pro Cys Ala Val Thr Lys Arg Asn Asn Leu Arg Lys Ala Leu 305 310 315 320 Gln Glu Tyr Ala Ala Lys Phe Asp Pro Cys Gln Cys Ala Pro Cys Pro 325 330 335 Asn Asn Gly Arg Pro Thr Leu Ser Gly Thr Glu Cys Leu Cys Val Cys 340 345 350 Gln Ser Gly Thr Tyr Gly Glu Asn Cys Glu Lys Gln Ser Pro Asp Tyr 355 360 365 Lys Ser Asn Ala Val Asp Gly Gln Trp Gly Cys Trp Ser Ser Trp Ser 370 375 380 Thr Cys Asp Ala Thr Tyr Lys Arg Ser Arg Thr Arg Glu Cys Asn Asn 385 390 395 400 Pro Ala Pro Gln Arg Gly Gly Lys Arg Cys Glu Gly Glu Lys Arg Gln 405 410 415 Glu Glu Asp Cys Thr Phe Ser Ile Met Glu Asn Asn Gly Gln Pro Cys 420 425 430 Ile Asn Asp Asp Glu Glu Met Lys Glu Val Asp Leu Pro Glu Ile Glu 435 440 445 Ala Asp Ser Gly Cys Pro Gln Pro Val Pro Pro Glu Asn Gly Phe Ile 450 455 460 Arg Asn Glu Lys Gln Leu Tyr Leu Val Gly Glu Asp Val Glu Ile Ser 465 470 475 480 Cys Leu Thr Gly Phe Glu Thr Val Gly Tyr Gln Tyr Phe Arg Cys Leu 485 490 495 Pro Asp Gly Thr Trp Arg Gln Gly Asp Val Glu Cys Gln Arg Thr Glu 500 505 510 Cys Ile Lys Pro Val Val Gln Glu Val Leu Thr Ile Thr Pro Phe Gln 515 520 525 Arg Leu Tyr Arg Ile Gly Glu Ser Ile Glu Leu Thr Cys Pro Lys Gly 530 535 540 Phe Val Val Ala Gly Pro Ser Arg Tyr Thr Cys Gln Gly Asn Ser Trp 545 550 555 560 Thr Pro Pro Ile Ser Asn Ser Leu Thr Cys Glu Lys Asp Thr Leu Thr 565 570 575 Lys Leu Lys Gly His Cys Gln Leu Gly Gln Lys Gln Ser Gly Ser Glu 580 585 590 Cys Ile Cys Met Ser Pro Glu Glu Asp Cys Ser His His Ser Glu Asp 595 600 605 Leu Cys Val Phe Asp Thr Asp Ser Asn Asp Tyr Phe Thr Ser Pro Ala 610 615 620 Cys Lys Phe Leu Ala Glu Lys Cys Leu Asn Asn Gln Gln Leu His Phe 625 630 635 640 Leu His Ile Gly Ser Cys Gln Asp Gly Arg Gln Leu Glu Trp Gly Leu 645 650 655 Glu Arg Thr Arg Leu Ser Ser Asn Ser Thr Lys Lys Glu Ser Cys Gly 660 665 670 Tyr Asp Thr Cys Tyr Asp Trp Glu Lys Cys Ser Ala Ser Thr Ser Lys 675 680 685 Cys Val Cys Leu Leu Pro Pro Gln Cys Phe Lys Gly Gly Asn Gln Leu 690 695 700 Tyr Cys Val Lys Met Gly Ser Ser Thr Ser Glu Lys Thr Leu Asn Ile 705 710 715 720 Cys Glu Val Gly Thr Ile Arg Cys Ala Asn Arg Lys Met Glu Ile Leu 725 730 735 His Pro Gly Lys Cys Leu Ala 740 <210> SEQ ID NO 76 <211> LENGTH: 321 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 76 Met Glu Arg Lys Asn Gln Thr Ala Ile Thr Glu Phe Ile Ile Leu Gly 1 5 10 15 Phe Ser Asn Leu Asn Glu Leu Gln Phe Leu Leu Phe Thr Ile Phe Phe 20 25 30 Leu Thr Tyr Phe Cys Thr Leu Gly Gly Asn Ile Leu Ile Ile Leu Thr 35 40 45 Thr Val Thr Asp Pro His Leu His Thr Pro Met Tyr Tyr Phe Leu Gly 50 55 60 Asn Leu Ala Phe Ile Asp Ile Cys Tyr Thr Thr Ser Asn Val Pro Gln 65 70 75 80 Met Met Val His Leu Leu Ser Lys Lys Lys Ser Ile Ser Tyr Val Gly 85 90 95 Cys Val Val Gln Leu Phe Ala Phe Val Phe Phe Val Gly Ser Glu Cys 100 105 110 Leu Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Ser Val Ile Leu Ser Lys Val Leu Cys Asn Gln Leu 130 135 140 Ala Ala Ser Cys Trp Ala Ala Gly Phe Leu Asn Ser Val Val His Thr 145 150 155 160 Val Leu Thr Phe Cys Leu Pro Phe Cys Gly Asn Asn Gln Ile Asn Tyr 165 170 175 Phe Phe Cys Asp Ile Pro Pro Leu Leu Ile Leu Ser Cys Gly Asn Thr 180 185 190 Ser Val Asn Glu Leu Ala Leu Leu Ser Thr Gly Val Phe Ile Gly Trp 195 200 205 Thr Pro Phe Leu Cys Ile Val Leu Ser Tyr Ile Cys Ile Ile Ser Thr 210 215 220 Ile Leu Arg Ile Gln Ser Ser Glu Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ala Ile Val Phe Leu Phe Tyr Gly Ser Ala Ile 245 250 255 Phe Thr Tyr Val Arg Pro Ile Ser Thr Tyr Ser Leu Lys Lys Asp Arg 260 265 270 Leu Val Ser Val Leu Tyr Ser Val Val Thr Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Ile Lys Glu Ala Val Lys Thr Ile 290 295 300 Gly Ser Lys Trp Gln Pro Pro Ile Ser Ser Leu Asp Ser Lys Leu Thr 305 310 315 320 Tyr <210> SEQ ID NO 77 <211> LENGTH: 297 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 77 Met Asp Pro Gly Lys Asp Lys Glu Gly Val Pro Gln Pro Ser Gly Pro 1 5 10 15 Pro Ala Arg Lys Lys Phe Val Ile Pro Leu Asp Glu Asp Glu Val Pro 20 25 30 Pro Gly Val Ala Lys Pro Leu Phe Arg Ser Thr Gln Ser Leu Pro Thr 35 40 45 Val Asp Thr Ser Ala Gln Ala Ala Pro Gln Thr Tyr Ala Glu Tyr Ala 50 55 60 Ile Ser Gln Pro Leu Glu Gly Ala Gly Ala Thr Cys Pro Thr Gly Ser 65 70 75 80 Glu Pro Leu Ala Gly Glu Thr Pro Asn Gln Ala Leu Lys Pro Gly Ala 85 90 95 Lys Ser Asn Ser Ile Ile Val Ser Pro Arg Gln Arg Gly Asn Pro Val 100 105 110 Leu Lys Phe Val Arg Asn Val Pro Trp Glu Phe Gly Asp Val Ile Pro 115 120 125 Asp Tyr Val Leu Gly Gln Ser Thr Cys Ala Leu Phe Leu Ser Leu Arg 130 135 140 Tyr His Asn Leu His Pro Asp Tyr Ile His Gly Arg Leu Gln Ser Leu 145 150 155 160 Gly Lys Asn Phe Ala Leu Arg Val Leu Leu Val Gln Val Asp Val Lys 165 170 175 Asp Pro Gln Gln Ala Leu Lys Glu Leu Ala Lys Met Cys Ile Leu Ala 180 185 190 Asp Cys Thr Leu Ile Leu Ala Trp Ser Pro Glu Glu Ala Gly Arg Tyr 195 200 205 Leu Glu Thr Tyr Lys Ala Tyr Glu Gln Lys Pro Ala Asp Leu Leu Met 210 215 220 Glu Lys Leu Glu Gln Asp Phe Val Ser Arg Val Thr Glu Cys Leu Thr 225 230 235 240 Thr Val Lys Ser Val Asn Lys Thr Asp Ser Gln Thr Leu Leu Thr Thr 245 250 255 Phe Gly Ser Leu Glu Gln Leu Ile Ala Ala Ser Arg Glu Asp Leu Ala 260 265 270 Leu Cys Pro Gly Leu Gly Pro Gln Lys Ala Arg Arg Leu Phe Asp Val 275 280 285 Leu His Glu Pro Phe Leu Lys Val Pro 290 295 <210> SEQ ID NO 78 <211> LENGTH: 579 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 78 Met Leu Ala Asn Ser Ala Ser Val Arg Ile Leu Ile Lys Gly Gly Lys 1 5 10 15 Val Val Asn Asp Asp Cys Thr His Glu Ala Asp Val Tyr Ile Glu Asn 20 25 30 Gly Ile Ile Gln Gln Val Gly Arg Glu Leu Met Ile Pro Gly Gly Ala 35 40 45 Lys Val Ile Asp Ala Thr Gly Lys Leu Val Ile Pro Gly Gly Ile Asp 50 55 60 Thr Ser Thr His Phe His Gln Thr Phe Met Asn Ala Thr Cys Val Asp 65 70 75 80 Asp Phe Tyr His Gly Thr Lys Ala Ala Leu Val Gly Gly Thr Thr Met 85 90 95 Ile Ile Gly His Val Leu Pro Asp Lys Glu Thr Ser Leu Val Asp Ala 100 105 110 Tyr Glu Lys Cys Arg Gly Leu Ala Asp Pro Lys Val Cys Cys Asp Tyr 115 120 125 Ala Leu His Val Gly Ile Thr Trp Trp Ala Pro Lys Val Lys Ala Glu 130 135 140 Met Glu Thr Leu Val Arg Glu Lys Gly Val Asn Ser Phe Gln Met Phe 145 150 155 160 Met Thr Tyr Lys Asp Leu Asn Trp Asn Met Leu Arg Asp Ser Glu Leu 165 170 175 Tyr Gln Val Leu His Ala Cys Lys Asp Ile Gly Ala Ile Ala Arg Val 180 185 190 His Ala Glu Asn Gly Glu Leu Val Ala Glu Ala Ser Leu Gln Pro Arg 195 200 205 Ile Leu Asp Gly Gly Thr Pro Gly Ala Lys Glu Ala Leu Asp Leu Gly 210 215 220 Ile Thr Gly Pro Glu Gly Ile Glu Ile Ser Arg Pro Glu Glu Leu Glu 225 230 235 240 Ala Glu Ala Thr His Arg Val Ile Thr Ile Ala Asn Arg Thr His Cys 245 250 255 Pro Ile Tyr Leu Val Asn Val Ser Ser Ile Ser Ala Gly Asp Val Ile 260 265 270 Ala Ala Ala Lys Met Gln Gly Lys Val Val Leu Ala Glu Thr Thr Thr 275 280 285 Ala His Ala Thr Leu Thr Gly Leu His Tyr Tyr His Gln Asp Trp Ser 290 295 300 His Ala Ala Ala Tyr Val Thr Val Pro Pro Leu Arg Leu Asp Thr Asn 305 310 315 320 Thr Ser Thr Tyr Leu Met Ser Leu Leu Ala Asn Asp Thr Leu Asn Ile 325 330 335 Val Ala Ser Asp His Arg Pro Phe Thr Thr Lys Gln Lys Ala Met Gly 340 345 350 Lys Glu Asp Phe Thr Lys Ile Pro His Gly Val Ser Gly Val Gln Asp 355 360 365 Arg Met Ser Val Ile Trp Glu Arg Gly Val Val Gly Gly Lys Met Asp 370 375 380 Glu Asn Arg Phe Val Ala Val Thr Ser Ser Asn Ala Ala Lys Leu Leu 385 390 395 400 Asn Leu Tyr Pro Arg Lys Gly Arg Ile Ile Pro Gly Ala Asp Ala Asp 405 410 415 Val Val Val Trp Asp Pro Glu Ala Thr Lys Thr Ile Ser Ala Ser Thr 420 425 430 Gln Val Gln Gly Gly Asp Phe Asn Leu Tyr Glu Asn Met Arg Cys His 435 440 445 Gly Val Pro Leu Val Thr Ile Ser Arg Gly Arg Val Val Tyr Glu Asn 450 455 460 Gly Val Phe Met Cys Ala Glu Gly Thr Gly Lys Phe Cys Pro Leu Arg 465 470 475 480 Ser Phe Pro Asp Thr Val Tyr Lys Lys Leu Val Gln Arg Glu Lys Thr 485 490 495 Leu Lys Val Arg Gly Val Asp Arg Thr Pro Tyr Leu Gly Asp Val Ala 500 505 510 Val Val Val His Pro Gly Lys Lys Glu Met Gly Thr Pro Leu Ala Asp 515 520 525 Thr Pro Thr Arg Pro Val Thr Arg His Gly Gly Met Arg Asp Leu His 530 535 540 Glu Ser Ser Phe Ser Leu Ser Gly Ser Gln Ile Asp Asp His Val Pro 545 550 555 560 Lys Arg Ala Ser Ala Arg Ile Leu Ala Pro Pro Gly Gly Arg Ser Ser 565 570 575 Gly Ile Trp <210> SEQ ID NO 79 <211> LENGTH: 366 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 79 Val Thr Ala Val Ala Gln Gln Asn Gln Gly Glu Val Pro Glu Pro Gln 1 5 10 15 Asp Met Lys Val Ala Glu Val Leu Phe Asp Ala Ala Asp Ala Asn Ala 20 25 30 Ile Glu Glu Val Asn Leu Ala Tyr Glu Asn Val Lys Glu Val Asp Gly 35 40 45 Leu Asp Val Ser Lys Glu Gly Thr Glu Ala Trp Glu Ala Ala Met Lys 50 55 60 Arg Tyr Asp Glu Arg Ile Asp Arg Val Glu Thr Arg Ile Thr Ala Arg 65 70 75 80 Leu Arg Asp Gln Leu Gly Thr Ala Lys Asn Ala Asn Glu Met Phe Arg 85 90 95 Ile Phe Ser Arg Phe Asn Ala Leu Phe Val Arg Pro His Ile Arg Gly 100 105 110 Ala Ile Arg Glu Tyr Gln Thr Gln Leu Ile Gln Arg Val Lys Asp Asp 115 120 125 Ile Glu Ser Leu His Asp Lys Phe Lys Val Gln Tyr Pro Gln Ser Gln 130 135 140 Ala Cys Lys Met Ser His Val Arg Asp Leu Pro Pro Val Ser Gly Ser 145 150 155 160 Ile Ile Trp Ala Lys Gln Ile Asp Arg Gln Leu Thr Ala Tyr Met Lys 165 170 175 Arg Val Glu Asp Val Leu Gly Lys Gly Trp Glu Asn His Val Glu Gly 180 185 190 Gln Lys Leu Lys Gln Asp Gly Asp Ser Phe Arg Met Lys Leu Asn Thr 195 200 205 Gln Glu Ile Phe Asp Asp Trp Ala Arg Lys Val Gln Gln Arg Asn Leu 210 215 220 Gly Val Ser Gly Arg Ile Phe Thr Ile Glu Ser Thr Arg Val Arg Gly 225 230 235 240 Arg Thr Gly Asn Val Leu Lys Leu Lys Val Asn Phe Leu Pro Glu Ile 245 250 255 Ile Thr Leu Ser Lys Glu Val Arg Asn Leu Lys Trp Leu Gly Phe Arg 260 265 270 Val Pro Leu Ala Ile Val Asn Lys Ala His Gln Ala Asn Gln Leu Tyr 275 280 285 Pro Phe Ala Ile Ser Leu Ile Glu Ser Val Arg Thr Tyr Glu Arg Thr 290 295 300 Cys Glu Lys Val Glu Glu Arg Asn Thr Ile Ser Leu Leu Val Ala Gly 305 310 315 320 Leu Lys Lys Glu Val Gln Ala Leu Ile Ala Glu Gly Ile Ala Leu Val 325 330 335 Trp Glu Ser Tyr Lys Leu Asp Pro Tyr Val Gln Arg Leu Ala Glu Thr 340 345 350 Val Phe Asn Phe Gln Glu Lys Val Cys Ser His Val Ile Leu 355 360 365 <210> SEQ ID NO 80 <211> LENGTH: 1335 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 80 Met Ser Asp Ser Val Ile Leu Arg Ser Ile Lys Lys Phe Gly Glu Glu 1 5 10 15 Asn Asp Gly Phe Glu Ser Asp Lys Ser Trp Trp Ser Leu Asn Pro Tyr 20 25 30 Val Phe Leu Ile Arg Leu Gln Asp Glu Lys Lys Gly Asp Gly Val Arg 35 40 45 Val Gly Phe Phe Gln Leu Phe Arg Phe Ser Ser Ser Thr Asp Ile Trp 50 55 60 Leu Met Phe Val Gly Ser Leu Cys Ala Phe Leu His Gly Ile Ala Gln 65 70 75 80 Pro Gly Val Leu Leu Ile Phe Gly Thr Met Thr Asp Val Phe Ile Asp 85 90 95 Tyr Asp Val Glu Leu Gln Glu Leu Gln Ile Pro Gly Lys Ala Cys Val 100 105 110 Asn Asn Thr Ile Val Trp Thr Asn Ser Ser Leu Asn Gln Asn Met Thr 115 120 125 Asn Gly Thr Arg Cys Gly Leu Leu Asn Ile Glu Ser Glu Met Ile Lys 130 135 140 Phe Ala Ser Tyr Tyr Ala Gly Ile Ala Val Ala Val Leu Ile Thr Gly 145 150 155 160 Tyr Ile Gln Ile Cys Phe Trp Val Ile Ala Ala Ala Arg Gln Ile Gln 165 170 175 Lys Met Arg Lys Phe Tyr Phe Arg Arg Ile Met Arg Met Glu Ile Gly 180 185 190 Trp Phe Asp Cys Asn Ser Val Gly Glu Leu Asn Thr Arg Phe Ser Asp 195 200 205 Asp Ile Asn Lys Ile Asn Asp Ala Ile Ala Asp Gln Met Ala Leu Phe 210 215 220 Ile Gln Arg Met Thr Ser Thr Ile Cys Gly Phe Leu Leu Gly Phe Phe 225 230 235 240 Arg Gly Trp Lys Leu Thr Leu Val Ile Ile Ser Val Ser Pro Leu Ile 245 250 255 Gly Ile Gly Ala Ala Thr Ile Gly Leu Ser Val Ser Lys Phe Thr Asp 260 265 270 Tyr Glu Leu Lys Ala Tyr Ala Lys Ala Gly Val Val Ala Asp Glu Val 275 280 285 Ile Ser Ser Met Arg Thr Val Ala Ala Phe Gly Gly Glu Lys Arg Glu 290 295 300 Val Glu Arg Tyr Glu Lys Asn Leu Val Phe Ala Gln Arg Trp Gly Ile 305 310 315 320 Arg Lys Gly Ile Val Met Gly Phe Phe Thr Gly Phe Val Trp Cys Leu 325 330 335 Ile Phe Leu Cys Tyr Ala Leu Ala Phe Trp Tyr Gly Ser Thr Leu Val 340 345 350 Leu Asp Glu Gly Glu Tyr Thr Pro Gly Thr Leu Val Gln Ile Phe Leu 355 360 365 Ser Val Ile Val Gly Ala Leu Asn Leu Gly Asn Ala Ser Pro Cys Leu 370 375 380 Glu Ala Phe Ala Thr Gly Arg Ala Ala Ala Thr Ser Ile Phe Glu Thr 385 390 395 400 Ile Asp Arg Lys Pro Ile Ile Asp Cys Met Ser Glu Asp Gly Tyr Lys 405 410 415 Leu Asp Arg Ile Lys Gly Glu Ile Glu Phe His Asn Val Thr Phe His 420 425 430 Tyr Pro Ser Arg Pro Glu Val Lys Ile Leu Asn Asp Leu Asn Met Val 435 440 445 Ile Lys Pro Gly Glu Met Thr Ala Leu Val Gly Pro Ser Gly Ala Gly 450 455 460 Lys Ser Thr Ala Leu Gln Leu Ile Gln Arg Phe Tyr Asp Pro Cys Glu 465 470 475 480 Gly Met Val Thr Val Asp Gly His Asp Ile Arg Ser Leu Asn Ile Gln 485 490 495 Trp Leu Arg Asp Gln Ile Gly Ile Val Glu Gln Glu Pro Val Leu Phe 500 505 510 Ser Thr Thr Ile Ala Glu Asn Ile Arg Tyr Gly Arg Glu Asp Ala Thr 515 520 525 Met Glu Asp Ile Val Gln Ala Ala Lys Glu Ala Asn Ala Tyr Asn Phe 530 535 540 Ile Met Asp Leu Pro Gln Gln Phe Asp Thr Leu Val Gly Glu Gly Gly 545 550 555 560 Gly Gln Met Ser Gly Gly Gln Lys Gln Arg Val Ala Ile Ala Arg Ala 565 570 575 Leu Ile Arg Asn Pro Lys Ile Leu Leu Leu Asp Met Ala Thr Ser Ala 580 585 590 Leu Asp Asn Glu Ser Glu Ala Met Val Gln Glu Val Leu Ser Lys Ile 595 600 605 Gln His Gly His Thr Ile Ile Ser Val Ala His Arg Leu Ser Thr Val 610 615 620 Arg Ala Ala Asp Thr Ile Ile Gly Phe Glu His Gly Thr Ala Val Glu 625 630 635 640 Arg Gly Thr His Glu Glu Leu Leu Glu Arg Lys Gly Val Tyr Phe Thr 645 650 655 Leu Val Thr Leu Gln Ser Gln Gly Asn Gln Ala Leu Asn Glu Glu Asp 660 665 670 Ile Lys Gly Lys Cys Phe Phe Pro Ile Leu Val Leu Asp Ala Thr Glu 675 680 685 Asp Asp Met Leu Ala Arg Thr Phe Ser Arg Gly Ser Tyr Gln Asp Ser 690 695 700 Leu Arg Ala Ser Ile Arg Gln Arg Ser Lys Ser Gln Leu Ser Tyr Leu 705 710 715 720 Val His Glu Pro Pro Leu Ala Val Val Asp His Lys Ser Thr Tyr Glu 725 730 735 Glu Asp Arg Lys Asp Lys Asp Ile Pro Val Gln Glu Glu Val Glu Pro 740 745 750 Ala Pro Val Arg Arg Ile Leu Lys Phe Ser Ala Pro Glu Trp Pro Tyr 755 760 765 Met Leu Val Gly Ser Val Gly Ala Ala Val Asn Gly Thr Val Thr Pro 770 775 780 Leu Tyr Ala Phe Leu Phe Ser Gln Ile Leu Gly Thr Phe Ser Ile Pro 785 790 795 800 Asp Lys Glu Glu Gln Arg Ser Gln Ile Asn Gly Val Cys Leu Leu Phe 805 810 815 Val Ala Met Gly Cys Val Ser Leu Phe Thr Gln Phe Leu Gln Gly Tyr 820 825 830 Ala Phe Ala Lys Ser Gly Glu Leu Leu Thr Lys Arg Leu Arg Lys Phe 835 840 845 Gly Phe Arg Ala Met Leu Gly Gln Asp Ile Ala Trp Phe Asp Asp Leu 850 855 860 Arg Asn Ser Pro Gly Ala Leu Thr Thr Arg Leu Ala Thr Asp Ala Ser 865 870 875 880 Gln Val Gln Gly Ala Ala Gly Ser Gln Ile Gly Met Ile Val Asn Ser 885 890 895 Phe Thr Asn Val Thr Val Ala Met Ile Ile Ala Phe Ser Phe Ser Trp 900 905 910 Lys Leu Ser Leu Val Ile Leu Cys Phe Phe Pro Phe Leu Ala Leu Ser 915 920 925 Gly Ala Thr Gln Thr Arg Met Leu Thr Gly Phe Ala Ser Arg Asp Lys 930 935 940 Gln Ala Leu Glu Met Val Gly Gln Ile Thr Asn Glu Ala Leu Ser Asn 945 950 955 960 Ile Arg Thr Val Ala Gly Ile Gly Lys Glu Arg Arg Phe Ile Glu Ala 965 970 975 Leu Glu Thr Glu Leu Glu Lys Pro Phe Lys Thr Ala Ile Gln Lys Ala 980 985 990 Asn Ile Tyr Gly Phe Cys Phe Ala Phe Ala Gln Cys Ile Met Phe Ile 995 1000 1005 Ala Asn Ser Ala Ser Tyr Arg Tyr Gly Gly Tyr Leu Ile Ser Asn Glu 1010 1015 1020 Gly Leu His Phe Ser Tyr Val Phe Arg Val Ile Ser Ala Val Val Leu 1025 1030 1035 1040 Ser Ala Thr Ala Leu Gly Arg Ala Phe Ser Tyr Thr Pro Ser Tyr Ala 1045 1050 1055 Lys Ala Lys Ile Ser Ala Ala Arg Phe Phe Gln Leu Leu Asp Arg Gln 1060 1065 1070 Pro Pro Ile Ser Val Tyr Asn Thr Ala Gly Glu Lys Trp Asp Asn Phe 1075 1080 1085 Gln Gly Lys Ile Asp Phe Val Asp Cys Lys Phe Thr Tyr Pro Ser Arg 1090 1095 1100 Pro Asp Ser Gln Val Leu Asn Gly Leu Ser Val Ser Ile Ser Pro Gly 1105 1110 1115 1120 Gln Thr Leu Ala Phe Val Gly Ser Ser Gly Cys Gly Lys Ser Thr Ser 1125 1130 1135 Ile Gln Leu Leu Glu Arg Phe Tyr Asp Pro Asp Gln Gly Lys Val Met 1140 1145 1150 Ile Asp Gly His Asp Ser Lys Lys Val Asn Val Gln Phe Leu Arg Ser 1155 1160 1165 Asn Ile Gly Ile Val Ser Gln Glu Pro Val Leu Phe Ala Cys Ser Ile 1170 1175 1180 Met Asp Asn Ile Lys Tyr Gly Asp Asn Thr Lys Glu Ile Pro Met Glu 1185 1190 1195 1200 Arg Val Ile Ala Ala Ala Lys Gln Ala Gln Leu His Asp Phe Val Met 1205 1210 1215 Ser Leu Pro Glu Lys Tyr Glu Thr Asn Val Gly Ser Gln Gly Ser Gln 1220 1225 1230 Leu Ser Arg Gly Glu Lys Gln Arg Ile Ala Ile Ala Arg Ala Ile Val 1235 1240 1245 Arg Asp Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr Ser Ala Leu Asp 1250 1255 1260 Thr Glu Ser Glu Lys Thr Val Gln Val Ala Leu Asp Lys Ala Arg Glu 1265 1270 1275 1280 Gly Arg Thr Cys Ile Val Ile Ala His Arg Leu Ser Thr Ile Gln Asn 1285 1290 1295 Ala Asp Ile Ile Ala Val Met Ala Gln Gly Val Val Ile Glu Lys Gly 1300 1305 1310 Thr His Glu Glu Leu Met Ala Gln Lys Gly Ala Tyr Tyr Lys Leu Val 1315 1320 1325 Thr Thr Gly Ser Pro Ile Ser 1330 1335 <210> SEQ ID NO 81 <211> LENGTH: 1279 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 81 Met Asp Leu Glu Ala Ala Lys Asn Gly Thr Ala Trp Arg Pro Thr Ser 1 5 10 15 Ala Glu Gly Asp Phe Glu Leu Gly Ile Ser Ser Lys Gln Lys Arg Lys 20 25 30 Lys Thr Lys Thr Val Lys Met Ile Gly Val Leu Thr Leu Phe Arg Tyr 35 40 45 Ser Asp Trp Gln Asp Lys Leu Phe Met Ser Leu Gly Thr Ile Met Ala 50 55 60 Ile Ala His Gly Ser Gly Leu Pro Leu Met Met Ile Val Phe Gly Glu 65 70 75 80 Met Thr Asp Lys Phe Val Asp Thr Ala Gly Asn Phe Ser Phe Pro Val 85 90 95 Asn Phe Ser Leu Ser Leu Leu Asn Pro Gly Lys Ile Leu Glu Glu Glu 100 105 110 Met Thr Arg Tyr Ala Tyr Tyr Tyr Ser Gly Leu Gly Ala Gly Val Leu 115 120 125 Val Ala Ala Tyr Ile Gln Val Ser Phe Trp Thr Leu Ala Ala Gly Arg 130 135 140 Gln Ile Arg Lys Ile Arg Gln Lys Phe Phe His Ala Ile Leu Arg Gln 145 150 155 160 Glu Ile Gly Trp Phe Asp Ile Asn Asp Thr Thr Glu Leu Asn Thr Arg 165 170 175 Leu Thr Asp Asp Ile Ser Lys Ile Ser Glu Gly Ile Gly Asp Lys Val 180 185 190 Gly Met Phe Phe Gln Ala Val Ala Thr Phe Phe Ala Gly Phe Ile Val 195 200 205 Gly Phe Ile Arg Gly Trp Lys Leu Thr Leu Val Ile Met Ala Ile Ser 210 215 220 Pro Ile Leu Gly Leu Ser Ala Ala Val Trp Ala Lys Ile Leu Ser Ala 225 230 235 240 Phe Ser Asp Lys Glu Leu Ala Ala Tyr Ala Lys Ala Gly Ala Val Ala 245 250 255 Glu Glu Ala Leu Gly Ala Ile Arg Thr Val Ile Ala Phe Gly Gly Gln 260 265 270 Asn Lys Glu Leu Glu Arg Tyr Gln Lys His Leu Glu Asn Ala Lys Glu 275 280 285 Ile Gly Ile Lys Lys Ala Ile Ser Ala Asn Ile Ser Met Gly Ile Ala 290 295 300 Phe Leu Leu Ile Tyr Ala Ser Tyr Ala Leu Ala Phe Trp Tyr Gly Ser 305 310 315 320 Thr Leu Val Ile Ser Lys Glu Tyr Thr Ile Gly Asn Ala Met Thr Val 325 330 335 Phe Phe Ser Ile Leu Ile Gly Ala Phe Ser Val Gly Gln Ala Ala Pro 340 345 350 Cys Ile Asp Ala Phe Ala Asn Ala Arg Gly Ala Ala Tyr Val Ile Phe 355 360 365 Asp Ile Ile Asp Asn Asn Pro Lys Ile Asp Ser Phe Ser Glu Arg Gly 370 375 380 His Lys Pro Asp Ser Ile Lys Gly Asn Leu Glu Phe Asn Asp Val His 385 390 395 400 Phe Ser Tyr Pro Ser Arg Ala Asn Val Lys Ile Leu Lys Gly Leu Asn 405 410 415 Leu Lys Val Gln Ser Gly Gln Thr Val Ala Leu Val Gly Ser Ser Gly 420 425 430 Cys Gly Lys Ser Thr Thr Val Gln Leu Ile Gln Arg Leu Tyr Asp Pro 435 440 445 Asp Glu Gly Thr Ile Asn Ile Asp Gly Gln Asp Ile Arg Asn Phe Asn 450 455 460 Val Asn Tyr Leu Arg Glu Ile Ile Gly Val Val Ser Gln Glu Pro Val 465 470 475 480 Leu Phe Ser Thr Thr Ile Ala Glu Asn Ile Cys Tyr Gly Arg Gly Asn 485 490 495 Val Thr Met Asp Glu Ile Lys Lys Ala Val Lys Glu Ala Asn Ala Tyr 500 505 510 Glu Phe Ile Met Lys Leu Pro Gln Lys Phe Asp Thr Leu Val Gly Glu 515 520 525 Arg Gly Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala 530 535 540 Arg Ala Leu Val Arg Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr 545 550 555 560 Ser Ala Leu Asp Thr Glu Ser Glu Ala Glu Val Gln Ala Ala Leu Asp 565 570 575 Lys Ala Arg Glu Gly Arg Thr Thr Ile Val Ile Ala His Arg Leu Ser 580 585 590 Thr Val Arg Asn Ala Asp Val Ile Ala Gly Phe Glu Asp Gly Val Ile 595 600 605 Val Glu Gln Gly Ser His Ser Glu Leu Met Lys Lys Glu Gly Val Tyr 610 615 620 Phe Lys Leu Val Asn Met Gln Thr Ser Gly Ser Gln Ile Gln Ser Glu 625 630 635 640 Glu Phe Glu Leu Asn Asp Glu Lys Ala Ala Thr Arg Met Ala Pro Asn 645 650 655 Gly Trp Lys Ser Arg Leu Phe Arg His Ser Thr Gln Lys Asn Leu Lys 660 665 670 Asn Ser Gln Met Cys Gln Lys Ser Leu Asp Val Glu Thr Asp Gly Leu 675 680 685 Glu Ala Asn Val Pro Pro Val Ser Phe Leu Lys Val Leu Lys Leu Asn 690 695 700 Lys Thr Glu Trp Pro Tyr Phe Val Val Gly Thr Val Cys Ala Ile Ala 705 710 715 720 Asn Gly Gly Leu Gln Pro Ala Phe Ser Val Ile Phe Ser Glu Ile Ile 725 730 735 Ala Ile Phe Gly Pro Gly Asp Asp Ala Val Lys Gln Gln Lys Cys Asn 740 745 750 Ile Phe Ser Leu Ile Phe Leu Phe Leu Gly Ile Ile Ser Phe Phe Thr 755 760 765 Phe Phe Leu Gln Gly Phe Thr Phe Gly Lys Ala Gly Glu Ile Leu Thr 770 775 780 Arg Arg Leu Arg Ser Met Ala Phe Lys Ala Met Leu Arg Gln Asp Met 785 790 795 800 Ser Trp Phe Asp Asp His Lys Asn Ser Thr Gly Ala Leu Ser Thr Arg 805 810 815 Leu Ala Thr Asp Ala Ala Gln Val Gln Gly Ala Thr Gly Thr Arg Leu 820 825 830 Ala Leu Ile Ala Gln Asn Ile Ala Asn Leu Gly Thr Gly Ile Ile Ile 835 840 845 Ser Phe Ile Tyr Gly Trp Gln Leu Thr Leu Leu Leu Leu Ala Val Val 850 855 860 Pro Ile Ile Ala Val Ser Gly Ile Val Glu Met Lys Leu Leu Ala Gly 865 870 875 880 Asn Ala Lys Arg Asp Lys Lys Glu Leu Glu Ala Ala Gly Lys Ile Ala 885 890 895 Thr Glu Ala Ile Glu Asn Ile Arg Thr Val Val Ser Leu Thr Gln Glu 900 905 910 Arg Lys Phe Glu Ser Met Tyr Val Glu Lys Leu Tyr Gly Pro Tyr Arg 915 920 925 Asn Ser Val Gln Lys Ala His Ile Tyr Gly Ile Thr Phe Ser Ile Ser 930 935 940 Gln Ala Phe Met Tyr Phe Ser Tyr Ala Gly Cys Phe Arg Phe Gly Ala 945 950 955 960 Tyr Leu Ile Val Asn Gly His Met Arg Phe Arg Asp Val Ile Leu Val 965 970 975 Phe Ser Ala Ile Val Phe Gly Ala Val Ala Leu Gly His Ala Ser Ser 980 985 990 Phe Ala Pro Asp Tyr Ala Lys Ala Lys Leu Ser Ala Ala His Leu Phe 995 1000 1005 Met Leu Phe Glu Arg Gln Pro Leu Ile Asp Ser Tyr Ser Glu Glu Gly 1010 1015 1020 Leu Lys Pro Asp Lys Phe Glu Gly Asn Ile Thr Phe Asn Glu Val Val 1025 1030 1035 1040 Phe Asn Tyr Pro Thr Arg Ala Asn Val Pro Val Leu Gln Gly Leu Ser 1045 1050 1055 Leu Glu Val Lys Lys Gly Gln Thr Leu Ala Leu Val Gly Ser Ser Gly 1060 1065 1070 Cys Gly Lys Ser Thr Val Val Gln Leu Leu Glu Arg Phe Tyr Asp Pro 1075 1080 1085 Leu Ala Gly Thr Val Leu Leu Asp Gly Gln Glu Ala Lys Lys Leu Asn 1090 1095 1100 Val Gln Trp Leu Arg Ala Gln Leu Gly Ile Val Ser Gln Glu Pro Ile 1105 1110 1115 1120 Leu Phe Asp Cys Ser Ile Ala Glu Asn Ile Ala Tyr Gly Asp Asn Ser 1125 1130 1135 Arg Val Val Ser Gln Asp Glu Ile Val Ser Ala Ala Lys Ala Ala Asn 1140 1145 1150 Ile His Pro Phe Ile Glu Thr Leu Pro His Lys Tyr Glu Thr Arg Val 1155 1160 1165 Gly Asp Lys Gly Thr Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala 1170 1175 1180 Ile Ala Arg Ala Leu Ile Arg Gln Pro Gln Ile Leu Leu Leu Asp Glu 1185 1190 1195 1200 Ala Thr Ser Ala Leu Asp Thr Glu Ser Glu Lys Val Val Gln Glu Ala 1205 1210 1215 Leu Asp Lys Ala Arg Glu Gly Arg Thr Cys Ile Val Ile Ala His Arg 1220 1225 1230 Leu Ser Thr Ile Gln Asn Ala Asp Leu Ile Val Val Phe Gln Asn Gly 1235 1240 1245 Arg Val Lys Glu His Gly Thr His Gln Gln Leu Leu Ala Gln Lys Gly 1250 1255 1260 Ile Tyr Phe Ser Met Val Ser Val Gln Ala Gly Thr Gln Asn Leu 1265 1270 1275 <210> SEQ ID NO 82 <211> LENGTH: 1280 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 82 Met Asp Leu Glu Gly Asp Arg Asn Gly Gly Ala Lys Lys Lys Asn Phe 1 5 10 15 Phe Lys Leu Asn Asn Lys Ser Glu Lys Asp Lys Lys Glu Lys Lys Pro 20 25 30 Thr Val Ser Val Phe Ser Met Phe Arg Tyr Ser Asn Trp Leu Asp Lys 35 40 45 Leu Tyr Met Val Val Gly Thr Leu Ala Ala Ile Ile His Gly Ala Gly 50 55 60 Leu Pro Leu Met Met Leu Val Phe Gly Glu Met Thr Asp Ile Phe Ala 65 70 75 80 Asn Ala Gly Asn Leu Glu Asp Leu Met Ser Asn Ile Thr Asn Arg Ser 85 90 95 Asp Ile Asn Asp Thr Gly Phe Phe Met Asn Leu Glu Glu Asp Met Thr 100 105 110 Arg Tyr Ala Tyr Tyr Tyr Ser Gly Ile Gly Ala Gly Val Leu Val Ala 115 120 125 Ala Tyr Ile Gln Val Ser Phe Trp Cys Leu Ala Ala Gly Arg Gln Ile 130 135 140 His Lys Ile Arg Lys Gln Phe Phe His Ala Ile Met Arg Gln Glu Ile 145 150 155 160 Gly Trp Phe Asp Val His Asp Val Gly Glu Leu Asn Thr Arg Leu Thr 165 170 175 Asp Asp Val Ser Lys Ile Asn Glu Gly Ile Gly Asp Lys Ile Gly Met 180 185 190 Phe Phe Gln Ser Met Ala Thr Phe Phe Thr Gly Phe Ile Val Gly Phe 195 200 205 Thr Arg Gly Trp Lys Leu Thr Leu Val Ile Leu Ala Ile Ser Pro Val 210 215 220 Leu Gly Leu Ser Ala Ala Val Trp Ala Lys Ile Leu Ser Ser Phe Thr 225 230 235 240 Asp Lys Glu Leu Leu Ala Tyr Ala Lys Ala Gly Ala Val Ala Glu Glu 245 250 255 Val Leu Ala Ala Ile Arg Thr Val Ile Ala Phe Gly Gly Gln Lys Lys 260 265 270 Glu Leu Glu Arg Tyr Asn Lys Asn Leu Glu Glu Ala Lys Arg Ile Gly 275 280 285 Ile Lys Lys Ala Ile Thr Ala Asn Ile Ser Ile Gly Ala Ala Phe Leu 290 295 300 Leu Ile Tyr Ala Ser Tyr Ala Leu Ala Phe Trp Tyr Gly Thr Thr Leu 305 310 315 320 Val Leu Ser Gly Glu Tyr Ser Ile Gly Gln Val Leu Thr Val Phe Phe 325 330 335 Ser Val Leu Ile Gly Ala Phe Ser Val Gly Gln Ala Ser Pro Ser Ile 340 345 350 Glu Ala Phe Ala Asn Ala Arg Gly Ala Ala Tyr Glu Ile Phe Lys Ile 355 360 365 Ile Asp Asn Lys Pro Ser Ile Asp Ser Tyr Ser Lys Ser Gly His Lys 370 375 380 Pro Asp Asn Ile Lys Gly Asn Leu Glu Phe Arg Asn Val His Phe Ser 385 390 395 400 Tyr Pro Ser Arg Lys Glu Val Lys Ile Leu Lys Gly Leu Asn Leu Lys 405 410 415 Val Gln Ser Gly Gln Thr Val Ala Leu Val Gly Asn Ser Gly Cys Gly 420 425 430 Lys Ser Thr Thr Val Gln Leu Met Gln Arg Leu Tyr Asp Pro Thr Glu 435 440 445 Gly Met Val Ser Val Asp Gly Gln Asp Ile Arg Thr Ile Asn Val Arg 450 455 460 Phe Leu Arg Glu Ile Ile Gly Val Val Ser Gln Glu Pro Val Leu Phe 465 470 475 480 Ala Thr Thr Ile Ala Glu Asn Ile Arg Tyr Gly Arg Glu Asn Val Thr 485 490 495 Met Asp Glu Ile Glu Lys Ala Val Lys Glu Ala Asn Ala Tyr Asp Phe 500 505 510 Ile Met Lys Leu Pro His Lys Phe Asp Thr Leu Val Gly Glu Arg Gly 515 520 525 Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala Arg Ala 530 535 540 Leu Val Arg Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr Ser Ala 545 550 555 560 Leu Asp Thr Glu Ser Glu Ala Val Val Gln Val Ala Leu Asp Lys Ala 565 570 575 Arg Lys Gly Arg Thr Thr Ile Val Ile Ala His Arg Leu Ser Thr Val 580 585 590 Arg Asn Ala Asp Val Ile Ala Gly Phe Asp Asp Gly Val Ile Val Glu 595 600 605 Lys Gly Asn His Asp Glu Leu Met Lys Glu Lys Gly Ile Tyr Phe Lys 610 615 620 Leu Val Thr Met Gln Thr Ala Gly Asn Glu Val Glu Leu Glu Asn Ala 625 630 635 640 Ala Asp Glu Ser Lys Ser Glu Ile Asp Ala Leu Glu Met Ser Ser Asn 645 650 655 Asp Ser Arg Ser Ser Leu Ile Arg Lys Arg Ser Thr Arg Arg Ser Val 660 665 670 Arg Gly Ser Gln Ala Gln Asp Arg Lys Leu Ser Thr Lys Glu Ala Leu 675 680 685 Asp Glu Ser Ile Pro Pro Val Ser Phe Trp Arg Ile Met Lys Leu Asn 690 695 700 Leu Thr Glu Trp Pro Tyr Phe Val Val Gly Val Phe Cys Ala Ile Ile 705 710 715 720 Asn Gly Gly Leu Gln Pro Ala Phe Ala Ile Ile Phe Ser Lys Ile Ile 725 730 735 Gly Val Phe Thr Arg Ile Asp Asp Pro Glu Thr Lys Arg Gln Asn Ser 740 745 750 Asn Leu Phe Ser Leu Leu Phe Leu Ala Leu Gly Ile Ile Ser Phe Ile 755 760 765 Thr Phe Phe Leu Gln Gly Phe Thr Phe Gly Lys Ala Gly Glu Ile Leu 770 775 780 Thr Lys Arg Leu Arg Tyr Met Val Phe Arg Ser Met Leu Arg Gln Asp 785 790 795 800 Val Ser Trp Phe Asp Asp Pro Lys Asn Thr Thr Gly Ala Leu Thr Thr 805 810 815 Arg Leu Ala Asn Asp Ala Ala Gln Val Lys Gly Ala Ile Gly Ser Arg 820 825 830 Leu Ala Val Ile Thr Gln Asn Ile Ala Asn Leu Gly Thr Gly Ile Ile 835 840 845 Ile Ser Phe Ile Tyr Gly Trp Gln Leu Thr Leu Leu Leu Leu Ala Ile 850 855 860 Val Pro Ile Ile Ala Ile Ala Gly Val Val Glu Met Lys Met Leu Ser 865 870 875 880 Gly Gln Ala Leu Lys Asp Lys Lys Glu Leu Glu Gly Ser Gly Lys Ile 885 890 895 Ala Thr Glu Ala Ile Glu Asn Phe Arg Thr Val Val Ser Leu Thr Gln 900 905 910 Glu Gln Lys Phe Glu His Met Tyr Ala Gln Ser Leu Gln Val Pro Tyr 915 920 925 Arg Asn Ser Leu Arg Lys Ala His Ile Phe Gly Ile Thr Phe Ser Phe 930 935 940 Thr Gln Ala Met Met Tyr Phe Ser Tyr Ala Gly Cys Phe Arg Phe Gly 945 950 955 960 Ala Tyr Leu Val Ala His Lys Leu Met Ser Phe Glu Asp Val Leu Leu 965 970 975 Val Phe Ser Ala Val Val Phe Gly Ala Met Ala Val Gly Gln Val Ser 980 985 990 Ser Phe Ala Pro Asp Tyr Ala Lys Ala Lys Ile Ser Ala Ala His Ile 995 1000 1005 Ile Met Ile Ile Glu Lys Thr Pro Leu Ile Asp Ser Tyr Ser Thr Glu 1010 1015 1020 Gly Leu Met Pro Asn Thr Leu Glu Gly Asn Val Thr Phe Gly Glu Val 1025 1030 1035 1040 Val Phe Asn Tyr Pro Thr Arg Pro Asp Ile Pro Val Leu Gln Gly Leu 1045 1050 1055 Ser Leu Glu Val Lys Lys Gly Gln Thr Leu Ala Leu Val Gly Ser Ser 1060 1065 1070 Gly Cys Gly Lys Ser Thr Val Val Gln Leu Leu Glu Arg Phe Tyr Asp 1075 1080 1085 Pro Leu Ala Gly Lys Val Leu Leu Asp Gly Lys Glu Ile Lys Arg Leu 1090 1095 1100 Asn Val Gln Trp Leu Arg Ala His Leu Gly Ile Val Ser Gln Glu Pro 1105 1110 1115 1120 Ile Leu Phe Asp Cys Ser Ile Ala Glu Asn Ile Ala Tyr Gly Asp Asn 1125 1130 1135 Ser Arg Val Val Ser Gln Glu Glu Ile Val Arg Ala Ala Lys Glu Ala 1140 1145 1150 Asn Ile His Ala Phe Ile Glu Ser Leu Pro Asn Lys Tyr Ser Thr Lys 1155 1160 1165 Val Gly Asp Lys Gly Thr Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile 1170 1175 1180 Ala Ile Ala Arg Ala Leu Val Arg Gln Pro His Ile Leu Leu Leu Asp 1185 1190 1195 1200 Glu Ala Thr Ser Ala Leu Asp Thr Glu Ser Glu Lys Val Val Gln Glu 1205 1210 1215 Ala Leu Asp Lys Ala Arg Glu Gly Arg Thr Cys Ile Val Ile Ala His 1220 1225 1230 Arg Leu Ser Thr Ile Gln Asn Ala Asp Leu Ile Val Val Phe Gln Asn 1235 1240 1245 Gly Arg Val Lys Glu His Gly Thr His Gln Gln Leu Leu Ala Gln Lys 1250 1255 1260 Gly Ile Tyr Phe Ser Met Val Ser Val Gln Ala Gly Thr Lys Arg Gln 1265 1270 1275 1280 <210> SEQ ID NO 83 <211> LENGTH: 378 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 83 Met Leu Leu Thr Val Tyr Cys Val Arg Arg Asp Leu Ser Glu Val Thr 1 5 10 15 Phe Ser Leu Gln Val Asp Ala Asp Phe Glu Leu His Asn Phe Arg Ala 20 25 30 Leu Cys Glu Leu Glu Ser Gly Ile Pro Ala Ala Glu Ser Gln Ile Val 35 40 45 Tyr Ala Glu Arg Pro Leu Thr Asp Asn His Arg Ser Leu Ala Ser Tyr 50 55 60 Gly Leu Lys Asp Gly Asp Val Val Ile Leu Arg Gln Lys Glu Asn Ala 65 70 75 80 Asp Pro Arg Pro Pro Val Gln Phe Pro Asn Leu Pro Arg Ile Asp Phe 85 90 95 Ser Ser Ile Ala Val Pro Gly Thr Ser Ser Pro Arg Gln Arg Gln Pro 100 105 110 Pro Gly Thr Gln Gln Ser His Ser Ser Pro Gly Glu Ile Thr Ser Ser 115 120 125 Pro Gln Gly Leu Asp Asn Pro Ala Leu Leu Arg Asp Met Leu Leu Ala 130 135 140 Asn Pro His Glu Leu Ser Leu Leu Lys Glu Arg Asn Pro Pro Leu Ala 145 150 155 160 Glu Ala Leu Leu Ser Gly Asp Leu Glu Lys Phe Ser Arg Val Leu Val 165 170 175 Glu Gln Gln Gln Asp Arg Ala Arg Arg Glu Gln Glu Arg Ile Arg Leu 180 185 190 Phe Ser Ala Asp Pro Phe Asp Leu Glu Ala Gln Ala Lys Ile Glu Glu 195 200 205 Asp Ile Arg Gln Gln Asn Ile Glu Glu Asn Met Thr Ile Ala Met Glu 210 215 220 Glu Ala Pro Glu Ser Phe Gly Gln Val Val Met Leu Tyr Ile Asn Cys 225 230 235 240 Lys Val Asn Gly His Pro Val Lys Ala Phe Val Asp Ser Gly Ala Gln 245 250 255 Met Thr Ile Met Ser Gln Ala Cys Ala Glu Arg Cys Asn Ile Met Arg 260 265 270 Leu Val Asp Arg Arg Trp Ala Gly Ile Ala Lys Gly Val Gly Thr Gln 275 280 285 Lys Ile Ile Gly Arg Val His Leu Ala Gln Val Gln Ile Glu Gly Asp 290 295 300 Phe Leu Pro Cys Ser Phe Ser Ile Leu Glu Glu Gln Pro Met Asp Met 305 310 315 320 Leu Leu Gly Leu Asp Met Leu Lys Arg His Gln Cys Ser Ile Asp Leu 325 330 335 Lys Lys Asn Val Leu Val Ile Gly Thr Thr Gly Ser Gln Thr Thr Phe 340 345 350 Leu Pro Glu Gly Glu Leu Pro Glu Cys Ala Arg Leu Ala Tyr Gly Ala 355 360 365 Gly Arg Glu Asp Val Arg Pro Glu Glu Ile 370 375 <210> SEQ ID NO 84 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 84 Gln Thr Gly Pro Ser Val Thr Val Thr Cys Thr Glu Gly Lys Trp Asn 1 5 10 15 Lys Gln Cys Arg Ile Lys Cys Glu Asp Thr Ala Pro His Ala Val Leu 20 25 30 Pro Ser Gly Ser Glu Cys Ala Thr Ser Cys Leu Asp His Asn Ser Glu 35 40 45 Ser Ile Ile Leu Pro Met Asn Val Thr Val Arg Asp Ile Pro His Trp 50 55 60 Leu Asn Pro Thr Arg Val Glu Val Ser Asp Gln Gly His Leu 65 70 75 <210> SEQ ID NO 85 <211> LENGTH: 417 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 85 Met Ser Ala Thr Leu Ile Leu Glu Pro Pro Gly Arg Cys Cys Trp Asn 1 5 10 15 Glu Pro Val Arg Ile Ala Val Arg Gly Leu Ala Pro Glu Gln Arg Val 20 25 30 Thr Leu Arg Ala Ser Leu Arg Asp Glu Lys Gly Ala Leu Phe Arg Ala 35 40 45 His Ala Arg Tyr Cys Ala Asp Ala Arg Gly Glu Leu Asp Leu Glu Arg 50 55 60 Ala Pro Ala Leu Gly Gly Ser Phe Ala Gly Leu Glu Pro Met Gly Leu 65 70 75 80 Leu Trp Ala Leu Glu Pro Glu Lys Pro Phe Trp Arg Phe Leu Lys Arg 85 90 95 Asp Val Gln Ile Pro Phe Val Val Glu Leu Glu Val Leu Asp Gly His 100 105 110 Asp Pro Glu Pro Gly Arg Leu Leu Cys Gln Ala Gln His Glu Arg His 115 120 125 Phe Leu Pro Pro Gly Val Arg Arg Gln Ser Val Arg Ala Gly Arg Val 130 135 140 Arg Ala Thr Leu Phe Leu Pro Pro Gly Pro Gly Pro Phe Pro Gly Ile 145 150 155 160 Ile Asp Ile Phe Gly Ile Gly Gly Gly Leu Leu Glu Tyr Arg Ala Ser 165 170 175 Leu Leu Ala Gly His Gly Phe Ala Thr Leu Ala Leu Ala Tyr Tyr Asn 180 185 190 Phe Glu Asp Leu Pro Asn Asn Met Asp Asn Ile Ser Leu Glu Tyr Phe 195 200 205 Glu Glu Ala Val Cys Tyr Met Leu Gln His Pro Gln Val Lys Gly Pro 210 215 220 Gly Ile Gly Leu Leu Gly Ile Ser Leu Gly Ala Asp Ile Cys Leu Ser 225 230 235 240 Met Ala Ser Phe Leu Lys Asn Val Ser Ala Thr Val Ser Ile Asn Gly 245 250 255 Ser Gly Ile Ser Gly Asn Thr Ala Ile Asn Tyr Lys His Ser Ser Ile 260 265 270 Pro Pro Leu Gly Tyr Asp Leu Arg Arg Ile Lys Val Ala Phe Ser Gly 275 280 285 Leu Val Asp Ile Val Asp Ile Arg Asn Ala Leu Val Gly Gly Tyr Lys 290 295 300 Asn Pro Ser Met Ile Pro Ile Glu Lys Ala Gln Gly Pro Ile Leu Leu 305 310 315 320 Ile Val Gly Gln Asp Asp His Asn Trp Arg Ser Glu Leu Tyr Ala Gln 325 330 335 Thr Val Ser Glu Arg Leu Gln Ala His Gly Lys Glu Lys Pro Gln Ile 340 345 350 Ile Cys Tyr Pro Gly Thr Gly His Tyr Ile Glu Pro Pro Tyr Phe Pro 355 360 365 Leu Cys Pro Ala Ser Leu His Arg Leu Leu Asn Lys His Val Ile Trp 370 375 380 Gly Gly Glu Pro Arg Ala His Ser Lys Ala Gln Glu Asp Ala Trp Lys 385 390 395 400 Gln Ile Leu Ala Phe Phe Cys Lys His Leu Gly Gly Thr Gln Lys Thr 405 410 415 Ala <210> SEQ ID NO 86 <211> LENGTH: 1066 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION: (116)...(117) <223> OTHER INFORMATION: Xaa = Any Amino Acid <400> SEQUENCE: 86 Ile Leu His Gly Glu His Thr Leu Ser His Gln Asp Asn Phe Ser Pro 1 5 10 15 Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Ser Tyr Asp Leu Arg Gly 20 25 30 Ala Ala Ser Leu His Cys Thr Pro Gln Gly Asp Trp Ser Pro Glu Ala 35 40 45 Pro Arg Cys Thr Val Lys Ser Cys Asp Asp Phe Leu Gly Gln Leu Pro 50 55 60 His Gly Arg Val Leu Leu Pro Leu Asn Leu Gln Leu Gly Ala Lys Val 65 70 75 80 Ser Phe Val Cys Asp Glu Gly Phe Arg Leu Lys Gly Arg Ser Ala Ser 85 90 95 His Cys Val Leu Ala Gly Met Lys Ala Leu Trp Asn Ser Ser Val Pro 100 105 110 Val Cys Glu Xaa Xaa Met Ile Lys Thr Val Phe Leu Phe Phe Ser Leu 115 120 125 Pro Ile Ser Asn Asn Ala His Glu Asn Pro Lys Glu Val Ala Ile His 130 135 140 Leu His Ser Gln Gly Gly Ser Ser Val His Pro Arg Thr Leu Gln Thr 145 150 155 160 Asn Glu Glu Asn Ser Arg Tyr Ile His Thr Glu Phe Lys Met Phe Ser 165 170 175 Thr Thr Gln Ile Ser Lys Met Glu Thr Gly Leu Glu Tyr Asp Ile Ala 180 185 190 Leu Ala Asn Asn Glu Cys Lys Asn Ser Tyr Ser Leu Val Thr Arg Glu 195 200 205 Ile Phe Val Ile His Tyr Ile Asp Cys Ala Leu Pro Phe Pro Gly Ile 210 215 220 Ile Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Thr Ser Ile 225 230 235 240 Ser Arg Glu Tyr Phe His Tyr Gly Ser Val Val Thr Tyr His Cys Asn 245 250 255 Leu Gly Ser Arg Gly Lys Lys Val Phe Glu Leu Val Gly Glu Pro Ser 260 265 270 Ile Tyr Cys Thr Ser Lys Asp Asp Gln Val Gly Ile Trp Ser Gly Pro 275 280 285 Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu 290 295 300 Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu 305 310 315 320 Val Val Glu Phe Arg Cys Gln Pro Gly Phe Gly Met Lys Gly Pro Ser 325 330 335 His Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser 340 345 350 Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg 355 360 365 Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr 370 375 380 Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ser Thr Tyr Leu His Cys 385 390 395 400 Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Arg Cys Glu Val Lys 405 410 415 Ser Cys Asp Asp Phe Leu Gly Gln Leu Pro Asn Gly His Val Leu Phe 420 425 430 Pro Leu Asn Leu Gln Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu 435 440 445 Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly 450 455 460 Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys Glu Arg Val Thr 465 470 475 480 Phe Gln Ala Asn Leu Ser Pro Ser Ser Val Gln Tyr Leu Thr His Asp 485 490 495 Thr Leu Arg Thr Glu Glu Ser Ser Asp Tyr Ser Thr Trp Leu Gln Asn 500 505 510 Ile Phe Phe Pro Thr Gly Lys Ser Cys Glu Thr Pro Pro Val Pro Val 515 520 525 Asn Gly Met Val His Val Ile Thr Asp Ile His Val Gly Ser Arg Ile 530 535 540 Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser Ala 545 550 555 560 Glu Cys Ile Leu Ser Gly Asn Thr Ala His Trp Ser Met Lys Pro Pro 565 570 575 Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Asn Ile Thr Asn Gly 580 585 590 Tyr Phe Ile Ser Thr Asp Arg Glu Tyr Phe His Tyr Gly Ser Val Val 595 600 605 Thr Tyr His Cys Asn Leu Gly Ser Arg Gly Arg Lys Val Phe Glu Leu 610 615 620 Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Lys Asp Asp Gln Val Val 625 630 635 640 Val Trp Ser Gly Pro Val Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr 645 650 655 Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu 660 665 670 Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val 675 680 685 Met Lys Gly Pro His Arg Val Gln Cys Gln Ala Leu Asn Lys Trp Glu 690 695 700 Pro Glu Leu Pro Ser Cys Ser Arg Gly Tyr Ser Lys Arg Asn Ser Pro 705 710 715 720 Ile Thr Asn Lys Tyr Ser Gly Thr Val Leu Ser Thr Met Cys Gln Pro 725 730 735 Pro Pro Glu Ile Leu His Gly Glu His Thr Leu Ser His Gln Asp Asn 740 745 750 Phe Leu Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Ser Tyr Asp 755 760 765 Leu Arg Gly Ala Ala Ser Leu His Cys Met Pro Gln Gly Asp Trp Thr 770 775 780 Pro Glu Ala Pro Arg Cys Thr Gly Ala Ser Leu Ser Pro Ser His Gly 785 790 795 800 Ser Leu Thr Pro Val Val Leu Phe Phe Leu Leu Val Lys Ser Cys Asp 805 810 815 Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val Leu Phe Pro Leu Asn 820 825 830 Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys Asp Glu Gly Ser Ala 835 840 845 Ser His Cys Val Leu Ala Gly Thr Lys Ala Leu Trp Asn Ser Ser Val 850 855 860 Pro Val Cys Glu Gln Ile Phe Cys Pro Asn Pro Pro Ala Ile Leu Asn 865 870 875 880 Gly Arg His Thr Gly Thr Pro Pro Gly Asp Ile Pro Tyr Gly Lys Glu 885 890 895 Val Ser Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Met Thr Phe Asn 900 905 910 Leu Ile Gly Glu Ser Thr Ile Arg Arg Thr Ser Glu Pro His Gly Asn 915 920 925 Gly Val Trp Ser Ser Pro Ala Pro Arg Cys Glu Leu Pro Val Gly Ala 930 935 940 Asp Gln Cys Asn Val Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Asn 945 950 955 960 Leu Thr Asp Asp Phe Glu Phe Pro Ile Gly Thr Tyr Leu Asn Tyr Glu 965 970 975 Cys Arg Pro Gly Tyr Ser Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys 980 985 990 Asn Ser Val Trp Thr Ser Ala Lys Asp Lys Cys Lys Arg Lys Ser Cys 995 1000 1005 Arg Asn Pro Pro Asp Pro Val Asn Gly Met Ala His Val Ile Lys Asp 1010 1015 1020 Ile Gln Phe Arg Ser Gln Ile Lys Tyr Ser Cys Pro Lys Gly Tyr Arg 1025 1030 1035 1040 Leu Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asn Thr Val 1045 1050 1055 Ile Trp Asp Asn Lys Thr Pro Val Cys Asp 1060 1065 <210> SEQ ID NO 87 <211> LENGTH: 683 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 87 Ile Cys Cys Pro Asp Asp Pro Gln Pro Ala Lys Asp Gln Leu Ala Thr 1 5 10 15 Val Pro Lys Asp Ile Pro Leu Asp Cys Asp Cys Val Leu Thr Gly Glu 20 25 30 Asp Ile Leu Gly Glu Val Ala Asn Arg Thr Ala Gln Gly Leu Glu Gly 35 40 45 Leu Val Ser Asp Ser Ala Cys Thr Val Gly Thr Ile Asp Ala Glu Gln 50 55 60 Leu Ser Asp Thr Asp Ser Val Gln Met Phe Leu Glu Leu Glu Lys Glu 65 70 75 80 Cys Leu Cys Glu Glu Gly Val Thr Pro Leu Val Glu Leu Gln Asn Gln 85 90 95 Ile Ser Ser Glu Gly Leu Ala Ala Ser Gln Asp Ala Glu Asn Leu Leu 100 105 110 Val Ile Ser His Phe Ser Gly Ala Ala Leu Glu Lys Glu Gln His Leu 115 120 125 Gly Leu Leu His Val Arg Ala Lys Asp Tyr Asp Thr Arg Leu Asp Cys 130 135 140 Gly Tyr Phe Asn Thr Leu Asp Ser Ser Gln Val Pro Asn Ala Val Glu 145 150 155 160 Leu Ile Ala His Val Asp Ile Met Arg Asp Thr Ser Thr Val Ser Lys 165 170 175 Glu Glu Cys Glu Lys Val Pro Phe Ser Pro Arg Thr Ala Glu Phe Lys 180 185 190 Ser Arg Gln Pro Ala Asp Leu Asp Ser Leu Glu Lys Leu Asp Pro Gly 195 200 205 Gly Leu Leu Asn Ser Asp His Arg Val Ser His Glu Glu Lys Leu Ser 210 215 220 Gly Phe Ile Ala Ser Glu Leu Ala Lys Asp Asn Gly Ser Leu Ser Gln 225 230 235 240 Gly Asp Cys Ser Gln Thr Glu Gly Asn Gly Glu Glu Cys Ile Glu Arg 245 250 255 Val Thr Phe Ser Phe Ala Phe Asn His Glu Leu Thr Asp Val Thr Ser 260 265 270 Gly Pro Glu Val Glu Val Leu Tyr Glu Ser Asn Leu Leu Thr Asp Glu 275 280 285 Ile His Leu Glu Ser Gly Asn Val Thr Val Asn Gln Glu Asn Asn Ser 290 295 300 Leu Thr Ser Met Gly Asn Val Val Thr Cys Glu Leu Ser Val Glu Lys 305 310 315 320 Val Cys Asp Glu Asp Gly Glu Ala Lys Glu Leu Asp Tyr Gln Ala Thr 325 330 335 Leu Leu Glu Asp Gln Ala Pro Ala His Phe His Arg Asn Phe Pro Glu 340 345 350 Gln Val Phe Gln Asp Leu Gln Arg Lys Ser Pro Glu Ser Glu Ile Leu 355 360 365 Ser Leu His Leu Leu Val Glu Glu Leu Arg Leu Asn Pro Asp Gly Val 370 375 380 Glu Thr Val Asn Asp Thr Lys Pro Glu Leu Asn Val Ala Ser Ser Glu 385 390 395 400 Gly Gly Glu Met Glu Arg Arg Asp Ser Asp Ser Phe Leu Asn Ile Phe 405 410 415 Pro Glu Lys Gln Val Thr Lys Ala Gly Asn Thr Glu Pro Val Leu Glu 420 425 430 Glu Trp Ile Pro Val Leu Gln Arg Pro Ser Arg Thr Ala Ala Val Pro 435 440 445 Thr Val Lys Asp Ala Leu Asp Ala Ala Leu Pro Ser Pro Glu Glu Gly 450 455 460 Thr Ser Ile Ala Ala Val Pro Ala Pro Glu Gly Thr Ala Val Val Ala 465 470 475 480 Ala Leu Val Pro Phe Pro His Glu Asp Ile Leu Val Ala Ser Ile Val 485 490 495 Ser Leu Glu Glu Glu Asp Val Thr Ala Ala Ala Val Ser Ala Pro Glu 500 505 510 Arg Ala Thr Val Pro Ala Val Thr Val Ser Val Pro Glu Gly Thr Ala 515 520 525 Ala Val Ala Ala Val Ser Ser Pro Glu Glu Thr Ala Pro Ala Val Ala 530 535 540 Ala Ala Ile Thr Gln Glu Gly Met Ser Ala Val Ala Gly Phe Ser Pro 545 550 555 560 Glu Trp Ala Ala Leu Ala Val Thr Val Pro Ile Thr Glu Glu Asp Ala 565 570 575 Ala Ala Val Pro Thr Pro Glu Val Ala Ala Ile Pro Ala Ala Ser Val 580 585 590 Pro Thr Pro Glu Val Pro Ala Ile Pro Ala Ala Ala Val Pro Pro Met 595 600 605 Glu Glu Val Ser Pro Ile Gly Val Pro Phe Leu Gly Val Ser Ala His 610 615 620 Thr Asp Ser Val Pro Ile Ser Glu Glu Gly Thr Pro Val Leu Glu Glu 625 630 635 640 Ala Ser Ser Thr Gly Met Trp Ile Lys Glu Asp Leu Asp Ser Leu Val 645 650 655 Phe Gly Ile Lys Glu Val Thr Ser Thr Val Leu His Gly Lys Val Pro 660 665 670 Leu Ala Ala Thr Ala Gly Leu Asn Ser Asp Glu 675 680 <210> SEQ ID NO 88 <211> LENGTH: 174 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 88 Ser Glu Gly Asn Lys Arg Arg Leu Ser Thr Ala Ile Ala Leu Met Gly 1 5 10 15 Arg Ser Ser Val Ile Phe Leu Asp Glu Pro Ser Thr Gly Met Asp Pro 20 25 30 Val Ala Arg Arg Leu Leu Trp Asn Met Val Thr Lys Thr Arg Glu Ser 35 40 45 Gly Lys Ala Ile Val Met Thr Ser His Ser Met Glu Glu Cys Asp Ala 50 55 60 Leu Cys Thr Ser Leu Ala Ile Met Val Gln Gly Lys Phe Thr Cys Leu 65 70 75 80 Gly Ser Pro Gln His Leu Lys Ser Lys Phe Gly Asn Ile Tyr Ile Leu 85 90 95 Lys Val Lys Val Lys Thr Glu Asp Lys Leu Glu Asp Phe Lys Cys Tyr 100 105 110 Val Ala Thr Thr Phe Pro Gly Glu Ile Ala Met Val Thr Val Phe Leu 115 120 125 Leu Leu Leu Leu Lys Val Phe Gly Ile Leu Glu Glu Ala Lys Glu Gln 130 135 140 Phe Asp Leu Glu Asp Tyr Ser Val Ser Gln Ile Thr Leu Glu Gln Val 145 150 155 160 Phe Leu Thr Phe Ala Asn Pro Glu Lys Ala Ser Ser Asp Asp 165 170 <210> SEQ ID NO 89 <211> LENGTH: 124 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 89 Asp Cys Gly Pro Pro Pro Glu Leu Pro Phe Ala Phe Pro Ile Asn Pro 1 5 10 15 Leu Tyr Asp Thr Glu Phe Lys Thr Gly Thr Thr Leu Lys Tyr Thr Cys 20 25 30 His Pro Gly His Gly Lys Ile Asn Ser Ser Arg Leu Ile Cys Asp Ala 35 40 45 Lys Asp Ser Trp Asn Tyr Ser Ile Phe Cys Ala Ile Ala Lys Cys Glu 50 55 60 Pro Pro Pro Asp Ile Arg Asn Gly Lys His Ser Gly Gly Asp Gln Glu 65 70 75 80 Phe Tyr Thr Tyr Ala Ser Ser Val Thr Tyr Ser Cys Asn Pro Tyr Phe 85 90 95 Ser Leu Ile Gly Asn Val Ser Ile Ser Cys Thr Val Glu Asn Glu Thr 100 105 110 Ile Gly Val Trp Ser Pro Asn Pro Pro Ile Cys Glu 115 120 <210> SEQ ID NO 90 <211> LENGTH: 294 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 90 Ile Ser Lys Asp Arg Lys Glu Arg Val His Gln Gly Met Val Arg Ala 1 5 10 15 Ala Thr Val Gly Tyr Gly Ile Leu Arg Glu Gly Gly Ser Ala Val Asp 20 25 30 Ala Val Glu Gly Ala Val Val Ala Leu Glu Asp Asp Pro Glu Phe Asn 35 40 45 Ala Gly Cys Gly Ser Val Leu Asn Thr Asn Gly Glu Val Glu Met Asp 50 55 60 Ala Ser Ile Met Asp Gly Lys Asp Leu Ser Ala Gly Ala Val Ser Ala 65 70 75 80 Val Gln Cys Ile Ala Asn Pro Ile Lys Leu Ala Arg Leu Val Met Glu 85 90 95 Lys Thr Pro His Cys Phe Leu Thr Asp Gln Gly Ala Ala Gln Phe Ala 100 105 110 Ala Ala Met Gly Val Pro Glu Ile Pro Gly Glu Lys Leu Val Thr Glu 115 120 125 Arg Asn Lys Lys Arg Leu Glu Lys Glu Lys His Glu Lys Gly Ala Gln 130 135 140 Lys Thr Asp Cys Gln Lys Asn Leu Gly Thr Val Gly Ala Val Ala Leu 145 150 155 160 Asp Cys Lys Gly Asn Val Ala Tyr Ala Thr Ser Thr Gly Gly Ile Val 165 170 175 Asn Lys Met Val Gly Arg Val Gly Asp Ser Pro Cys Leu Gly Ala Gly 180 185 190 Gly Tyr Ala Asp Asn Asp Ile Gly Ala Val Ser Thr Thr Gly His Gly 195 200 205 Glu Ser Ile Leu Lys Val Asn Leu Ala Arg Leu Thr Leu Phe His Ile 210 215 220 Glu Gln Gly Lys Thr Val Glu Glu Ala Ala Asp Leu Ser Leu Gly Tyr 225 230 235 240 Met Lys Ser Arg Val Lys Gly Leu Gly Gly Leu Ile Val Val Ser Lys 245 250 255 Thr Gly Asp Trp Val Ala Lys Trp Thr Ser Thr Ser Met Pro Trp Ala 260 265 270 Ala Ala Lys Asp Gly Lys Leu His Phe Gly Ile Asp Pro Asp Asp Thr 275 280 285 Thr Ile Thr Asp Leu Pro 290 <210> SEQ ID NO 91 <211> LENGTH: 467 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 91 Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys Asp Glu Gly Phe Arg 1 5 10 15 Leu Lys Gly Arg Ser Ala Ser His Cys Val Leu Ala Gly Met Lys Ala 20 25 30 Leu Trp Asn Ser Ser Val Pro Val Cys Glu Arg Ile Ile Cys Gly Leu 35 40 45 Pro Pro Thr Ile Ala Asn Gly Asp Phe Thr Ser Ile Ser Arg Glu Tyr 50 55 60 Phe His Tyr Gly Ser Val Val Thr Tyr His Cys Asn Leu Gly Ser Arg 65 70 75 80 Gly Lys Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr 85 90 95 Ser Lys Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys 100 105 110 Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile Leu 115 120 125 Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu Phe 130 135 140 Arg Cys Gln Pro Gly Phe Gly Met Lys Gly Pro Ser His Val Lys Cys 145 150 155 160 Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg Val 165 170 175 Cys Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg Asp 180 185 190 Lys Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro 195 200 205 Gly Tyr Asp Leu Arg Gly Ser Thr Tyr Leu His Cys Thr Pro Gln Gly 210 215 220 Asp Trp Ser Pro Ala Ala Pro Arg Cys Glu Val Lys Ser Cys Asp Asp 225 230 235 240 Phe Leu Gly Gln Leu Pro Asn Gly His Val Leu Phe Pro Leu Asn Leu 245 250 255 Gln Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln Leu 260 265 270 Lys Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser Leu 275 280 285 Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Asn Pro 290 295 300 Pro Ala Ile Leu Asn Gly Arg His Thr Gly Thr Pro Pro Gly Asp Ile 305 310 315 320 Pro Tyr Gly Lys Glu Val Ser Tyr Thr Cys Asp Pro His Pro Asp Arg 325 330 335 Gly Met Thr Phe Asn Leu Ile Gly Glu Ser Thr Ile Arg Arg Thr Ser 340 345 350 Glu Pro His Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys Glu 355 360 365 Leu Pro Val Gly Ala Asp Gln Cys Asn Val Pro Glu Trp Leu Pro Phe 370 375 380 Ala Arg Pro Thr Asn Leu Thr Asp Asp Phe Glu Phe Pro Ile Gly Thr 385 390 395 400 Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg Pro Phe Ser 405 410 415 Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Ser Ala Lys Asp Lys Cys 420 425 430 Lys Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn Gly Met Ala 435 440 445 His Val Ile Lys Asp Ile Gln Phe Arg Ser Gln Ile Lys Tyr Ser Cys 450 455 460 Pro Lys Gly 465 <210> SEQ ID NO 92 <211> LENGTH: 446 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 92 His Gly Arg Val Leu Leu Pro Leu Asn Leu Gln Leu Gly Ala Lys Val 1 5 10 15 Ser Phe Val Cys Asp Glu Gly Phe Arg Leu Lys Gly Arg Ser Ala Ser 20 25 30 His Cys Val Leu Ala Gly Met Lys Ala Leu Trp Asn Ser Ser Val Pro 35 40 45 Val Cys Glu Arg Ile Ile Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly 50 55 60 Asp Phe Thr Ser Ile Ser Arg Glu Tyr Phe His Tyr Gly Ser Val Val 65 70 75 80 Thr Tyr His Cys Asn Leu Gly Ser Arg Gly Lys Lys Val Phe Glu Leu 85 90 95 Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Lys Asp Asp Gln Val Gly 100 105 110 Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr 115 120 125 Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu 130 135 140 Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Gly 145 150 155 160 Met Lys Gly Pro Ser His Val Lys Cys Gln Ala Leu Asn Lys Trp Glu 165 170 175 Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val 180 185 190 Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly 195 200 205 Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ser 210 215 220 Thr Tyr Leu His Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro 225 230 235 240 Arg Cys Glu Val Lys Ser Cys Asp Asp Phe Leu Gly Gln Leu Pro Asn 245 250 255 Gly His Val Leu Phe Pro Leu Asn Leu Gln Leu Gly Ala Lys Val Asp 260 265 270 Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr 275 280 285 Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val 290 295 300 Cys Glu Gln Ile Phe Cys Pro Asn Pro Pro Ala Ile Leu Asn Gly Arg 305 310 315 320 His Thr Gly Thr Pro Pro Gly Asp Ile Pro Tyr Gly Lys Glu Val Ser 325 330 335 Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Met Thr Phe Asn Leu Ile 340 345 350 Gly Glu Ser Thr Ile Arg Arg Thr Ser Glu Pro His Gly Asn Gly Val 355 360 365 Trp Ser Ser Pro Ala Pro Arg Cys Glu Leu Pro Val Gly Ala Gly Gln 370 375 380 Tyr Pro Leu Pro His Ile Leu Asn Gly Phe Arg Ile Cys Ser Glu Val 385 390 395 400 Glu Val Phe Glu Tyr Leu Asn Ala Val Thr Asp Ser Cys Asp Pro Ala 405 410 415 Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile Tyr Cys 420 425 430 Gly Asp Asn Ser Val Trp Asn His Ala Ala Pro Glu Cys Lys 435 440 445 

1. A method of cleaving a peptide bond in a desired protein comprising contacting the desired protein with a protease comprising a sequence selected from the group consisting of SEQ ID NOs. 1-92, under conditions wherein the protease hydrolyzes at least one peptide bond in the desired protein.
 2. A method for identifying a compound that modulates the activity of a protease comprising: (a) contacting a protease having an amino acid sequence selected from the group consisting SEQ ID NOs. 1-92, or a functional fragment or variant thereof, with a test compound; (b) measuring the activity of the protease before and after the contacting step; and (c) determining whether the test compound modulates the activity of the protease.
 3. The method according to claim 2, wherein step (c) comprises measuring the level of proteolytic activity or hydrolytic activity.
 4. The method according to claim 2, wherein step (c) comprises measuring the amount of product generated from cleavage of a substrate by the protease.
 5. The method according to claim 2, wherein the test compound is an inhibitor of proteolytic function of the protease.
 6. A method for identifying a compound that modulates the activity of a protease in a cell comprising: (a) expressing, in a cell, a protease having an amino acid sequence selected from the group consisting SEQ ID NOs 1-92; (b) exposing the cell to a test compound; and (c) monitoring an alteration in cell phenotype or proteolytic activity.
 7. A method for treating a disease or disorder by administering to a patient in need of such treatment a compound that modulates the activity of a protease having an amino acid sequence selected from the group consisting of SEQ ID NOs 1-92.
 8. The method according to claim 7, wherein the patient is a mammal.
 9. The method according to claim 7, wherein the mammal is selected from the group consisting of a human, primate, rat, mouse, rabbit, pig, cattle, sheep, goat, cat and dog.
 10. The method according to claim 9, wherein the mammal is a human.
 11. The method according to claim 7, wherein the disease or disorder is selected from the group consisting of cancers, immune-related diseases and disorders, cardiovascular disease, brain or neuronal-associated diseases, and metabolic disorders.
 12. The method according to claim 11, wherein said disease or disorders are cancers.
 13. The method according to claim 12, wherein the cancers involve at least one gene selected from the group consisting of: GD2, Lewis-Y, 72 kd glycoprotein, CO17-1A, TAG-72, CSAg-P, 45kd glycoprotein, HT-29 ag, NG2, A33, 38kd gp, MUC-1, CEA, EGFR, HER2, HER3, HER4, HN-1 ligand, CA125, Syndecan-1, Lewis-X, PgP, FAP, EDG Receptors, ED-B, Laminin-5, Cox-2, AlphaVbeta3 integrin, AlphaVbeta5 integrin, uPAR, Endoglin and the Folate receptor osteopontin.
 14. The method according to claim 13, wherein the gene is at least one of CEA, TAG72, EDB, FAP, AlphaVbeta3 integrin and AlphaVbeta5 integrin.
 15. The method according to claim 12, wherein said cancers are cancers of tissues or cancers of hematopoietic origin
 16. The method according to claim 7, wherein the compound modulates protease activity in vitro.
 17. A method for treating a disease or disorder, comprising administering to a patient in need of such treatment a pharmaceutical composition comprising a protease having an amino acid sequence selected from the group consisting of SEQ ID NOs 1-92.
 18. A method for detection of a protease in a sample as a diagnostic tool for a disease or disorder, comprising (a) contacting the sample with a nucleic acid probe which hybridizes under hybridization assay conditions to a nucleic acid target, the target encoding a protease having an amino acid sequence selected from the group consisting of SEQ ID NOs 1-92, or fragments thereof, or the complements of the sequences and fragments thereof; and (b) detecting the presence or amount of the probe:target region hybrid as an indication of the disease.
 19. A method for detection of a protease in a sample as a diagnostic tool for a disease or disorder, comprising: (a) comparing a nucleic acid target region encoding a protease in a sample, wherein the protease has an amino acid sequence selected from the group consisting of SEQ ID NOs 1-92 or one or more fragments thereof, with a control nucleic acid target region encoding the protease polypeptide, or one or more fragments thereof; and (b) detecting differences in nucleotide or predicted amino acid sequence or amount between the target region and the control target region, as an indication of said disease or disorder.
 20. An antibody that binds to a part of a protein comprising the sequence described in any one of SEQ ID NOs. 1-92. 